JP2020509092A5 - - Google Patents

Info

Publication number

JP2020509092A5

JP2020509092A5 JP2019568840A JP2019568840A JP2020509092A5 JP 2020509092 A5 JP2020509092 A5 JP 2020509092A5 JP 2019568840 A JP2019568840 A JP 2019568840A JP 2019568840 A JP2019568840 A JP 2019568840A JP 2020509092 A5 JP2020509092 A5 JP 2020509092A5

Authority

JP

Japan

Prior art keywords

aqueous solution

ophthalmic preparation

glycerol

damage

epithelial cells

Prior art date

2018-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 30
• 239000007864 aqueous solution Substances 0.000 claims 18
• 238000002360 preparation method Methods 0.000 claims 18
• 210000002919 epithelial cell Anatomy 0.000 claims 7
• NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 6
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 6
• 229920002125 Sokalan® Polymers 0.000 claims 6
• 229960001631 carbomer Drugs 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 6
• 238000010186 staining Methods 0.000 claims 4
• 230000007794 irritation Effects 0.000 claims 3
• 239000000243 solution Substances 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 239000003963 antioxidant agent Substances 0.000 claims 2
• 235000006708 antioxidants Nutrition 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 2
• 229960001160 latanoprost Drugs 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000003755 preservative agent Substances 0.000 claims 2
• 229940010747 sodium hyaluronate Drugs 0.000 claims 2
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• KZMRYBLIGYQPPP-UHFFFAOYSA-M 3-[[4-[(2-chlorophenyl)-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-n-ethylanilino]methyl]benzenesulfonate Chemical compound C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)Cl)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 KZMRYBLIGYQPPP-UHFFFAOYSA-M 0.000 claims 1
• 239000000872 buffer Substances 0.000 claims 1
• 239000006172 buffering agent Substances 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 229910017053 inorganic salt Inorganic materials 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 229930187593 rose bengal Natural products 0.000 claims 1
• AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 claims 1
• 229940081623 rose bengal Drugs 0.000 claims 1
• STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1