JP2020527174A5 - - Google Patents
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- JP2020527174A5 JP2020527174A5 JP2020523235A JP2020523235A JP2020527174A5 JP 2020527174 A5 JP2020527174 A5 JP 2020527174A5 JP 2020523235 A JP2020523235 A JP 2020523235A JP 2020523235 A JP2020523235 A JP 2020523235A JP 2020527174 A5 JP2020527174 A5 JP 2020527174A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycloalkyl
- haloalkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762531951P | 2017-07-13 | 2017-07-13 | |
| US62/531,951 | 2017-07-13 | ||
| PCT/US2018/042128 WO2019014618A1 (en) | 2017-07-13 | 2018-07-13 | HETEROCYCLIC INHIBITORS OF KINASE ATR |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527174A JP2020527174A (ja) | 2020-09-03 |
| JP2020527174A5 true JP2020527174A5 (enExample) | 2021-08-12 |
| JP7159307B2 JP7159307B2 (ja) | 2022-10-24 |
Family
ID=64998660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523235A Active JP7159307B2 (ja) | 2017-07-13 | 2018-07-13 | Ａｔｒキナーゼの複素環式阻害剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10392376B2 (enExample) |
| EP (1) | EP3651768B1 (enExample) |
| JP (1) | JP7159307B2 (enExample) |
| KR (1) | KR102676822B1 (enExample) |
| CN (2) | CN111867590B (enExample) |
| AU (1) | AU2018301696B8 (enExample) |
| CA (1) | CA3069693A1 (enExample) |
| DK (1) | DK3651768T3 (enExample) |
| ES (1) | ES2974334T3 (enExample) |
| FI (1) | FI3651768T3 (enExample) |
| HR (1) | HRP20240368T1 (enExample) |
| HU (1) | HUE066043T2 (enExample) |
| IL (1) | IL271930B (enExample) |
| LT (1) | LT3651768T (enExample) |
| MX (1) | MX2020000386A (enExample) |
| NZ (1) | NZ761374A (enExample) |
| PH (1) | PH12020500072A1 (enExample) |
| PL (1) | PL3651768T3 (enExample) |
| PT (1) | PT3651768T (enExample) |
| RS (1) | RS65466B1 (enExample) |
| SI (1) | SI3651768T1 (enExample) |
| SM (1) | SMT202400106T1 (enExample) |
| WO (1) | WO2019014618A1 (enExample) |
| ZA (1) | ZA202000148B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10421765B2 (en) | 2017-05-26 | 2019-09-24 | Board Of Regents, The University Of Texas System | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase |
| US10377591B2 (en) | 2017-07-07 | 2019-08-13 | Zebra Technologies Corporation | Input handling for media processing devices |
| DK3651768T3 (da) * | 2017-07-13 | 2024-03-18 | Univ Texas | Heterocykliske inhibitorer af atr-kinase |
| US10800774B2 (en) | 2017-08-17 | 2020-10-13 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
| JP7235338B2 (ja) * | 2017-09-08 | 2023-03-08 | ニューウェーブ・ファーマスーティカル・インコーポレイテッド | Ａｔｒ阻害剤としての置換ピロロピリジン |
| CN112218631B (zh) * | 2018-03-16 | 2023-12-22 | 德州大学系统董事会 | Atr激酶的杂环抑制剂 |
| CN112771047A (zh) * | 2018-09-27 | 2021-05-07 | 重庆复创医药研究有限公司 | 作为RET激酶抑制剂的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物 |
| KR102803409B1 (ko) * | 2019-06-06 | 2025-05-07 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | Atr 키나제 억제제로서의 2,4,6-삼치환된 피리미딘 화합물 |
| CN113121524B (zh) * | 2019-12-31 | 2023-04-25 | 南京创济生物医药有限公司 | 杂环亚砜亚胺化合物及其中间体、制备方法和应用 |
| EP4159734B1 (en) | 2020-05-29 | 2025-08-13 | Wuxi Life Fountain Biotech Co., Ltd. | Fluoropyrrolopyridine compound and application thereof |
| CN116134022B (zh) * | 2020-07-03 | 2025-03-18 | 上海德琪医药科技有限公司 | Atr抑制剂和其用途 |
| CN116848113A (zh) * | 2021-02-10 | 2023-10-03 | 南京再明医药有限公司 | 作为hpk1抑制剂的双环类化合物及其应用 |
| JP2024517906A (ja) * | 2021-05-12 | 2024-04-23 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | スルホンイミドイル含有ａｔｒ阻害剤化合物 |
| CN117500789A (zh) * | 2021-06-17 | 2024-02-02 | 杭州中美华东制药有限公司 | 一种吡啶硼酸酯的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081338A1 (en) * | 2000-04-25 | 2001-11-01 | Actelion Pharmaceuticals Ltd | Substituted sulfonylaminopyrimidines |
| WO2004052315A2 (en) * | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0501999D0 (en) * | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| BRPI0706395A2 (pt) * | 2006-01-11 | 2011-03-22 | Astrazeneca Ab | composto, uso do mesmo, métodos para produzir um efeito anti-proliferativo em um animal de sangue quente e para tratar doença, composição farmacêutica, e, processo para preparar um composto |
| WO2008023159A1 (en) | 2006-08-24 | 2008-02-28 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| EP2064203A1 (en) * | 2006-09-14 | 2009-06-03 | AstraZeneca AB | 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| JP2008115166A (ja) * | 2006-10-10 | 2008-05-22 | Daiichi Sankyo Co Ltd | ピリジルフェニルメチルスルホン誘導体 |
| WO2008125833A1 (en) | 2007-04-12 | 2008-10-23 | Piramed Limited | Pharmaceutical compounds |
| US20080292588A1 (en) | 2007-05-17 | 2008-11-27 | Anadys Pharmaceuticals, Inc. | 1-methyl-benzo[1,2,4]thiadiazine 1-oxide derivatives |
| US20100227858A1 (en) | 2007-07-09 | 2010-09-09 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| CN101796048A (zh) * | 2007-07-09 | 2010-08-04 | 阿斯利康(瑞典)有限公司 | 用于治疗增殖病症的三取代的嘧啶衍生物 |
| CN101801962A (zh) | 2007-07-09 | 2010-08-11 | 阿斯利康(瑞典)有限公司 | 用于治疗增殖疾病的三取代嘧啶衍生物 |
| EA018708B1 (ru) | 2007-07-09 | 2013-10-30 | Астразенека Аб | ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K |
| EP2264026A4 (en) | 2008-03-06 | 2012-03-28 | Msd Kk | ALKYLAMINOPYRIDINDERIVATE |
| AU2009266806A1 (en) | 2008-07-03 | 2010-01-07 | Exelixis Inc. | CDK modulators |
| MX2011004953A (es) * | 2008-11-10 | 2011-12-14 | Vertex Pharma | Compuestos utiles como inhibidores de cinasa atr. |
| TW201028410A (en) | 2008-12-22 | 2010-08-01 | Astrazeneca Ab | Chemical compounds 610 |
| WO2010120996A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| JP2013032290A (ja) | 2009-11-20 | 2013-02-14 | Dainippon Sumitomo Pharma Co Ltd | 新規縮合ピリミジン誘導体 |
| WO2011103715A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Task channel antagonists |
| WO2011106276A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Task channel antagonists |
| EP2542536B1 (en) | 2010-03-04 | 2015-01-21 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
| WO2011143419A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Pyrazines useful as inhibitors of atr kinase |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| WO2012147890A1 (ja) | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
| WO2014089379A1 (en) | 2012-12-07 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| TWI649318B (zh) | 2013-04-19 | 2019-02-01 | 英塞特控股公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| WO2015085132A1 (en) | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
| TWI656121B (zh) * | 2014-08-04 | 2019-04-11 | 德商拜耳製藥公司 | ２－（嗎啉－４－基）－１，７－萘啶 |
| US9663535B2 (en) | 2014-10-13 | 2017-05-30 | Atrin Pharmaceuticals LLC | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors |
| AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
| US10421765B2 (en) | 2017-05-26 | 2019-09-24 | Board Of Regents, The University Of Texas System | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase |
| DK3651768T3 (da) | 2017-07-13 | 2024-03-18 | Univ Texas | Heterocykliske inhibitorer af atr-kinase |
| US10800774B2 (en) | 2017-08-17 | 2020-10-13 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
| CN112218631B (zh) | 2018-03-16 | 2023-12-22 | 德州大学系统董事会 | Atr激酶的杂环抑制剂 |
-
2018
- 2018-07-13 DK DK18831104.7T patent/DK3651768T3/da active
- 2018-07-13 ES ES18831104T patent/ES2974334T3/es active Active
- 2018-07-13 HR HRP20240368TT patent/HRP20240368T1/hr unknown
- 2018-07-13 CN CN201880051484.9A patent/CN111867590B/zh active Active
- 2018-07-13 CA CA3069693A patent/CA3069693A1/en active Pending
- 2018-07-13 SM SM20240106T patent/SMT202400106T1/it unknown
- 2018-07-13 SI SI201831077T patent/SI3651768T1/sl unknown
- 2018-07-13 LT LTEPPCT/US2018/042128T patent/LT3651768T/lt unknown
- 2018-07-13 JP JP2020523235A patent/JP7159307B2/ja active Active
- 2018-07-13 PT PT188311047T patent/PT3651768T/pt unknown
- 2018-07-13 WO PCT/US2018/042128 patent/WO2019014618A1/en not_active Ceased
- 2018-07-13 KR KR1020207004080A patent/KR102676822B1/ko active Active
- 2018-07-13 RS RS20240297A patent/RS65466B1/sr unknown
- 2018-07-13 IL IL271930A patent/IL271930B/en unknown
- 2018-07-13 AU AU2018301696A patent/AU2018301696B8/en active Active
- 2018-07-13 PL PL18831104.7T patent/PL3651768T3/pl unknown
- 2018-07-13 FI FIEP18831104.7T patent/FI3651768T3/fi active
- 2018-07-13 EP EP18831104.7A patent/EP3651768B1/en active Active
- 2018-07-13 US US16/035,310 patent/US10392376B2/en active Active
- 2018-07-13 CN CN202311427557.9A patent/CN117466884A/zh active Pending
- 2018-07-13 HU HUE18831104A patent/HUE066043T2/hu unknown
- 2018-07-13 NZ NZ761374A patent/NZ761374A/en unknown
- 2018-07-13 MX MX2020000386A patent/MX2020000386A/es unknown
-
2019
- 2019-07-10 US US16/507,851 patent/US10800769B2/en active Active
-
2020
- 2020-01-09 PH PH12020500072A patent/PH12020500072A1/en unknown
- 2020-01-09 ZA ZA2020/00148A patent/ZA202000148B/en unknown
- 2020-09-01 US US17/009,428 patent/US11434233B2/en active Active
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