JP2020530778A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020530778A5 JP2020530778A5 JP2020523236A JP2020523236A JP2020530778A5 JP 2020530778 A5 JP2020530778 A5 JP 2020530778A5 JP 2020523236 A JP2020523236 A JP 2020523236A JP 2020523236 A JP2020523236 A JP 2020523236A JP 2020530778 A5 JP2020530778 A5 JP 2020530778A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant dna
- dna molecule
- virus
- mir
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000053602 DNA Human genes 0.000 claims description 157
- 108020004511 Recombinant DNA Proteins 0.000 claims description 139
- 239000000203 mixture Substances 0.000 claims description 62
- 241000700605 Viruses Species 0.000 claims description 53
- 210000004027 cell Anatomy 0.000 claims description 46
- 102000040430 polynucleotide Human genes 0.000 claims description 40
- 108091033319 polynucleotide Proteins 0.000 claims description 40
- 239000002157 polynucleotide Substances 0.000 claims description 40
- 230000003612 virological effect Effects 0.000 claims description 39
- 239000002679 microRNA Substances 0.000 claims description 38
- 239000002245 particle Substances 0.000 claims description 38
- 230000001225 therapeutic effect Effects 0.000 claims description 38
- 108020004414 DNA Proteins 0.000 claims description 33
- 229920001184 polypeptide Polymers 0.000 claims description 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 108700011259 MicroRNAs Proteins 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 22
- 201000011510 cancer Diseases 0.000 claims description 19
- 108090000994 Catalytic RNA Proteins 0.000 claims description 18
- 102000053642 Catalytic RNA Human genes 0.000 claims description 18
- 239000002105 nanoparticle Substances 0.000 claims description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 108091092562 ribozyme Proteins 0.000 claims description 18
- 108020004682 Single-Stranded DNA Proteins 0.000 claims description 17
- -1 chemocaines Proteins 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 239000000427 antigen Substances 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108091026890 Coding region Proteins 0.000 claims description 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 239000003446 ligand Substances 0.000 claims description 12
- 108091070946 miR-128 stem-loop Proteins 0.000 claims description 12
- 108091070501 miRNA Proteins 0.000 claims description 12
- 150000002632 lipids Chemical class 0.000 claims description 11
- 102000004127 Cytokines Human genes 0.000 claims description 10
- 108090000695 Cytokines Proteins 0.000 claims description 10
- 239000013604 expression vector Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 230000010076 replication Effects 0.000 claims description 9
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 8
- 102000000844 Cell Surface Receptors Human genes 0.000 claims description 8
- 108010012236 Chemokines Proteins 0.000 claims description 8
- 102000019034 Chemokines Human genes 0.000 claims description 8
- 108091007780 MiR-122 Proteins 0.000 claims description 8
- 108091027966 Mir-137 Proteins 0.000 claims description 8
- 108091027766 Mir-143 Proteins 0.000 claims description 8
- 241000711975 Vesicular stomatitis virus Species 0.000 claims description 8
- 108091028606 miR-1 stem-loop Proteins 0.000 claims description 8
- 108091051828 miR-122 stem-loop Proteins 0.000 claims description 8
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 8
- 108091031479 miR-204 stem-loop Proteins 0.000 claims description 8
- 108091032382 miR-204-1 stem-loop Proteins 0.000 claims description 8
- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims description 8
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims description 8
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims description 8
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims description 8
- 108091035328 miR-217 stem-loop Proteins 0.000 claims description 8
- 108091039135 miR-217-1 stem-loop Proteins 0.000 claims description 8
- 108091029206 miR-217-2 stem-loop Proteins 0.000 claims description 8
- 108091063841 miR-219 stem-loop Proteins 0.000 claims description 8
- 108091070636 miR-219a stem-loop Proteins 0.000 claims description 8
- 108091069025 single-strand RNA Proteins 0.000 claims description 8
- 241000991587 Enterovirus C Species 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 230000002458 infectious effect Effects 0.000 claims description 7
- 241001529453 unidentified herpesvirus Species 0.000 claims description 7
- KWVJHCQQUFDPLU-YEUCEMRASA-N 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KWVJHCQQUFDPLU-YEUCEMRASA-N 0.000 claims description 6
- ZLGYVWRJIZPQMM-HHHXNRCGSA-N 2-azaniumylethyl [(2r)-2,3-di(dodecanoyloxy)propyl] phosphate Chemical compound CCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCC ZLGYVWRJIZPQMM-HHHXNRCGSA-N 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 6
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 6
- 230000000692 anti-sense effect Effects 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 210000001808 exosome Anatomy 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 239000013612 plasmid Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims description 5
- 241000709687 Coxsackievirus Species 0.000 claims description 5
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 5
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 5
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims description 5
- 108091008028 Immune checkpoint receptors Proteins 0.000 claims description 5
- 102000037978 Immune checkpoint receptors Human genes 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 241000709664 Picornaviridae Species 0.000 claims description 5
- 201000007270 liver cancer Diseases 0.000 claims description 5
- 208000014018 liver neoplasm Diseases 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 108020005345 3' Untranslated Regions Proteins 0.000 claims description 4
- 241000239290 Araneae Species 0.000 claims description 4
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims description 4
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 4
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- 101001040800 Homo sapiens Integral membrane protein GPR180 Proteins 0.000 claims description 4
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 4
- 108010003272 Hyaluronate lyase Proteins 0.000 claims description 4
- 102000001974 Hyaluronidases Human genes 0.000 claims description 4
- 102100021244 Integral membrane protein GPR180 Human genes 0.000 claims description 4
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 4
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims description 4
- 108091028066 Mir-126 Proteins 0.000 claims description 4
- 102100040557 Osteopontin Human genes 0.000 claims description 4
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims description 4
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims description 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 4
- 241000239226 Scorpiones Species 0.000 claims description 4
- 241000270295 Serpentes Species 0.000 claims description 4
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 4
- 239000002041 carbon nanotube Substances 0.000 claims description 4
- 229910021393 carbon nanotube Inorganic materials 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 231100000433 cytotoxic Toxicity 0.000 claims description 4
- 230000001472 cytotoxic effect Effects 0.000 claims description 4
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 4
- 229940088598 enzyme Drugs 0.000 claims description 4
- 238000010914 gene-directed enzyme pro-drug therapy Methods 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
- 229960002773 hyaluronidase Drugs 0.000 claims description 4
- 239000010954 inorganic particle Substances 0.000 claims description 4
- 239000002122 magnetic nanoparticle Substances 0.000 claims description 4
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims description 4
- 208000021937 marginal zone lymphoma Diseases 0.000 claims description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 4
- 239000002071 nanotube Substances 0.000 claims description 4
- 241000283073 Equus caballus Species 0.000 claims description 3
- 102000013382 Gelatinases Human genes 0.000 claims description 3
- 108010026132 Gelatinases Proteins 0.000 claims description 3
- 108010006035 Metalloproteases Proteins 0.000 claims description 3
- 102000005741 Metalloproteases Human genes 0.000 claims description 3
- 101710160107 Outer membrane protein A Proteins 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 102000009572 RNA Polymerase II Human genes 0.000 claims description 3
- 108010009460 RNA Polymerase II Proteins 0.000 claims description 3
- 241001632234 Senecavirus Species 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 241000701447 unidentified baculovirus Species 0.000 claims description 3
- 239000003981 vehicle Substances 0.000 claims description 3
- 101000830706 Agalychnis dacnicolor Tryptophyllin-1 Proteins 0.000 claims description 2
- 101001023095 Anemonia sulcata Delta-actitoxin-Avd1a Proteins 0.000 claims description 2
- 101000924591 Apis mellifera Apamin Proteins 0.000 claims description 2
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 101000641989 Araneus ventricosus Kunitz-type U1-aranetoxin-Av1a Proteins 0.000 claims description 2
- 241000711404 Avian avulavirus 1 Species 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 108030001720 Bontoxilysin Proteins 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims description 2
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 2
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 101000835996 Caenorhabditis elegans Slit homolog 1 protein Proteins 0.000 claims description 2
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims description 2
- 101001028691 Carybdea rastonii Toxin CrTX-A Proteins 0.000 claims description 2
- 102000011727 Caspases Human genes 0.000 claims description 2
- 108010076667 Caspases Proteins 0.000 claims description 2
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims description 2
- 101000685083 Centruroides infamatus Beta-toxin Cii1 Proteins 0.000 claims description 2
- 101000685085 Centruroides noxius Toxin Cn1 Proteins 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 101001028688 Chironex fleckeri Toxin CfTX-1 Proteins 0.000 claims description 2
- 101710164760 Chlorotoxin Proteins 0.000 claims description 2
- 102000029816 Collagenase Human genes 0.000 claims description 2
- 108060005980 Collagenase Proteins 0.000 claims description 2
- 101000644407 Cyriopagopus schmidti U6-theraphotoxin-Hs1a Proteins 0.000 claims description 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims description 2
- 102000003849 Cytochrome P450 Human genes 0.000 claims description 2
- 102000000311 Cytosine Deaminase Human genes 0.000 claims description 2
- 108010080611 Cytosine Deaminase Proteins 0.000 claims description 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 2
- 101000783349 Daboia russelii Cytotoxin drCT-1 Proteins 0.000 claims description 2
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 2
- 241000702421 Dependoparvovirus Species 0.000 claims description 2
- 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 claims description 2
- 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 claims description 2
- 101100007584 Entamoeba histolytica CPNP gene Proteins 0.000 claims description 2
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 2
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 2
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 2
- 101150112743 HSPA5 gene Proteins 0.000 claims description 2
- 108090001102 Hammerhead ribozyme Proteins 0.000 claims description 2
- 208000005331 Hepatitis D Diseases 0.000 claims description 2
- 102100022128 High mobility group protein B2 Human genes 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims description 2
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 2
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 2
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims description 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 2
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 2
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 2
- 101001045791 Homo sapiens High mobility group protein B2 Proteins 0.000 claims description 2
- 101001033715 Homo sapiens Insulinoma-associated protein 1 Proteins 0.000 claims description 2
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims description 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 2
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims description 2
- 101000613820 Homo sapiens Osteopontin Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 2
- 241000712431 Influenza A virus Species 0.000 claims description 2
- 241000713196 Influenza B virus Species 0.000 claims description 2
- 102100039091 Insulinoma-associated protein 1 Human genes 0.000 claims description 2
- 102000003816 Interleukin-13 Human genes 0.000 claims description 2
- 108090000176 Interleukin-13 Proteins 0.000 claims description 2
- 102000000588 Interleukin-2 Human genes 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108010008292 L-Amino Acid Oxidase Proteins 0.000 claims description 2
- 102000007070 L-amino-acid oxidase Human genes 0.000 claims description 2
- 241000712902 Lassa mammarenavirus Species 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims description 2
- 101710124843 Mauriporin Proteins 0.000 claims description 2
- 241000712079 Measles morbillivirus Species 0.000 claims description 2
- 108010036176 Melitten Proteins 0.000 claims description 2
- 102000003735 Mesothelin Human genes 0.000 claims description 2
- 108090000015 Mesothelin Proteins 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 2
- 101000744155 Naja atra Cytotoxin 3 Proteins 0.000 claims description 2
- 102000004459 Nitroreductase Human genes 0.000 claims description 2
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims description 2
- 108010081689 Osteopontin Proteins 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 102000016387 Pancreatic elastase Human genes 0.000 claims description 2
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 101000679608 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) Cysteine rich necrotrophic effector Tox1 Proteins 0.000 claims description 2
- 101000940390 Phyllomedusa sauvagei Tryptophyllin-1 Proteins 0.000 claims description 2
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 101001120041 Protobothrops flavoviridis L-amino-acid oxidase Proteins 0.000 claims description 2
- 241000125945 Protoparvovirus Species 0.000 claims description 2
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims description 2
- 108010068097 Rad51 Recombinase Proteins 0.000 claims description 2
- 102000002490 Rad51 Recombinase Human genes 0.000 claims description 2
- 101100111629 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR2 gene Proteins 0.000 claims description 2
- 241000837158 Senecavirus A Species 0.000 claims description 2
- 241000700584 Simplexvirus Species 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 102000006601 Thymidine Kinase Human genes 0.000 claims description 2
- 108020004440 Thymidine kinase Proteins 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims description 2
- 210000001106 artificial yeast chromosome Anatomy 0.000 claims description 2
- 201000000053 blastoma Diseases 0.000 claims description 2
- 229940053031 botulinum toxin Drugs 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- QPAKKWCQMHUHNI-GQIQPHNSSA-N chlorotoxin Chemical compound C([C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]4CSSC[C@@H](C(N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC4=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)=O)NC(=O)[C@@H](N)CCSC)C1=CC=C(O)C=C1 QPAKKWCQMHUHNI-GQIQPHNSSA-N 0.000 claims description 2
- 229960005534 chlorotoxin Drugs 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 229960002424 collagenase Drugs 0.000 claims description 2
- 108010063294 contortrostatin Proteins 0.000 claims description 2
- 229940127276 delta-like ligand 3 Drugs 0.000 claims description 2
- 201000008184 embryoma Diseases 0.000 claims description 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 2
- 229910003472 fullerene Inorganic materials 0.000 claims description 2
- 108010062699 gamma-Glutamyl Hydrolase Proteins 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 101150028578 grp78 gene Proteins 0.000 claims description 2
- 208000029570 hepatitis D virus infection Diseases 0.000 claims description 2
- 208000029824 high grade glioma Diseases 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 201000011614 malignant glioma Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 claims description 2
- YVIIHEKJCKCXOB-STYWVVQQSA-N molport-023-276-178 Chemical compound C([C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(N[C@@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)=O)CC(C)C)[C@@H](C)O)C(N)=O)C1=CNC=N1 YVIIHEKJCKCXOB-STYWVVQQSA-N 0.000 claims description 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 2
- 108020001162 nitroreductase Proteins 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- 230000002476 tumorcidal effect Effects 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 claims description 2
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims 9
- 230000007017 scission Effects 0.000 claims 9
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 108020005004 Guide RNA Proteins 0.000 claims 1
- 241000700562 Myxoma virus Species 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 1
- 241001068263 Replication competent viruses Species 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 108091007428 primary miRNA Proteins 0.000 claims 1
- 241000114864 ssRNA viruses Species 0.000 description 8
- 108700005077 Viral Genes Proteins 0.000 description 6
- 241001493065 dsRNA viruses Species 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108060003393 Granulin Proteins 0.000 description 2
- 101150041636 NEC1 gene Proteins 0.000 description 2
- 101150098384 NEC2 gene Proteins 0.000 description 2
- 108010089430 Phosphoproteins Proteins 0.000 description 2
- 102000007982 Phosphoproteins Human genes 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102000034287 fluorescent proteins Human genes 0.000 description 2
- 108091006047 fluorescent proteins Proteins 0.000 description 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 2
- 229940099552 hyaluronan Drugs 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000003362 replicative effect Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 108091007505 ADAM17 Proteins 0.000 description 1
- 241000702423 Adeno-associated virus - 2 Species 0.000 description 1
- 101150072608 CVC1 gene Proteins 0.000 description 1
- 101150010802 CVC2 gene Proteins 0.000 description 1
- 101100476210 Caenorhabditis elegans rnt-1 gene Proteins 0.000 description 1
- 101100504458 Cercopithecine herpesvirus 9 (strain DHV) gI gene Proteins 0.000 description 1
- 101150026402 DBP gene Proteins 0.000 description 1
- 101150040913 DUT gene Proteins 0.000 description 1
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101100263193 Gallid herpesvirus 2 (strain GA) US1206 gene Proteins 0.000 description 1
- 101150109586 Gk gene Proteins 0.000 description 1
- 101150064935 HELI gene Proteins 0.000 description 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 description 1
- 101100048372 Human cytomegalovirus (strain AD169) H301 gene Proteins 0.000 description 1
- 101100427508 Human cytomegalovirus (strain AD169) UL39 gene Proteins 0.000 description 1
- 101100048373 Human cytomegalovirus (strain Merlin) UL18 gene Proteins 0.000 description 1
- 101100179089 Human herpesvirus 1 (strain 17) ICP22 gene Proteins 0.000 description 1
- 101001042049 Human herpesvirus 1 (strain 17) Transcriptional regulator ICP22 Proteins 0.000 description 1
- 101000999690 Human herpesvirus 2 (strain HG52) E3 ubiquitin ligase ICP22 Proteins 0.000 description 1
- 101150090364 ICP0 gene Proteins 0.000 description 1
- 101150027427 ICP4 gene Proteins 0.000 description 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
- 101150047390 MCP gene Proteins 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101150093191 RIR1 gene Proteins 0.000 description 1
- 101150030723 RIR2 gene Proteins 0.000 description 1
- 101150103019 SCP gene Proteins 0.000 description 1
- 101150110861 TRM2 gene Proteins 0.000 description 1
- 101150048584 TRM3 gene Proteins 0.000 description 1
- 101150102071 TRX1 gene Proteins 0.000 description 1
- 101150037769 TRX2 gene Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 101150111135 UL1 gene Proteins 0.000 description 1
- 101150087840 UL11 gene Proteins 0.000 description 1
- 101150023763 UL12 gene Proteins 0.000 description 1
- 101150036407 UL14 gene Proteins 0.000 description 1
- 101150104047 UL17 gene Proteins 0.000 description 1
- 101150109748 UL19 gene Proteins 0.000 description 1
- 101150050388 UL20 gene Proteins 0.000 description 1
- 101150004957 UL25 gene Proteins 0.000 description 1
- 101150060044 UL26 gene Proteins 0.000 description 1
- 101150003230 UL27 gene Proteins 0.000 description 1
- 101150072074 UL28 gene Proteins 0.000 description 1
- 101150008036 UL29 gene Proteins 0.000 description 1
- 101150068034 UL30 gene Proteins 0.000 description 1
- 101150019585 UL31 gene Proteins 0.000 description 1
- 101150081727 UL32 gene Proteins 0.000 description 1
- 101150017804 UL33 gene Proteins 0.000 description 1
- 101150087430 UL34 gene Proteins 0.000 description 1
- 101150023000 UL35 gene Proteins 0.000 description 1
- 101150085237 UL36 gene Proteins 0.000 description 1
- 101150036065 UL37 gene Proteins 0.000 description 1
- 101150090946 UL38 gene Proteins 0.000 description 1
- 101150100826 UL40 gene Proteins 0.000 description 1
- 101150099321 UL42 gene Proteins 0.000 description 1
- 101150004685 UL48 gene Proteins 0.000 description 1
- 101150066971 UL49 gene Proteins 0.000 description 1
- 101150099617 UL5 gene Proteins 0.000 description 1
- 101150011902 UL52 gene Proteins 0.000 description 1
- 101150009795 UL54 gene Proteins 0.000 description 1
- 101150033660 UL6 gene Proteins 0.000 description 1
- 101150095805 UL7 gene Proteins 0.000 description 1
- 101150033561 UL8 gene Proteins 0.000 description 1
- 101150026859 UL9 gene Proteins 0.000 description 1
- 101150053425 US1 gene Proteins 0.000 description 1
- 101150003185 US12 gene Proteins 0.000 description 1
- 101150047715 US3 gene Proteins 0.000 description 1
- 101150102598 US4 gene Proteins 0.000 description 1
- 101150041938 US5 gene Proteins 0.000 description 1
- 101150096955 US6 gene Proteins 0.000 description 1
- 101150037168 US7 gene Proteins 0.000 description 1
- 101150092158 US8 gene Proteins 0.000 description 1
- 230000003302 anti-idiotype Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 101150029683 gB gene Proteins 0.000 description 1
- 101150036031 gD gene Proteins 0.000 description 1
- 101150072564 gE gene Proteins 0.000 description 1
- 101150020597 gG gene Proteins 0.000 description 1
- 101150055782 gH gene Proteins 0.000 description 1
- 101150030521 gI gene Proteins 0.000 description 1
- 101150064645 gJ gene Proteins 0.000 description 1
- 101150015940 gL gene Proteins 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 101710130522 mRNA export factor Proteins 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000000581 natural killer T-cell Anatomy 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 101150046896 trm1 gene Proteins 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023166265A JP2023165916A (ja) | 2017-07-14 | 2023-09-27 | カプセル封入ポリヌクレオチド及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532886P | 2017-07-14 | 2017-07-14 | |
| US62/532,886 | 2017-07-14 | ||
| US201862648651P | 2018-03-27 | 2018-03-27 | |
| US62/648,651 | 2018-03-27 | ||
| PCT/US2018/042136 WO2019014623A1 (en) | 2017-07-14 | 2018-07-13 | Encapsulated polynucleotides and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023166265A Division JP2023165916A (ja) | 2017-07-14 | 2023-09-27 | カプセル封入ポリヌクレオチド及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530778A JP2020530778A (ja) | 2020-10-29 |
| JP2020530778A5 true JP2020530778A5 (https=) | 2021-08-12 |
Family
ID=65002120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523236A Pending JP2020530778A (ja) | 2017-07-14 | 2018-07-13 | カプセル封入ポリヌクレオチド及び使用方法 |
| JP2023166265A Pending JP2023165916A (ja) | 2017-07-14 | 2023-09-27 | カプセル封入ポリヌクレオチド及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023166265A Pending JP2023165916A (ja) | 2017-07-14 | 2023-09-27 | カプセル封入ポリヌクレオチド及び使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200224220A1 (https=) |
| EP (1) | EP3652325A4 (https=) |
| JP (2) | JP2020530778A (https=) |
| KR (1) | KR20200036873A (https=) |
| CN (1) | CN111212914A (https=) |
| AU (1) | AU2018301701A1 (https=) |
| BR (1) | BR112020000839A2 (https=) |
| CA (1) | CA3069821A1 (https=) |
| IL (1) | IL271969A (https=) |
| MX (1) | MX2020000495A (https=) |
| RU (1) | RU2020106730A (https=) |
| SG (1) | SG11202000312UA (https=) |
| WO (1) | WO2019014623A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018306455A1 (en) | 2017-07-26 | 2020-02-27 | Virogin Biotech Canada Ltd | Oncolytic viral vectors and uses thereof |
| TW202545984A (zh) | 2017-08-09 | 2025-12-01 | 美商生物化學醫療公司 | 核酸分子及其用途 |
| MX2020007010A (es) | 2018-01-05 | 2020-12-10 | Ottawa Hospital Res Inst | Vectores modificados de orthopoxvirus. |
| EP3765048B1 (en) * | 2018-03-12 | 2025-08-27 | Mayo Foundation for Medical Education and Research | Using infectious nucleic acid to treat cancer |
| WO2020033863A1 (en) | 2018-08-09 | 2020-02-13 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| EP3880812A4 (en) * | 2018-11-13 | 2022-09-07 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| EP3906039A4 (en) * | 2019-01-04 | 2023-01-18 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| JP2022526094A (ja) * | 2019-03-14 | 2022-05-23 | マサチューセッツ インスティテュート オブ テクノロジー | 操作された単純ヘルペスウイルス－１（ｈｓｖ－１）ベクターおよびその使用 |
| CN114514323A (zh) * | 2019-08-05 | 2022-05-17 | 复诺健生物科技加拿大有限公司 | 遗传修饰的肠病毒载体 |
| CA3157063A1 (en) * | 2019-10-10 | 2021-04-15 | Oncorus, Inc. | Dual viruses and dual oncolytic viruses and methods of treatment |
| US20230416308A1 (en) * | 2020-05-29 | 2023-12-28 | Oncorus, Inc. | Encapsulated rna replicons and methods of use |
| BR112022025217A2 (pt) * | 2020-06-11 | 2023-01-03 | Etherna Immunotherapies Nv | Nanopartículas lipídicas |
| US20230242994A1 (en) * | 2020-07-10 | 2023-08-03 | Shanghai Miran Biotech Co., Ltd. | Fluorescent cross-linked rnase h mutant conjugate, mirna combination and application thereof |
| AU2022206676A1 (en) * | 2021-01-06 | 2023-08-24 | Elevatebio Technologies, Inc. | Encapsulated rna polynucleotides and methods of use |
| CN113368261A (zh) * | 2021-06-17 | 2021-09-10 | 苏州大学 | 一种非病毒载体及其制备方法与应用 |
| US20250027107A1 (en) | 2021-10-18 | 2025-01-23 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| TW202409286A (zh) * | 2022-05-20 | 2024-03-01 | 加拿大商復諾健生物科技加拿大有限公司 | 基因組穩定性增強之基因改造腸病毒載體 |
| JP7229412B1 (ja) | 2022-06-14 | 2023-02-27 | キユーピー株式会社 | 脂質ナノ粒子及びその製造方法 |
| CN118634238A (zh) * | 2022-06-27 | 2024-09-13 | 浙江大学 | 抗口腔肿瘤药物活性成分及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060026854A (ko) * | 2003-05-28 | 2006-03-24 | 위스콘신 얼럼나이 리서어치 화운데이션 | ＰｏｌⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터 |
| WO2005030139A2 (en) * | 2003-09-26 | 2005-04-07 | Novartis Ag | Seneca valley virus based compositions and methods for treating disease |
| US7473418B2 (en) * | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| GB0810912D0 (en) * | 2008-06-13 | 2008-07-23 | Inst Animal Health Ltd | Vector |
| CA2738472A1 (en) * | 2008-09-26 | 2010-04-22 | Tocagen Inc. | Gene therapy vectors and cytosine deaminases |
| CA2782366A1 (en) * | 2009-12-16 | 2011-07-14 | Opko Curna, Llc | Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1 |
| WO2013083753A2 (en) * | 2011-12-07 | 2013-06-13 | Institut Pasteur | Identification of a swine parecho-like virus and applications |
| EP2839015B1 (en) * | 2012-04-18 | 2020-04-29 | Ramot at Tel-Aviv University Ltd. | Lipidated glycosaminoglycan particles for the delivery of nucleic acids |
| JP6396891B2 (ja) * | 2013-04-17 | 2018-09-26 | 新日本製薬株式会社 | 遺伝子改変コクサッキーウイルス |
| US10513711B2 (en) * | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
| EP3307308A2 (en) * | 2015-06-10 | 2018-04-18 | Hookipa Biotech AG | Hpv vaccines |
| CN108601802A (zh) * | 2015-12-02 | 2018-09-28 | 纪念斯隆-凯特林癌症中心 | 塞尼卡谷病毒（svv）细胞受体靶向的肿瘤治疗 |
-
2018
- 2018-07-13 AU AU2018301701A patent/AU2018301701A1/en not_active Abandoned
- 2018-07-13 MX MX2020000495A patent/MX2020000495A/es unknown
- 2018-07-13 JP JP2020523236A patent/JP2020530778A/ja active Pending
- 2018-07-13 SG SG11202000312UA patent/SG11202000312UA/en unknown
- 2018-07-13 RU RU2020106730A patent/RU2020106730A/ru unknown
- 2018-07-13 EP EP18832967.6A patent/EP3652325A4/en not_active Withdrawn
- 2018-07-13 CA CA3069821A patent/CA3069821A1/en active Pending
- 2018-07-13 WO PCT/US2018/042136 patent/WO2019014623A1/en not_active Ceased
- 2018-07-13 US US16/630,990 patent/US20200224220A1/en not_active Abandoned
- 2018-07-13 BR BR112020000839-7A patent/BR112020000839A2/pt not_active Application Discontinuation
- 2018-07-13 KR KR1020207004226A patent/KR20200036873A/ko not_active Ceased
- 2018-07-13 CN CN201880057021.3A patent/CN111212914A/zh active Pending
-
2020
- 2020-01-12 IL IL271969A patent/IL271969A/en unknown
-
2023
- 2023-09-27 JP JP2023166265A patent/JP2023165916A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020530778A5 (https=) | ||
| RU2020106730A (ru) | Инкапсулированные полинуклеотиды и способы их применения | |
| Yang et al. | Oncolytic virotherapy: From bench to bedside | |
| JP7249323B2 (ja) | 腫瘍溶解性ウイルスベクター及びその使用 | |
| Amer | Gene therapy for cancer: present status and future perspective | |
| JP2020532951A5 (https=) | ||
| Antonio Chiocca | Oncolytic viruses | |
| Barth et al. | Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas | |
| Varghese et al. | Oncolytic herpes simplex virus vectors for cancer virotherapy | |
| CN113453699A (zh) | 包封的rna多核苷酸及使用方法 | |
| CN113164484A (zh) | 具有降低的神经毒性的hsv载体 | |
| Kardani et al. | Oncolytic herpes simplex viruses for the treatment of glioma and targeting glioblastoma stem-like cells | |
| CN113348246A (zh) | 包封多核苷酸及使用方法 | |
| Parsel et al. | Nucleic acid targeting: towards personalized therapy for head and neck cancer | |
| Selznick et al. | Molecular strategies for the treatment of malignant glioma—genes, viruses, and vaccines | |
| Rayati et al. | Gene therapy in glioblastoma multiforme: Can it be a role changer? | |
| JP7557738B2 (ja) | がん治療のための腫瘍溶解性ウイルス | |
| Yue et al. | Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives | |
| Yang et al. | Nanoparticle-mediated delivery of oncolytic viral genomes: an innovative strategy for tumor-targeted immunotherapy | |
| JP2024512053A (ja) | 転写及び翻訳の二重調節を受ける腫瘍溶解性単純ヘルペスウイルスベクター | |
| Choi et al. | Engineered adult stem cells: a promising tool for anti-cancer therapy | |
| Annan et al. | Gene therapy in the treatment of human cancer | |
| Sonabend et al. | Gene therapy trials for the treatment of high-grade gliomas | |
| Domingo-Musibay et al. | Gene and virotherapy for hematological malignancies | |
| CN114514323A (zh) | 遗传修饰的肠病毒载体 |