JP2020505408A5 - - Google Patents
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- JP2020505408A5 JP2020505408A5 JP2019540650A JP2019540650A JP2020505408A5 JP 2020505408 A5 JP2020505408 A5 JP 2020505408A5 JP 2019540650 A JP2019540650 A JP 2019540650A JP 2019540650 A JP2019540650 A JP 2019540650A JP 2020505408 A5 JP2020505408 A5 JP 2020505408A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- composition according
- composition
- inhibitor
- hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 109
- 239000003112 inhibitor Substances 0.000 claims description 93
- 102000009659 Vesicular Monoamine Transport Proteins Human genes 0.000 claims description 83
- 108010020033 Vesicular Monoamine Transport Proteins Proteins 0.000 claims description 83
- 230000003389 potentiating effect Effects 0.000 claims description 35
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims description 34
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 208000035475 disorder Diseases 0.000 claims description 25
- 206010067484 Adverse reaction Diseases 0.000 claims description 20
- 208000000269 Hyperkinesis Diseases 0.000 claims description 20
- 230000006838 adverse reaction Effects 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000012458 free base Substances 0.000 claims description 19
- 208000007220 Cytochrome P-450 CYP2D6 Inhibitors Diseases 0.000 claims description 18
- 208000020016 psychiatric disease Diseases 0.000 claims description 16
- -1 isoquinoline-2-yl Chemical group 0.000 claims description 14
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 claims description 12
- 208000019022 Mood disease Diseases 0.000 claims description 9
- 230000000926 neurological effect Effects 0.000 claims description 9
- 201000000980 schizophrenia Diseases 0.000 claims description 9
- 206010001540 Akathisia Diseases 0.000 claims description 8
- 208000023105 Huntington disease Diseases 0.000 claims description 8
- 208000001431 Psychomotor Agitation Diseases 0.000 claims description 8
- 208000011580 syndromic disease Diseases 0.000 claims description 8
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 7
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 7
- 229960002296 paroxetine Drugs 0.000 claims description 7
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 6
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 6
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims description 6
- 229960002464 fluoxetine Drugs 0.000 claims description 6
- 206010022437 insomnia Diseases 0.000 claims description 6
- 229960001404 quinidine Drugs 0.000 claims description 6
- 208000006820 Arthralgia Diseases 0.000 claims description 5
- 206010008748 Chorea Diseases 0.000 claims description 5
- 206010019233 Headaches Diseases 0.000 claims description 5
- 206010028813 Nausea Diseases 0.000 claims description 5
- 208000032140 Sleepiness Diseases 0.000 claims description 5
- 206010041349 Somnolence Diseases 0.000 claims description 5
- 206010044565 Tremor Diseases 0.000 claims description 5
- 206010047700 Vomiting Diseases 0.000 claims description 5
- 230000001078 anti-cholinergic effect Effects 0.000 claims description 5
- 208000012601 choreatic disease Diseases 0.000 claims description 5
- 231100000869 headache Toxicity 0.000 claims description 5
- 230000008693 nausea Effects 0.000 claims description 5
- 230000008673 vomiting Effects 0.000 claims description 5
- 208000012661 Dyskinesia Diseases 0.000 claims description 4
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 208000020925 Bipolar disease Diseases 0.000 claims description 3
- 206010010219 Compulsions Diseases 0.000 claims description 3
- 208000027534 Emotional disease Diseases 0.000 claims description 3
- 208000027776 Extrapyramidal disease Diseases 0.000 claims description 3
- 208000001914 Fragile X syndrome Diseases 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 206010026749 Mania Diseases 0.000 claims description 3
- 102000003946 Prolactin Human genes 0.000 claims description 3
- 108010057464 Prolactin Proteins 0.000 claims description 3
- 206010039424 Salivary hypersecretion Diseases 0.000 claims description 3
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 3
- 208000016620 Tourette disease Diseases 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 208000029560 autism spectrum disease Diseases 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical group CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 3
- 229960001058 bupropion Drugs 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 238000011260 co-administration Methods 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 229960002866 duloxetine Drugs 0.000 claims description 3
- 230000010437 erythropoiesis Effects 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims description 3
- 229960004503 metoclopramide Drugs 0.000 claims description 3
- 230000009251 neurologic dysfunction Effects 0.000 claims description 3
- 208000015015 neurological dysfunction Diseases 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 229940097325 prolactin Drugs 0.000 claims description 3
- 230000000241 respiratory effect Effects 0.000 claims description 3
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 3
- 229960002073 sertraline Drugs 0.000 claims description 3
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 3
- 229960002722 terbinafine Drugs 0.000 claims description 3
- 230000004584 weight gain Effects 0.000 claims description 3
- 235000019786 weight gain Nutrition 0.000 claims description 3
- 208000026451 salivation Diseases 0.000 claims description 2
- 239000002207 metabolite Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 59
- GEJDGVNQKABXKG-CFKGEZKQSA-N [(2r,3r,11br)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1h-benzo[a]quinolizin-2-yl] (2s)-2-amino-3-methylbutanoate Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](OC(=O)[C@@H](N)C(C)C)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 GEJDGVNQKABXKG-CFKGEZKQSA-N 0.000 description 26
- 229950006411 valbenazine Drugs 0.000 description 26
- MLAYZCMWRNQKQX-UHFFFAOYSA-N 2-hydroxy-1h-isoquinoline Chemical compound C1=CC=C2C=CN(O)CC2=C1 MLAYZCMWRNQKQX-UHFFFAOYSA-N 0.000 description 14
- 230000036470 plasma concentration Effects 0.000 description 8
- 230000000155 isotopic effect Effects 0.000 description 4
- 206010003591 Ataxia Diseases 0.000 description 2
- 208000012639 Balance disease Diseases 0.000 description 2
- 208000014094 Dystonic disease Diseases 0.000 description 2
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 description 2
- 208000016285 Movement disease Diseases 0.000 description 2
- 208000002033 Myoclonus Diseases 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000010118 dystonia Diseases 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960004295 valine Drugs 0.000 description 2
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022113075A JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024093040A JP2024113134A (ja) | 2017-01-27 | 2024-06-07 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451605P | 2017-01-27 | 2017-01-27 | |
| US62/451,605 | 2017-01-27 | ||
| PCT/US2017/055965 WO2018140095A2 (en) | 2017-01-27 | 2017-10-10 | Methods for the administration of certain vmat2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113075A Division JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505408A JP2020505408A (ja) | 2020-02-20 |
| JP2020505408A5 true JP2020505408A5 (enExample) | 2020-11-19 |
| JP7107950B2 JP7107950B2 (ja) | 2022-07-27 |
Family
ID=62978647
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540557A Active JP7199359B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540570A Active JP7199361B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540568A Active JP7199360B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2020520311A Active JP7090151B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540650A Active JP7107950B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022008580A Withdrawn JP2022040408A (ja) | 2017-01-27 | 2022-01-24 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022113075A Withdrawn JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160177A Withdrawn JP2022174343A (ja) | 2017-01-27 | 2022-10-04 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160831A Withdrawn JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160833A Withdrawn JP2022174345A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2023149999A Pending JP2023161033A (ja) | 2017-01-27 | 2023-09-15 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092148A Pending JP2024107167A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092152A Pending JP2024107168A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092155A Pending JP2024107169A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024093040A Pending JP2024113134A (ja) | 2017-01-27 | 2024-06-07 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2025126262A Pending JP2025146959A (ja) | 2017-01-27 | 2025-07-29 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540557A Active JP7199359B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540570A Active JP7199361B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2019540568A Active JP7199360B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2020520311A Active JP7090151B2 (ja) | 2017-01-27 | 2017-10-10 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Family Applications After (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008580A Withdrawn JP2022040408A (ja) | 2017-01-27 | 2022-01-24 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022113075A Withdrawn JP2022137219A (ja) | 2017-01-27 | 2022-07-14 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160177A Withdrawn JP2022174343A (ja) | 2017-01-27 | 2022-10-04 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160831A Withdrawn JP2022174344A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2022160833A Withdrawn JP2022174345A (ja) | 2017-01-27 | 2022-10-05 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2023149999A Pending JP2023161033A (ja) | 2017-01-27 | 2023-09-15 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092148A Pending JP2024107167A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092152A Pending JP2024107168A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024092155A Pending JP2024107169A (ja) | 2017-01-27 | 2024-06-06 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2024093040A Pending JP2024113134A (ja) | 2017-01-27 | 2024-06-07 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| JP2025126262A Pending JP2025146959A (ja) | 2017-01-27 | 2025-07-29 | 特定のｖｍａｔ２インヒビターを投与するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US10874648B2 (enExample) |
| JP (16) | JP7199359B2 (enExample) |
| KR (14) | KR20190108147A (enExample) |
| CN (6) | CN110740732A (enExample) |
| AU (7) | AU2017395703B2 (enExample) |
| CA (5) | CA3051829A1 (enExample) |
| EA (5) | EA201991780A1 (enExample) |
| MX (6) | MX393077B (enExample) |
| MY (5) | MY202219A (enExample) |
| PH (6) | PH12022553251A1 (enExample) |
| SG (3) | SG11201906885TA (enExample) |
| WO (5) | WO2018140092A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3368534T3 (pl) | 2015-10-30 | 2021-07-12 | Neurocrine Biosciences, Inc. | Ditosylan walbenazyny i jego polimorfy |
| CN121045173A (zh) | 2015-12-23 | 2025-12-02 | 纽罗克里生物科学有限公司 | 制备3-异丁基-9,10-二甲氧基-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯的盐的方法 |
| MX393077B (es) | 2017-01-27 | 2025-03-24 | Neurocrine Biosciences Inc | Métodos para la administración de ciertos inhibidores de proteína transportadora transportador de monoamina vesicular (vmat2). |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705305D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| IL301770B2 (en) | 2017-09-21 | 2024-06-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
| SG11202003194YA (en) | 2017-10-10 | 2020-05-28 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| WO2019129100A1 (zh) | 2017-12-26 | 2019-07-04 | 苏州科睿思制药有限公司 | 一种Valbenazine二对甲苯磺酸盐的晶型及其制备方法和用途 |
| BR112020021700A2 (pt) | 2018-04-25 | 2021-01-26 | Shinkei Therapeutics Llc | dispositivo de distribuição transdérmica de tetrabenazina |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| US20200345663A1 (en) * | 2018-06-10 | 2020-11-05 | Axsome Therapeutics, Inc. | Methods of modulating tetrabenazine metabolites plasma levels using bupropion |
| CN112867491A (zh) | 2018-08-15 | 2021-05-28 | 纽罗克里生物科学有限公司 | 施用某些vmat2抑制剂的方法 |
| CA3136466A1 (en) * | 2019-05-09 | 2020-11-12 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| JP2022545387A (ja) * | 2019-08-14 | 2022-10-27 | エフ．ホフマン－ラ ロシュ アーゲー | がんの処置方法 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| US20230051268A1 (en) * | 2019-12-20 | 2023-02-16 | Eisai R&D Management Co., Ltd. | Use of lemborexant for treating insomnia |
| JP2024525424A (ja) | 2021-06-30 | 2024-07-12 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 脳性麻痺によるジスキネジアの処置における使用のためのバルベナジン |
| EP4362944A1 (en) | 2021-06-30 | 2024-05-08 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
| CA3228824A1 (en) * | 2021-08-16 | 2023-02-23 | Yuhua Li | Polymer depot compositions for sustained release delivery of vmat2 inhibitors |
| EP4387679A1 (en) | 2021-08-20 | 2024-06-26 | Neurocrine Biosciences, Inc. | Methods of screening for vmat2 inhibitors |
| EP4398893A4 (en) * | 2021-09-10 | 2025-07-16 | ATAI Life Sciences AG | IBOGAINE COMBINATION THERAPY |
| WO2023076568A1 (en) * | 2021-10-29 | 2023-05-04 | Neurocrine Biosciences, Inc. | Valbenazine compositions |
| EP4489754A1 (en) | 2022-03-07 | 2025-01-15 | Neurocrine Biosciences, Inc. | Valbenazine, a vmat2 inhibitor, as a free base a tosylate or ditosylate salt, for use in the treatment of chorea associated with huntington's disease |
| TW202430220A (zh) * | 2022-11-16 | 2024-08-01 | 逸達生物科技股份有限公司 | 用於囊泡單胺轉運蛋白2 (vmat2) 抑制劑之補給型組合物 |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2025038938A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of huntington's chorea |
| WO2025096823A1 (en) | 2023-11-01 | 2025-05-08 | Neurocrine Biosciences, Inc. | Improvement, maintenance or reduction of decline of motor function associated with huntington disease using valbenazine |
| WO2025188830A1 (en) | 2024-03-06 | 2025-09-12 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
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- 2020-12-17 US US17/125,190 patent/US20210169862A1/en not_active Abandoned
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2022
- 2022-01-24 JP JP2022008580A patent/JP2022040408A/ja not_active Withdrawn
- 2022-05-12 AU AU2022203201A patent/AU2022203201B2/en active Active
- 2022-05-17 AU AU2022203327A patent/AU2022203327A1/en not_active Abandoned
- 2022-07-14 JP JP2022113075A patent/JP2022137219A/ja not_active Withdrawn
- 2022-10-04 JP JP2022160177A patent/JP2022174343A/ja not_active Withdrawn
- 2022-10-05 JP JP2022160831A patent/JP2022174344A/ja not_active Withdrawn
- 2022-10-05 JP JP2022160833A patent/JP2022174345A/ja not_active Withdrawn
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2023
- 2023-09-15 JP JP2023149999A patent/JP2023161033A/ja active Pending
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2024
- 2024-06-06 JP JP2024092148A patent/JP2024107167A/ja active Pending
- 2024-06-06 JP JP2024092152A patent/JP2024107168A/ja active Pending
- 2024-06-06 JP JP2024092155A patent/JP2024107169A/ja active Pending
- 2024-06-07 JP JP2024093040A patent/JP2024113134A/ja active Pending
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2025
- 2025-07-29 JP JP2025126262A patent/JP2025146959A/ja active Pending
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