JP2020532551A - Rho関連コイルドコイルキナーゼ(ROCK)阻害剤としてのビニルヘテロ環 - Google Patents
Rho関連コイルドコイルキナーゼ(ROCK)阻害剤としてのビニルヘテロ環 Download PDFInfo
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- JP2020532551A JP2020532551A JP2020512687A JP2020512687A JP2020532551A JP 2020532551 A JP2020532551 A JP 2020532551A JP 2020512687 A JP2020512687 A JP 2020512687A JP 2020512687 A JP2020512687 A JP 2020512687A JP 2020532551 A JP2020532551 A JP 2020532551A
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- 0 CCCN=*N*C(CC)C(C)N Chemical compound CCCN=*N*C(CC)C(C)N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553885P | 2017-09-03 | 2017-09-03 | |
| US62/553,885 | 2017-09-03 | ||
| PCT/US2018/049225 WO2019046795A1 (en) | 2017-09-03 | 2018-08-31 | VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532551A true JP2020532551A (ja) | 2020-11-12 |
| JP2020532551A5 JP2020532551A5 (enExample) | 2021-10-14 |
Family
ID=65526110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512687A Pending JP2020532551A (ja) | 2017-09-03 | 2018-08-31 | Rho関連コイルドコイルキナーゼ(ROCK)阻害剤としてのビニルヘテロ環 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11542256B2 (enExample) |
| EP (1) | EP3676262A4 (enExample) |
| JP (1) | JP2020532551A (enExample) |
| CN (1) | CN111406051A (enExample) |
| AU (1) | AU2018326785B2 (enExample) |
| CA (1) | CA3073956A1 (enExample) |
| IL (1) | IL272939A (enExample) |
| WO (1) | WO2019046795A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025515296A (ja) * | 2022-04-20 | 2025-05-14 | シャンハイ ジムン バイオファーマ,インコーポレーテッド | Rho関連プロテインキナーゼ阻害剤ならびにその調製および応用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020532551A (ja) | 2017-09-03 | 2020-11-12 | アンジオン バイオメディカ コーポレーション | Rho関連コイルドコイルキナーゼ(ROCK)阻害剤としてのビニルヘテロ環 |
| CN114502163A (zh) * | 2019-07-22 | 2022-05-13 | 安吉昂生物医药公司 | 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙炔基杂环 |
| TW202132285A (zh) * | 2019-11-13 | 2021-09-01 | 美商愛彼特生物製藥股份有限公司 | 經取代異吲哚啉基2,2’-聯嘧啶基化合物、其類似物及使用其之方法 |
| EP4185579A1 (en) * | 2020-07-21 | 2023-05-31 | Angion Biomedica Corp. | Inhibitors of rho-associated coiled-coil kinase |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
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-
2018
- 2018-08-31 JP JP2020512687A patent/JP2020532551A/ja active Pending
- 2018-08-31 CN CN201880056952.1A patent/CN111406051A/zh active Pending
- 2018-08-31 US US16/643,805 patent/US11542256B2/en active Active
- 2018-08-31 EP EP18851935.9A patent/EP3676262A4/en not_active Withdrawn
- 2018-08-31 WO PCT/US2018/049225 patent/WO2019046795A1/en not_active Ceased
- 2018-08-31 CA CA3073956A patent/CA3073956A1/en active Pending
- 2018-08-31 AU AU2018326785A patent/AU2018326785B2/en not_active Ceased
-
2020
- 2020-02-27 IL IL272939A patent/IL272939A/en unknown
Patent Citations (8)
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|---|---|---|---|---|
| JP2003531112A (ja) * | 1999-12-22 | 2003-10-21 | メルク フロスト カナダ アンド カンパニー | 置換8−アリールキノリン系ホスホジエステラーゼ−4阻害薬 |
| JP2008509175A (ja) * | 2004-08-13 | 2008-03-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 1,5−ジフェニルピラゾール |
| JP2010501003A (ja) * | 2006-08-16 | 2010-01-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピラジン化合物、その使用及び調製方法 |
| JP2010504295A (ja) * | 2006-09-21 | 2010-02-12 | ノバルティス アーゲー | サイトカイン介在疾患の処置に有用なピロール誘導体 |
| WO2008120810A1 (ja) * | 2007-03-29 | 2008-10-09 | Sumitomo Chemical Company, Limited | 化合物、光電変換素子及び光電気化学電池 |
| WO2011011312A1 (en) * | 2009-07-22 | 2011-01-27 | Merck Sharp & Dohme Corp. | Quinolinone pde2 inhibitors |
| WO2013089087A1 (ja) * | 2011-12-15 | 2013-06-20 | 富士フイルム株式会社 | 光電変換素子及び色素増感太陽電池 |
| WO2015190467A1 (ja) * | 2014-06-11 | 2015-12-17 | 富士フイルム株式会社 | 光電変換素子、色素増感太陽電池、金属錯体色素、色素溶液、およびターピリジン化合物またはそのエステル化物 |
Non-Patent Citations (3)
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| JONNATAN J. SANTOS ET AL.: "Exploring the coordination chemistry of isomerizable terpyridine derivatives for successful analyses", ANALYST, vol. 137, JPN6022031874, 18 June 2012 (2012-06-18), pages 4045 - 4051, ISSN: 0005210625 * |
| KEVIN QINA ET AL.: "Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinase and Crystallographic", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, JPN6022031873, 3 March 2009 (2009-03-03), US, pages 1814 - 1827, ISSN: 0005210624 * |
| YAN ZHANG ET AL.: "Switchable sensitizers stepwise lighting up lanthanide emissions", SCIENTIFIC REPORTS, vol. 5, no. 9335, JPN6022031875, 20 March 2015 (2015-03-20), pages 1 - 5, ISSN: 0005210626 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025515296A (ja) * | 2022-04-20 | 2025-05-14 | シャンハイ ジムン バイオファーマ,インコーポレーテッド | Rho関連プロテインキナーゼ阻害剤ならびにその調製および応用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL272939A (en) | 2020-04-30 |
| US20200231576A1 (en) | 2020-07-23 |
| AU2018326785A1 (en) | 2020-04-09 |
| WO2019046795A1 (en) | 2019-03-07 |
| CA3073956A1 (en) | 2019-03-07 |
| EP3676262A4 (en) | 2021-03-31 |
| CN111406051A (zh) | 2020-07-10 |
| EP3676262A1 (en) | 2020-07-08 |
| US11542256B2 (en) | 2023-01-03 |
| AU2018326785B2 (en) | 2023-03-02 |
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