JP2020526534A5 - - Google Patents
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- JP2020526534A5 JP2020526534A5 JP2020500862A JP2020500862A JP2020526534A5 JP 2020526534 A5 JP2020526534 A5 JP 2020526534A5 JP 2020500862 A JP2020500862 A JP 2020500862A JP 2020500862 A JP2020500862 A JP 2020500862A JP 2020526534 A5 JP2020526534 A5 JP 2020526534A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- composition according
- multiple myeloma
- activator
- Prior art date
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530778P | 2017-07-10 | 2017-07-10 | |
| US62/530,778 | 2017-07-10 | ||
| US201762593185P | 2017-11-30 | 2017-11-30 | |
| US62/593,185 | 2017-11-30 | ||
| US201862675581P | 2018-05-23 | 2018-05-23 | |
| US62/675,581 | 2018-05-23 | ||
| PCT/US2018/041230 WO2019014100A1 (en) | 2017-07-10 | 2018-07-09 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020526534A JP2020526534A (ja) | 2020-08-31 |
| JP2020526534A5 true JP2020526534A5 (https=) | 2022-11-02 |
| JP7258009B2 JP7258009B2 (ja) | 2023-04-14 |
Family
ID=63036419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500862A Active JP7258009B2 (ja) | 2017-07-10 | 2018-07-09 | 抗増殖化合物及びその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US10357489B2 (https=) |
| EP (2) | EP4467143B1 (https=) |
| JP (1) | JP7258009B2 (https=) |
| KR (1) | KR102656934B1 (https=) |
| CN (1) | CN110869021B (https=) |
| AU (2) | AU2018301335B2 (https=) |
| CA (1) | CA3069138A1 (https=) |
| CL (1) | CL2020000060A1 (https=) |
| CO (1) | CO2020000193A2 (https=) |
| DK (1) | DK3651766T3 (https=) |
| EC (1) | ECSP20001149A (https=) |
| ES (1) | ES2992913T3 (https=) |
| FI (1) | FI3651766T3 (https=) |
| HR (1) | HRP20241553T1 (https=) |
| HU (1) | HUE069137T2 (https=) |
| IL (1) | IL271889B2 (https=) |
| LT (1) | LT3651766T (https=) |
| MX (1) | MX2023000085A (https=) |
| PL (1) | PL3651766T3 (https=) |
| PT (1) | PT3651766T (https=) |
| RS (1) | RS66162B1 (https=) |
| SA (1) | SA520411007B1 (https=) |
| SG (1) | SG11202000143PA (https=) |
| SI (1) | SI3651766T1 (https=) |
| SM (1) | SMT202400470T1 (https=) |
| TW (2) | TWI791552B (https=) |
| WO (1) | WO2019014100A1 (https=) |
| ZA (1) | ZA202000157B (https=) |
Families Citing this family (36)
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| EP4467143B1 (en) * | 2017-07-10 | 2026-03-11 | Celgene Corporation | Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile |
| EP3773576A4 (en) | 2018-03-26 | 2021-12-29 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
| FI3784663T3 (fi) | 2018-04-23 | 2023-10-06 | Celgene Corp | Substituoituja 4-aminoisoindoliini-1,3-dioniyhdisteitä ja niiden käyttö lymfooman hoitamiseksi |
| PL3796912T3 (pl) * | 2018-05-23 | 2023-09-11 | Celgene Corporation | Związki przeciwproliferacyjne i przeciwciało bispecyficzne przeciwko bcma i cd3 do zastosowania kombinowanego |
| KR102718800B1 (ko) | 2018-05-23 | 2024-10-18 | 셀진 코포레이션 | 다발성 골수종의 치료 및 4-(4-(4-(((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조니트릴에 대한 바이오마커의 용도 |
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| TW202019474A (zh) * | 2018-07-11 | 2020-06-01 | 美商西建公司 | 抗bcma嵌合抗原受體之用途 |
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| AR119715A1 (es) * | 2019-04-12 | 2022-01-05 | Celgene Corp | Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona |
| PL4048278T3 (pl) | 2019-10-21 | 2024-03-18 | Celgene Corporation | Sposoby leczenia złośliwych nowotworów hematologicznych z zastosowaniem 2-(2,6-dioksopiperydyn-3-ylo)-4-((2-fluoro-4-((3- morfolinoazetydyn-1-ylo)metylo)benzylo)amino)izoindolino-1,3-dionu |
| WO2021105335A1 (en) | 2019-11-27 | 2021-06-03 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
| JP7852923B2 (ja) | 2019-11-27 | 2026-04-28 | キャプター セラピューティクス エス．エー． | セレブロンに結合するピペリジン－２，６－ジオン誘導体、及びその使用方法 |
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| US20230165872A1 (en) * | 2020-04-28 | 2023-06-01 | Juno Therapeutics, Inc. | Combination of bcma-directed t cell therapy and an immunomodulatory compound |
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| CN113896711A (zh) * | 2020-07-06 | 2022-01-07 | 北京诺诚健华医药科技有限公司 | 杂环类免疫调节剂 |
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| BR112023000817A2 (pt) * | 2020-07-20 | 2023-02-07 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Derivado de isoindolina contendo enxofre, e método de preparação do mesmo e uso médico do mesmo |
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| WO2022146151A1 (en) | 2020-12-30 | 2022-07-07 | Captor Therapeutics S.A. | Novel compounds which bind to cereblon, and methods of use thereof |
| CN114685429A (zh) * | 2020-12-31 | 2022-07-01 | 江苏恒瑞医药股份有限公司 | 碳链环己二酰亚胺类化合物、其制备方法及其在医药上的应用 |
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| KR20240013793A (ko) * | 2021-05-27 | 2024-01-30 | 셀진 코포레이션 | 조합 요법을 사용하는 다발성 골수종의 치료 방법 |
| WO2022255890A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| WO2022255889A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| CA3223636A1 (en) | 2021-08-06 | 2023-02-09 | Christopher Walton CARROLL | Compositions and methods for selective degradation of engineered proteins |
| CN116023319A (zh) * | 2021-10-25 | 2023-04-28 | 英格尔医药科技(上海)有限公司 | 制备布瓦西坦的方法 |
| AU2023210002A1 (en) * | 2022-01-19 | 2024-08-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Crystalline form of sulfur-containing isoindoline derivative |
| CN116462660A (zh) * | 2022-01-19 | 2023-07-21 | 江苏恒瑞医药股份有限公司 | 一种异喹啉酮类化合物的盐及其晶型 |
| WO2024167423A1 (en) | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
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2018
- 2018-07-09 EP EP24192984.3A patent/EP4467143B1/en active Active
- 2018-07-09 SI SI201831174T patent/SI3651766T1/sl unknown
- 2018-07-09 EP EP18746444.1A patent/EP3651766B1/en active Active
- 2018-07-09 CA CA3069138A patent/CA3069138A1/en active Pending
- 2018-07-09 FI FIEP18746444.1T patent/FI3651766T3/fi active
- 2018-07-09 IL IL271889A patent/IL271889B2/en unknown
- 2018-07-09 HU HUE18746444A patent/HUE069137T2/hu unknown
- 2018-07-09 TW TW107123698A patent/TWI791552B/zh active
- 2018-07-09 RS RS20241263A patent/RS66162B1/sr unknown
- 2018-07-09 CN CN201880045745.6A patent/CN110869021B/zh active Active
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