CA3073956A1 - Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors - Google Patents

Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors Download PDF

Info

Publication number
CA3073956A1
CA3073956A1 CA3073956A CA3073956A CA3073956A1 CA 3073956 A1 CA3073956 A1 CA 3073956A1 CA 3073956 A CA3073956 A CA 3073956A CA 3073956 A CA3073956 A CA 3073956A CA 3073956 A1 CA3073956 A1 CA 3073956A1
Authority
CA
Canada
Prior art keywords
vinyl
pyrimidin
bipyrimidin
isoindoline
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3073956A
Other languages
English (en)
French (fr)
Inventor
An-Hu Li
Dibyendu Dana
Dong Sung Lim
Satishkumar GADHIYA
Dawoon Jung
Prakash Narayan
Quaisar ALI
Swarnalatha PAKA
Itzhak D. Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elicio Therapeutics Inc
Original Assignee
Angion Biomedica Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angion Biomedica Corp filed Critical Angion Biomedica Corp
Publication of CA3073956A1 publication Critical patent/CA3073956A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3073956A 2017-09-03 2018-08-31 Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors Pending CA3073956A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553885P 2017-09-03 2017-09-03
US62/553,885 2017-09-03
PCT/US2018/049225 WO2019046795A1 (en) 2017-09-03 2018-08-31 VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE

Publications (1)

Publication Number Publication Date
CA3073956A1 true CA3073956A1 (en) 2019-03-07

Family

ID=65526110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3073956A Pending CA3073956A1 (en) 2017-09-03 2018-08-31 Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors

Country Status (8)

Country Link
US (1) US11542256B2 (enExample)
EP (1) EP3676262A4 (enExample)
JP (1) JP2020532551A (enExample)
CN (1) CN111406051A (enExample)
AU (1) AU2018326785B2 (enExample)
CA (1) CA3073956A1 (enExample)
IL (1) IL272939A (enExample)
WO (1) WO2019046795A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020532551A (ja) 2017-09-03 2020-11-12 アンジオン バイオメディカ コーポレーション Ｒｈｏ関連コイルドコイルキナーゼ（ＲＯＣＫ）阻害剤としてのビニルヘテロ環
CN114502163A (zh) * 2019-07-22 2022-05-13 安吉昂生物医药公司 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙炔基杂环
TW202132285A (zh) * 2019-11-13 2021-09-01 美商愛彼特生物製藥股份有限公司 經取代異吲哚啉基2,2’-聯嘧啶基化合物、其類似物及使用其之方法
EP4185579A1 (en) * 2020-07-21 2023-05-31 Angion Biomedica Corp. Inhibitors of rho-associated coiled-coil kinase
WO2023202642A1 (zh) * 2022-04-20 2023-10-26 上海挚盟医药科技有限公司 Rho相关蛋白激酶抑制剂及其制备和应用
US12600722B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
US12600723B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322756A (en) 1992-07-09 1994-06-21 Xerox Corporation Magnetic fluids and method of preparation
MY134008A (en) 1999-12-22 2007-11-30 Merck Frosst Canada Inc Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors
WO2002072578A2 (en) 2001-03-08 2002-09-19 Millennium Pharmaceuticals (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases
DE102004039280A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
CR9465A (es) 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
CA2660560A1 (en) * 2006-08-16 2008-02-21 Boehringer Ingelheim International Gmbh Pyrazine compounds, their use and methods of preparation
CA2662359A1 (en) * 2006-09-21 2008-03-27 Novartis Ag Pyrrole derivatives useful for the treatment of cytokine-mediated diseases
US7758972B2 (en) 2006-09-26 2010-07-20 Semiconductor Energy Laboratory Co., Ltd. Stilbene derivative, light emitting element, light emitting device, and electronic appliance
WO2008054599A2 (en) 2006-09-27 2008-05-08 Surface Logix, Inc. Rho kinase inhibitors
EP2116522B1 (en) * 2007-02-28 2013-09-18 JNC Corporation Pentacyclic liquid crystal compound having cf<sb>2</sb>o bonding group, liquid crystal composition and liquid crystal display
US20100101643A1 (en) 2007-03-29 2010-04-29 Sumitomo Chemical Company, Limited Compound, photoelectric converter and photoelectrochemical cell
MX2011009568A (es) 2009-03-09 2011-12-06 Surface Logix Inc Inhibidores de la rho cinasa.
US8680116B2 (en) 2009-07-22 2014-03-25 Merck Sharp & Dohme Corp. Quinolinone PDE2 inhibitors
WO2011107608A1 (en) 2010-03-02 2011-09-09 Amakem Nv Heterocyclic amides as rock inhibitors
WO2012040499A2 (en) 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
JP5809954B2 (ja) 2011-12-15 2015-11-11 富士フイルム株式会社 光電変換素子及び色素増感太陽電池
PL2903618T3 (pl) 2012-10-05 2022-09-19 Kadmon Corporation, Llc Inhibitory kinazy rho
US20150297679A1 (en) 2012-12-14 2015-10-22 The Brigham And Women's Hospital, Inc. Methods and assays relating to macrophage differentiation
SMT201700317T1 (it) 2013-01-29 2017-09-07 Redx Pharma Plc Derivati piridinici in qualità di inibitori rock teneri
WO2015157556A1 (en) 2014-04-09 2015-10-15 Kadmon Corporation, Llc Treatment of gvhd
KR101808982B1 (ko) 2014-06-11 2017-12-13 후지필름 가부시키가이샤 광전 변환 소자, 색소 증감 태양 전지, 금속 착체 색소, 색소 용액, 및 터피리딘 화합물 또는 그 에스터화물
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
WO2016081554A1 (en) 2014-11-18 2016-05-26 Neostem Oncology, Llc Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use
EA201791258A1 (ru) 2015-01-09 2017-12-29 Джилид Аполло, Ллс Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US9687483B2 (en) 2015-01-26 2017-06-27 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors
TW201706265A (zh) 2015-03-09 2017-02-16 必治妥美雅史谷比公司 做為Ｒｈｏ激酶（ＲＯＣＫ）抑制劑之內醯胺
CN107921036A (zh) 2015-05-29 2018-04-17 优势医疗公司 用于减少视力丧失的组合物和方法
ES2839220T3 (es) 2015-06-16 2021-07-05 Univ Kyoto Procedimiento de fabricación de plaquetas de alto rendimiento
EP3439658B1 (en) 2016-04-04 2021-11-24 ChemoCentryx, Inc. Soluble c5ar antagonists
JP2019112307A (ja) 2016-04-28 2019-07-11 宇部興産株式会社 置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
JP2019517523A (ja) 2016-06-03 2019-06-24 ケモセントリックス， インコーポレイテッド 肝線維症を治療する方法
CN107019698A (zh) 2016-08-04 2017-08-08 上海市第十人民医院 Rock2抑制剂在制备炎症性肠病药物中的应用
EP3512935B1 (en) 2016-09-13 2022-02-23 President and Fellows of Harvard College Methods relating to intestinal organ-on-a-chip
KR101892154B1 (ko) 2017-02-22 2018-08-28 한국과학기술연구원 Ｒｈｏ-연관된 단백질 키나제 저해제를 포함하는 면역 반응 증강용 조성물 및 이를 이용한 방법
CN106916145B (zh) 2017-03-06 2019-06-04 上海应用技术大学 SLx-2119的合成方法
WO2018167103A1 (en) 2017-03-13 2018-09-20 Genfit Pharmaceutical compositions for combination therapy
JP2020510071A (ja) 2017-03-16 2020-04-02 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング 特発性肺線維症の治療
JP7266531B2 (ja) 2017-04-18 2023-04-28 ジェンフィ エラフィブラノール又はその誘導体と抗ｎａｓｈ剤、抗線維化剤又は抗胆汁うっ滞性剤の組合せ
CN110799187B (zh) 2017-06-30 2023-10-03 汇科锦公司 螺内酯化合物
JP2020532551A (ja) 2017-09-03 2020-11-12 アンジオン バイオメディカ コーポレーション Ｒｈｏ関連コイルドコイルキナーゼ（ＲＯＣＫ）阻害剤としてのビニルヘテロ環
GB201715930D0 (en) 2017-09-30 2017-11-15 Upside Biotechnologies Ltd Cell Culture Medium
GB201715928D0 (en) 2017-09-30 2017-11-15 Auckland Uniservices Ltd Method
CA3077395A1 (en) 2017-10-30 2019-05-09 Chemocentryx, Inc. Deuterated compounds as immunomodulators
WO2019099457A1 (en) 2017-11-14 2019-05-23 Quixgen, Inc. Benzodioxinone compounds
IL308604B2 (en) 2017-12-06 2025-08-01 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis
WO2019126424A1 (en) 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
MX2020006460A (es) 2017-12-22 2020-11-06 Chemocentryx Inc Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar.
BR112020019822A2 (pt) 2018-04-02 2021-03-16 Chemocentryx, Inc. Profármacos de antagonistas bicíclicos fundidos de c5ar
US20190328721A1 (en) 2018-04-25 2019-10-31 Korea Institute Of Science And Technology Method of activating dendritic cells
CN110200972A (zh) 2019-05-10 2019-09-06 南京市儿童医院 Kd025在制备防治慢性肾纤维化的药物中的用途
CN114502163A (zh) 2019-07-22 2022-05-13 安吉昂生物医药公司 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙炔基杂环
EP4185579A1 (en) 2020-07-21 2023-05-31 Angion Biomedica Corp. Inhibitors of rho-associated coiled-coil kinase

Also Published As

Publication number Publication date
IL272939A (en) 2020-04-30
US20200231576A1 (en) 2020-07-23
AU2018326785A1 (en) 2020-04-09
WO2019046795A1 (en) 2019-03-07
JP2020532551A (ja) 2020-11-12
EP3676262A4 (en) 2021-03-31
CN111406051A (zh) 2020-07-10
EP3676262A1 (en) 2020-07-08
US11542256B2 (en) 2023-01-03
AU2018326785B2 (en) 2023-03-02

Similar Documents

Publication Publication Date Title
US11542256B2 (en) Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors
US11504359B2 (en) Antifibrotic compounds and uses thereof
US8513433B2 (en) Small molecule inhibitors of PARP activity
WO2010088000A2 (en) Antifibrotic compounds and uses thereof
AU2003301224C1 (en) Pyrazole derivatives modulators of Hepatocyte Growth Factor (Scatter Factor) activity
AU2003301224B2 (en) Pyrazole derivatives modulators of Hepatocyte Growth Factor (Scatter Factor) activity
CA2767331A1 (en) Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
US11434234B2 (en) Methods and agents for treating disease
US20220281841A1 (en) Ethynylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors
US20230295131A1 (en) Inhibitors of rho-associated coiled-coil kinase
US9597321B2 (en) Antifibrotic compounds and uses thereof
HK40021008A (en) Anti-fibrotic compounds and uses thereof