|
JPS4934761B1
(https=)
|
1969-03-10 |
1974-09-18 |
|
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US5080898A
(en)
|
1982-05-12 |
1992-01-14 |
The University Hospital |
Enzymatically active toxin coupled to a cell-specific ligand
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4894443A
(en)
|
1984-02-08 |
1990-01-16 |
Cetus Corporation |
Toxin conjugates
|
|
US5668255A
(en)
|
1984-06-07 |
1997-09-16 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
US6022950A
(en)
|
1984-06-07 |
2000-02-08 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5135736A
(en)
|
1988-08-15 |
1992-08-04 |
Neorx Corporation |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
|
|
WO1991009871A1
(en)
|
1989-12-22 |
1991-07-11 |
Seragen Incorporated |
Hybrid molecules having translocation region and cell-binding region
|
|
US5635384A
(en)
|
1990-06-11 |
1997-06-03 |
Dowelanco |
Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
|
|
US5621083A
(en)
|
1991-11-04 |
1997-04-15 |
Xoma Corporation |
Immunotoxins comprising ribosome-inactivating proteins
|
|
WO1994026910A1
(en)
|
1993-05-12 |
1994-11-24 |
Xoma Corporation |
Immunotoxins comprising gelonin and an antibody
|
|
US6146850A
(en)
|
1991-11-04 |
2000-11-14 |
Xoma Corporation |
Proteins encoding gelonin sequences
|
|
US5552144A
(en)
|
1992-01-22 |
1996-09-03 |
Microcarb, Inc. |
Immunogenic shiga-like toxin II variant mutants
|
|
US5612474A
(en)
|
1994-06-30 |
1997-03-18 |
Eli Lilly And Company |
Acid labile immunoconjugate intermediates
|
|
AU3374795A
(en)
|
1994-08-29 |
1996-03-22 |
Prizm Pharmaceuticals, Inc. |
Conjugates of vascular endothelial growth factor with targeted agents
|
|
CA2218601A1
(en)
|
1995-03-24 |
1996-10-03 |
Ophidian Pharmaceuticals, Inc. |
Treatment for verotoxin-producing escherichia coli
|
|
US5667786A
(en)
|
1995-06-07 |
1997-09-16 |
Novavax, Inc. |
Method for treating tumors with a toxin
|
|
US5858682A
(en)
|
1996-08-02 |
1999-01-12 |
Pharmingen |
E2A/pbx1 fusion protein specific monoclonal antibodies
|
|
JP2001500730A
(ja)
|
1996-09-10 |
2001-01-23 |
ヘンリー エム ジャクソン ファンデーション フォージ アドバンスメント オブ ミリタリー メディシン |
ヒスチジン―タグ付き志賀毒素およびトキソイド、該毒素およびトキソイドとの融合タンパク質ならびにそれらの精製及び調製方法
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
FR2766193B1
(fr)
|
1997-07-18 |
2001-09-14 |
Inst Curie |
Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique
|
|
CA2222993A1
(en)
|
1998-02-04 |
1999-08-04 |
The Ontario Cancer Institute |
A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries
|
|
WO1999062526A2
(en)
|
1998-06-05 |
1999-12-09 |
Mayo Foundation For Medical Education And Research |
Use of genetically engineered antibodies to cd38 to treat multiple myeloma
|
|
US7157418B1
(en)
|
1998-07-22 |
2007-01-02 |
Osprey Pharmaceuticals, Ltd. |
Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
|
|
DE69910216T2
(de)
|
1998-07-22 |
2004-02-19 |
Osprey Pharmaceuticals Ltd., Calgary |
Konjugate zur behandlung von entzündungskrankheiten und von assozierter gewebeschädigung
|
|
US6770456B1
(en)
|
1998-07-29 |
2004-08-03 |
Ludwig Institute For Cancer Research |
Endogenous retrovirus tumor associated nucleic acids and antigens
|
|
US7527787B2
(en)
|
2005-10-19 |
2009-05-05 |
Ibc Pharmaceuticals, Inc. |
Multivalent immunoglobulin-based bioactive assemblies
|
|
US7312318B2
(en)
|
2002-03-01 |
2007-12-25 |
Immunomedics, Inc. |
Internalizing anti-CD74 antibodies and methods of use
|
|
US7144991B2
(en)
|
1999-06-07 |
2006-12-05 |
Aletheon Pharmaceuticals, Inc. |
Streptavidin expressed gene fusions and methods of use thereof
|
|
US6492498B1
(en)
|
1999-11-15 |
2002-12-10 |
Regents Of The University Of Minnesota |
Multimeric immunotoxins
|
|
US7267973B2
(en)
|
2000-03-22 |
2007-09-11 |
Sibtech, Inc. |
Nucleic acids encoding recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor
|
|
US20010031485A1
(en)
|
2000-03-22 |
2001-10-18 |
Sibtech, Inc. |
Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
US20020127247A1
(en)
|
2000-11-17 |
2002-09-12 |
Allergen Sales, Inc. |
Modified clostridial neurotoxins with altered biological persistence
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
AU2003208097A1
(en)
|
2002-02-04 |
2003-09-02 |
Hideo Yoshida |
Anticancer agents using vero toxin variants
|
|
AU2003213580A1
(en)
|
2002-02-26 |
2003-09-09 |
Genencor International, Inc. |
Subtilisin carlsberg proteins with reduced immunogenicity
|
|
SE0201863D0
(en)
|
2002-06-18 |
2002-06-18 |
Cepep Ab |
Cell penetrating peptides
|
|
TWI335821B
(en)
|
2002-12-16 |
2011-01-11 |
Genentech Inc |
Immunoglobulin variants and uses thereof
|
|
AU2003303374A1
(en)
|
2002-12-20 |
2004-07-22 |
The Johns Hopkins University |
Treatment of metastatic cancer with the b-subunit of shiga toxin
|
|
WO2005000902A1
(en)
|
2003-06-30 |
2005-01-06 |
Mu-Hyeon Choe |
The dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same
|
|
US8147832B2
(en)
|
2003-08-14 |
2012-04-03 |
Merck Patent Gmbh |
CD20-binding polypeptide compositions and methods
|
|
US7982011B2
(en)
|
2003-11-25 |
2011-07-19 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-cd22 antibodies and immunoconjugates
|
|
EP1687016A4
(en)
|
2003-11-25 |
2009-07-29 |
Anjin Corp |
GENETIC VARIANT OF DIPHTHERIC TOXIN
|
|
AU2005235811B2
(en)
|
2004-02-06 |
2011-11-03 |
Morphosys Ag |
Anti-CD38 human antibodies and uses therefor
|
|
EP1727827B1
(en)
|
2004-03-26 |
2010-05-12 |
Molecular Templates, Inc. |
Library of toxin mutants, and methods of using same
|
|
JP5225069B2
(ja)
|
2005-03-23 |
2013-07-03 |
ゲンマブ エー／エス |
多発性骨髄腫の治療のためのｃｄ３８に対する抗体
|
|
US7771955B2
(en)
|
2005-06-09 |
2010-08-10 |
University Of Maryland |
Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
RU2421242C2
(ru)
|
2005-07-25 |
2011-06-20 |
Трабьон Фармасьютикалз, Инк. |
Применение однократной дозы cd20-специфических связывающих молекул
|
|
EP1945660B1
(en)
|
2005-09-26 |
2014-05-07 |
Molecular Templates, Inc. |
Library from toxin mutants, and methods of using same
|
|
EP1969000A2
(en)
|
2005-12-06 |
2008-09-17 |
Centre National de la Recherche Scientifique |
Cell penetrating peptides for intracellular delivery of molecules
|
|
US7579318B2
(en)
|
2005-12-06 |
2009-08-25 |
Centre De La Recherche De La Scientifique |
Cell penetrating peptides for intracellular delivery of molecules
|
|
WO2007071061A1
(en)
|
2005-12-23 |
2007-06-28 |
Viventia Biotech Inc. |
Methods for generating and screening fusion protein libraries and uses thereof
|
|
ES2532985T3
(es)
|
2006-02-16 |
2015-04-06 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Proteínas quiméricas de toxoide de Shiga
|
|
US7373982B2
(en)
|
2006-03-21 |
2008-05-20 |
Halliburton Energy Services, Inc. |
Cements for use across formations containing gas hydrates
|
|
EP2097529A4
(en)
|
2006-12-29 |
2010-03-24 |
Osprey Pharmaceuticals Usa Inc |
METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF
|
|
CN101657464A
(zh)
|
2007-02-02 |
2010-02-24 |
贝勒研究院 |
与靶向人源化单克隆抗体复合的多变量抗原
|
|
AU2008279550B2
(en)
|
2007-06-21 |
2012-08-09 |
Angelica Therapeutics, Inc. |
Modified toxins
|
|
US7887801B2
(en)
|
2007-07-13 |
2011-02-15 |
Topotarget Germany Ag |
Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
|
|
EP2187971A2
(en)
|
2007-08-01 |
2010-05-26 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
|
WO2009032954A1
(en)
|
2007-09-04 |
2009-03-12 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
|
|
US20100298238A1
(en)
|
2007-10-08 |
2010-11-25 |
Rutgers, The State University |
Nontoxic shiga-like toxin mutant compositions and methods
|
|
CA2705289A1
(en)
|
2007-11-13 |
2009-05-22 |
The Scripps Research Institute |
Production of cytotoxic antibody-toxin fusion in eukaryotic algae
|
|
US8315343B2
(en)
|
2007-12-17 |
2012-11-20 |
Telefonaktiebolaget Lm Ericsson (Publ) |
Multi-antenna receiver interference cancellation method and apparatus
|
|
WO2009110944A1
(en)
|
2008-02-29 |
2009-09-11 |
Angelica Therapeutics, Inc. |
Modified toxins
|
|
CN102159243B
(zh)
|
2008-07-21 |
2015-08-19 |
免疫医疗公司 |
用于改良的治疗特征的抗体的结构变体
|
|
US20100093563A1
(en)
|
2008-09-22 |
2010-04-15 |
Robert Anthony Williamson |
Methods and vectors for display of molecules and displayed molecules and collections
|
|
WO2010085539A1
(en)
|
2009-01-23 |
2010-07-29 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Methods and compositions based on shiga toxin type 2 protein
|
|
AU2010240569A1
(en)
|
2009-04-20 |
2011-10-20 |
Pfizer Inc. |
Control of protein glycosylation and compositions and methods relating thereto
|
|
JP2012533587A
(ja)
|
2009-07-22 |
2012-12-27 |
セニックス バイオサイエンス ゲーエムベーハー |
自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
|
|
US9174169B2
(en)
|
2009-08-14 |
2015-11-03 |
Unifrax I Llc |
Mounting mat for exhaust gas treatment device
|
|
EP2371864A1
(en)
|
2010-03-23 |
2011-10-05 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies for treatment of cancer
|
|
EP2576621B1
(en)
|
2010-05-27 |
2019-04-10 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
GB201013989D0
(en)
|
2010-08-20 |
2010-10-06 |
Univ Southampton |
Biological materials and methods of using the same
|
|
WO2012038950A1
(en)
|
2010-09-20 |
2012-03-29 |
Ramot At Tel-Aviv University Ltd. |
Activatable toxin complexes comprising a cleavable inhibitory peptide
|
|
PL219845B1
(pl)
|
2011-01-05 |
2015-07-31 |
Adamed Spółka Z Ograniczoną Odpowiedzialnością |
Przeciwnowotworowe białko fuzyjne
|
|
US20140065172A1
(en)
|
2011-01-26 |
2014-03-06 |
Cenix Bioscience Gmbh |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2012104344A1
(en)
|
2011-02-01 |
2012-08-09 |
Genmab A/S |
Human antibodies and antibody-drug conjugates against cd74
|
|
EP2673297A2
(en)
|
2011-02-11 |
2013-12-18 |
Zyngenia, Inc. |
Monovalent and multivalent multispecific complexes and uses thereof
|
|
US8895006B2
(en)
|
2011-03-04 |
2014-11-25 |
Rutgers, The State University Of New Jersey |
Ricin ribosome binding protein compositions and methods of use thereof
|
|
SG194787A1
(en)
|
2011-05-06 |
2013-12-30 |
Us Gov Health & Human Serv |
Recombinant immunotoxin targeting mesothelin
|
|
WO2012162418A1
(en)
|
2011-05-23 |
2012-11-29 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for heterodimeric targeting ligands
|
|
PL397167A1
(pl)
|
2011-11-28 |
2013-06-10 |
Adamed Spólka Z Ograniczona Odpowiedzialnoscia |
Przeciwnowotworowe bialko fuzyjne
|
|
CA2865243A1
(en)
|
2012-02-23 |
2013-08-29 |
President And Fellows Of Harvard College |
Modified microbial toxin receptor for delivering agents into cells
|
|
EP2740493A1
(en)
|
2012-12-05 |
2014-06-11 |
Institut Curie |
Conjugates of the B-subunit of Shiga toxin for anticancer therapies
|
|
EP3666795A1
(en)
|
2013-03-12 |
2020-06-17 |
Molecular Templates, Inc. |
Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
|
|
EP2778173A1
(en)
|
2013-03-15 |
2014-09-17 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Antibody directed against anthrax toxins and its uses
|
|
GB2519786A
(en)
|
2013-10-30 |
2015-05-06 |
Sergej Michailovic Kiprijanov |
Multivalent antigen-binding protein molecules
|
|
CN112851769A
(zh)
|
2014-01-27 |
2021-05-28 |
分子模板公司 |
用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
|
|
US20160177284A1
(en)
|
2014-01-27 |
2016-06-23 |
Molecular Templates, Inc. |
Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
|
|
US20210138076A2
(en)
|
2014-01-27 |
2021-05-13 |
Molecular Templates, Inc. |
Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
|
|
US20220401568A1
(en)
|
2014-01-27 |
2022-12-22 |
Molecular Templates, Inc. |
Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
|
|
WO2015120058A2
(en)
|
2014-02-05 |
2015-08-13 |
Molecular Templates, Inc. |
Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
|
|
JP6935195B2
(ja)
|
2014-03-11 |
2021-09-15 |
モレキュラー テンプレーツ, インク.Molecular Templates, Inc. |
結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
|
|
ES2809729T3
(es)
|
2014-03-11 |
2021-03-05 |
Molecular Templates Inc |
Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2
|
|
US11142584B2
(en)
|
2014-03-11 |
2021-10-12 |
Molecular Templates, Inc. |
CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
|
|
TWI674257B
(zh)
|
2014-03-14 |
2019-10-11 |
日商拉夸里亞創藥股份有限公司 |
作為ｔｒｐｍ８拮抗劑之氮雜螺衍生物
|
|
CN106604934A
(zh)
|
2014-06-11 |
2017-04-26 |
分子模板公司 |
耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
|
|
WO2015191883A1
(en)
|
2014-06-12 |
2015-12-17 |
Dophen Biomedical |
Homogenous antibody drug conjugates via enzymatic methods
|
|
ES2806776T3
(es)
*
|
2014-06-18 |
2021-02-18 |
Chemotherapeutisches Forschungsinstitut Georg Speyer Haus |
Células NK-92 que expresan CAR como agentes terapéuticos celulares
|
|
CN105713087B
(zh)
|
2014-11-12 |
2020-05-08 |
北京康乐卫士生物技术股份有限公司 |
人乳头瘤病毒58型单克隆抗体及其应用
|
|
EP3253799B1
(en)
|
2015-02-05 |
2020-12-02 |
Molecular Templates, Inc. |
Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
|
|
EP3957738A1
(en)
|
2015-03-04 |
2022-02-23 |
IGM Biosciences, Inc. |
Cd20 binding molecules and uses thereof
|
|
EP3303373B1
(en)
|
2015-05-30 |
2020-04-08 |
Molecular Templates, Inc. |
De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
|
|
KR20180030085A
(ko)
|
2015-07-26 |
2018-03-21 |
몰레큘러 템플레이츠, 인코퍼레이션. |
시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
|
|
ES2883297T3
(es)
|
2016-03-29 |
2021-12-07 |
Stcube Inc |
Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
WO2018080812A1
(en)
|
2016-10-30 |
2018-05-03 |
Henlix, Inc. |
Anti-pd-l1 antibodies and variants
|
|
WO2018106895A1
(en)
|
2016-12-07 |
2018-06-14 |
Molecular Templates, Inc. |
Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
|
|
EP3434693A4
(en)
|
2016-12-26 |
2019-10-02 |
Dankook University Cheonan Campus Industry Academic Cooperation Foundation |
COMPOSITION FOR THE DIFFERENTIATION OF DENTAL STRAIN CELLS IN ODONTOBLAST FIELD CELLS AND MONOCLONAL IGG OR IGM-TYPE ANTIBODIES WITH SPECIFIC BINDING TO SURFACES OF ODOBOBLAST FIELD CELLS
|
|
MX2019008840A
(es)
|
2017-01-25 |
2019-09-09 |
Molecular Templates Inc |
Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
|
|
WO2018159615A1
(en)
|
2017-02-28 |
2018-09-07 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification with protein l
|
|
DK3592769T3
(da)
|
2017-03-09 |
2024-08-12 |
Genmab As |
Antistoffer mod pd-l1
|
|
EP3689893A4
(en)
|
2017-09-25 |
2021-12-15 |
JSR Corporation |
IMMUNOGLOBULIN-BINDING PROTEIN AND AFFINITY CARRIERS THEREFORE
|
|
CN110612117B
(zh)
*
|
2018-04-17 |
2024-04-12 |
分子模板公司 |
包含去免疫化的志贺毒素a亚基支架的her2靶向分子
|
|
WO2020081493A1
(en)
|
2018-10-16 |
2020-04-23 |
Molecular Templates, Inc. |
Pd-l1 binding proteins
|
|
WO2020154475A1
(en)
|
2019-01-23 |
2020-07-30 |
Molecular Templates, Inc. |
Proteins comprising modified immunoglobulin variable light chains
|
|
MX2022003195A
(es)
|
2019-09-18 |
2022-04-11 |
Molecular Templates Inc |
Moleculas de union a pd-l1 que comprenden andamios de la subunidad a de la toxina shiga.
|