RU2019130955A - Глазные капли для лечения раздражения, не вызванного инфекцией - Google Patents
Глазные капли для лечения раздражения, не вызванного инфекцией Download PDFInfo
- Publication number
- RU2019130955A RU2019130955A RU2019130955A RU2019130955A RU2019130955A RU 2019130955 A RU2019130955 A RU 2019130955A RU 2019130955 A RU2019130955 A RU 2019130955A RU 2019130955 A RU2019130955 A RU 2019130955A RU 2019130955 A RU2019130955 A RU 2019130955A
- Authority
- RU
- Russia
- Prior art keywords
- aqueous solution
- instilling
- glycerol
- irritation
- damage
- Prior art date
Links
- 230000007794 irritation Effects 0.000 title claims 7
- 239000003889 eye drop Substances 0.000 title 1
- 229940012356 eye drops Drugs 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 39
- 239000007864 aqueous solution Substances 0.000 claims 16
- 235000011187 glycerol Nutrition 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- 210000002919 epithelial cell Anatomy 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- 229920002125 Sokalan® Polymers 0.000 claims 4
- 229960001631 carbomer Drugs 0.000 claims 4
- 210000000795 conjunctiva Anatomy 0.000 claims 4
- 210000004087 cornea Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- KZMRYBLIGYQPPP-UHFFFAOYSA-M 3-[[4-[(2-chlorophenyl)-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-n-ethylanilino]methyl]benzenesulfonate Chemical compound C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)Cl)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 KZMRYBLIGYQPPP-UHFFFAOYSA-M 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762467139P | 2017-03-05 | 2017-03-05 | |
| US62/467,139 | 2017-03-05 | ||
| PCT/IL2018/050184 WO2018163151A1 (en) | 2017-03-05 | 2018-02-19 | Eye drops for treatment of irritation not due to infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019130955A true RU2019130955A (ru) | 2021-04-07 |
| RU2019130955A3 RU2019130955A3 (enExample) | 2021-06-24 |
Family
ID=61656085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019130955A RU2019130955A (ru) | 2017-03-05 | 2018-02-19 | Глазные капли для лечения раздражения, не вызванного инфекцией |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11033513B2 (enExample) |
| EP (2) | EP4385565A3 (enExample) |
| JP (1) | JP7258778B2 (enExample) |
| KR (1) | KR102652879B1 (enExample) |
| CN (1) | CN110891555B (enExample) |
| AU (1) | AU2018230262B2 (enExample) |
| BR (1) | BR112019018367A2 (enExample) |
| CA (1) | CA3055523C (enExample) |
| ES (1) | ES3036888T3 (enExample) |
| IL (1) | IL269133B2 (enExample) |
| MX (1) | MX388961B (enExample) |
| PL (1) | PL3592339T3 (enExample) |
| RU (1) | RU2019130955A (enExample) |
| WO (1) | WO2018163151A1 (enExample) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| US5895645A (en) * | 1995-01-31 | 1999-04-20 | Bausch & Lomb Incorporated | Opthalmic solution for artificial tears |
| JP3093661B2 (ja) * | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
| AR004214A1 (es) * | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| IL120005A (en) * | 1997-01-14 | 2000-08-31 | Ramot University Authority Of | Pharmaceutical compositions for the treatment of the eye |
| US5800807A (en) * | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| IL168603A (en) * | 2005-05-16 | 2011-05-31 | Resdevco Res And Dev Co | Pharmaceutical or cosmetic composition for the prevention and treatment of irritation of mucous cells or skin cells |
| DE102005055275A1 (de) | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
| IL212725A (en) * | 2011-05-05 | 2016-06-30 | Resdevco Res And Dev Co | Glycerol Preparation for Non-surgical Conjunctivochalysis |
| DK2783689T3 (da) * | 2011-11-24 | 2019-12-16 | Toyo Sugar Refining Co Ltd | Keratoconjunctivitis-beskyttelsesmiddel eller keratoconjunctivitis-lidelse-hæmmende middel |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
-
2018
- 2018-02-19 EP EP24173992.9A patent/EP4385565A3/en active Pending
- 2018-02-19 CA CA3055523A patent/CA3055523C/en active Active
- 2018-02-19 WO PCT/IL2018/050184 patent/WO2018163151A1/en not_active Ceased
- 2018-02-19 IL IL269133A patent/IL269133B2/en unknown
- 2018-02-19 KR KR1020197029124A patent/KR102652879B1/ko active Active
- 2018-02-19 ES ES18711415T patent/ES3036888T3/es active Active
- 2018-02-19 RU RU2019130955A patent/RU2019130955A/ru unknown
- 2018-02-19 AU AU2018230262A patent/AU2018230262B2/en active Active
- 2018-02-19 MX MX2019010471A patent/MX388961B/es unknown
- 2018-02-19 CN CN201880029944.8A patent/CN110891555B/zh active Active
- 2018-02-19 JP JP2019568840A patent/JP7258778B2/ja active Active
- 2018-02-19 EP EP18711415.2A patent/EP3592339B1/en active Active
- 2018-02-19 PL PL18711415.2T patent/PL3592339T3/pl unknown
- 2018-02-19 BR BR112019018367A patent/BR112019018367A2/pt not_active Application Discontinuation
-
2019
- 2019-09-04 US US16/560,084 patent/US11033513B2/en active Active
-
2021
- 2021-03-03 US US17/191,191 patent/US11426361B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190129065A (ko) | 2019-11-19 |
| CA3055523C (en) | 2024-10-01 |
| RU2019130955A3 (enExample) | 2021-06-24 |
| US11033513B2 (en) | 2021-06-15 |
| US11426361B2 (en) | 2022-08-30 |
| MX2019010471A (es) | 2020-02-12 |
| IL269133B1 (en) | 2024-05-01 |
| MX388961B (es) | 2025-03-20 |
| CN110891555A (zh) | 2020-03-17 |
| PL3592339T3 (pl) | 2025-09-01 |
| KR102652879B1 (ko) | 2024-03-29 |
| EP4385565A2 (en) | 2024-06-19 |
| IL269133B2 (en) | 2024-09-01 |
| AU2018230262A1 (en) | 2019-09-26 |
| WO2018163151A1 (en) | 2018-09-13 |
| EP3592339B1 (en) | 2025-04-30 |
| US20190388361A1 (en) | 2019-12-26 |
| EP4385565A3 (en) | 2024-08-21 |
| BR112019018367A2 (pt) | 2020-04-07 |
| AU2018230262B2 (en) | 2024-01-18 |
| US20210186892A1 (en) | 2021-06-24 |
| CN110891555B (zh) | 2023-12-26 |
| EP3592339A1 (en) | 2020-01-15 |
| CA3055523A1 (en) | 2018-09-13 |
| ES3036888T3 (en) | 2025-09-25 |
| JP7258778B2 (ja) | 2023-04-17 |
| JP2020509092A (ja) | 2020-03-26 |
| EP3592339C0 (en) | 2025-04-30 |
| IL269133A (en) | 2019-11-28 |
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