CN111212914A - 包封的多核苷酸和使用方法 - Google Patents

包封的多核苷酸和使用方法 Download PDF

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Publication number
CN111212914A
CN111212914A CN201880057021.3A CN201880057021A CN111212914A CN 111212914 A CN111212914 A CN 111212914A CN 201880057021 A CN201880057021 A CN 201880057021A CN 111212914 A CN111212914 A CN 111212914A
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mir
recombinant dna
dna molecule
virus
cell
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CN201880057021.3A
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Chinese (zh)
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米切尔·H·菲尼尔
爱德华·肯尼迪
洛伦娜·勒纳
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Aloway Biotechnology
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Oncorus Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N2770/32011—Picornaviridae
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    • C12N2770/32023—Virus like particles [VLP]
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/32043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201880057021.3A 2017-07-14 2018-07-13 包封的多核苷酸和使用方法 Pending CN111212914A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762532886P 2017-07-14 2017-07-14
US62/532,886 2017-07-14
US201862648651P 2018-03-27 2018-03-27
US62/648,651 2018-03-27
PCT/US2018/042136 WO2019014623A1 (en) 2017-07-14 2018-07-13 Encapsulated polynucleotides and methods of use

Publications (1)

Publication Number Publication Date
CN111212914A true CN111212914A (zh) 2020-05-29

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ID=65002120

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CN201880057021.3A Pending CN111212914A (zh) 2017-07-14 2018-07-13 包封的多核苷酸和使用方法

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US (1) US20200224220A1 (https=)
EP (1) EP3652325A4 (https=)
JP (2) JP2020530778A (https=)
KR (1) KR20200036873A (https=)
CN (1) CN111212914A (https=)
AU (1) AU2018301701A1 (https=)
BR (1) BR112020000839A2 (https=)
CA (1) CA3069821A1 (https=)
IL (1) IL271969A (https=)
MX (1) MX2020000495A (https=)
RU (1) RU2020106730A (https=)
SG (1) SG11202000312UA (https=)
WO (1) WO2019014623A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113368261A (zh) * 2021-06-17 2021-09-10 苏州大学 一种非病毒载体及其制备方法与应用
CN115381849A (zh) * 2022-06-27 2022-11-25 浙江大学 抗口腔肿瘤药物活性成分及其用途
CN116133640A (zh) * 2020-06-11 2023-05-16 伊泽阿恩埃免疫疗法股份有限公司 脂质纳米颗粒

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US11612625B2 (en) 2017-07-26 2023-03-28 Oncorus, Inc. Oncolytic viral vectors and uses thereof
NZ762100A (en) 2017-08-09 2025-12-19 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
SG11202006457YA (en) 2018-01-05 2020-08-28 Ottawa Hospital Res Inst Modified orthopoxvirus vectors
CN111867609A (zh) * 2018-03-12 2020-10-30 梅约医学教育与研究基金会 用感染性核酸治疗癌症
EP3833766A1 (en) 2018-08-09 2021-06-16 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
MX2021005448A (es) * 2018-11-13 2021-08-11 Oncorus Inc Polinucleotidos encapsulados y metodos de uso.
JP2022516318A (ja) * 2019-01-04 2022-02-25 オンコラス， インコーポレイテッド カプセル化ポリヌクレオチド及び使用方法
WO2020185298A1 (en) * 2019-03-14 2020-09-17 Massachusetts Institute Of Technology Engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
US20220267799A1 (en) * 2019-08-05 2022-08-25 Virogin Biotech Canada Ltd Genetically modified enterovirus vectors
CA3157063A1 (en) * 2019-10-10 2021-04-15 Oncorus, Inc. Dual viruses and dual oncolytic viruses and methods of treatment
CA3180557A1 (en) * 2020-05-29 2021-12-02 Lorena Lerner Encapsulated rna replicons and methods of use
US20230242994A1 (en) * 2020-07-10 2023-08-03 Shanghai Miran Biotech Co., Ltd. Fluorescent cross-linked rnase h mutant conjugate, mirna combination and application thereof
WO2022150485A1 (en) * 2021-01-06 2022-07-14 Oncorus, Inc. Encapsulated rna polynucleotides and methods of use
WO2023069948A1 (en) 2021-10-18 2023-04-27 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
WO2023225371A1 (en) * 2022-05-20 2023-11-23 Virogin Biotech Canada Ltd Genetically modified enterovirus vectors with enhanced genomic stability
JP7229412B1 (ja) 2022-06-14 2023-02-27 キユーピー株式会社 脂質ナノ粒子及びその製造方法

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CN102131526A (zh) * 2008-06-13 2011-07-20 动物健康研究院 载体
CN102712927A (zh) * 2009-12-16 2012-10-03 库尔纳公司 通过抑制膜结合转录因子肽酶，位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
WO2013083753A2 (en) * 2011-12-07 2013-06-13 Institut Pasteur Identification of a swine parecho-like virus and applications

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WO2005028658A2 (en) * 2003-05-28 2005-03-31 Wisconsin Alumni Research Foundation Recombinant influenza vectors with a polii promoter and ribozymes
MXPA06003318A (es) * 2003-09-26 2006-06-08 Novartis Ag Composiciones a base de virus de seneca valley y metodos para tratar la enfermedad.
US7473418B2 (en) * 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
CN102227503B (zh) * 2008-09-26 2015-10-21 托卡根公司 重组载体
CA2868238A1 (en) * 2012-04-18 2013-10-24 Ramot At Tel Aviv University Ltd. Lipidated glycosaminoglycan particles for the delivery of nucleic acids
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN102131526A (zh) * 2008-06-13 2011-07-20 动物健康研究院 载体
CN102712927A (zh) * 2009-12-16 2012-10-03 库尔纳公司 通过抑制膜结合转录因子肽酶，位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
WO2013083753A2 (en) * 2011-12-07 2013-06-13 Institut Pasteur Identification of a swine parecho-like virus and applications

Non-Patent Citations (1)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116133640A (zh) * 2020-06-11 2023-05-16 伊泽阿恩埃免疫疗法股份有限公司 脂质纳米颗粒
CN113368261A (zh) * 2021-06-17 2021-09-10 苏州大学 一种非病毒载体及其制备方法与应用
CN115381849A (zh) * 2022-06-27 2022-11-25 浙江大学 抗口腔肿瘤药物活性成分及其用途

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Publication number Publication date
EP3652325A4 (en) 2021-09-15
MX2020000495A (es) 2020-08-20
JP2023165916A (ja) 2023-11-17
IL271969A (en) 2020-02-27
BR112020000839A2 (pt) 2020-07-21
JP2020530778A (ja) 2020-10-29
SG11202000312UA (en) 2020-02-27
CA3069821A1 (en) 2019-01-17
US20200224220A1 (en) 2020-07-16
EP3652325A1 (en) 2020-05-20
KR20200036873A (ko) 2020-04-07
AU2018301701A1 (en) 2020-02-27
WO2019014623A1 (en) 2019-01-17
RU2020106730A (ru) 2021-08-16

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