CN110381986B - 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 - Google Patents

用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 Download PDF

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Publication number
CN110381986B
CN110381986B CN201780069945.0A CN201780069945A CN110381986B CN 110381986 B CN110381986 B CN 110381986B CN 201780069945 A CN201780069945 A CN 201780069945A CN 110381986 B CN110381986 B CN 110381986B
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fviii
administered
recombinant polypeptide
cys
leu
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Chinese (zh)
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CN110381986A (zh
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S·佩斯特尔
E·拉凯
T·韦默
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CSL Behring Lengnau AG
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CSL Behring Recombinant Facility AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201780069945.0A 2016-11-11 2017-11-10 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 Active CN110381986B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198497 2016-11-11
EP16198497.6 2016-11-11
PCT/EP2017/078840 WO2018087271A1 (en) 2016-11-11 2017-11-10 Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder

Publications (2)

Publication Number Publication Date
CN110381986A CN110381986A (zh) 2019-10-25
CN110381986B true CN110381986B (zh) 2023-08-18

Family

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Family Applications (1)

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CN201780069945.0A Active CN110381986B (zh) 2016-11-11 2017-11-10 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽

Country Status (12)

Country Link
US (1) US11890327B2 (enExample)
EP (1) EP3538134B1 (enExample)
JP (1) JP2020504082A (enExample)
KR (1) KR20190073576A (enExample)
CN (1) CN110381986B (enExample)
AU (1) AU2017358865A1 (enExample)
CA (1) CA3043397A1 (enExample)
DK (1) DK3538134T3 (enExample)
ES (1) ES2908008T3 (enExample)
SG (2) SG11201903954WA (enExample)
TW (1) TW201828974A (enExample)
WO (1) WO2018087271A1 (enExample)

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EA201691111A1 (ru) 2014-01-10 2017-01-30 Байоджен Ма Инк. Химерные белки фактора viii и их применение
KR20190090827A (ko) 2016-12-02 2019-08-02 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
KR102914074B1 (ko) 2018-05-18 2026-01-16 바이오버라티브 테라퓨틱스 인크. A형 혈우병의 치료 방법
WO2021001522A1 (en) 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
WO2021094344A1 (en) 2019-11-11 2021-05-20 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii
KR102647642B1 (ko) * 2021-05-04 2024-03-15 (주)케어젠 혈액 응고 활성을 갖는 펩타이드와 이의 용도

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CN104411716A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的化合物
CN105163751A (zh) * 2013-04-22 2015-12-16 杰特有限公司 复合物
CN105452289A (zh) * 2013-06-12 2016-03-30 诺和诺德股份有限公司 适用于治疗血友病的化合物

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CN104411716A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的化合物
CN105163751A (zh) * 2013-04-22 2015-12-16 杰特有限公司 复合物
CN105452289A (zh) * 2013-06-12 2016-03-30 诺和诺德股份有限公司 适用于治疗血友病的化合物

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Publication number Publication date
DK3538134T3 (da) 2022-02-07
EP3538134A1 (en) 2019-09-18
ES2908008T3 (es) 2022-04-27
CN110381986A (zh) 2019-10-25
SG11201903954WA (en) 2019-05-30
JP2020504082A (ja) 2020-02-06
WO2018087271A1 (en) 2018-05-17
EP3538134B1 (en) 2021-12-29
US11890327B2 (en) 2024-02-06
AU2017358865A1 (en) 2019-05-09
TW201828974A (zh) 2018-08-16
SG10201912768YA (en) 2020-02-27
US20210268071A1 (en) 2021-09-02
CA3043397A1 (en) 2018-05-17
KR20190073576A (ko) 2019-06-26

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