JP2020517698A5 - - Google Patents
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- Publication number
- JP2020517698A5 JP2020517698A5 JP2019558390A JP2019558390A JP2020517698A5 JP 2020517698 A5 JP2020517698 A5 JP 2020517698A5 JP 2019558390 A JP2019558390 A JP 2019558390A JP 2019558390 A JP2019558390 A JP 2019558390A JP 2020517698 A5 JP2020517698 A5 JP 2020517698A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- pyrimidin
- amine
- pyridine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1cc*(Cc2c(C)ncnc2)cc1 Chemical compound Cc1cc*(Cc2c(C)ncnc2)cc1 0.000 description 3
- RIKMMFOAQPJVMX-UHFFFAOYSA-O Cc1c[nH][nH+]c1 Chemical compound Cc1c[nH][nH+]c1 RIKMMFOAQPJVMX-UHFFFAOYSA-O 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022144957A JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491526P | 2017-04-28 | 2017-04-28 | |
| US201762491475P | 2017-04-28 | 2017-04-28 | |
| US201762491484P | 2017-04-28 | 2017-04-28 | |
| US201762491573P | 2017-04-28 | 2017-04-28 | |
| US62/491,475 | 2017-04-28 | ||
| US62/491,526 | 2017-04-28 | ||
| US62/491,484 | 2017-04-28 | ||
| US62/491,573 | 2017-04-28 | ||
| US201862650232P | 2018-03-29 | 2018-03-29 | |
| US62/650,232 | 2018-03-29 | ||
| PCT/IB2018/052919 WO2018198077A2 (en) | 2017-04-28 | 2018-04-26 | 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022144957A Division JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517698A JP2020517698A (ja) | 2020-06-18 |
| JP2020517698A5 true JP2020517698A5 (OSRAM) | 2021-06-10 |
| JP7247102B2 JP7247102B2 (ja) | 2023-03-28 |
Family
ID=62148436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558390A Active JP7247102B2 (ja) | 2017-04-28 | 2018-04-26 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
| JP2022144957A Pending JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022144957A Pending JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11458138B2 (OSRAM) |
| EP (1) | EP3615537B1 (OSRAM) |
| JP (2) | JP7247102B2 (OSRAM) |
| KR (1) | KR20190142776A (OSRAM) |
| CN (3) | CN114703144A (OSRAM) |
| AU (2) | AU2018260495B2 (OSRAM) |
| BR (1) | BR112019022512A2 (OSRAM) |
| CA (1) | CA3056906A1 (OSRAM) |
| CL (1) | CL2019003049A1 (OSRAM) |
| CO (1) | CO2019011873A2 (OSRAM) |
| CR (1) | CR20190483A (OSRAM) |
| CU (2) | CU20200080A7 (OSRAM) |
| DO (1) | DOP2019000273A (OSRAM) |
| EC (1) | ECSP19076732A (OSRAM) |
| ES (1) | ES2983611T3 (OSRAM) |
| IL (2) | IL269293B (OSRAM) |
| JO (1) | JOP20190257A1 (OSRAM) |
| MA (1) | MA49285A (OSRAM) |
| MX (1) | MX2019012756A (OSRAM) |
| PE (1) | PE20200292A1 (OSRAM) |
| PH (1) | PH12019502436A1 (OSRAM) |
| SG (1) | SG11201908615RA (OSRAM) |
| TW (1) | TW201843140A (OSRAM) |
| UY (1) | UY37703A (OSRAM) |
| WO (1) | WO2018198077A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108699557B (zh) | 2015-12-04 | 2025-08-15 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| CN114456176B (zh) | 2016-03-28 | 2024-08-30 | 因赛特公司 | 作为tam抑制剂的吡咯并三嗪化合物 |
| KR20190130608A (ko) | 2017-03-22 | 2019-11-22 | 노파르티스 아게 | 면역종양학을 위한 조성물 및 방법 |
| JOP20190257A1 (ar) | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| KR102739325B1 (ko) | 2017-09-27 | 2024-12-09 | 인사이트 코포레이션 | Tam 억제제로서 유용한 피롤로트리아진 유도체의 염 |
| EP3804707A4 (en) | 2018-06-08 | 2022-03-16 | Nissan Chemical Corporation | KINASE INHIBITOR |
| US11241438B2 (en) | 2018-06-29 | 2022-02-08 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
| CA3115998A1 (en) * | 2018-10-16 | 2020-04-23 | The Schepens Eye Research Institute, Inc. | Bioadhesive for soft tissue repair |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
| EP3896158A4 (en) * | 2018-12-11 | 2022-11-02 | Kyoto University | METHODS OF INDUCING A DELETION IN GENOMIC DNA |
| TW202043199A (zh) | 2019-01-30 | 2020-12-01 | 日商日產化學股份有限公司 | 醯肼化合物及激酶抑制劑 |
| CN112707905B (zh) * | 2019-10-25 | 2024-07-02 | 武汉誉祥医药科技有限公司 | 一种三并杂环化合物及其制备方法和用途 |
| GB201915829D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| GB201915831D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| WO2021108483A1 (en) * | 2019-11-27 | 2021-06-03 | Genentech, Inc. | Therapeutic compounds |
| US12617785B2 (en) * | 2020-02-05 | 2026-05-05 | The Rockefeller University | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN111443068B (zh) * | 2020-03-06 | 2023-06-27 | 天津大学 | 具有多重刺激响应特性的纯有机室温磷光材料及筛选方法和应用 |
| US20230348852A1 (en) | 2020-04-27 | 2023-11-02 | Novartis Ag | Methods and compositions for ocular cell therapy |
| PE20230845A1 (es) * | 2020-04-28 | 2023-05-23 | Global Blood Therapeutics Inc | Pirimidinas cicloalquiladas como inhibidores de la ferroportina |
| CN112305126A (zh) * | 2020-11-02 | 2021-02-02 | 宁夏贝利特生物科技有限公司 | 一种硝酸胍含量的测定方法 |
| AU2022284188A1 (en) * | 2021-06-04 | 2023-11-30 | Genentech, Inc. | 2, 8-diazaspiro [4.5] decane compounds |
| CN117795330A (zh) * | 2021-08-23 | 2024-03-29 | Emd密理博公司 | 用于光聚合电泳凝胶的系统和方法 |
| CN115974868B (zh) * | 2022-11-07 | 2024-04-12 | 安徽理工大学 | 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用 |
| WO2024211621A1 (en) * | 2023-04-04 | 2024-10-10 | Children's Hospital Los Angeles | Lats kinase inhibitor to treat retinal degeneration |
| CN119462609B (zh) * | 2024-10-25 | 2025-12-26 | 烟台皓元生物医药科技有限公司 | 一种lats抑制剂vt02956的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065392A1 (en) | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| EP1871377A1 (en) | 2005-02-25 | 2008-01-02 | Kudos Pharmaceuticals Ltd | 2,4-diamino-pyridopyrimidine derivatives and their use as mtor inhibitors |
| WO2008122614A1 (en) | 2007-04-06 | 2008-10-16 | Novartis Ag | 2, 6-naphthyridine derivatives as protein kinase modulators |
| EP2318377B1 (en) | 2008-07-31 | 2013-08-21 | Genentech, Inc. | Pyrimidine compounds, compositions and methods of use |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| US9347041B2 (en) * | 2011-07-15 | 2016-05-24 | Osaka University | Method for preparing corneal endothelial cell |
| CA2845191A1 (en) | 2011-09-27 | 2013-04-04 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EA030253B1 (ru) * | 2012-09-28 | 2018-07-31 | Кэнсэр Ресерч Текнолоджи Лимитед | Азахиназолиновые ингибиторы атипичной протеинкиназы c |
| CN111206032B (zh) * | 2013-12-12 | 2024-07-19 | 布罗德研究所有限公司 | 用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用 |
| TWI675836B (zh) | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑 |
| EP3197557A1 (en) | 2014-09-24 | 2017-08-02 | Friedrich Miescher Institute for Biomedical Research | Lats and breast cancer |
| TW201718536A (zh) | 2015-08-03 | 2017-06-01 | 必治妥美雅史谷比公司 | 可作為ＴＮＦα調節劑之雜環化合物 |
| US20200216906A1 (en) | 2015-08-25 | 2020-07-09 | President And Fellows Of Harvard College | Methods and compositions relating to the diagnosis and treatment of cancer |
| JOP20190257A1 (ar) | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
-
2017
- 2017-06-16 JO JOP/2019/0257A patent/JOP20190257A1/ar unknown
-
2018
- 2018-04-26 ES ES18723981T patent/ES2983611T3/es active Active
- 2018-04-26 BR BR112019022512-9A patent/BR112019022512A2/pt not_active IP Right Cessation
- 2018-04-26 JP JP2019558390A patent/JP7247102B2/ja active Active
- 2018-04-26 MX MX2019012756A patent/MX2019012756A/es unknown
- 2018-04-26 EP EP18723981.9A patent/EP3615537B1/en active Active
- 2018-04-26 KR KR1020197034688A patent/KR20190142776A/ko not_active Withdrawn
- 2018-04-26 CU CU2020000080A patent/CU20200080A7/es unknown
- 2018-04-26 UY UY0001037703A patent/UY37703A/es not_active Application Discontinuation
- 2018-04-26 CR CR20190483A patent/CR20190483A/es unknown
- 2018-04-26 CN CN202210409194.5A patent/CN114703144A/zh not_active Withdrawn
- 2018-04-26 AU AU2018260495A patent/AU2018260495B2/en not_active Ceased
- 2018-04-26 MA MA049285A patent/MA49285A/fr unknown
- 2018-04-26 WO PCT/IB2018/052919 patent/WO2018198077A2/en not_active Ceased
- 2018-04-26 PE PE2019002107A patent/PE20200292A1/es unknown
- 2018-04-26 CN CN201880027586.7A patent/CN110573511B/zh active Active
- 2018-04-26 US US15/963,816 patent/US11458138B2/en active Active
- 2018-04-26 TW TW107114216A patent/TW201843140A/zh unknown
- 2018-04-26 CN CN202210409770.6A patent/CN114621222B/zh active Active
- 2018-04-26 CU CU2019000086A patent/CU20190086A7/es unknown
- 2018-04-26 SG SG11201908615R patent/SG11201908615RA/en unknown
- 2018-04-26 CA CA3056906A patent/CA3056906A1/en active Pending
-
2019
- 2019-09-11 IL IL269293A patent/IL269293B/en unknown
- 2019-10-24 DO DO2019000273A patent/DOP2019000273A/es unknown
- 2019-10-24 CL CL2019003049A patent/CL2019003049A1/es unknown
- 2019-10-25 EC ECSENADI201976732A patent/ECSP19076732A/es unknown
- 2019-10-25 CO CONC2019/0011873A patent/CO2019011873A2/es unknown
- 2019-10-28 PH PH12019502436A patent/PH12019502436A1/en unknown
-
2021
- 2021-12-14 AU AU2021286281A patent/AU2021286281A1/en not_active Abandoned
-
2022
- 2022-05-09 IL IL292857A patent/IL292857A/en unknown
- 2022-08-18 US US17/820,613 patent/US20230190751A1/en not_active Abandoned
- 2022-09-13 JP JP2022144957A patent/JP2022188056A/ja active Pending
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