JP2020504082A5 - - Google Patents

Info

Publication number

JP2020504082A5

JP2020504082A5 JP2019524345A JP2019524345A JP2020504082A5 JP 2020504082 A5 JP2020504082 A5 JP 2020504082A5 JP 2019524345 A JP2019524345 A JP 2019524345A JP 2019524345 A JP2019524345 A JP 2019524345A JP 2020504082 A5 JP2020504082 A5 JP 2020504082A5

Authority

JP

Japan

Prior art keywords

fviii

administered

pharmaceutical composition

recombinant polypeptide

composition according

Prior art date

2017-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 54
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 53
• 229920001184 polypeptide Polymers 0.000 claims description 52
• 102100026735 Coagulation factor VIII Human genes 0.000 claims description 42
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 42
• 108010047303 von Willebrand Factor Proteins 0.000 claims description 17
• 102100036537 von Willebrand factor Human genes 0.000 claims description 17
• 229960001134 von willebrand factor Drugs 0.000 claims description 17
• 102000009027 Albumins Human genes 0.000 claims description 9
• 108010088751 Albumins Proteins 0.000 claims description 9
• 230000000694 effects Effects 0.000 claims description 8
• 108010054218 Factor VIII Proteins 0.000 claims 39
• 102000001690 Factor VIII Human genes 0.000 claims 39
• 239000008194 pharmaceutical composition Substances 0.000 claims 35
• 229960000301 factor viii Drugs 0.000 claims 30
• 208000015294 blood coagulation disease Diseases 0.000 claims 8
• 238000011260 co-administration Methods 0.000 claims 7
• 230000002265 prevention Effects 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 3
• 229920001612 Hydroxyethyl starch Polymers 0.000 claims 2
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 2
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 239000000539 dimer Substances 0.000 claims 2
• 229940050526 hydroxyethylstarch Drugs 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 102100036774 Afamin Human genes 0.000 claims 1
• 101710149366 Afamin Proteins 0.000 claims 1
• 101800001415 Bri23 peptide Proteins 0.000 claims 1
• 102400000107 C-terminal peptide Human genes 0.000 claims 1
• 101800000655 C-terminal peptide Proteins 0.000 claims 1
• 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 1
• 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 1
• 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
• 208000009292 Hemophilia A Diseases 0.000 claims 1
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000004357 Transferases Human genes 0.000 claims 1
• 108090000992 Transferases Proteins 0.000 claims 1
• 102000050760 Vitamin D-binding protein Human genes 0.000 claims 1
• 108700021020 Vitamin D-binding protein Proteins 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• -1 alpha- Fetproteins Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 238000010494 dissociation reaction Methods 0.000 claims 1
• 230000005593 dissociations Effects 0.000 claims 1
• 150000004665 fatty acids Chemical group 0.000 claims 1
• 229940084986 human chorionic gonadotropin Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
• 230000004962 physiological condition Effects 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 230000006798 recombination Effects 0.000 claims 1
• 238000005215 recombination Methods 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 description 22
• 241000699670 Mus sp. Species 0.000 description 20
• 238000001990 intravenous administration Methods 0.000 description 17
• 230000036470 plasma concentration Effects 0.000 description 9
• 238000000034 method Methods 0.000 description 7
• 241000282887 Suidae Species 0.000 description 4
• 238000010521 absorption reaction Methods 0.000 description 4
• 108010025139 recombinant factor VIII SQ Proteins 0.000 description 1