JP2020511117A5 - - Google Patents
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- Publication number
- JP2020511117A5 JP2020511117A5 JP2019533330A JP2019533330A JP2020511117A5 JP 2020511117 A5 JP2020511117 A5 JP 2020511117A5 JP 2019533330 A JP2019533330 A JP 2019533330A JP 2019533330 A JP2019533330 A JP 2019533330A JP 2020511117 A5 JP2020511117 A5 JP 2020511117A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- strand
- cdna
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims description 79
- 238000000034 method Methods 0.000 claims description 76
- 239000002299 complementary DNA Substances 0.000 claims description 61
- 150000007523 nucleic acids Chemical group 0.000 claims description 60
- 238000006243 chemical reaction Methods 0.000 claims description 50
- 238000004519 manufacturing process Methods 0.000 claims description 40
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 34
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
- 108091034117 Oligonucleotide Proteins 0.000 claims description 20
- 108020004999 messenger RNA Proteins 0.000 claims description 20
- 108020004707 nucleic acids Proteins 0.000 claims description 20
- 102000039446 nucleic acids Human genes 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 239000002773 nucleotide Substances 0.000 claims description 15
- 125000003729 nucleotide group Chemical group 0.000 claims description 15
- 238000012986 modification Methods 0.000 claims description 13
- 230000004048 modification Effects 0.000 claims description 13
- 102000003960 Ligases Human genes 0.000 claims description 10
- 108090000364 Ligases Proteins 0.000 claims description 10
- 108091008874 T cell receptors Proteins 0.000 claims description 10
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 10
- 125000006850 spacer group Chemical group 0.000 claims description 10
- 230000036647 reaction Effects 0.000 claims description 8
- 230000006820 DNA synthesis Effects 0.000 claims description 6
- 230000000295 complement effect Effects 0.000 claims description 6
- 108020004635 Complementary DNA Proteins 0.000 claims description 5
- 238000000137 annealing Methods 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 2
- 230000003321 amplification Effects 0.000 claims description 2
- 230000000692 anti-sense effect Effects 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 230000009089 cytolysis Effects 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 108091081021 Sense strand Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023169621A JP2023169422A (ja) | 2016-12-23 | 2023-09-29 | 結合ポリペプチドおよびそれを作製する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438712P | 2016-12-23 | 2016-12-23 | |
| US62/438,712 | 2016-12-23 | ||
| PCT/US2017/068204 WO2018119402A1 (en) | 2016-12-23 | 2017-12-22 | Binding polypeptides and methods of making the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023169621A Division JP2023169422A (ja) | 2016-12-23 | 2023-09-29 | 結合ポリペプチドおよびそれを作製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511117A JP2020511117A (ja) | 2020-04-16 |
| JP2020511117A5 true JP2020511117A5 (https=) | 2021-02-12 |
| JP7360324B2 JP7360324B2 (ja) | 2023-10-12 |
Family
ID=61054491
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533330A Active JP7360324B2 (ja) | 2016-12-23 | 2017-12-22 | 結合ポリペプチドおよびそれを作製する方法 |
| JP2023169621A Pending JP2023169422A (ja) | 2016-12-23 | 2023-09-29 | 結合ポリペプチドおよびそれを作製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023169621A Pending JP2023169422A (ja) | 2016-12-23 | 2023-09-29 | 結合ポリペプチドおよびそれを作製する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11820979B2 (https=) |
| EP (1) | EP3559028A1 (https=) |
| JP (2) | JP7360324B2 (https=) |
| KR (2) | KR102702552B1 (https=) |
| CN (1) | CN110366557B (https=) |
| AU (1) | AU2017382367B2 (https=) |
| BR (1) | BR112019013096A2 (https=) |
| CA (1) | CA3045696A1 (https=) |
| CL (2) | CL2019001757A1 (https=) |
| CO (1) | CO2019006663A2 (https=) |
| IL (2) | IL315727A (https=) |
| MX (1) | MX2019007356A (https=) |
| MY (1) | MY201744A (https=) |
| RU (1) | RU2019123063A (https=) |
| WO (1) | WO2018119402A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3781677A4 (en) * | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| CN109161572B (zh) * | 2018-07-05 | 2021-11-12 | 中国海洋大学 | 单链环状核酸及其制备方法和应用 |
| WO2020097395A1 (en) | 2018-11-08 | 2020-05-14 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
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-
2017
- 2017-12-22 KR KR1020197021677A patent/KR102702552B1/ko active Active
- 2017-12-22 JP JP2019533330A patent/JP7360324B2/ja active Active
- 2017-12-22 MY MYPI2019003039A patent/MY201744A/en unknown
- 2017-12-22 AU AU2017382367A patent/AU2017382367B2/en active Active
- 2017-12-22 MX MX2019007356A patent/MX2019007356A/es unknown
- 2017-12-22 RU RU2019123063A patent/RU2019123063A/ru unknown
- 2017-12-22 CN CN201780086589.3A patent/CN110366557B/zh active Active
- 2017-12-22 IL IL315727A patent/IL315727A/en unknown
- 2017-12-22 EP EP17835907.1A patent/EP3559028A1/en not_active Ceased
- 2017-12-22 CA CA3045696A patent/CA3045696A1/en active Pending
- 2017-12-22 US US15/852,718 patent/US11820979B2/en active Active
- 2017-12-22 BR BR112019013096A patent/BR112019013096A2/pt unknown
- 2017-12-22 WO PCT/US2017/068204 patent/WO2018119402A1/en not_active Ceased
- 2017-12-22 IL IL267565A patent/IL267565B2/en unknown
- 2017-12-22 KR KR1020247029164A patent/KR20240133790A/ko active Pending
-
2019
- 2019-06-21 CO CONC2019/0006663A patent/CO2019006663A2/es unknown
- 2019-06-21 CL CL2019001757A patent/CL2019001757A1/es unknown
-
2022
- 2022-02-24 CL CL2022000454A patent/CL2022000454A1/es unknown
-
2023
- 2023-09-29 JP JP2023169621A patent/JP2023169422A/ja active Pending
- 2023-10-05 US US18/481,497 patent/US20240141334A1/en not_active Abandoned
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