CA3069693A1 - Heterocyclic inhibitors of atr kinase - Google Patents

Heterocyclic inhibitors of atr kinase Download PDF

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Publication number
CA3069693A1
CA3069693A1 CA3069693A CA3069693A CA3069693A1 CA 3069693 A1 CA3069693 A1 CA 3069693A1 CA 3069693 A CA3069693 A CA 3069693A CA 3069693 A CA3069693 A CA 3069693A CA 3069693 A1 CA3069693 A1 CA 3069693A1
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CA
Canada
Prior art keywords
compound
recited
chosen
salt
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3069693A
Other languages
English (en)
French (fr)
Inventor
Maria Emilia Di Francesco
Philip Jones
Christopher Lawrence Carroll
Jason Bryant CROSS
Suyambu Kesava Vijayan RAMASWAMY
Michael Garrett JOHNSON
Sarah Lively
David Lapointe
Original Assignee
Chempartner Corp
Shangpharma LLC
Artios Pharma Ltd
The University of Texas System
Shangpharma Innovation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chempartner Corp, Shangpharma LLC, Artios Pharma Ltd, The University of Texas System, Shangpharma Innovation Inc filed Critical Chempartner Corp
Publication of CA3069693A1 publication Critical patent/CA3069693A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3069693A 2017-07-13 2018-07-13 Heterocyclic inhibitors of atr kinase Pending CA3069693A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762531951P 2017-07-13 2017-07-13
US62/531,951 2017-07-13
PCT/US2018/042128 WO2019014618A1 (en) 2017-07-13 2018-07-13 HETEROCYCLIC INHIBITORS OF KINASE ATR

Publications (1)

Publication Number Publication Date
CA3069693A1 true CA3069693A1 (en) 2019-01-17

Family

ID=64998660

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3069693A Pending CA3069693A1 (en) 2017-07-13 2018-07-13 Heterocyclic inhibitors of atr kinase

Country Status (23)

Country Link
US (3) US10392376B2 (enExample)
EP (1) EP3651768B1 (enExample)
JP (1) JP7159307B2 (enExample)
KR (1) KR102676822B1 (enExample)
CN (2) CN117466884B (enExample)
AU (1) AU2018301696B8 (enExample)
CA (1) CA3069693A1 (enExample)
DK (1) DK3651768T3 (enExample)
ES (1) ES2974334T3 (enExample)
FI (1) FI3651768T3 (enExample)
HR (1) HRP20240368T1 (enExample)
HU (1) HUE066043T2 (enExample)
IL (1) IL271930B (enExample)
LT (1) LT3651768T (enExample)
MX (1) MX2020000386A (enExample)
PH (1) PH12020500072A1 (enExample)
PL (1) PL3651768T3 (enExample)
PT (1) PT3651768T (enExample)
RS (1) RS65466B1 (enExample)
SI (1) SI3651768T1 (enExample)
SM (1) SMT202400106T1 (enExample)
WO (1) WO2019014618A1 (enExample)
ZA (1) ZA202000148B (enExample)

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WO2018218197A2 (en) 2017-05-26 2018-11-29 Board Of Regents, The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of atr kinase
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HRP20240368T1 (hr) * 2017-07-13 2024-08-30 Board Of Regents, The University Of Texas System Heterociklički inhibitori atr kinaze
JP7290627B2 (ja) 2017-08-17 2023-06-13 ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム Atrキナーゼの複素環式阻害剤
JP7235338B2 (ja) * 2017-09-08 2023-03-08 ニューウェーブ・ファーマスーティカル・インコーポレイテッド Atr阻害剤としての置換ピロロピリジン
JP7341156B2 (ja) * 2018-03-16 2023-09-08 ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム Atrキナーゼの複素環式阻害剤
TW202028209A (zh) * 2018-09-27 2020-08-01 大陸商重慶複創醫藥研究有限公司 作為RET激酶抑制劑的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物
EP3967694A4 (en) * 2019-06-06 2022-12-07 Beijing Tide Pharmaceutical Co., Ltd. 2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR-KINASE INHIBITOR
CN113121524B (zh) * 2019-12-31 2023-04-25 南京创济生物医药有限公司 杂环亚砜亚胺化合物及其中间体、制备方法和应用
EP4155307A4 (en) 2020-05-20 2023-09-13 Beijing Tide Pharmaceutical Co., Ltd. 2,4,6-TRIS-SUBSTITUTED PYRIMIDINE COMPOUNDS AS ATR KINASE INHIBITORS
AU2021282122B2 (en) * 2020-05-29 2023-09-21 Wuxi Life Fountain Biotech Co., Ltd Fluoropyrrolopyridine compound and application thereof
IL299510A (en) * 2020-07-03 2023-02-01 Antengene Discovery Ltd Atr inhibitors and uses thereof
WO2022171034A1 (zh) * 2021-02-10 2022-08-18 江苏先声药业有限公司 作为hpk1抑制剂的双环类化合物及其应用
EP4332103A4 (en) * 2021-05-12 2025-09-03 Chia Tai Tianqing Pharmaceutical Group Co Ltd ATR INHIBITOR COMPOUND CONTAINING A SULFOXIMINE
WO2022262143A1 (zh) * 2021-06-17 2022-12-22 杭州中美华东制药有限公司 一种吡啶硼酸酯的制备方法
GB2703674A (en) * 2024-10-14 2026-08-05 Artios Pharma Ltd Novel composition

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Also Published As

Publication number Publication date
KR102676822B1 (ko) 2024-06-19
PH12020500072A1 (en) 2020-11-09
AU2018301696B8 (en) 2023-03-23
NZ761374A (en) 2025-10-31
JP7159307B2 (ja) 2022-10-24
US10800769B2 (en) 2020-10-13
EP3651768A1 (en) 2020-05-20
US10392376B2 (en) 2019-08-27
AU2018301696A1 (en) 2020-02-27
HUE066043T2 (hu) 2024-07-28
CN117466884B (zh) 2026-07-24
HRP20240368T1 (hr) 2024-08-30
AU2018301696B2 (en) 2022-10-27
PL3651768T3 (pl) 2024-09-02
EP3651768A4 (en) 2021-04-07
WO2019014618A1 (en) 2019-01-17
EP3651768B1 (en) 2023-12-20
IL271930A (en) 2020-02-27
US20190016713A1 (en) 2019-01-17
PT3651768T (pt) 2024-03-20
AU2018301696A8 (en) 2023-03-23
CN111867590B (zh) 2023-11-17
US20200102296A1 (en) 2020-04-02
IL271930B (en) 2022-07-01
RS65466B1 (sr) 2024-05-31
US11434233B2 (en) 2022-09-06
JP2020527174A (ja) 2020-09-03
US20210047311A1 (en) 2021-02-18
SMT202400106T1 (it) 2024-05-14
SI3651768T1 (sl) 2024-05-31
MX2020000386A (es) 2020-08-06
DK3651768T3 (da) 2024-03-18
CN117466884A (zh) 2024-01-30
FI3651768T3 (fi) 2024-03-14
ES2974334T3 (es) 2024-06-26
ZA202000148B (en) 2024-08-28
LT3651768T (lt) 2024-04-25
KR20200028441A (ko) 2020-03-16
CN111867590A (zh) 2020-10-30

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