|
GB9207381D0
(en)
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
|
AU760549B2
(en)
|
1998-04-03 |
2003-05-15 |
University Of Iowa Research Foundation, The |
Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
|
|
WO2004030634A2
(en)
|
2002-10-02 |
2004-04-15 |
Alnylam Pharmaceuticals Inc. |
Therapeutic compositions
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
WO2004090108A2
(en)
|
2003-04-03 |
2004-10-21 |
Alnylam Pharmaceuticals |
Irna conjugates
|
|
US8969543B2
(en)
|
2003-04-03 |
2015-03-03 |
Bioneer Corporation |
SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
|
CA2521464C
(en)
|
2003-04-09 |
2013-02-05 |
Alnylam Pharmaceuticals, Inc. |
Irna conjugates
|
|
NZ542687A
(en)
|
2003-04-13 |
2010-02-26 |
Enzon Pharmaceuticals Inc |
Polymeric oligonucleotide prodrugs
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
JP4991288B2
(ja)
|
2003-04-17 |
2012-08-01 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
US20100170000A9
(en)
|
2004-10-25 |
2010-07-01 |
Devgen Nv |
Rna constructs
|
|
AU2006275579B2
(en)
|
2005-08-01 |
2012-10-04 |
Purdue Research Foundation |
Multivalent RNA nanoparticles for delivery of active agents to a cell
|
|
KR101221589B1
(ko)
|
2006-04-07 |
2013-01-15 |
이데라 파마슈티칼즈, 인코포레이티드 |
Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물
|
|
US20080214436A1
(en)
|
2007-01-26 |
2008-09-04 |
City Of Hope |
Methods and compositions for the treatment of cancer or other diseases
|
|
US8748405B2
(en)
|
2007-01-26 |
2014-06-10 |
City Of Hope |
Methods and compositions for the treatment of cancer or other diseases
|
|
US20080287383A1
(en)
|
2007-03-02 |
2008-11-20 |
Nastech Pharmaceutical Company Inc. |
Nucleic acid compounds for inhibiting erbb gene expression and uses thereof
|
|
US20080311040A1
(en)
*
|
2007-03-06 |
2008-12-18 |
Flagship Ventures |
METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
|
|
EP2357231A2
(en)
|
2007-07-09 |
2011-08-17 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory RNA (SIMRA) compounds
|
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2010021720A1
(en)
|
2008-08-19 |
2010-02-25 |
Nektar Therapeutics |
Conjugates of small-interfering nucleic acids
|
|
US8637194B2
(en)
|
2008-09-02 |
2014-01-28 |
Bio-Nano Power, Llc |
Bio-nano power cells and their uses
|
|
CN102282155B
(zh)
|
2008-12-02 |
2017-06-09 |
日本波涛生命科学公司 |
磷原子修饰的核酸的合成方法
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
JP5529895B2
(ja)
*
|
2009-02-04 |
2014-06-25 |
ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション |
細胞内の伝達能が増加した低分子干渉ｒｎａ複合体
|
|
KR101141544B1
(ko)
|
2009-03-13 |
2012-05-03 |
한국과학기술원 |
에스아이알엔에이 다중 접합체 및 이의 제조방법
|
|
EP2470656B1
(en)
|
2009-08-27 |
2015-05-06 |
Idera Pharmaceuticals, Inc. |
Composition for inhibiting gene expression and uses thereof
|
|
KR101678876B1
(ko)
|
2010-01-15 |
2016-11-23 |
한국과학기술원 |
복합 유전자를 표적하는 ｓｉＲＮＡ 다중 접합체 및 이의 제조방법
|
|
SI2539451T1
(sl)
|
2010-02-24 |
2016-04-29 |
Arrowhead Research Corporation |
Sestavki za ciljano dostavo sirna
|
|
WO2011109380A1
(en)
|
2010-03-01 |
2011-09-09 |
The Children's Hospital Of Philadelphia |
Nucleic acids for targeting multiple regions of the hcv genome
|
|
CN103796657B
(zh)
|
2011-07-19 |
2017-07-11 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
AU2012308320C1
(en)
|
2011-09-14 |
2018-08-23 |
Translate Bio Ma, Inc. |
Multimeric oligonucleotide compounds
|
|
KR101340290B1
(ko)
*
|
2011-09-14 |
2013-12-11 |
한국과학기술원 |
유전자 표적용 ｓｉＲＮＡ 하이드로젤 및 그 제조방법
|
|
US20150247141A1
(en)
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
US9956294B2
(en)
|
2013-01-18 |
2018-05-01 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Targeted sensitization of non-del(5q) malignant cells
|
|
KR101629681B1
(ko)
|
2013-06-24 |
2016-06-14 |
건국대학교 산학협력단 |
다중 리간드가 도입된 에스아이알엔에이 접합체
|
|
GB201311840D0
(en)
*
|
2013-07-02 |
2013-08-14 |
Univ Aberdeen |
Control of varroa mite infestation
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
SG10201804960RA
(en)
|
2013-12-12 |
2018-07-30 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
|
CA2935426C
(en)
|
2014-01-30 |
2023-07-25 |
F. Hoffmann-La Roche Ag |
Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
|
|
WO2016110691A1
(en)
*
|
2015-01-06 |
2016-07-14 |
The University Court Of The University Of Aberdeen |
Enhanced rnai mediated gene regulation
|
|
IL316159A
(en)
|
2015-06-15 |
2024-12-01 |
Mpeg La Llc |
Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
|
|
US10758624B2
(en)
|
2015-07-02 |
2020-09-01 |
City Of Hope |
Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
|
|
WO2017075030A1
(en)
|
2015-10-26 |
2017-05-04 |
Rana Therapeutics, Inc. |
Methods and compositions for increasing smn expression
|
|
KR102528260B1
(ko)
|
2016-01-05 |
2023-05-04 |
유니버시티 오브 레스터 |
필요로 하는 대상체에서 섬유증의 억제 방법
|
|
WO2018030338A1
(ja)
|
2016-08-08 |
2018-02-15 |
浩文 山本 |
アジュバント組成物
|
|
SG11201906728TA
(en)
|
2017-02-06 |
2019-08-27 |
Mpeg La Llc |
Multimeric oligonucleotides having decreased kidney clearance
|
|
CN120330183A
(zh)
|
2017-06-02 |
2025-07-18 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
EP3733683A4
(en)
|
2017-11-30 |
2022-04-06 |
GeneMind Biosciences Company Limited |
NUCLEOSIDE ANALOGUES, METHOD OF MANUFACTURE AND USE
|
|
EP3935168A4
(en)
|
2019-03-04 |
2024-04-10 |
Mpeg La, LLC |
MULTIMERIC OLIGONUCLEOTIDES WITH IMPROVED BIOACTIVITY
|
|
JP2022543191A
(ja)
|
2019-07-30 |
2022-10-11 |
エムペグ エルエイ リミテッド ライアビリティ カンパニー |
増強された生理活性を有する多量体オリゴヌクレオチドの皮下送達
|
|
CA3178559A1
(en)
|
2020-05-19 |
2021-11-25 |
Jonathan Miles Brown |
Orthogonally linked multimeric oligonucleotides
|