JP2014510037A5 - - Google Patents
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- Publication number
- JP2014510037A5 JP2014510037A5 JP2013549896A JP2013549896A JP2014510037A5 JP 2014510037 A5 JP2014510037 A5 JP 2014510037A5 JP 2013549896 A JP2013549896 A JP 2013549896A JP 2013549896 A JP2013549896 A JP 2013549896A JP 2014510037 A5 JP2014510037 A5 JP 2014510037A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- aryl
- heteroaryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN184MU2011 | 2011-01-21 | ||
| IN184/MUM/2011 | 2011-01-21 | ||
| PCT/GB2012/050132 WO2012098416A1 (en) | 2011-01-21 | 2012-01-23 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510037A JP2014510037A (ja) | 2014-04-24 |
| JP2014510037A5 true JP2014510037A5 (enExample) | 2015-03-12 |
| JP5905028B2 JP5905028B2 (ja) | 2016-04-20 |
Family
ID=45540888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549896A Active JP5905028B2 (ja) | 2011-01-21 | 2012-01-23 | ジアリールアセチレンヒドラジドを含有するチロシンキナーゼ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9024021B2 (enExample) |
| EP (1) | EP2665709B1 (enExample) |
| JP (1) | JP5905028B2 (enExample) |
| KR (1) | KR101892574B1 (enExample) |
| CN (1) | CN103502217B (enExample) |
| AU (1) | AU2012208388C1 (enExample) |
| BR (1) | BR112013018212B1 (enExample) |
| CA (1) | CA2825367C (enExample) |
| EA (1) | EA024194B8 (enExample) |
| ES (1) | ES2608829T3 (enExample) |
| MX (1) | MX336051B (enExample) |
| WO (1) | WO2012098416A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351123B2 (en) | 2017-03-15 | 2022-06-07 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013256227B2 (en) | 2012-05-02 | 2017-06-15 | Georgetown University | Treating neural disease with tyrosine kinase inhibitors |
| CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
| EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
| GB2518873A (en) * | 2013-10-03 | 2015-04-08 | Agency Science Tech & Res | Bicyclic alkyne derivatives and uses thereof |
| JP6744218B2 (ja) | 2013-11-15 | 2020-08-19 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | Ｅｂｎａ１阻害剤およびそれらの使用方法 |
| BR112017024481B1 (pt) | 2015-05-14 | 2020-11-17 | The Wistar Institute Of Anatomy And Biology | composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo |
| MX2017014752A (es) * | 2015-05-18 | 2018-03-23 | Sun Pharma Advanced Res Co Ltd | Nuevos etinos de amidoheteroaril aroil hidrazida. |
| KR20170096599A (ko) * | 2016-02-16 | 2017-08-24 | 한국과학기술연구원 | 단백질 키나아제 저해제인 신규 2,3,5-치환된 싸이오펜 화합물 |
| MY193754A (en) * | 2016-06-02 | 2022-10-27 | Sun Pharma Advanced Res Co Ltd | Treatment for parkinson's disease |
| EA037697B1 (ru) * | 2016-06-02 | 2021-05-12 | Сан Фарма Адвансед Ресёрч Компани Лимитед | Лечение болезни паркинсона |
| WO2018167803A1 (en) * | 2017-03-15 | 2018-09-20 | Sun Pharma Advanced Research Company Limited | Novel amorphous dispersion of cyclopropanecarboxylic acid (5-{5-[ n'-(2-chloro-6-methylbenzoyl) hydrazinocarbonyl] -2-methyl-phenylethynyl}-pyridin-2-yl) amide |
| CN112543634A (zh) | 2018-05-17 | 2021-03-23 | 威斯达研究所 | Ebna1抑制剂晶体形式及其制备和使用方法 |
| EP3883935A4 (en) | 2018-11-20 | 2022-08-10 | Georgetown University | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE, MYODEGENERATIVE AND LYSOSOMA STORAGE DISEASES |
| AU2020292703A1 (en) | 2019-06-11 | 2022-01-27 | Sun Pharma Advanced Research Company Ltd. | Treatment for synucleinopathies |
| KR20220120638A (ko) * | 2019-12-26 | 2022-08-30 | 베이징 이노케어 파마 테크 씨오., 엘티디. | (s)-1-(1-아크릴로일피롤리딘-3-일)-3-((3,5-디메톡시페닐)에티닐)-5-(메틸아미노)-1h-피라졸-4-카르복사미드의 결정질 형태 |
| US20230295153A1 (en) | 2020-02-28 | 2023-09-21 | Daegu-Gyeongbuk Medical Innovation Foundation | 3-((8-((1h-pyrazol-4-yl)amino)imidazo[1,2-a]pyridin-3-yl)ethinyl)-n-phenylbenzamide derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer |
| EP4188351A1 (en) | 2020-07-31 | 2023-06-07 | Sun Pharma Advanced Research Company Ltd | N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl) ethynyl]-benzohydrazide for treatment of alzheimer's disease |
| TW202317530A (zh) | 2021-06-29 | 2023-05-01 | 日商住友化學股份有限公司 | 雜環化合物及含有其之組成物之抗藥性有害節肢動物防除方法 |
| IL318812A (en) | 2022-08-25 | 2025-04-01 | Sun Pharma Advanced Res Co Ltd | Methods for treating chronic myeloid leukemia using the tyrosine kinase inhibitor vedovatinib |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| PT1169038E (pt) | 1999-04-15 | 2012-10-26 | Bristol Myers Squibb Co | Inibidores cíclicos da proteína tirosina cinase |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| DE602005017129D1 (de) | 2004-03-22 | 2009-11-26 | Lilly Co Eli | Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten |
| JP5200939B2 (ja) * | 2005-12-23 | 2013-06-05 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 二環式ヘテロアリール化合物 |
| CN101389338B (zh) * | 2005-12-23 | 2013-06-26 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2009100536A1 (en) * | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
-
2012
- 2012-01-23 US US13/980,108 patent/US9024021B2/en active Active
- 2012-01-23 AU AU2012208388A patent/AU2012208388C1/en active Active
- 2012-01-23 JP JP2013549896A patent/JP5905028B2/ja active Active
- 2012-01-23 WO PCT/GB2012/050132 patent/WO2012098416A1/en not_active Ceased
- 2012-01-23 CA CA2825367A patent/CA2825367C/en active Active
- 2012-01-23 MX MX2013008296A patent/MX336051B/es unknown
- 2012-01-23 CN CN201280014166.8A patent/CN103502217B/zh active Active
- 2012-01-23 EA EA201370166A patent/EA024194B8/ru unknown
- 2012-01-23 ES ES12701370.4T patent/ES2608829T3/es active Active
- 2012-01-23 EP EP12701370.4A patent/EP2665709B1/en active Active
- 2012-01-23 BR BR112013018212-1A patent/BR112013018212B1/pt active IP Right Grant
- 2012-01-23 KR KR1020137021626A patent/KR101892574B1/ko active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351123B2 (en) | 2017-03-15 | 2022-06-07 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide |
| US12194153B2 (en) | 2017-03-15 | 2025-01-14 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n′-(2-chloro-6-methyl-benzoyl) hydrazide |