JP2020513021A5 - - Google Patents
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- Publication number
- JP2020513021A5 JP2020513021A5 JP2019555001A JP2019555001A JP2020513021A5 JP 2020513021 A5 JP2020513021 A5 JP 2020513021A5 JP 2019555001 A JP2019555001 A JP 2019555001A JP 2019555001 A JP2019555001 A JP 2019555001A JP 2020513021 A5 JP2020513021 A5 JP 2020513021A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- salt
- represented
- formula
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 20
- 0 C[C@@](CC(C[C@](C)[C@@]1O[C@@](CN)[C@](*)C[C@@]1*)=O)[C@](*)C=CI Chemical compound C[C@@](CC(C[C@](C)[C@@]1O[C@@](CN)[C@](*)C[C@@]1*)=O)[C@](*)C=CI 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022106421A JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482030P | 2017-04-05 | 2017-04-05 | |
| US62/482,030 | 2017-04-05 | ||
| US201762526677P | 2017-06-29 | 2017-06-29 | |
| US62/526,677 | 2017-06-29 | ||
| US201762586416P | 2017-11-15 | 2017-11-15 | |
| US15/814,105 | 2017-11-15 | ||
| US62/586,416 | 2017-11-15 | ||
| US15/814,105 US9938288B1 (en) | 2017-04-05 | 2017-11-15 | Macrocyclic compound and uses thereof |
| PCT/US2018/025887 WO2018187331A1 (en) | 2017-04-05 | 2018-04-03 | Macrocyclic compound and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106421A Division JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513021A JP2020513021A (ja) | 2020-04-30 |
| JP2020513021A5 true JP2020513021A5 (https=) | 2021-05-13 |
| JP7168580B2 JP7168580B2 (ja) | 2022-11-09 |
Family
ID=63104288
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019555001A Active JP7168580B2 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2018071700A Active JP6366873B1 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2022106421A Active JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A Active JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071700A Active JP6366873B1 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2022106421A Active JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A Active JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US11725015B2 (https=) |
| EP (2) | EP4119563A3 (https=) |
| JP (4) | JP7168580B2 (https=) |
| KR (2) | KR102836514B1 (https=) |
| CN (2) | CN110831946B (https=) |
| AU (2) | AU2018250147B2 (https=) |
| CA (1) | CA3056945A1 (https=) |
| CL (1) | CL2019002854A1 (https=) |
| CO (1) | CO2019011538A2 (https=) |
| DK (1) | DK3606928T3 (https=) |
| EC (1) | ECSP19075677A (https=) |
| ES (1) | ES2931533T3 (https=) |
| HR (1) | HRP20221385T1 (https=) |
| HU (1) | HUE060466T2 (https=) |
| IL (2) | IL288991B2 (https=) |
| JO (1) | JOP20190234B1 (https=) |
| LT (1) | LT3606928T (https=) |
| MA (1) | MA48027B1 (https=) |
| MD (1) | MD3606928T2 (https=) |
| MX (1) | MX389899B (https=) |
| NZ (2) | NZ757372A (https=) |
| PE (1) | PE20200602A1 (https=) |
| PH (1) | PH12019502197A1 (https=) |
| PL (1) | PL3606928T3 (https=) |
| PT (1) | PT3606928T (https=) |
| RS (1) | RS63755B1 (https=) |
| SA (1) | SA519410259B1 (https=) |
| SG (1) | SG11201908603PA (https=) |
| SI (1) | SI3606928T1 (https=) |
| SM (1) | SMT202200455T1 (https=) |
| TW (3) | TWI781163B (https=) |
| UA (1) | UA124399C2 (https=) |
| WO (1) | WO2018187331A1 (https=) |
| ZA (1) | ZA201906279B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| SMT202200455T1 (it) * | 2017-04-05 | 2023-01-13 | Harvard College | Composto macrociclico e relativi usi |
| WO2019010363A1 (en) * | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | HALICHONDRINES SYNTHESIS |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019099646A1 (en) * | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
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| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) * | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) * | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| DE4229425A1 (de) | 1992-09-03 | 1994-03-10 | Kodak Ag | Vorrichtung zum stapelweisen Ablegen und Ausrichten von einzeln zugeführten Blättern |
| US5426194A (en) * | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| US5352804A (en) * | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| JP2818381B2 (ja) | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| JP2001305734A (ja) | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| US7842815B2 (en) * | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| US20060154312A1 (en) | 2004-12-09 | 2006-07-13 | Sergei Agoulnik | Tubulin isotype screening in cancer therapy using halichondrin B analogs |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| CN101657990B (zh) | 2007-03-07 | 2014-03-19 | 交互数字技术公司 | 用于产生和处理MAC-ehs协议数据单元的方法和设备 |
| US20100254996A1 (en) | 2007-06-18 | 2010-10-07 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| CN101910180A (zh) | 2007-11-16 | 2010-12-08 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应 |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| WO2012096926A2 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| JP2015501818A (ja) | 2011-12-16 | 2015-01-19 | アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． | ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法 |
| CA2860446C (en) | 2011-12-29 | 2017-01-10 | Alphora Research Inc. | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| SG11201404432QA (en) * | 2012-11-30 | 2014-10-30 | Hangzhou Zylox Pharma Co Ltd | Rafamycin analogs and methods for making same |
| CA2909209A1 (en) | 2013-05-15 | 2014-11-20 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| EP3016957A4 (en) | 2013-07-03 | 2016-11-30 | Alphora Res Inc | SYNTHETIC METHOD FOR THE PRODUCTION OF CYCLIC C1-KETO ANALOGUE OF HALICHONDRIN B AND USEFUL INTERMEDIATE PRODUCTS, INCLUDING INTERMEDIATE PRODUCTS WITH -SO2- (P-TOLYL) GROUPS |
| BR112016009452B1 (pt) | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| EP3077399B1 (en) | 2013-12-06 | 2019-02-20 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10208058B2 (en) | 2014-09-09 | 2019-02-19 | Cipla Limited | Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX392296B (es) | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| US10562859B2 (en) * | 2015-07-01 | 2020-02-18 | Signalchem Lifesciences Corporation | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use |
| PE20231050A1 (es) | 2016-03-02 | 2023-07-11 | Eisai Randd Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| EP3582804A1 (en) | 2017-02-20 | 2019-12-25 | Polyphor Ag | Pharmaceutical combinations for treating cancer |
| SMT202200455T1 (it) * | 2017-04-05 | 2023-01-13 | Harvard College | Composto macrociclico e relativi usi |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019009956A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | SUMMARY OF MEDIUM MEDIATED KETONE |
| US20230135188A1 (en) | 2017-07-06 | 2023-05-04 | President And Fellows Of Harvard College | Fe/cu-mediated ketone synthesis |
| WO2019010363A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | HALICHONDRINES SYNTHESIS |
| WO2019099646A1 (en) * | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
| WO2022019921A1 (en) | 2020-07-24 | 2022-01-27 | President And Fellows Of Harvard College | Ketone synthesis and applications |
-
2018
- 2018-04-03 SM SM20220455T patent/SMT202200455T1/it unknown
- 2018-04-03 MX MX2019011982A patent/MX389899B/es unknown
- 2018-04-03 IL IL288991A patent/IL288991B2/en unknown
- 2018-04-03 KR KR1020247003838A patent/KR102836514B1/ko active Active
- 2018-04-03 MA MA48027A patent/MA48027B1/fr unknown
- 2018-04-03 JO JOP/2019/0234A patent/JOP20190234B1/ar active
- 2018-04-03 EP EP22187494.4A patent/EP4119563A3/en active Pending
- 2018-04-03 RS RS20221078A patent/RS63755B1/sr unknown
- 2018-04-03 KR KR1020197032300A patent/KR102634732B1/ko active Active
- 2018-04-03 NZ NZ757372A patent/NZ757372A/en unknown
- 2018-04-03 CA CA3056945A patent/CA3056945A1/en active Pending
- 2018-04-03 WO PCT/US2018/025887 patent/WO2018187331A1/en not_active Ceased
- 2018-04-03 TW TW107111975A patent/TWI781163B/zh active
- 2018-04-03 HR HRP20221385TT patent/HRP20221385T1/hr unknown
- 2018-04-03 HU HUE18719390A patent/HUE060466T2/hu unknown
- 2018-04-03 AU AU2018250147A patent/AU2018250147B2/en active Active
- 2018-04-03 PL PL18719390.9T patent/PL3606928T3/pl unknown
- 2018-04-03 DK DK18719390.9T patent/DK3606928T3/da active
- 2018-04-03 JP JP2019555001A patent/JP7168580B2/ja active Active
- 2018-04-03 PE PE2019001975A patent/PE20200602A1/es unknown
- 2018-04-03 SG SG11201908603P patent/SG11201908603PA/en unknown
- 2018-04-03 SI SI201830813T patent/SI3606928T1/sl unknown
- 2018-04-03 UA UAA201910898A patent/UA124399C2/uk unknown
- 2018-04-03 TW TW112141425A patent/TWI863657B/zh active
- 2018-04-03 CN CN201880033165.5A patent/CN110831946B/zh active Active
- 2018-04-03 MD MDE20200167T patent/MD3606928T2/ro unknown
- 2018-04-03 JP JP2018071700A patent/JP6366873B1/ja active Active
- 2018-04-03 EP EP18719390.9A patent/EP3606928B1/en active Active
- 2018-04-03 NZ NZ798392A patent/NZ798392A/en unknown
- 2018-04-03 LT LTEPPCT/US2018/025887T patent/LT3606928T/lt unknown
- 2018-04-03 TW TW111137406A patent/TWI836643B/zh active
- 2018-04-03 ES ES18719390T patent/ES2931533T3/es active Active
- 2018-04-03 PT PT187193909T patent/PT3606928T/pt unknown
- 2018-04-03 CN CN202210696425.5A patent/CN115093429B/zh active Active
-
2019
- 2019-09-23 ZA ZA2019/06279A patent/ZA201906279B/en unknown
- 2019-09-24 PH PH12019502197A patent/PH12019502197A1/en unknown
- 2019-10-03 IL IL269788A patent/IL269788B/en unknown
- 2019-10-04 CL CL2019002854A patent/CL2019002854A1/es unknown
- 2019-10-06 SA SA519410259A patent/SA519410259B1/ar unknown
- 2019-10-17 CO CONC2019/0011538A patent/CO2019011538A2/es unknown
- 2019-10-23 EC ECSENADI201975677A patent/ECSP19075677A/es unknown
-
2021
- 2021-02-04 US US17/167,480 patent/US11725015B2/en active Active
-
2022
- 2022-06-30 JP JP2022106421A patent/JP7400025B2/ja active Active
- 2022-12-20 AU AU2022291454A patent/AU2022291454B2/en active Active
-
2023
- 2023-06-21 US US18/339,227 patent/US12421248B2/en active Active
- 2023-12-06 JP JP2023206236A patent/JP7696416B2/ja active Active
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