JP2020531520A5 - - Google Patents

Info

Publication number

JP2020531520A5

JP2020531520A5 JP2020511254A JP2020511254A JP2020531520A5 JP 2020531520 A5 JP2020531520 A5 JP 2020531520A5 JP 2020511254 A JP2020511254 A JP 2020511254A JP 2020511254 A JP2020511254 A JP 2020511254A JP 2020531520 A5 JP2020531520 A5 JP 2020531520A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

concentration

composition according

item

seq

Prior art date

2018-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 133
• 239000000203 mixture Substances 0.000 claims description 51
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 24
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 24
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 23
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 23
• 229920000053 polysorbate 80 Polymers 0.000 claims description 23
• 229940068968 polysorbate 80 Drugs 0.000 claims description 23
• 239000003963 antioxidant agent Substances 0.000 claims description 21
• 230000003078 antioxidant effect Effects 0.000 claims description 21
• 150000003573 thiols Chemical class 0.000 claims description 21
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 17
• 229930182817 methionine Natural products 0.000 claims description 17
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 11
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 6
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 5
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 5
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 5
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 5
• 208000024827 Alzheimer disease Diseases 0.000 claims description 4
• 230000002159 abnormal effect Effects 0.000 claims description 3
• 238000009825 accumulation Methods 0.000 claims description 3
• 229960003589 arginine hydrochloride Drugs 0.000 claims description 3
• 210000003169 central nervous system Anatomy 0.000 claims description 3
• 208000010877 cognitive disease Diseases 0.000 claims description 3
• 230000008021 deposition Effects 0.000 claims description 3
• 150000001413 amino acids Chemical group 0.000 claims 4
• 229960003180 glutathione Drugs 0.000 claims 2
• 108010024636 Glutathione Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 20
• 239000012634 fragment Substances 0.000 description 18
• 238000000034 method Methods 0.000 description 16
• 229930006000 Sucrose Natural products 0.000 description 9
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
• 239000005720 sucrose Substances 0.000 description 9
• 108010053070 Glutathione Disulfide Proteins 0.000 description 7
• YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 6
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 6
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 4
• LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
• 229960003067 cystine Drugs 0.000 description 4
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1