CN111295188A - 调节毛发生长的组合物和方法 - Google Patents

调节毛发生长的组合物和方法 Download PDF

Info

Publication number
CN111295188A
CN111295188A CN201880063141.4A CN201880063141A CN111295188A CN 111295188 A CN111295188 A CN 111295188A CN 201880063141 A CN201880063141 A CN 201880063141A CN 111295188 A CN111295188 A CN 111295188A
Authority
CN
China
Prior art keywords
acid
electron transport
transport chain
pharmaceutical composition
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880063141.4A
Other languages
English (en)
Chinese (zh)
Inventor
W·E·劳瑞
H·R·克里斯托夫
M·米兰达
A·弗洛雷斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN111295188A publication Critical patent/CN111295188A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pain & Pain Management (AREA)
CN201880063141.4A 2017-09-29 2018-09-28 调节毛发生长的组合物和方法 Pending CN111295188A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566031P 2017-09-29 2017-09-29
US62/566,031 2017-09-29
PCT/US2018/053351 WO2019067860A1 (en) 2017-09-29 2018-09-28 COMPOSITIONS AND METHODS FOR MODULATION OF HAIR GROWTH

Publications (1)

Publication Number Publication Date
CN111295188A true CN111295188A (zh) 2020-06-16

Family

ID=65903207

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880063141.4A Pending CN111295188A (zh) 2017-09-29 2018-09-28 调节毛发生长的组合物和方法

Country Status (16)

Country Link
US (1) US20200253917A1 (enExample)
EP (1) EP3687528A4 (enExample)
JP (1) JP2020536048A (enExample)
KR (1) KR20200062242A (enExample)
CN (1) CN111295188A (enExample)
AU (1) AU2018339064A1 (enExample)
BR (1) BR112020003349A2 (enExample)
CA (1) CA3077359A1 (enExample)
CL (1) CL2020000676A1 (enExample)
EA (1) EA202090855A1 (enExample)
IL (1) IL272827A (enExample)
MX (1) MX2020002389A (enExample)
PE (1) PE20210464A1 (enExample)
PH (1) PH12020500300A1 (enExample)
SG (2) SG11202001516QA (enExample)
WO (1) WO2019067860A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113694063A (zh) * 2021-08-31 2021-11-26 佛山市第一人民医院（中山大学附属佛山医院） 一种组合物及其应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110300583A (zh) 2017-02-24 2019-10-01 加利福尼亚大学董事会 利用mpc1抑制剂促进毛发生长的组合物和方法
KR20250151619A (ko) 2017-06-30 2025-10-21 더 리전트 오브 더 유니버시티 오브 캘리포니아 모발 성장을 조절하기 위한 조성물 및 방법
KR102561912B1 (ko) * 2021-04-09 2023-07-31 차의과학대학교 산학협력단 세팔로틴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 탈모방지 또는 발모촉진용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000057A1 (en) * 1990-06-26 1992-01-09 Janssen Pharmaceutica N.V. Method of treating alopecia
WO2001062237A2 (en) * 2000-02-23 2001-08-30 Orentreich Foundation For The Advancement Of Science, Inc. Compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus
US20090269418A1 (en) * 2004-09-17 2009-10-29 Biomas Ltd Compositions and Methods for Inducing Hair Growth
US20100305187A1 (en) * 2007-09-05 2010-12-02 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Methods and compounds for treating diseases caused by reactive oxygen species

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099396A2 (en) * 2005-06-07 2007-09-07 Foamix Ltd. Antibiotic kit and composition and uses thereof
US8343962B2 (en) * 2006-03-06 2013-01-01 Nuvo Research Inc. Topical formulation
US9308181B2 (en) * 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
JP2014500275A (ja) * 2010-12-06 2014-01-09 フォリカ，インコーポレイテッド 禿頭症を治療するため、および毛髪の成長を促進するための方法
CN106880693A (zh) * 2017-03-22 2017-06-23 广州国草夏方生物科技有限公司 一种治疗脂溢性脱发的生发液组合物及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000057A1 (en) * 1990-06-26 1992-01-09 Janssen Pharmaceutica N.V. Method of treating alopecia
WO2001062237A2 (en) * 2000-02-23 2001-08-30 Orentreich Foundation For The Advancement Of Science, Inc. Compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus
US20090269418A1 (en) * 2004-09-17 2009-10-29 Biomas Ltd Compositions and Methods for Inducing Hair Growth
US20100305187A1 (en) * 2007-09-05 2010-12-02 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Methods and compounds for treating diseases caused by reactive oxygen species

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THOMAS E HICKEY ET AL.: "Demodectic mange in a tamarin (Saguinus geoffroyi)", 《LABORATORY ANIMAL SCIENCE》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113694063A (zh) * 2021-08-31 2021-11-26 佛山市第一人民医院（中山大学附属佛山医院） 一种组合物及其应用

Also Published As

Publication number Publication date
PH12020500300A1 (en) 2020-11-09
EA202090855A1 (ru) 2020-06-26
SG11202001516QA (en) 2020-03-30
US20200253917A1 (en) 2020-08-13
MX2020002389A (es) 2020-10-01
CA3077359A1 (en) 2019-04-04
WO2019067860A1 (en) 2019-04-04
BR112020003349A2 (pt) 2020-08-18
IL272827A (en) 2020-04-30
SG10202109849SA (en) 2021-10-28
JP2020536048A (ja) 2020-12-10
CL2020000676A1 (es) 2020-09-25
AU2018339064A1 (en) 2020-02-27
EP3687528A1 (en) 2020-08-05
PE20210464A1 (es) 2021-03-08
EP3687528A4 (en) 2021-07-21
KR20200062242A (ko) 2020-06-03

Similar Documents

Publication Publication Date Title
US20230190736A1 (en) Small molecule therapeutics for the treatment of viral infections
JP2023040211A (ja) トレハロースの非経口投与によるタンパク質凝集ミオパシーおよび神経変性疾患の治療
CN111295188A (zh) 调节毛发生长的组合物和方法
CN102470124B (zh) 细胞保护剂
TW200916101A (en) Telomerase activating compounds and methods of use thereof
WO1998015267A1 (en) Method for the treatment of neurological or neuropsychiatric disorders
US20230414550A1 (en) Combination of kynurenine and antigen presenting cells (apc) as therapeutics and methods for their use in immune modulation
CN105072909A (zh) 应用控制食欲不振的化合物的组合物和方法
US20120164242A1 (en) Novel methods for modulating melanin production
US20210128596A1 (en) Compositions and methods for treating septic cardiomyopathy
HK40026046A (en) Compositions and methods for modulating hair growth
US20230040125A1 (en) Targeting the intrinsic apoptotic machinery in glioblastoma
CN110769855A (zh) 用于治疗视网膜病变的组合物和方法
CN111032035A (zh) 用于替司他赛和卡培他滨的给药方案
CN119698284A (zh) 用于治疗X-ALD的甲状腺β激动剂给药方案
CN106507666A9 (zh) 1，3‑丙二磺酸或其药学上可接受的盐用于治疗肉样瘤病的用途
WO2025166338A2 (en) Systemic mpc inhibition to reverse signs of aging
RU2804771C1 (ru) Комплексное антиангиогенное и гипоксия-ориентированное противоопухолевое средство
US12274686B2 (en) Specialized pro-resolving mediators (SPMs) as melanocyte growth promoter and pro-survival factors and uses thereof
US11464762B2 (en) Carcinogenesis inhibitor
WO2023239842A1 (en) Beta carbolines as topical anti-inflammatory agents for application to mucous membranes
JP2025527861A (ja) チオストレプトン投薬レジメン
CN120168445A (zh) 化合物aj-091在制备系统性硬化症治疗药物中的应用
US20210030714A1 (en) Compounds for use in the treatment of brain diseases
KR20030021955A (ko) 피토스핑고신 유도체를 유효 성분으로 포함하는 방사선치료 증진제

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40026046

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200616