JP2020515519A5 - - Google Patents

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JP2020515519A5
JP2020515519A5 JP2019538403A JP2019538403A JP2020515519A5 JP 2020515519 A5 JP2020515519 A5 JP 2020515519A5 JP 2019538403 A JP2019538403 A JP 2019538403A JP 2019538403 A JP2019538403 A JP 2019538403A JP 2020515519 A5 JP2020515519 A5 JP 2020515519A5
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pertuzumab
cancer
medicament
dose
use according
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JP2019538403A
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JP2020515519A (ja
JP6741875B2 (ja
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Priority claimed from PCT/US2018/013854 external-priority patent/WO2018136412A2/en
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JP2019538403A 2017-01-17 2018-01-16 皮下her2抗体製剤 Active JP6741875B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762447359P 2017-01-17 2017-01-17
US62/447,359 2017-01-17
PCT/US2018/013854 WO2018136412A2 (en) 2017-01-17 2018-01-16 Subcutaneous her2 antibody formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020102377A Division JP6769687B1 (ja) 2017-01-17 2020-06-12 皮下her2抗体製剤

Publications (3)

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JP2020515519A JP2020515519A (ja) 2020-05-28
JP2020515519A5 true JP2020515519A5 (enExample) 2020-07-27
JP6741875B2 JP6741875B2 (ja) 2020-08-19

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JP2019538403A Active JP6741875B2 (ja) 2017-01-17 2018-01-16 皮下her2抗体製剤
JP2020102377A Active JP6769687B1 (ja) 2017-01-17 2020-06-12 皮下her2抗体製剤
JP2020134301A Withdrawn JP2021006526A (ja) 2017-01-17 2020-08-07 皮下her2抗体製剤
JP2023110283A Pending JP2023145459A (ja) 2017-01-17 2023-07-04 皮下her2抗体製剤

Family Applications After (3)

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JP2020102377A Active JP6769687B1 (ja) 2017-01-17 2020-06-12 皮下her2抗体製剤
JP2020134301A Withdrawn JP2021006526A (ja) 2017-01-17 2020-08-07 皮下her2抗体製剤
JP2023110283A Pending JP2023145459A (ja) 2017-01-17 2023-07-04 皮下her2抗体製剤

Country Status (27)

Country Link
US (4) US10849849B2 (enExample)
EP (2) EP3868404A1 (enExample)
JP (4) JP6741875B2 (enExample)
KR (5) KR20200113292A (enExample)
CN (4) CN110167594B (enExample)
AU (3) AU2018210312B2 (enExample)
CA (1) CA3047349C (enExample)
CR (1) CR20190376A (enExample)
CY (1) CY1123586T1 (enExample)
DK (1) DK3570884T3 (enExample)
ES (1) ES2835376T3 (enExample)
HR (1) HRP20201866T1 (enExample)
HU (1) HUE052551T2 (enExample)
IL (2) IL288948B2 (enExample)
LT (1) LT3570884T (enExample)
MA (2) MA56006A (enExample)
MX (2) MX374501B (enExample)
MY (1) MY189536A (enExample)
PT (1) PT3570884T (enExample)
RS (1) RS61236B1 (enExample)
RU (1) RU2750821C2 (enExample)
SG (2) SG10202011384XA (enExample)
SI (1) SI3570884T1 (enExample)
SM (1) SMT202000640T1 (enExample)
TW (3) TWI841849B (enExample)
UA (1) UA123292C2 (enExample)
WO (1) WO2018136412A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
PL4234033T3 (pl) 2011-10-14 2025-04-28 F. Hoffmann-La Roche Ag Zastosowania i wyrób przemysłowy zawierający pertuzumab, inhibitor dimeryzacji HER2
EP3800204A1 (en) 2013-04-16 2021-04-07 F. Hoffmann-La Roche AG Pertuzumab variants and evaluation thereof
CR20190376A (es) * 2017-01-17 2019-11-20 Genentech Inc Formulaciones de anticuerpos de her2 subcutáneas
KR20190096384A (ko) 2017-03-02 2019-08-19 제넨테크, 인크. Her2-양성 유방암 어쥬번트 치료
WO2020017901A1 (ko) * 2018-07-19 2020-01-23 (주)셀트리온 안정한 액체 약제학적 제제
KR20210081332A (ko) 2018-09-12 2021-07-01 실버백 테라퓨틱스, 인크. 면역 자극성 접합체를 사용한 질환의 치료를 위한 조성물
WO2020060179A1 (ko) * 2018-09-18 2020-03-26 삼성바이오에피스 주식회사 완충화제를 포함하지 않는 트라스투주맙 항체 안정화 제제
CN113474360B (zh) 2019-02-18 2025-01-07 伊莱利利公司 治疗性抗体制剂
US20220249685A1 (en) 2019-06-19 2022-08-11 Silverback Therapeutics, Inc. Anti-mesothelin antibodies and immunoconjugates thereof
KR20210059646A (ko) * 2019-11-15 2021-05-25 삼성바이오에피스 주식회사 항체 의약품용 액상 조성물
PE20221281A1 (es) * 2019-12-09 2022-09-05 Genentech Inc Formulaciones de anticuerpos anti-pd-l1
JP7735291B2 (ja) 2020-02-21 2025-09-08 エーアールエス ファーマシューティカルズ、インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
CN113827717A (zh) * 2020-06-23 2021-12-24 三生国健药业(上海)股份有限公司 抗her2单克隆抗体冻干制剂及制备方法
CN113827718A (zh) * 2020-06-24 2021-12-24 上海宝济药业有限公司 一种含有透明质酸酶的制剂及其应用
JP2023532122A (ja) * 2020-06-29 2023-07-26 ジェネンテック, インコーポレイテッド ペルツズマブにトラスツズマブを加えた固定用量配合剤
KR20230047361A (ko) 2020-07-01 2023-04-07 아르스 파마슈티컬스 인크. 항-asgr1 항체 접합체 및 이의 용도
JP7593781B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593782B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593784B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593785B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
CN114652687B (zh) * 2020-12-23 2024-02-20 盛禾(中国)生物制药有限公司 一种去岩藻糖基化的抗Her2抗体冻干粉针剂的制备方法
CA3196999A1 (en) * 2020-12-28 2022-07-07 Masano HUANG Methods of treating tumors
WO2022146947A1 (en) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
WO2022141232A1 (zh) * 2020-12-30 2022-07-07 上海宝济药业有限公司 一种重组人透明质酸酶制剂及其应用
WO2023019556A1 (zh) * 2021-08-20 2023-02-23 齐鲁制药有限公司 一种高浓度抗her2的抗体制剂及其用途
KR20240058127A (ko) * 2021-09-15 2024-05-03 자임워크스 비씨 인코포레이티드 항-her2 이중 파라토프 항체를 이용한 암 치료 방법
CN118843461A (zh) 2022-03-14 2024-10-25 基因泰克公司 针对乳腺癌的组合疗法
KR20250004776A (ko) * 2022-04-13 2025-01-08 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이성 항체의 약학 조성물 및 사용 방법
JP2025513510A (ja) * 2022-04-20 2025-04-24 アルトス バイオロジックス インク. オクレリズマブを含む薬学的組成物とその用途
WO2024220520A2 (en) * 2023-04-21 2024-10-24 Board Of Regents, The University Of Texas System T-cell receptors targeting her2 and methods of use thereof
CN121041473A (zh) * 2024-05-29 2025-12-02 烟台蓝纳成生物技术股份有限公司 一种双功能性融合蛋白、放射性核素标记物及其应用

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0491675A1 (en) 1984-01-30 1992-06-24 Imperial Cancer Research Technology Limited Improvements relating to growth factors
US5401638A (en) 1986-06-04 1995-03-28 Oncogene Science, Inc. Detection and quantification of neu related proteins in the biological fluids of humans
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
CA1339946C (en) 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1990014357A1 (en) 1989-05-19 1990-11-29 Genentech, Inc. Her2 extracellular domain
DE68926248T2 (de) 1989-09-29 1996-12-19 Oncogene Science Inc p100 "neu" menschlisches Protein and Verwendung dieses Proteins zum Nachweis von preneoplasmatischen- oder neoplasmatischen beim Menschen
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
IL101943A0 (en) 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
JP3951062B2 (ja) 1991-09-19 2007-08-01 ジェネンテック・インコーポレーテッド 少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、2官能性F(ab’)2抗体の産生のための使用
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
PT2275119E (pt) 1995-07-27 2013-11-21 Genentech Inc Formulação de proteína liofilizada isotónica estável
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
PT1897890E (pt) 1996-11-27 2010-02-23 Genentech Inc Purificação por afinidade de um polipéptido numa matriz de proteína a
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
ZA9811162B (en) 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
EP1064027B1 (en) 1998-03-27 2008-06-18 Genentech, Inc. Apo-2 ligand-anti-her-2 antibody synergism
JP4469933B2 (ja) 1998-05-06 2010-06-02 ジェネンテック, インコーポレイテッド イオン交換クロマトグラフィによるタンパク質精製
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
ES2320311T3 (es) 1999-05-14 2009-05-21 Genentech, Inc. Tratamiento con anticuerpos anti-erbb2.
CN100381172C (zh) 1999-06-25 2008-04-16 吉尼泰克公司 使用抗-ErbB2抗体治疗前列腺癌
US20040013667A1 (en) 1999-06-25 2004-01-22 Genentech, Inc. Treatment with anti-ErbB2 antibodies
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
US20030086924A1 (en) 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
CA2382100A1 (en) 1999-08-27 2001-03-08 Genentech, Inc. Dosages for treatment with anti-erbb2 antibodies
US6632979B2 (en) 2000-03-16 2003-10-14 Genentech, Inc. Rodent HER2 tumor model
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US20200048362A1 (en) 2000-03-16 2020-02-13 Immunogen, Inc. Methods of treatment using anti-erbb antibody-maytansinoid conjugates
WO2001089566A1 (en) 2000-05-19 2001-11-29 Genentech, Inc. Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
US7833525B2 (en) 2000-12-28 2010-11-16 Bhami Shenoy Crystals of whole antibodies and fragments thereof and methods for making and using them
US6695940B2 (en) 2001-04-05 2004-02-24 Alan D. Devoe Laminate thin-wall ceramic tubes, including with integral stress wrappings, thickened ends and/or internal baffles, particularly for solid oxide fuel cells
EP1300146A1 (en) 2001-10-03 2003-04-09 Boehringer Ingelheim International GmbH Pharmaceutical composition for the treatment of animal mammary tumors
US20040048525A1 (en) 2002-01-28 2004-03-11 Sagucio Esteban N. Watercycle for wet rider
EP1501856B1 (en) 2002-04-10 2012-12-19 Genentech, Inc. Anti-her2 antibody variants
EP2263691B1 (en) 2002-07-15 2012-08-29 F.Hoffmann-La Roche Ag Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4)
US6982719B2 (en) 2002-07-15 2006-01-03 Sun Microsystems, Inc. Switching sample buffer context in response to sample requests for real-time sample filtering and video generation
US7129840B2 (en) 2002-09-03 2006-10-31 Ricoh Company, Ltd. Document security system
IL262513B (en) 2002-09-11 2022-09-01 Genentech Inc Protein purification
EP1572972A4 (en) 2002-11-21 2007-11-21 Genentech Inc THERAPY OF NON-MALIGNER DISEASES OR DISORDER WITH ANTI-ERBB2 ANTIBODIES
TW555245U (en) 2003-01-29 2003-09-21 Hon Hai Prec Ind Co Ltd Cable connector assembly
BRPI0408116B1 (pt) 2003-03-05 2022-09-20 Halozyme, Inc Polipeptídeos de hialuronidase solúveis conjugados a polímero, composições farmacêuticas compreendendo polipeptídeos ph20 solúveis, seus usos e processo de preparação, e ácidos nucléicos que codificam polipeptídeos de hialuronidase solúveis
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20050025753A1 (en) 2003-04-30 2005-02-03 Wei Han Methods for production of non-disease causing hemoglobin by ex vivo oligonucleotide gene editing of human stem/progenitor cells
HUE029951T2 (en) 2003-07-28 2017-04-28 Genentech Inc Reduction of Protein A Dissolution in Protein A Affinity Chromatography
JP4969440B2 (ja) 2004-04-08 2012-07-04 デビッド, ビー. エイガス, 疼痛治療のためのErbBアンタゴニスト
US7195440B2 (en) 2004-05-27 2007-03-27 Lambert Charles F Agricultural silo auger system apparatus and method
NZ579482A (en) 2004-06-01 2011-02-25 Genentech Inc Antibody drug conjugates and methods
SV2006002143A (es) 2004-06-16 2006-01-26 Genentech Inc Uso de un anticuerpo para el tratamiento del cancer resistente al platino
KR20190035967A (ko) 2004-07-22 2019-04-03 제넨테크, 인크. Her2 항체 조성물
JP2008510466A (ja) 2004-08-19 2008-04-10 ジェネンテック・インコーポレーテッド エフェクター機能が変更しているポリペプチド変異体
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
WO2006063042A2 (en) 2004-12-07 2006-06-15 Genentech, Inc. Selecting patients for therapy with a her inhibitor
BRPI0518104B8 (pt) 2005-01-21 2021-05-25 Genentech Inc artigo industrializado e uso de anticorpo her2
EP1850874B1 (en) 2005-02-23 2013-10-16 Genentech, Inc. Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
TW200642695A (en) 2005-03-08 2006-12-16 Genentech Inc Methods for identifying tumors responsive to treatment with her dimerization inhibitors (HDIs)
US20060212956A1 (en) 2005-03-14 2006-09-21 Genentech, Inc. Animal model of ligand activated HER2 expressing tumors
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Herceptin(登録商標)補助療法
US20070009976A1 (en) 2005-07-06 2007-01-11 Helmut Lenz Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody
PE20070207A1 (es) 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
US7700299B2 (en) 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
US20070148131A1 (en) 2005-12-05 2007-06-28 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of binding partners
TW200812615A (en) 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
US20080038271A1 (en) 2006-06-05 2008-02-14 Amler Lukas C Extending survival of cancer patients with elevated levels of EGF or TGF-alpha
SG174090A1 (en) 2006-08-21 2011-09-29 Hoffmann La Roche Tumor therapy with an anti-vegf antibody
WO2008031531A1 (en) 2006-09-15 2008-03-20 F. Hoffmann-La Roche Ag Tumor therapy with a combination of anti-her2 antibodies
JP2010520225A (ja) 2007-03-02 2010-06-10 ジェネンテック, インコーポレイテッド 低her3発現に基づくher二量化インヒビターに対する応答を予測する方法
EP1997534A1 (en) 2007-05-31 2008-12-03 Pierre Fabre Medicament Cancer treatment combination therapy comprising vinflunine and trastuzumab
KR101169243B1 (ko) 2007-06-06 2012-08-02 에프. 호프만-라 로슈 아게 종양 항원에 결합하는 비-표지된 제 1 단클론 항체 및 nir 형광 표지로 표지된 비-교차 반응성 제 2 단클론 항체로 이루어진 조성물
EP2171090B1 (en) 2007-06-08 2013-04-03 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
BRPI0816769A2 (pt) 2007-09-12 2016-11-29 Hoffmann La Roche combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
PL2215117T5 (pl) 2007-10-30 2018-06-29 Genentech, Inc. Oczyszczanie przeciwciał za pomocą chromatografii kationowymiennej
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
JP2011513432A (ja) 2008-03-06 2011-04-28 ジェネンテック, インコーポレイテッド c−met及びHERアンタゴニストの併用療法
NZ621433A (en) 2008-03-18 2015-10-30 Genentech Inc Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
US9235334B2 (en) 2008-05-09 2016-01-12 Genesis Industries, Llc Managing landbases and machine operations performed thereon
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
CA2761280A1 (en) 2009-05-29 2010-12-02 F. Hoffmann-La Roche Ag Modulators for her2 signaling in her2 expressing patients with gastric cancer
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
CA2818669A1 (en) 2010-12-09 2012-06-14 Barbara Klencke Treatment of her2-positive cancer with paclitaxel and trastuzumab-mcc-dm1
EP2683413A1 (en) 2011-03-07 2014-01-15 F.Hoffmann-La Roche Ag In vivo selection of therapeutically active antibodies
JP2012228007A (ja) * 2011-04-15 2012-11-15 Asmo Co Ltd バスバー装置、ステータ、モータ及びステータの製造方法
PL4234033T3 (pl) 2011-10-14 2025-04-28 F. Hoffmann-La Roche Ag Zastosowania i wyrób przemysłowy zawierający pertuzumab, inhibitor dimeryzacji HER2
US9376715B2 (en) 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
US20130195851A1 (en) 2011-12-23 2013-08-01 Genentech, Inc. Articles of manufacture and methods for co-administration of antibodies
JP5933830B2 (ja) 2012-06-08 2016-06-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 癌の処置用のホスホイノシチド3キナーゼ阻害化合物と化学療法剤との変異体選択性及び組み合わせ
CN102961745B (zh) * 2012-09-27 2015-02-18 苏州康聚生物科技有限公司 抗体组合物制剂及其应用
MX363188B (es) 2012-11-30 2019-03-13 Hoffmann La Roche Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1.
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
EP3800204A1 (en) 2013-04-16 2021-04-07 F. Hoffmann-La Roche AG Pertuzumab variants and evaluation thereof
LT3083686T (lt) 2013-12-17 2020-01-10 F. Hoffmann-La Roche Ag Vėžinių ligų gydymo būdai naudojant pd-1 ašies rišimosi antagonistus ir taksanus
JP2017513901A (ja) 2014-04-25 2017-06-01 ジェネンテック, インコーポレイテッド トラスツズマブ−mcc−dm1及びペルツズマブにより早期の乳癌を処置する方法
WO2016011422A2 (en) * 2014-07-17 2016-01-21 Czerniecki Brian J Manufacturing of multi-dose injection ready dendritic cell vaccines and combination therapy for blocking her2 and her3
AU2015318001B2 (en) 2014-09-15 2021-03-25 Genentech, Inc. Antibody formulations
EP3197500A1 (en) 2014-09-17 2017-08-02 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
CN104784105A (zh) * 2015-04-17 2015-07-22 北京大学 一种单克隆抗体药物的凝胶组合物
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
EP3267657A1 (de) 2016-07-06 2018-01-10 Siemens Aktiengesellschaft Netzwerksystem, cloud-anschluss und verfahren zur identifikation von netzwerkgeräten
EP3534948A1 (en) 2016-11-04 2019-09-11 Genentech, Inc. Treatment of her2-positive breast cancer
EP3562844A1 (en) 2016-12-28 2019-11-06 Genentech, Inc. Treatment of advanced her2 expressing cancer
CR20190376A (es) 2017-01-17 2019-11-20 Genentech Inc Formulaciones de anticuerpos de her2 subcutáneas
KR20190096384A (ko) 2017-03-02 2019-08-19 제넨테크, 인크. Her2-양성 유방암 어쥬번트 치료
KR20190140952A (ko) 2017-04-24 2019-12-20 제넨테크, 인크. 막관통 및 인접막 도메인에서의 erbb2/her2 돌연변이
JP2023532122A (ja) 2020-06-29 2023-07-26 ジェネンテック, インコーポレイテッド ペルツズマブにトラスツズマブを加えた固定用量配合剤
AU2021308283A1 (en) 2020-07-14 2023-02-02 F. Hoffmann-La Roche Ag Assays for fixed dose combinations
EP4259662A1 (en) 2020-12-11 2023-10-18 Genentech, Inc. Combination therapies for treatment of her2 cancer

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