JP2020505407A5 - - Google Patents
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- JP2020505407A5 JP2020505407A5 JP2019540570A JP2019540570A JP2020505407A5 JP 2020505407 A5 JP2020505407 A5 JP 2020505407A5 JP 2019540570 A JP2019540570 A JP 2019540570A JP 2019540570 A JP2019540570 A JP 2019540570A JP 2020505407 A5 JP2020505407 A5 JP 2020505407A5
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- hexahydro
- Prior art date
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- 239000000203 mixture Substances 0.000 claims description 108
- 102000009659 Vesicular Monoamine Transport Proteins Human genes 0.000 claims description 96
- 108010020033 Vesicular Monoamine Transport Proteins Proteins 0.000 claims description 96
- 239000003112 inhibitor Substances 0.000 claims description 89
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims description 57
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims description 57
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 230000004060 metabolic process Effects 0.000 claims description 26
- 208000035475 disorder Diseases 0.000 claims description 25
- 239000012458 free base Substances 0.000 claims description 21
- 206010067484 Adverse reaction Diseases 0.000 claims description 20
- 208000000269 Hyperkinesis Diseases 0.000 claims description 20
- 230000006838 adverse reaction Effects 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 208000020016 psychiatric disease Diseases 0.000 claims description 16
- -1 isoquinoline-2-yl Chemical group 0.000 claims description 14
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
- 208000019022 Mood disease Diseases 0.000 claims description 9
- 230000000926 neurological effect Effects 0.000 claims description 9
- 201000000980 schizophrenia Diseases 0.000 claims description 9
- 206010001540 Akathisia Diseases 0.000 claims description 8
- 208000023105 Huntington disease Diseases 0.000 claims description 8
- 208000001431 Psychomotor Agitation Diseases 0.000 claims description 8
- 208000011580 syndromic disease Diseases 0.000 claims description 8
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 6
- 206010022437 insomnia Diseases 0.000 claims description 6
- 208000006820 Arthralgia Diseases 0.000 claims description 5
- 206010008748 Chorea Diseases 0.000 claims description 5
- 206010019233 Headaches Diseases 0.000 claims description 5
- 206010028813 Nausea Diseases 0.000 claims description 5
- 208000032140 Sleepiness Diseases 0.000 claims description 5
- 206010041349 Somnolence Diseases 0.000 claims description 5
- 206010044565 Tremor Diseases 0.000 claims description 5
- 206010047700 Vomiting Diseases 0.000 claims description 5
- 230000001078 anti-cholinergic effect Effects 0.000 claims description 5
- 208000012601 choreatic disease Diseases 0.000 claims description 5
- 231100000869 headache Toxicity 0.000 claims description 5
- 230000008693 nausea Effects 0.000 claims description 5
- 230000008673 vomiting Effects 0.000 claims description 5
- 208000012661 Dyskinesia Diseases 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 208000020925 Bipolar disease Diseases 0.000 claims description 3
- 206010010219 Compulsions Diseases 0.000 claims description 3
- 208000027534 Emotional disease Diseases 0.000 claims description 3
- 208000027776 Extrapyramidal disease Diseases 0.000 claims description 3
- 208000001914 Fragile X syndrome Diseases 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 206010026749 Mania Diseases 0.000 claims description 3
- 102000003946 Prolactin Human genes 0.000 claims description 3
- 108010057464 Prolactin Proteins 0.000 claims description 3
- 206010039424 Salivary hypersecretion Diseases 0.000 claims description 3
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 3
- 208000016620 Tourette disease Diseases 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 208000029560 autism spectrum disease Diseases 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 230000009251 neurologic dysfunction Effects 0.000 claims description 3
- 208000015015 neurological dysfunction Diseases 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 229940097325 prolactin Drugs 0.000 claims description 3
- 230000000241 respiratory effect Effects 0.000 claims description 3
- 230000004584 weight gain Effects 0.000 claims description 3
- 235000019786 weight gain Nutrition 0.000 claims description 3
- 208000008630 Sialorrhea Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 64
- GEJDGVNQKABXKG-CFKGEZKQSA-N [(2r,3r,11br)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1h-benzo[a]quinolizin-2-yl] (2s)-2-amino-3-methylbutanoate Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](OC(=O)[C@@H](N)C(C)C)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 GEJDGVNQKABXKG-CFKGEZKQSA-N 0.000 description 28
- 229950006411 valbenazine Drugs 0.000 description 28
- 206010021034 Hypometabolism Diseases 0.000 description 21
- MLAYZCMWRNQKQX-UHFFFAOYSA-N 2-hydroxy-1h-isoquinoline Chemical compound C1=CC=C2C=CN(O)CC2=C1 MLAYZCMWRNQKQX-UHFFFAOYSA-N 0.000 description 14
- 230000036470 plasma concentration Effects 0.000 description 8
- 206010003591 Ataxia Diseases 0.000 description 2
- 208000012639 Balance disease Diseases 0.000 description 2
- 208000014094 Dystonic disease Diseases 0.000 description 2
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 description 2
- 208000016285 Movement disease Diseases 0.000 description 2
- 208000002033 Myoclonus Diseases 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000010118 dystonia Diseases 0.000 description 2
- 230000010437 erythropoiesis Effects 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 230000000155 isotopic effect Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 208000026451 salivation Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960004295 valine Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022160831A JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092152A JP2024107168A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451605P | 2017-01-27 | 2017-01-27 | |
| US62/451,605 | 2017-01-27 | ||
| PCT/US2017/055980 WO2018140096A1 (en) | 2017-01-27 | 2017-10-10 | Methods for the administration of certain vmat2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022160831A Division JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505407A JP2020505407A (ja) | 2020-02-20 |
| JP2020505407A5 true JP2020505407A5 (enExample) | 2020-11-19 |
| JP7199361B2 JP7199361B2 (ja) | 2023-01-05 |
Family
ID=62978647
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520311A Active JP7090151B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540568A Active JP7199360B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540570A Active JP7199361B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540650A Active JP7107950B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540557A Active JP7199359B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022008580A Withdrawn JP2022040408A (ja) | 2017-01-27 | 2022-01-24 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022113075A Withdrawn JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160177A Withdrawn JP2022174343A (ja) | 2017-01-27 | 2022-10-04 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160831A Withdrawn JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160833A Withdrawn JP2022174345A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2023149999A Pending JP2023161033A (ja) | 2017-01-27 | 2023-09-15 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092152A Pending JP2024107168A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092148A Pending JP2024107167A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092155A Pending JP2024107169A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024093040A Active JP7828390B2 (ja) | 2017-01-27 | 2024-06-07 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2025126262A Pending JP2025146959A (ja) | 2017-01-27 | 2025-07-29 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520311A Active JP7090151B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540568A Active JP7199360B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Family Applications After (13)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540650A Active JP7107950B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540557A Active JP7199359B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022008580A Withdrawn JP2022040408A (ja) | 2017-01-27 | 2022-01-24 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022113075A Withdrawn JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160177A Withdrawn JP2022174343A (ja) | 2017-01-27 | 2022-10-04 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160831A Withdrawn JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160833A Withdrawn JP2022174345A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2023149999A Pending JP2023161033A (ja) | 2017-01-27 | 2023-09-15 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092152A Pending JP2024107168A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092148A Pending JP2024107167A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092155A Pending JP2024107169A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024093040A Active JP7828390B2 (ja) | 2017-01-27 | 2024-06-07 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2025126262A Pending JP2025146959A (ja) | 2017-01-27 | 2025-07-29 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (10) | US20190381016A1 (enExample) |
| JP (16) | JP7090151B2 (enExample) |
| KR (14) | KR20230169457A (enExample) |
| CN (6) | CN116712434A (enExample) |
| AU (7) | AU2017395700B2 (enExample) |
| CA (5) | CA3051830A1 (enExample) |
| EA (5) | EA201991786A1 (enExample) |
| MX (6) | MX393077B (enExample) |
| MY (5) | MY191077A (enExample) |
| PH (6) | PH12022553251A1 (enExample) |
| SG (3) | SG11201906891RA (enExample) |
| WO (5) | WO2018140096A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL284874B2 (en) | 2015-10-30 | 2023-10-01 | Neurocrine Biosciences Inc | Valbenazine salts and polymorphs thereof |
| LT3394057T (lt) | 2015-12-23 | 2022-06-27 | Neurocrine Biosciences, Inc. | Sintezės būdas, skirtas pagaminti (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1-a]izochinolin-2-ilo 2-amino-3-metilbutanoato di(4-metilbenzensulfonatą) |
| KR20230169457A (ko) | 2017-01-27 | 2023-12-15 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705305D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| RS66714B1 (sr) | 2017-09-21 | 2025-05-30 | Neurocrine Biosciences Inc | Formulacija visoke doze valbenazina i sastavi, postupci i kompleti povezani sa njim |
| MX2020003421A (es) | 2017-10-10 | 2020-07-20 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores del transportador vesicular de monoamina 2 (vmat2). |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| EP3733666B1 (en) | 2017-12-26 | 2022-09-21 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of valbenazine di-p-toluenesulfonate, preparation method thereof and use thereof |
| DK3784237T3 (da) | 2018-04-25 | 2024-01-08 | Shinkei Therapeutics Inc | Indretning til transdermal levering af tetrabenazin |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| US20200345663A1 (en) * | 2018-06-10 | 2020-11-05 | Axsome Therapeutics, Inc. | Methods of modulating tetrabenazine metabolites plasma levels using bupropion |
| MA53239A (fr) * | 2018-08-15 | 2022-05-04 | Neurocrine Biosciences Inc | Procédés d'administration de certains inhibiteurs de vmat2 |
| MX2021013132A (es) * | 2019-05-09 | 2021-11-25 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores del transportador 2 vesicular de monoaminas (vmat2). |
| TW202114676A (zh) * | 2019-08-14 | 2021-04-16 | 瑞士商Ｆ 賀夫曼 賀許公司 | 治療癌症之方法 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| KR20220119065A (ko) * | 2019-12-20 | 2022-08-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 불면증 치료를 위한 렘보렉산트의 용도 |
| CA3220946A1 (en) | 2021-06-30 | 2023-01-05 | Angel S. Angelov | Valbenazine for use in the add-on treatment of schizophrenia |
| US20240342160A1 (en) | 2021-06-30 | 2024-10-17 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of dyskinesia due to cerebral palsy |
| IL310584A (en) * | 2021-08-16 | 2024-04-01 | Foresee Pharmaceuticals Co Ltd | Depot polymer formulations for sustained release administration of VMAT2 inhibitors |
| EP4387679A1 (en) | 2021-08-20 | 2024-06-26 | Neurocrine Biosciences, Inc. | Methods of screening for vmat2 inhibitors |
| WO2023039187A1 (en) * | 2021-09-10 | 2023-03-16 | ATAI Life Sciences AG | Ibogaine combination treatment |
| US20250000805A1 (en) * | 2021-10-29 | 2025-01-02 | Neurocrine Biosciences, Inc. | Valbenazine compositions |
| AU2023232134A1 (en) | 2022-03-07 | 2024-10-03 | Neurocrine Biosciences, Inc. | Valbenazine, a vmat2 inhibitor, as a free base a tosylate or ditosylate salt, for use in the treatment of chorea associated with huntington's disease |
| US20240156723A1 (en) * | 2022-11-16 | 2024-05-16 | Foresee Pharmaceuticals Co., Ltd. | Depot compositions for vesicular monoamine transporter 2 (vmat2) inhbitors |
| WO2025038938A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of huntington's chorea |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2025096823A1 (en) | 2023-11-01 | 2025-05-08 | Neurocrine Biosciences, Inc. | Improvement, maintenance or reduction of decline of motor function associated with huntington disease using valbenazine |
| WO2025188830A1 (en) | 2024-03-06 | 2025-09-12 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
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