CN110248665A - 具有降低的肾清除的多聚体寡核苷酸 - Google Patents

具有降低的肾清除的多聚体寡核苷酸 Download PDF

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Publication number
CN110248665A
CN110248665A CN201880010283.4A CN201880010283A CN110248665A CN 110248665 A CN110248665 A CN 110248665A CN 201880010283 A CN201880010283 A CN 201880010283A CN 110248665 A CN110248665 A CN 110248665A
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oligonucleotide
multimeric
oligonucleotides
stranded
multimeric oligonucleotide
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Chinese (zh)
Inventor
J.M.布朗
H-P.沃恩洛彻
K.K.H.纽曼
P.哈德威格
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Mpeg La Co Ltd
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Mpeg La Co Ltd
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201880010283.4A 2017-02-06 2018-02-06 具有降低的肾清除的多聚体寡核苷酸 Pending CN110248665A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762455231P 2017-02-06 2017-02-06
US62/455,231 2017-02-06
US201762522363P 2017-06-20 2017-06-20
US62/522,363 2017-06-20
US201762561853P 2017-09-22 2017-09-22
US62/561,853 2017-09-22
PCT/US2018/017062 WO2018145086A1 (en) 2017-02-06 2018-02-06 Multimeric oligonucleotides having decreased kidney clearance

Publications (1)

Publication Number Publication Date
CN110248665A true CN110248665A (zh) 2019-09-17

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CN201880010283.4A Pending CN110248665A (zh) 2017-02-06 2018-02-06 具有降低的肾清除的多聚体寡核苷酸

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US (2) US11078484B2 (https=)
EP (1) EP3576752A4 (https=)
JP (1) JP7183167B2 (https=)
KR (2) KR102776167B1 (https=)
CN (1) CN110248665A (https=)
AU (1) AU2018215684B2 (https=)
CA (1) CA3051480A1 (https=)
IL (2) IL307726A (https=)
MX (1) MX2019009347A (https=)
SG (1) SG11201906728TA (https=)
WO (1) WO2018145086A1 (https=)

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EP3935168A4 (en) * 2019-03-04 2024-04-10 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH IMPROVED BIOACTIVITY
JP2022528487A (ja) * 2019-03-29 2022-06-13 ユニバーシティ・オブ・マサチューセッツ Ｃ９ｏｒｆ７２のオリゴヌクレオチドベースの調節
US11629347B2 (en) 2019-05-06 2023-04-18 University Of Massachusetts Anti-C9ORF72 oligonucleotides and related methods
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US20180223284A1 (en) 2018-08-09
IL267806B1 (en) 2023-11-01
KR20240010750A (ko) 2024-01-24
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JP7183167B2 (ja) 2022-12-05
KR20190115445A (ko) 2019-10-11
IL267806B2 (en) 2024-03-01
AU2018215684B2 (en) 2024-03-07
JP2020518552A (ja) 2020-06-25
AU2018215684A1 (en) 2019-08-01
US11078484B2 (en) 2021-08-03
WO2018145086A1 (en) 2018-08-09
IL267806A (en) 2019-09-26
IL307726A (en) 2023-12-01
US12378551B2 (en) 2025-08-05
US20210380979A1 (en) 2021-12-09
EP3576752A4 (en) 2020-12-16
KR102776167B1 (ko) 2025-03-05
EP3576752A1 (en) 2019-12-11
CA3051480A1 (en) 2018-08-09
MX2019009347A (es) 2019-10-07
SG11201906728TA (en) 2019-08-27

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