JP2020518780A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020518780A5 JP2020518780A5 JP2019559711A JP2019559711A JP2020518780A5 JP 2020518780 A5 JP2020518780 A5 JP 2020518780A5 JP 2019559711 A JP2019559711 A JP 2019559711A JP 2019559711 A JP2019559711 A JP 2019559711A JP 2020518780 A5 JP2020518780 A5 JP 2020518780A5
- Authority
- JP
- Japan
- Prior art keywords
- container
- composition
- module
- item
- modules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 83
- 238000000034 method Methods 0.000 claims description 68
- 238000001035 drying Methods 0.000 claims description 30
- 238000007710 freezing Methods 0.000 claims description 24
- 230000008014 freezing Effects 0.000 claims description 24
- 238000004108 freeze drying Methods 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 230000003750 conditioning effect Effects 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000005057 refrigeration Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013529 heat transfer fluid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762500466P | 2017-05-02 | 2017-05-02 | |
| US62/500,466 | 2017-05-02 | ||
| PCT/US2018/030629 WO2018204484A1 (en) | 2017-05-02 | 2018-05-02 | Freeze-drying methods and related products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020518780A JP2020518780A (ja) | 2020-06-25 |
| JP2020518780A5 true JP2020518780A5 (enExample) | 2021-06-17 |
| JP7295032B2 JP7295032B2 (ja) | 2023-06-20 |
Family
ID=64017000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019559711A Active JP7295032B2 (ja) | 2017-05-02 | 2018-05-02 | 凍結乾燥方法および関連製品 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11340014B2 (enExample) |
| EP (1) | EP3619489A4 (enExample) |
| JP (1) | JP7295032B2 (enExample) |
| WO (1) | WO2018204484A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY197621A (en) * | 2014-08-04 | 2023-06-28 | Genentech Inc | Apparatus and methods for sealing a medicament within a medical delivery device |
| WO2018204484A1 (en) * | 2017-05-02 | 2018-11-08 | Massachusetts Institute Of Technology | Freeze-drying methods and related products |
| EP3590893A1 (en) * | 2018-07-04 | 2020-01-08 | Elajo Technology Solutions AB | Method and arrangement for dewaterng sludge |
| DE102018218758A1 (de) * | 2018-11-02 | 2020-05-07 | OPTIMA pharma GmbH | Vorrichtung und Verfahren zum Gefriertrocknen |
| CN109974426A (zh) * | 2019-01-08 | 2019-07-05 | 林遂铭 | 一种干燥机 |
| US10921058B2 (en) * | 2019-01-27 | 2021-02-16 | Vinamit Usa Llc | Fully automatic convection current vacuum freeze drying method |
| US11243029B2 (en) * | 2019-04-26 | 2022-02-08 | Purdue Research Foundation | Process monitoring and control for lyophilization using a wireless sensor network |
| GB2589347A (en) * | 2019-11-27 | 2021-06-02 | Fluorogenics Ltd | Freeze-drying apparatus and method |
| US12402217B2 (en) * | 2020-03-30 | 2025-08-26 | Midea Group Co., Ltd. | Microwave cooking appliance with adaptive thermal sensing cycle |
| TWI860477B (zh) * | 2020-05-18 | 2024-11-01 | 日商Ｍｉｉ股份有限公司 | 真空凍結乾燥裝置及真空凍結乾燥方法 |
| EP4161690A4 (en) * | 2020-06-05 | 2024-06-19 | Merck Sharp & Dohme LLC | DEVICE AND METHOD FOR MICROWAVE VACUUM DRYING OF STERILE PRODUCTS |
| WO2022046273A1 (en) * | 2020-08-31 | 2022-03-03 | Massachusetts Institute Of Technology | Lyophilization systems and methods |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| CA3141419A1 (en) * | 2021-01-18 | 2022-07-18 | Rodrick Jolly | Vacuum grain drying apparatus |
| JP7085088B1 (ja) * | 2021-08-03 | 2022-06-16 | 株式会社エムアイアイ | 凍結乾燥物 |
| EP4590478A1 (en) * | 2021-09-21 | 2025-07-30 | Stephen B. Maguire | Resin drying systems with capability to continuously supply dried resin |
| CN114136058A (zh) * | 2021-12-13 | 2022-03-04 | 上海德瀛睿创半导体科技有限公司 | 烘干设备及加工系统 |
| NL2030238B1 (en) * | 2021-12-22 | 2023-06-29 | Rheavita Bv | Device and method for freeze-drying liquid-containing composition |
| CN115176958B (zh) * | 2022-07-01 | 2024-01-09 | 福建利众诚食品有限公司 | 基于冻干食品的转载方法及转载装置 |
| CN115342603A (zh) * | 2022-08-30 | 2022-11-15 | 中国科学院理化技术研究所 | 循环风冷冻干燥系统及方法 |
| JP7680062B2 (ja) * | 2023-07-03 | 2025-05-20 | 大川原化工機株式会社 | 真空噴霧凍結乾燥装置における粉末体の取出装置及び真空噴霧凍結乾燥装置における粉末体の取出方法、並びに、真空噴霧凍結乾燥装置 |
| CN116659210B (zh) * | 2023-07-26 | 2023-10-27 | 江苏安欣医疗科技有限公司 | 用于直线型切割吻合器生产加工的随动烘干输送机 |
| CN119197046B (zh) * | 2024-07-10 | 2025-11-14 | 天津科技大学 | 单位剂量灌装的药品旋转冷冻干燥装置 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2285336A (en) | 1939-02-25 | 1942-06-02 | Owens Illinois Glass Co | Automatic drying apparatus |
| DE1178788B (de) * | 1959-10-07 | 1964-09-24 | Leybold Hochvakuum Anlagen | Rohrfoermige, aus Teilkammern zusammen-gesetzte Vakuum-Gefriertrocknungsanlage |
| US3203108A (en) | 1962-11-28 | 1965-08-31 | Samuel M Broadwin | Centrifugal freeze drying apparatus |
| DE2615815A1 (de) | 1976-04-10 | 1977-10-27 | Boehringer Mannheim Gmbh | Maschine zum kontinuierlichen herstellen und verpacken von gefriertrocknungsgut |
| GB9505523D0 (en) * | 1995-03-18 | 1995-05-03 | Wellcome Found | Lyophilization process |
| US5723508A (en) * | 1996-01-25 | 1998-03-03 | Northwestern University | Method of fabricating emulsion freeze-dried scaffold bodies and resulting products |
| GB0013714D0 (en) | 2000-06-07 | 2000-07-26 | Acton Elizabeth | Method and apparatus for freezing tissue |
| WO2005105253A1 (en) | 2004-05-01 | 2005-11-10 | Agresearch Limited | Drying process and apparatus |
| GB0525115D0 (en) * | 2005-12-09 | 2006-01-18 | Oxford Biosensors Ltd | Freeze drying of target substances |
| DE102008031809A1 (de) | 2008-06-27 | 2009-12-31 | Optima Group Pharma Gmbh | Halterung |
| PT2525675E (pt) * | 2010-01-18 | 2015-08-21 | Enwave Corp | Secagem a vácuo por microondas de matérias orgânicas |
| PL3222952T3 (pl) | 2011-09-06 | 2019-09-30 | Rv Holding B.V. | Sposób i układ liofilizacji kompozycji do wstrzykiwania, zwłaszcza kompozycji farmaceutycznych |
| ITMI20131016A1 (it) * | 2013-06-19 | 2014-12-20 | I M A Ind Macchine Automatic He S P A | Sistema di alimentazione in una macchina liofilizzatrice per il settore farmaceutico |
| US11384980B2 (en) * | 2013-10-17 | 2022-07-12 | Joseph P. Triglia, Jr. | System and method for reducing moisture in materials or plants using microwave radiation and RF energy |
| WO2015191599A2 (en) * | 2014-06-09 | 2015-12-17 | Terumo Bct, Inc. | Lyophilization |
| WO2015188248A1 (en) * | 2014-06-11 | 2015-12-17 | Enwave Corporation | Microwave vacuum-drying of organic materials |
| WO2016191799A1 (en) | 2015-06-04 | 2016-12-08 | Freeze Dry Industries Pty Ltd | Freeze drying improvements |
| CN204917150U (zh) | 2015-07-10 | 2015-12-30 | 楚天科技股份有限公司 | 一种输瓶装置及其冻干机进出料系统 |
| MX2018002795A (es) | 2015-09-07 | 2018-04-24 | Mochida Pharm Co Ltd | Preparacion de acido alginico secada por congelacion. |
| CN105928327A (zh) | 2016-06-15 | 2016-09-07 | 超滤动力（安徽）有限公司 | 多单元并联式冷冻型干燥机 |
| SI3392584T1 (sl) * | 2017-04-21 | 2020-09-30 | Gea Lyophil Gmbh | Zamrzovalni sušilnik in postopek za induciranje nukleacije v proizvodih |
| WO2018204484A1 (en) * | 2017-05-02 | 2018-11-08 | Massachusetts Institute Of Technology | Freeze-drying methods and related products |
| US20210190425A1 (en) * | 2017-11-22 | 2021-06-24 | Ima Life North America Inc. | Spray freeze drying on a substrate |
| US10921058B2 (en) * | 2019-01-27 | 2021-02-16 | Vinamit Usa Llc | Fully automatic convection current vacuum freeze drying method |
| US11054185B1 (en) * | 2020-02-24 | 2021-07-06 | Lyophilization Technology, Inc. | Apparatus for lyophilization of products contained in product delivery units |
-
2018
- 2018-05-02 WO PCT/US2018/030629 patent/WO2018204484A1/en not_active Ceased
- 2018-05-02 JP JP2019559711A patent/JP7295032B2/ja active Active
- 2018-05-02 EP EP18794019.2A patent/EP3619489A4/en active Pending
- 2018-05-02 US US16/610,485 patent/US11340014B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020518780A5 (enExample) | ||
| US11340014B2 (en) | Freeze-drying methods and related products | |
| CN110945305B (zh) | 冷冻干燥机和用于在产品中诱导成核的方法 | |
| ES2853249T3 (es) | Recuperación de energía en un sistema de liofilización | |
| JP7049373B2 (ja) | 製品を真空凍結乾燥するためのプロセス | |
| BR112017025819B1 (pt) | Sistema de liofilização para produto a granel, método para liofilizar um produto e método para liofilizar produto a granel contendo líquido | |
| ES2958224T3 (es) | Cámara de liofilización para un sistema de liofilización a granel | |
| Adams | Freeze-drying of biological materials | |
| JP2840351B2 (ja) | 香辛料及び同様の物質を殺菌するための装置及び方法 | |
| CN115867759B (zh) | 冷冻干燥系统和用于将包含液体的散装产品冷冻干燥的方法 | |
| JP3871957B2 (ja) | 凍結真空乾燥方法及び凍結真空乾燥装置 | |
| TWI612218B (zh) | 低溫阱 | |
| Gangurde et al. | Freeze drying: a review | |
| CN111373217A (zh) | 基质上的喷雾冷冻干燥 | |
| KR101944157B1 (ko) | 크라이오 트랩 | |
| US20190285341A1 (en) | Means and methods for selective shelf temperature control | |
| JP2021156457A (ja) | 凍結乾燥方法及び凍結乾燥装置 | |
| RU2705692C1 (ru) | Комплекс для вакуумной сублимационной сушки | |
| ES2955971T3 (es) | Sistema de liofilización a granel | |
| Heldner | Pharmaceutical Freeze‐Drying Systems | |
| CA3093834C (en) | Means and methods for selective shelf temperature control | |
| CN115867760B (zh) | 对无菌产品进行微波真空干燥的设备和方法 | |
| Wang | Exploring the use of atmospheric freeze drying (AFD) to produce dehydrated pharmaceutics in IV vials for potential continuous manufacturing | |
| CN112770642A (zh) | 模块化电磁加热系统 | |
| JP2025112989A (ja) | 凍結乾燥装置の凍結乾燥方法 |