JP2020504081A5 - - Google Patents

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Publication number
JP2020504081A5
JP2020504081A5 JP2019524343A JP2019524343A JP2020504081A5 JP 2020504081 A5 JP2020504081 A5 JP 2020504081A5 JP 2019524343 A JP2019524343 A JP 2019524343A JP 2019524343 A JP2019524343 A JP 2019524343A JP 2020504081 A5 JP2020504081 A5 JP 2020504081A5
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JP
Japan
Prior art keywords
fviii
polypeptide
pharmaceutical composition
composition according
endogenous
Prior art date
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JP2019524343A
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English (en)
Japanese (ja)
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JP7252890B2 (ja
JP2020504081A (ja
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Priority claimed from PCT/EP2017/078834 external-priority patent/WO2018087267A1/en
Publication of JP2020504081A publication Critical patent/JP2020504081A/ja
Publication of JP2020504081A5 publication Critical patent/JP2020504081A5/ja
Application granted granted Critical
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JP2019524343A 2016-11-11 2017-11-10 血友病を処置するための切断型フォン・ヴィルブランド因子ポリペプチド Active JP7252890B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198501 2016-11-11
EP16198501.5 2016-11-11
PCT/EP2017/078834 WO2018087267A1 (en) 2016-11-11 2017-11-10 Truncated von willebrand factor polypeptides for treating hemophilia

Publications (3)

Publication Number Publication Date
JP2020504081A JP2020504081A (ja) 2020-02-06
JP2020504081A5 true JP2020504081A5 (enExample) 2020-12-10
JP7252890B2 JP7252890B2 (ja) 2023-04-05

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ID=57288259

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019524343A Active JP7252890B2 (ja) 2016-11-11 2017-11-10 血友病を処置するための切断型フォン・ヴィルブランド因子ポリペプチド

Country Status (12)

Country Link
US (1) US11814421B2 (enExample)
EP (1) EP3538133B1 (enExample)
JP (1) JP7252890B2 (enExample)
KR (1) KR20190085021A (enExample)
CN (1) CN109922824A (enExample)
AU (1) AU2017358861B2 (enExample)
CA (1) CA3043250A1 (enExample)
DK (1) DK3538133T3 (enExample)
ES (1) ES2869339T3 (enExample)
SG (2) SG11201903950UA (enExample)
TW (1) TW201828975A (enExample)
WO (1) WO2018087267A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110950964B (zh) * 2018-09-26 2021-06-18 安源医药科技(上海)有限公司 突变型单链人凝血因子viii融合蛋白及其制备方法与用途
JP7576039B2 (ja) * 2019-03-19 2024-10-30 シーエスエル・イノベーション・プロプライエタリー・リミテッド 第ix因子バリアントおよび治療でのその使用
CN114072420B (zh) * 2019-07-04 2024-06-11 康诺贝林伦瑙有限公司 用于增加凝血因子viii的体外稳定性的截短的血管性血友病因子(vwf)
CN113862301A (zh) * 2021-08-25 2021-12-31 上海交通大学医学院附属瑞金医院 一种vwf前肽表达载体及其制备方法和应用

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US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4970300A (en) 1985-02-01 1990-11-13 New York University Modified factor VIII
AU6029594A (en) 1993-01-15 1994-08-15 Enzon, Inc. Factor viii - polymeric conjugates
JPH11501506A (ja) 1994-12-12 1999-02-09 ベス イスラエル デアコネス メディカル センター キメラ型サイトカインおよびその利用
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WO1997040145A1 (en) 1996-04-24 1997-10-30 The Regents Of The University Of Michigan Inactivation resistant factor viii
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NZ703366A (en) 2012-07-11 2018-03-23 Amunix Operating Inc Factor viii complex with xten and von willebrand factor protein, and uses thereof
ES2657291T3 (es) * 2013-04-22 2018-03-02 Csl Ltd. Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
JP2016522219A (ja) 2013-06-12 2016-07-28 ノヴォ ノルディスク アー/エス 血友病の治療に適する化合物
KR20230007555A (ko) * 2013-06-28 2023-01-12 바이오버라티브 테라퓨틱스 인크. Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
CN106659771B (zh) 2014-07-02 2021-09-24 康诺贝林伦瑙有限公司 修饰的von Willebrand因子
CN107787328B (zh) * 2015-05-22 2021-08-06 康诺贝林伦瑙有限公司 用于治疗血友病的截短的血管性血友病因子多肽
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RU2018128613A (ru) * 2016-01-07 2020-02-07 Цсл Беринг Ленгнау Аг Мутированный фактор фон виллебранда
RU2018128582A (ru) * 2016-01-07 2020-02-11 Цсл Беринг Ленгнау Аг Мутированный укороченный фактор фон виллебранда

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