|
US5244792A
(en)
|
1984-04-06 |
1993-09-14 |
Chiron Corporation |
Expression of recombinant glyoprotein B from herpes simplex virus
|
|
JPH0668B2
(ja)
|
1985-08-30 |
1994-01-05 |
財団法人化学及血清療法研究所 |
単純ヘルペスウイルス遺伝子が組込まれた組換えプラスミド
|
|
GB8918616D0
(en)
|
1989-08-15 |
1989-09-27 |
Univ Glasgow |
Herpes simplex virus type 1 mutant
|
|
US5725871A
(en)
|
1989-08-18 |
1998-03-10 |
Danbiosyst Uk Limited |
Drug delivery compositions comprising lysophosphoglycerolipid
|
|
US5707644A
(en)
|
1989-11-04 |
1998-01-13 |
Danbiosyst Uk Limited |
Small particle compositions for intranasal drug delivery
|
|
US5466468A
(en)
|
1990-04-03 |
1995-11-14 |
Ciba-Geigy Corporation |
Parenterally administrable liposome formulation comprising synthetic lipids
|
|
US5849571A
(en)
|
1990-10-10 |
1998-12-15 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Latency active herpes virus promoters and their use
|
|
US5849572A
(en)
|
1990-10-10 |
1998-12-15 |
Regents Of The University Of Michigan |
HSV-1 vector containing a lat promoter
|
|
US5399363A
(en)
|
1991-01-25 |
1995-03-21 |
Eastman Kodak Company |
Surface modified anticancer nanoparticles
|
|
US5756353A
(en)
|
1991-12-17 |
1998-05-26 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol-and liposome-based delivery
|
|
ES2105262T3
(es)
|
1992-05-18 |
1997-10-16 |
Minnesota Mining & Mfg |
Dispositivo de suministro de farmaco a traves de las mucosas.
|
|
US5879934A
(en)
|
1992-07-31 |
1999-03-09 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Herpes simplex virus strains for gene transfer
|
|
US5658724A
(en)
|
1992-07-31 |
1997-08-19 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Herpes simplex virus strains deficient for the essential immediate early genes ICP4 and ICP27 and methods for their production, growth and use
|
|
US5804413A
(en)
|
1992-07-31 |
1998-09-08 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Herpes simplex virus strains for gene transfer
|
|
US5543158A
(en)
|
1993-07-23 |
1996-08-06 |
Massachusetts Institute Of Technology |
Biodegradable injectable nanoparticles
|
|
GB9415369D0
(en)
|
1994-07-29 |
1994-09-21 |
Lynxvale Ltd |
Mutant virus
|
|
GB9415319D0
(en)
|
1994-07-29 |
1994-09-21 |
Medical Res Council |
HSV viral vector
|
|
IE80468B1
(en)
|
1995-04-04 |
1998-07-29 |
Elan Corp Plc |
Controlled release biodegradable nanoparticles containing insulin
|
|
US6261552B1
(en)
|
1997-05-22 |
2001-07-17 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Herpes simplex virus vectors
|
|
GB9700411D0
(en)
|
1997-01-10 |
1997-02-26 |
Univ London |
Eukaryotic gene expression cassette and uses thereof
|
|
US6071742A
(en)
|
1997-03-05 |
2000-06-06 |
Board Of Regents Of The University Of Nebraska |
Coxsackie virus as a vector for delivery of anti-inflammatory cytokines
|
|
US5998174A
(en)
|
1997-05-12 |
1999-12-07 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Multigene vectors
|
|
AU8605598A
(en)
|
1997-07-31 |
1999-02-22 |
University Of Pittsburgh |
Targeted hsv vectors
|
|
CA2315251A1
(en)
|
1997-12-17 |
1999-06-24 |
Immunex Corporation |
Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides
|
|
GB9810423D0
(en)
|
1998-05-15 |
1998-07-15 |
Cancer Res Campaign Tech |
Ionizing radiation or diathermy-switched gene therapy vectors and their use in antitumour therapy
|
|
EP1002864A1
(en)
|
1998-11-10 |
2000-05-24 |
Universita' degli studi di Bologna |
HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections
|
|
US6897057B1
(en)
|
1999-08-31 |
2005-05-24 |
The General Hospital Corporation |
Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
|
|
GB9930418D0
(en)
|
1999-12-22 |
2000-02-16 |
Neurovex Ltd |
Replication incompetent herpes virus vectors
|
|
EP1381280B1
(en)
|
2001-03-27 |
2011-05-11 |
Catherex, Inc. |
Viral vectors and their use in therapeutic methods
|
|
WO2002088327A1
(en)
|
2001-04-06 |
2002-11-07 |
Mount Sinai School Of Medicine Of New York University |
Methods for viral oncoapoptosis in cancer therapy
|
|
DE60232742D1
(de)
|
2001-10-04 |
2009-08-06 |
Immunex Corp |
Ul16-bindungsprotein 4
|
|
KR100900249B1
(ko)
|
2001-12-07 |
2009-05-29 |
포항공과대학교 산학협력단 |
SIVmac239의 면역원성 플라스미드 및 이들을 함유한AIDS DNA 백신
|
|
CA2476724A1
(en)
|
2002-03-01 |
2003-09-12 |
Sloan-Kettering Institute For Cancer Research |
Prevention of recurrence and metastasis of cancer
|
|
US8927251B2
(en)
|
2002-10-07 |
2015-01-06 |
The University Of Chicago |
Targeting of herpes simplex virus to specific receptors
|
|
CN1934260B
(zh)
|
2004-01-22 |
2013-03-13 |
株式会社载体研究所 |
利用含有巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子制造负链RNA病毒载体的方法
|
|
GB0406389D0
(en)
|
2004-03-22 |
2004-04-21 |
Istituto Superiore Di Sanito |
Recombinant herpes simplex virus and uses therefor
|
|
US7473418B2
(en)
|
2004-03-25 |
2009-01-06 |
Cell Genesys, Inc. |
Pan cancer oncolytic vectors and methods of use thereof
|
|
KR101295733B1
(ko)
|
2004-08-20 |
2013-08-13 |
비랄리틱스 리미티드 |
혈액암의 치료방법 및 조성물
|
|
AU2005302408B2
(en)
|
2004-10-28 |
2012-08-09 |
The Government of the United States of America as represented by the Department of Veterans Affairs |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
|
|
EP1843773A4
(en)
|
2005-01-17 |
2008-07-30 |
Viralytics Ltd |
METHOD AND COMPOSITION FOR TREATING NEOPLASIA
|
|
CA2609142C
(en)
*
|
2005-05-27 |
2016-02-09 |
Fondazione Centro San Raffaele Del Monte Tabor |
Therapeutic gene vectors comprising mirna target sequences
|
|
DK2341149T3
(en)
|
2005-08-26 |
2017-02-27 |
Dupont Nutrition Biosci Aps |
Use of CRISPR-associated genes (Cas)
|
|
US8980246B2
(en)
|
2005-09-07 |
2015-03-17 |
Sillajen Biotherapeutics, Inc. |
Oncolytic vaccinia virus cancer therapy
|
|
US20080008686A1
(en)
|
2006-07-10 |
2008-01-10 |
The Brigham And Women's Hospital, Inc. |
Tetracycline repressor regulated oncolytic viruses
|
|
BRPI0716427A2
(pt)
|
2006-08-11 |
2014-03-11 |
Dow Agrosciences Llc |
Recombinação homóloga mediada por nuclease de apêndice de zinco
|
|
US20100111873A1
(en)
|
2007-02-20 |
2010-05-06 |
Russell Stephen J |
Treating cancer with viral nucleic acid
|
|
EP2144632B1
(en)
|
2007-05-09 |
2016-11-16 |
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College |
Synthetic herpes simplex viruses type-1 for treatment of cancers
|
|
WO2008143875A1
(en)
|
2007-05-14 |
2008-11-27 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Targeted delivery of glycine receptors to excitable cells
|
|
WO2009111892A1
(en)
|
2008-03-14 |
2009-09-17 |
Ottawa Health Research Institute |
Microrna mediated oncolytic targeting
|
|
GB0807424D0
(en)
|
2008-04-23 |
2008-05-28 |
Isis Innovation |
Virus
|
|
NO2700405T3
(https=)
|
2008-05-29 |
2018-09-01 |
|
|
|
WO2009148488A2
(en)
|
2008-05-29 |
2009-12-10 |
The General Hospital Corporation |
Use of oncolytic herpes viruses for killing cancer stem cells
|
|
GB0810912D0
(en)
|
2008-06-13 |
2008-07-23 |
Inst Animal Health Ltd |
Vector
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
|
US10662227B2
(en)
|
2008-11-07 |
2020-05-26 |
Dupont Nutrition Biosciences Aps |
Bifidobacteria CRISPR sequences
|
|
JP2012520085A
(ja)
|
2009-03-13 |
2012-09-06 |
エーゲン、インコーポレイテッド |
生物活性rnaの送達のための組成物及び方法
|
|
US20100297072A1
(en)
|
2009-05-19 |
2010-11-25 |
Depinho Ronald A |
Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
|
|
WO2011119925A2
(en)
|
2010-03-25 |
2011-09-29 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthetic herpes simplex viruses for treatment of cancers
|
|
US20130071430A1
(en)
|
2010-04-09 |
2013-03-21 |
The University Of Tokyo |
Microrna-controlled recombinant vaccinia virus and use thereof
|
|
WO2011130749A2
(en)
|
2010-04-16 |
2011-10-20 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors
|
|
WO2012006181A2
(en)
|
2010-06-29 |
2012-01-12 |
Mount Sinai School Of Medicine |
Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer
|
|
CN103261213A
(zh)
|
2010-10-20 |
2013-08-21 |
杜邦营养生物科学有限公司 |
乳球菌CRISPR-Cas序列
|
|
AU2012249390B2
(en)
|
2011-04-27 |
2017-03-30 |
Amyris, Inc. |
Methods for genomic modification
|
|
WO2012164565A1
(en)
|
2011-06-01 |
2012-12-06 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for downregulating prokaryotic genes
|
|
EP2543734A1
(en)
|
2011-07-07 |
2013-01-09 |
Deutsches Krebsforschungszentrum |
Adeno-parvovirus chimera with enhanced oncolytical potential
|
|
US11951157B2
(en)
|
2011-10-11 |
2024-04-09 |
Universitat Zurich |
Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
|
|
EP2591796A1
(en)
|
2011-11-10 |
2013-05-15 |
Universität Zürich |
Combination medicament comprising IL-12 and an anti-CTLA-4 ligand for tumor therapy
|
|
EP2766035B1
(en)
|
2011-10-11 |
2018-03-28 |
Universität Zürich Prorektorat MNW |
Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
|
|
US20130156808A1
(en)
|
2011-11-22 |
2013-06-20 |
Stipan Jonjic |
Vaccine comprising beta-herpesvirus
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US20140363469A1
(en)
*
|
2012-01-19 |
2014-12-11 |
Alnylam Pharmaceuticals, Inc. |
Viral attenuation and vaccine production
|
|
US20150166969A1
(en)
|
2012-02-24 |
2015-06-18 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for the treatment of hemoglobinopathies
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
CN105008918A
(zh)
|
2013-01-04 |
2015-10-28 |
西托姆克斯治疗公司 |
用于检测生物系统中的蛋白酶活性的组合物和方法
|
|
MX374532B
(es)
*
|
2013-06-17 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
|
|
JP6726824B2
(ja)
|
2013-07-17 |
2020-07-22 |
ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション |
効率的な遺伝子送達用途のための非毒性hsvベクター及びその製造のための補完細胞
|
|
BR112016009465A8
(pt)
|
2013-10-28 |
2018-01-30 |
Univ Pittsburgh Commonwealth Sys Higher Education |
vetor de hsv oncolítico.
|
|
EP3110443A4
(en)
|
2014-02-27 |
2017-11-15 |
Viralytics Limited |
Combination method for treatment of cancer
|
|
EP3137105A4
(en)
*
|
2014-04-30 |
2017-12-27 |
President and Fellows of Harvard College |
Combination vaccine devices and methods of killing cancer cells
|
|
RU2696312C2
(ru)
|
2014-07-16 |
2019-08-01 |
Трансген Са |
Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек
|
|
CN107530416A
(zh)
|
2015-03-05 |
2018-01-02 |
西北大学 |
非神经侵染的病毒及其用途
|
|
US10083137B2
(en)
|
2015-04-02 |
2018-09-25 |
Atmel Corporation |
Peripheral interface circuit for serial memory
|
|
US9884704B2
(en)
|
2015-08-04 |
2018-02-06 |
Ernesto A. Aguero-Hernandez |
Clip-clamp with top lock device and method
|
|
US10210575B1
(en)
|
2015-08-12 |
2019-02-19 |
State Farm Mutual Automobile Insurance Company |
System and method of using an image object as a visual data container
|
|
JP6981973B2
(ja)
*
|
2015-10-01 |
2021-12-17 |
ヒート バイオロジクス,インコーポレイテッド |
I型及びii型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法
|
|
ES2994611T3
(en)
|
2015-10-19 |
2025-01-27 |
Cg Oncology Inc |
Methods of treating solid or lymphatic tumors by combination therapy
|
|
WO2017096201A1
(en)
|
2015-12-02 |
2017-06-08 |
Memorial Sloan-Kettering Cancer Center |
Seneca valley virus (svv) cellular receptor targeted oncotherapy
|
|
BR112018012180A2
(pt)
*
|
2015-12-17 |
2018-12-04 |
Psioxus Therapeutics Ltd |
vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr
|
|
US10612005B2
(en)
|
2016-01-08 |
2020-04-07 |
Replimune Limited |
Modified oncolytic virus
|
|
KR20180136435A
(ko)
|
2016-01-27 |
2018-12-24 |
온코루스, 인크. |
종양 살상형 바이러스 벡터 및 그의 용도
|
|
WO2017156349A1
(en)
|
2016-03-10 |
2017-09-14 |
Cold Genesys, Inc. |
Methods of treating solid or lymphatic tumors by combination therapy
|
|
AU2016403583B2
(en)
|
2016-04-22 |
2020-05-28 |
Immvira Co., Limited |
Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
|
|
CN109475613B
(zh)
|
2016-06-14 |
2024-02-20 |
匹兹堡大学-属高等教育联邦体系 |
使癌细胞对胞毒免疫细胞攻击敏感的nkg2d活化配体蛋白表达
|
|
AU2017290828A1
(en)
*
|
2016-06-30 |
2019-01-24 |
Virogin Biotech Canada Ltd |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
ES2972406T3
(es)
|
2016-08-01 |
2024-06-12 |
Virogin Biotech Canada Ltd |
Vectores del virus oncolítico del herpes simple que expresan moléculas estimuladoras del sistema inmunitario
|
|
JP2019527737A
(ja)
|
2016-08-09 |
2019-10-03 |
アルケヤール, アルモハナッドALKAYYAL, Almohanad |
Il12を発現する腫瘍溶解性ラブドウイルス
|
|
IL303187A
(en)
*
|
2016-08-29 |
2023-07-01 |
Akamis Bio Ltd |
Adenovirus with bispecific T cell activator
|
|
WO2018049248A1
(en)
|
2016-09-09 |
2018-03-15 |
Icellhealth Consulting Llc |
Oncolytic virus equipped with bispecific engager molecules
|
|
US20190275092A1
(en)
|
2016-11-01 |
2019-09-12 |
Dnatrix, Inc. |
Combination therapy for treatment of brain cancers
|
|
US11298420B2
(en)
|
2016-12-21 |
2022-04-12 |
Memgen, Llc |
Armed oncolytic viruses
|
|
KR20190098215A
(ko)
|
2016-12-21 |
2019-08-21 |
멤젠 엘엘씨 |
무장된 복제-가능 종양 분해 아데노바이러스
|
|
GB201700350D0
(en)
|
2017-01-09 |
2017-02-22 |
Replimune Ltd |
Altered virus
|
|
KR20200036873A
(ko)
|
2017-07-14 |
2020-04-07 |
온코루스, 인크. |
캡슐화된 폴리뉴클레오티드 및 사용 방법
|
|
US11612625B2
(en)
|
2017-07-26 |
2023-03-28 |
Oncorus, Inc. |
Oncolytic viral vectors and uses thereof
|
|
EP3875119A4
(en)
|
2018-10-30 |
2022-08-31 |
The University of Tokyo |
ONCOLYTIC VIRUS FOR CANCER THERAPY
|
|
CA3133972A1
(en)
|
2019-03-20 |
2020-09-24 |
Turnstone Biologics Inc. |
Methods for inducing an immune response against neoantigens
|
|
CA3133971A1
(en)
|
2019-03-20 |
2020-09-24 |
Turnstone Biologics Inc. |
Sequential heterologous boost oncolytic viral mmunotherapy
|
|
CA3157063A1
(en)
|
2019-10-10 |
2021-04-15 |
Oncorus, Inc. |
Dual viruses and dual oncolytic viruses and methods of treatment
|
|
WO2021101796A1
(en)
|
2019-11-18 |
2021-05-27 |
The Brigham And Women's Hospital, Inc. |
Codon optimized new generation regulatable fusogenic oncolytic herpes simplex virus type 1 virus and methods of use
|