JP2020530770A5 - - Google Patents
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- JP2020530770A5 JP2020530770A5 JP2020503056A JP2020503056A JP2020530770A5 JP 2020530770 A5 JP2020530770 A5 JP 2020530770A5 JP 2020503056 A JP2020503056 A JP 2020503056A JP 2020503056 A JP2020503056 A JP 2020503056A JP 2020530770 A5 JP2020530770 A5 JP 2020530770A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- binding domain
- amino acid
- acid sequence
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 239000002552 dosage form Substances 0.000 claims 13
- 239000012636 effector Substances 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 4
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 2
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 2
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 2
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 2
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000020411 cell activation Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 201000004404 Neurofibroma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- -1 elixirs Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535107P | 2017-07-20 | 2017-07-20 | |
| US62/535,107 | 2017-07-20 | ||
| US201762575820P | 2017-10-23 | 2017-10-23 | |
| US62/575,820 | 2017-10-23 | ||
| US201862648072P | 2018-03-26 | 2018-03-26 | |
| US62/648,072 | 2018-03-26 | ||
| PCT/EP2018/069850 WO2019016402A1 (en) | 2017-07-20 | 2018-07-20 | BINDING PROTEINS BINDING AT 5T4 AND 4-1BB, COMPOSITIONS AND METHODS RELATED THERETO |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530770A JP2020530770A (ja) | 2020-10-29 |
| JP2020530770A5 true JP2020530770A5 (OSRAM) | 2021-08-26 |
| JP7369113B2 JP7369113B2 (ja) | 2023-10-25 |
Family
ID=63113484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503056A Active JP7369113B2 (ja) | 2017-07-20 | 2018-07-20 | 癌胎児性抗原結合タンパク質、関連する化合物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10239949B2 (OSRAM) |
| EP (1) | EP3655439A1 (OSRAM) |
| JP (1) | JP7369113B2 (OSRAM) |
| KR (1) | KR102649757B1 (OSRAM) |
| CN (1) | CN111148763B (OSRAM) |
| AU (1) | AU2018304585B2 (OSRAM) |
| BR (1) | BR112020001180A2 (OSRAM) |
| CA (1) | CA3070272A1 (OSRAM) |
| CO (1) | CO2020001654A2 (OSRAM) |
| IL (1) | IL272103B2 (OSRAM) |
| MX (1) | MX2020000583A (OSRAM) |
| NZ (1) | NZ761636A (OSRAM) |
| PH (1) | PH12020500137A1 (OSRAM) |
| SG (1) | SG11202000503QA (OSRAM) |
| WO (1) | WO2019016402A1 (OSRAM) |
| ZA (1) | ZA202000961B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017252233A1 (en) | 2016-04-22 | 2018-11-15 | Alligator Bioscience Ab | Novel bispecific polypeptides against CD137 |
| KR20230166145A (ko) * | 2017-03-15 | 2023-12-06 | 옥스포드 바이오메디카(유케이) 리미티드 | 방법 |
| WO2019016402A1 (en) * | 2017-07-20 | 2019-01-24 | Aptevo Research And Development Llc | BINDING PROTEINS BINDING AT 5T4 AND 4-1BB, COMPOSITIONS AND METHODS RELATED THERETO |
| SG11202008399QA (en) | 2018-03-12 | 2020-09-29 | Genmab As | Antibodies |
| CA3147420A1 (en) | 2019-07-26 | 2021-02-04 | Abl Bio Inc. | Anti-egfr/anti-4-1bb bispecific antibody and use thereof |
| WO2021020846A1 (en) | 2019-07-26 | 2021-02-04 | Abl Bio Inc. | Anti-her2/anti-4-1bb bispecific antibody and use thereof |
| WO2021030488A1 (en) * | 2019-08-12 | 2021-02-18 | Bienvenue David Leonard | 4-1bb and ox40 binding proteins and related compositions and methods, antibodies against 4-1bb, antibodies against ox40 |
| EP4155319A4 (en) * | 2020-06-30 | 2024-06-12 | Nona Biosciences (Suzhou) Co., Ltd. | 4-1BB BINDING PROTEIN AND ITS USE |
| US20240301064A1 (en) * | 2021-02-23 | 2024-09-12 | Pandion Operations, Inc. | Pd-1 antibodies, polypeptides and uses thereof |
| JP2024522116A (ja) * | 2021-05-28 | 2024-06-11 | エックスワイワン セラピューティクス インコーポレイテッド | Ｍｕｃ１－ｃ／細胞外ドメイン（ｍｕｃ１－ｃ／ｅｃｄ）に対する多重特異性抗体構築物 |
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| AU2017252233A1 (en) * | 2016-04-22 | 2018-11-15 | Alligator Bioscience Ab | Novel bispecific polypeptides against CD137 |
| BR112019017628A2 (pt) | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
| WO2019016402A1 (en) | 2017-07-20 | 2019-01-24 | Aptevo Research And Development Llc | BINDING PROTEINS BINDING AT 5T4 AND 4-1BB, COMPOSITIONS AND METHODS RELATED THERETO |
-
2018
- 2018-07-20 WO PCT/EP2018/069850 patent/WO2019016402A1/en not_active Ceased
- 2018-07-20 IL IL272103A patent/IL272103B2/en unknown
- 2018-07-20 SG SG11202000503QA patent/SG11202000503QA/en unknown
- 2018-07-20 US US16/041,309 patent/US10239949B2/en active Active
- 2018-07-20 MX MX2020000583A patent/MX2020000583A/es unknown
- 2018-07-20 JP JP2020503056A patent/JP7369113B2/ja active Active
- 2018-07-20 CN CN201880060362.6A patent/CN111148763B/zh active Active
- 2018-07-20 US US16/632,144 patent/US11725060B2/en active Active
- 2018-07-20 NZ NZ761636A patent/NZ761636A/en unknown
- 2018-07-20 BR BR112020001180-0A patent/BR112020001180A2/pt unknown
- 2018-07-20 KR KR1020207004833A patent/KR102649757B1/ko active Active
- 2018-07-20 AU AU2018304585A patent/AU2018304585B2/en active Active
- 2018-07-20 CA CA3070272A patent/CA3070272A1/en active Pending
- 2018-07-20 EP EP18750355.2A patent/EP3655439A1/en active Pending
-
2019
- 2019-02-21 US US16/281,440 patent/US11312786B2/en active Active
-
2020
- 2020-01-20 PH PH12020500137A patent/PH12020500137A1/en unknown
- 2020-02-13 CO CONC2020/0001654A patent/CO2020001654A2/es unknown
- 2020-02-14 ZA ZA2020/00961A patent/ZA202000961B/en unknown
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