JP2019194236A5 - - Google Patents
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- JP2019194236A5 JP2019194236A5 JP2019127476A JP2019127476A JP2019194236A5 JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5 JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5
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- Prior art keywords
- compound
- salt
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- 150000001875 compounds Chemical class 0.000 claims 43
- 150000003839 salts Chemical class 0.000 claims 23
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022041396A JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051788P | 2014-09-17 | 2014-09-17 | |
| US62/051,788 | 2014-09-17 | ||
| US201562199927P | 2015-07-31 | 2015-07-31 | |
| US62/199,927 | 2015-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Division JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Division JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019194236A JP2019194236A (ja) | 2019-11-07 |
| JP2019194236A5 true JP2019194236A5 (https=) | 2019-12-19 |
Family
ID=55454109
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
| JP2019127476A Pending JP2019194236A (ja) | 2014-09-17 | 2019-07-09 | Ｍｋ２阻害剤およびその使用 |
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US9458175B2 (https=) |
| EP (2) | EP3912981A1 (https=) |
| JP (3) | JP6556225B2 (https=) |
| KR (1) | KR102457848B1 (https=) |
| CN (1) | CN106998692B (https=) |
| AU (1) | AU2015317741B2 (https=) |
| BR (1) | BR112017005266B1 (https=) |
| CA (1) | CA2961607C (https=) |
| CL (1) | CL2017000576A1 (https=) |
| CO (1) | CO2017003279A2 (https=) |
| CY (1) | CY1124215T1 (https=) |
| DK (1) | DK3193611T3 (https=) |
| EA (1) | EA037299B1 (https=) |
| EC (1) | ECSP17023281A (https=) |
| ES (1) | ES2874561T3 (https=) |
| HR (1) | HRP20210529T1 (https=) |
| HU (1) | HUE054347T2 (https=) |
| IL (1) | IL251051B (https=) |
| LT (1) | LT3193611T (https=) |
| MA (1) | MA40534B1 (https=) |
| MX (2) | MX373341B (https=) |
| PL (1) | PL3193611T3 (https=) |
| PT (1) | PT3193611T (https=) |
| RS (1) | RS62017B1 (https=) |
| SA (1) | SA517381115B1 (https=) |
| SG (2) | SG11201701861RA (https=) |
| SI (1) | SI3193611T1 (https=) |
| SM (1) | SMT202100311T1 (https=) |
| TW (1) | TWI744217B (https=) |
| WO (1) | WO2016044463A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2908098A1 (en) | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| RS62017B1 (sr) | 2014-09-17 | 2021-07-30 | Celgene Car Llc | Mk2 inhibitori i njihova upotreba |
| CN106632077B (zh) * | 2016-10-10 | 2019-01-22 | 上海再启生物技术有限公司 | 一种2-氨基-4-溴嘧啶的制备方法 |
| US11098057B2 (en) * | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| WO2018170200A1 (en) * | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| WO2018170203A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
| EP3596085A4 (en) * | 2017-03-16 | 2020-11-25 | Celgene CAR LLC | DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES |
| CN107058259A (zh) * | 2017-05-18 | 2017-08-18 | 南京中医药大学 | 分子标志物mk2基因及其应用 |
| WO2020072580A1 (en) * | 2018-10-02 | 2020-04-09 | Disc Medicine, Inc. | Matriptase 2 inhibitors and uses thereof |
| WO2020236636A1 (en) * | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| KR20220154094A (ko) * | 2020-02-14 | 2022-11-21 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Ulk1/2 억제제를 이용한 단일 및 병용 요법 |
| KR20220153582A (ko) | 2020-02-14 | 2022-11-18 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 마크로시클릭 ulk1/2 억제제 |
| US20230087078A1 (en) * | 2020-03-02 | 2023-03-23 | Washington University | Compositions and methods for the treatment of pancreatic cancer |
| KR20230044446A (ko) * | 2020-07-24 | 2023-04-04 | 브리스톨-마이어스 스큅 컴퍼니 | 급성 호흡기 장애의 치료 방법 |
| JP2023550347A (ja) * | 2020-11-12 | 2023-12-01 | アクティーヴァ セラピューティクス， インコーポレイテッド | 血管漏出障害および内皮バリア障害を処置することにおける使用のためのｍｋ２活性化化合物 |
| CN116670142A (zh) * | 2021-02-01 | 2023-08-29 | 细胞基因公司 | Mk2抑制剂、其合成和其中间体 |
| EP4079855A1 (en) * | 2021-04-20 | 2022-10-26 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Compound and method for the prophylaxis and treatment of leukemia |
| WO2023025298A1 (zh) * | 2021-08-27 | 2023-03-02 | 瑞石生物医药有限公司 | 喹啉并呋喃衍生物及其用途 |
| EP4464694A4 (en) | 2022-01-14 | 2026-04-01 | Shanghai Hansoh Biomedical Co Ltd | POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE |
| WO2024044731A1 (en) * | 2022-08-26 | 2024-02-29 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| EP4608401A2 (en) * | 2022-10-27 | 2025-09-03 | Bristol-Myers Squibb Company | Mk2 inhibitors and uses thereof |
| JP2026505836A (ja) * | 2023-02-07 | 2026-02-18 | セルジーン コーポレーション | Ｍｋ２キナーゼ分解剤として有用である化合物および組成物 |
| WO2024229401A2 (en) * | 2023-05-04 | 2024-11-07 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| CN121368484A (zh) * | 2023-06-26 | 2026-01-20 | 深圳信立泰药业股份有限公司 | 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用 |
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| US5441946A (en) | 1994-04-14 | 1995-08-15 | Rhone-Poulenc-Rorer Pharmaceuticals, Inc. | Phosphonate derivatives of lipophilic amines |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
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| EP1849781A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
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| WO2018170203A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
| EP3596085A4 (en) | 2017-03-16 | 2020-11-25 | Celgene CAR LLC | DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES |
| US11098057B2 (en) | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| WO2020236636A1 (en) | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| KR20230044446A (ko) | 2020-07-24 | 2023-04-04 | 브리스톨-마이어스 스큅 컴퍼니 | 급성 호흡기 장애의 치료 방법 |
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2015
- 2015-09-16 RS RS20210725A patent/RS62017B1/sr unknown
- 2015-09-16 SM SM20210311T patent/SMT202100311T1/it unknown
- 2015-09-16 EP EP21164056.0A patent/EP3912981A1/en active Pending
- 2015-09-16 SG SG11201701861RA patent/SG11201701861RA/en unknown
- 2015-09-16 JP JP2017515845A patent/JP6556225B2/ja active Active
- 2015-09-16 LT LTEP15842903.5T patent/LT3193611T/lt unknown
- 2015-09-16 TW TW104130645A patent/TWI744217B/zh active
- 2015-09-16 AU AU2015317741A patent/AU2015317741B2/en active Active
- 2015-09-16 MA MA40534A patent/MA40534B1/fr unknown
- 2015-09-16 BR BR112017005266-0A patent/BR112017005266B1/pt active IP Right Grant
- 2015-09-16 ES ES15842903T patent/ES2874561T3/es active Active
- 2015-09-16 MX MX2017003359A patent/MX373341B/es active IP Right Grant
- 2015-09-16 SI SI201531617T patent/SI3193611T1/sl unknown
- 2015-09-16 PT PT158429035T patent/PT3193611T/pt unknown
- 2015-09-16 EA EA201790380A patent/EA037299B1/ru not_active IP Right Cessation
- 2015-09-16 CN CN201580058026.4A patent/CN106998692B/zh active Active
- 2015-09-16 WO PCT/US2015/050495 patent/WO2016044463A2/en not_active Ceased
- 2015-09-16 EP EP15842903.5A patent/EP3193611B1/en active Active
- 2015-09-16 HR HRP20210529TT patent/HRP20210529T1/hr unknown
- 2015-09-16 CA CA2961607A patent/CA2961607C/en active Active
- 2015-09-16 DK DK15842903.5T patent/DK3193611T3/da active
- 2015-09-16 PL PL15842903T patent/PL3193611T3/pl unknown
- 2015-09-16 KR KR1020177010439A patent/KR102457848B1/ko active Active
- 2015-09-16 US US14/856,311 patent/US9458175B2/en active Active
- 2015-09-16 HU HUE15842903A patent/HUE054347T2/hu unknown
- 2015-09-16 SG SG10201902326XA patent/SG10201902326XA/en unknown
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2016
- 2016-09-29 US US15/280,157 patent/US9790235B2/en active Active
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2017
- 2017-03-09 IL IL25105117A patent/IL251051B/en active IP Right Grant
- 2017-03-09 CL CL2017000576A patent/CL2017000576A1/es unknown
- 2017-03-14 MX MX2020005213A patent/MX2020005213A/es unknown
- 2017-03-16 SA SA517381115A patent/SA517381115B1/ar unknown
- 2017-04-04 CO CONC2017/0003279A patent/CO2017003279A2/es unknown
- 2017-04-13 EC ECIEPI201723281A patent/ECSP17023281A/es unknown
- 2017-10-13 US US15/782,995 patent/US10253040B1/en active Active
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2019
- 2019-04-04 US US16/375,317 patent/US10577380B2/en active Active
- 2019-07-09 JP JP2019127476A patent/JP2019194236A/ja active Pending
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2020
- 2020-02-27 US US16/802,654 patent/US11584757B2/en active Active
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2021
- 2021-06-09 CY CY20211100504T patent/CY1124215T1/el unknown
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2022
- 2022-03-16 JP JP2022041396A patent/JP7375072B2/ja active Active