JP2020521772A5 - - Google Patents
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- Publication number
- JP2020521772A5 JP2020521772A5 JP2019565459A JP2019565459A JP2020521772A5 JP 2020521772 A5 JP2020521772 A5 JP 2020521772A5 JP 2019565459 A JP2019565459 A JP 2019565459A JP 2019565459 A JP2019565459 A JP 2019565459A JP 2020521772 A5 JP2020521772 A5 JP 2020521772A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- substituted
- alkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 8
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 7
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 7
- 125000004185 ester group Chemical group 0.000 claims 7
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 7
- 125000003368 amide group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000006720 (C1-C6) alkyl (C6-C10) aryl group Chemical group 0.000 claims 4
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 4
- -1 -NH-COR b Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000006721 (C5-C10) heteroaryl (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000006722 (C1-C6) alkyl (C5-C10) heteroaryl group Chemical group 0.000 claims 2
- 125000006718 (C3-C7) heterocycloalkenyl group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000004900 autophagic degradation Effects 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710364986.4 | 2017-05-22 | ||
| CN201710364986.4A CN108947985A (zh) | 2017-05-22 | 2017-05-22 | 用作自噬调节剂的化合物及其制备方法和用途 |
| PCT/CN2018/087446 WO2018214812A1 (zh) | 2017-05-22 | 2018-05-18 | 用作自噬调节剂的化合物及其制备方法和用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521772A JP2020521772A (ja) | 2020-07-27 |
| JP2020521772A5 true JP2020521772A5 (enExample) | 2021-07-26 |
| JP7237017B2 JP7237017B2 (ja) | 2023-03-10 |
Family
ID=64396259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565459A Active JP7237017B2 (ja) | 2017-05-22 | 2018-05-18 | オートファジーモジュレーターとして使用される化合物、ならびにその調製方法および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11319303B2 (enExample) |
| EP (1) | EP3632903B1 (enExample) |
| JP (1) | JP7237017B2 (enExample) |
| KR (1) | KR102580087B1 (enExample) |
| CN (3) | CN108947985A (enExample) |
| AU (1) | AU2018274378B2 (enExample) |
| BR (1) | BR112019024376A2 (enExample) |
| CA (1) | CA3061209A1 (enExample) |
| MX (1) | MX2019013816A (enExample) |
| WO (1) | WO2018214812A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108929373A (zh) * | 2017-05-22 | 2018-12-04 | 苏州偶领生物医药有限公司 | 一种共价键修饰哺乳动物atg8 同源物的方法 |
| CN112898316A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型吡咯化合物 |
| CN111187153B (zh) * | 2020-01-10 | 2022-09-13 | 山东亘元生物科技有限公司 | 一种1,3-环己二酮的制备方法 |
| US12378257B2 (en) | 2021-04-20 | 2025-08-05 | University Of Tennessee Research Foundation | Metabolically stable pyrimidinyl dihydroquinoxalinones as tubulin polymerization inhibitors |
| CN117440954A (zh) * | 2021-04-20 | 2024-01-23 | 田纳西大学研究基金会 | 作为微管蛋白聚合抑制剂的代谢稳定的嘧啶基二氢喹喔啉酮 |
| CN113956215B (zh) * | 2021-07-15 | 2022-08-12 | 暨南大学附属第一医院 | 一种多环芳基化合物在抗真菌药物制备中的应用 |
| WO2023147513A2 (en) * | 2022-01-28 | 2023-08-03 | Washington University | Compositions of autophagy modulating agents and uses thereof |
| CN114870569B (zh) * | 2022-04-11 | 2023-04-07 | 合肥工业大学 | 一种哌嗪基碳捕集剂的合成方法 |
| KR102800732B1 (ko) | 2022-08-04 | 2025-05-13 | 신은식 | 띠지 포장용 난좌 가이드장치 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6087238A (ja) * | 1983-09-16 | 1985-05-16 | ストウフアー・ケミカル・カンパニー | ２‐（２‐置換ベンゾイル）‐１，３‐シクロヘキサンジオン |
| DE3474297D1 (en) * | 1983-09-16 | 1988-11-03 | Stauffer Chemical Co | Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones |
| IL77349A (en) * | 1984-12-20 | 1990-07-12 | Stauffer Chemical Co | 2-(2'-nitrobenzoyl)-1,3-cyclohexanediones,their preparation and their use as herbicides |
| JPS62123145A (ja) * | 1985-11-22 | 1987-06-04 | Otsuka Chem Co Ltd | １，３−シクロヘキサンジオン誘導体及び該誘導体を有効成分とする水田用除草剤 |
| WO2006007864A1 (en) * | 2004-07-17 | 2006-01-26 | Max Planck Geselllschaft Zur Förderung Der Wissenschaft | Treating neurodegenerative conditions |
| BRPI0620396A2 (pt) * | 2005-12-23 | 2018-05-02 | Basf Se | médoto para o controle de ervas daninhas aquáticas |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2011017809A1 (en) * | 2009-08-11 | 2011-02-17 | The University Of British Columbia | Autophagy inhibitor compounds, compositions and methods for the use thereof in the treatment of cancer |
| EP2301347A1 (en) * | 2009-09-17 | 2011-03-30 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Plant additives and uses thereof to modulate the synthesis of membrane glycerolipids in planta |
| WO2011062964A1 (en) * | 2009-11-17 | 2011-05-26 | University Of Rochester | Compounds and methods for altering lifespan of eukaryotic organisms |
| EP2508607A1 (en) * | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| US20150197513A1 (en) * | 2012-08-09 | 2015-07-16 | Neuropore Therapies, Inc. | Aryl- and heteroaryl-substituted benzene derivatives as modulators of pi3-kinase signalling pathways |
| US9505767B2 (en) * | 2013-09-05 | 2016-11-29 | Genentech, Inc. | Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors |
| CN107849038A (zh) * | 2015-06-01 | 2018-03-27 | 达尔豪西大学 | S1pr2拮抗剂及其用途 |
| US20200123127A1 (en) | 2016-04-25 | 2020-04-23 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
| CN108929373A (zh) | 2017-05-22 | 2018-12-04 | 苏州偶领生物医药有限公司 | 一种共价键修饰哺乳动物atg8 同源物的方法 |
| CN108938612A (zh) | 2017-05-22 | 2018-12-07 | 苏州偶领生物医药有限公司 | 氨基亚甲基环己烷1,3-二酮化合物的用途 |
-
2017
- 2017-05-22 CN CN201710364986.4A patent/CN108947985A/zh not_active Withdrawn
-
2018
- 2018-05-18 WO PCT/CN2018/087446 patent/WO2018214812A1/zh not_active Ceased
- 2018-05-18 EP EP18805508.1A patent/EP3632903B1/en active Active
- 2018-05-18 US US16/614,465 patent/US11319303B2/en active Active
- 2018-05-18 JP JP2019565459A patent/JP7237017B2/ja active Active
- 2018-05-18 KR KR1020197036203A patent/KR102580087B1/ko active Active
- 2018-05-18 MX MX2019013816A patent/MX2019013816A/es unknown
- 2018-05-18 BR BR112019024376-3A patent/BR112019024376A2/pt active Search and Examination
- 2018-05-18 CN CN201880033785.9A patent/CN111148740B/zh active Active
- 2018-05-18 AU AU2018274378A patent/AU2018274378B2/en active Active
- 2018-05-18 CA CA3061209A patent/CA3061209A1/en active Pending
- 2018-05-18 CN CN202310882957.2A patent/CN116969904A/zh active Pending
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