CN114773439A - 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子 - Google Patents

用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子 Download PDF

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CN114773439A
CN114773439A CN202210595624.7A CN202210595624A CN114773439A CN 114773439 A CN114773439 A CN 114773439A CN 202210595624 A CN202210595624 A CN 202210595624A CN 114773439 A CN114773439 A CN 114773439A
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seq
cell
shiga toxin
amino acid
further embodiments
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埃里克·波马
埃林·威勒特
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Molecular Templates Inc
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Molecular Templates Inc
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
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CN202210595624.7A 2016-12-07 2017-12-07 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子 Pending CN114773439A (zh)

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Application Number Priority Date Filing Date Title
US201662431036P 2016-12-07 2016-12-07
US62/431,036 2016-12-07
CN201780085716.8A CN110494443B (zh) 2016-12-07 2017-12-07 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子
PCT/US2017/065074 WO2018106895A1 (en) 2016-12-07 2017-12-07 Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation

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CN201780085716.8A Active CN110494443B (zh) 2016-12-07 2017-12-07 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子

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EP (2) EP3551645A1 (https=)
JP (2) JP7075134B2 (https=)
KR (2) KR102580647B1 (https=)
CN (2) CN114773439A (https=)
AU (2) AU2017373962B2 (https=)
CA (1) CA3043333A1 (https=)
IL (3) IL266583B2 (https=)
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