JP2017518303A5 - - Google Patents
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- JP2017518303A5 JP2017518303A5 JP2016570806A JP2016570806A JP2017518303A5 JP 2017518303 A5 JP2017518303 A5 JP 2017518303A5 JP 2016570806 A JP2016570806 A JP 2016570806A JP 2016570806 A JP2016570806 A JP 2016570806A JP 2017518303 A5 JP2017518303 A5 JP 2017518303A5
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- Prior art keywords
- acid sequence
- amino acid
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- seq
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 104
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 104
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 104
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 83
- 108060003951 Immunoglobulin Proteins 0.000 claims description 15
- 102000018358 immunoglobulin Human genes 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 9
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 239000000539 dimer Substances 0.000 claims description 7
- 239000000710 homodimer Substances 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 description 42
- 102000016970 Follistatin Human genes 0.000 description 37
- 108010014612 Follistatin Proteins 0.000 description 37
- 210000003205 muscle Anatomy 0.000 description 35
- 108020001507 fusion proteins Proteins 0.000 description 11
- 102000037865 fusion proteins Human genes 0.000 description 11
- 230000004540 complement-dependent cytotoxicity Effects 0.000 description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
- 229960002897 heparin Drugs 0.000 description 6
- 229920000669 heparin Polymers 0.000 description 6
- 208000021642 Muscular disease Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 4
- 108010023082 activin A Proteins 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 201000006938 muscular dystrophy Diseases 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 2
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 description 2
- 101000931668 Homo sapiens Follistatin Proteins 0.000 description 2
- 108010056852 Myostatin Proteins 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 102000050536 human FST Human genes 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000001995 reticulocyte Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 description 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 108010023079 activin B Proteins 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 201000008319 inclusion body myositis Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007908P | 2014-06-04 | 2014-06-04 | |
| US62/007,908 | 2014-06-04 | ||
| PCT/US2015/034245 WO2015187977A1 (en) | 2014-06-04 | 2015-06-04 | Methods and compositions for treatment of disorders with follistatin polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142333A Division JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518303A JP2017518303A (ja) | 2017-07-06 |
| JP2017518303A5 true JP2017518303A5 (enExample) | 2018-02-08 |
| JP6568110B2 JP6568110B2 (ja) | 2019-08-28 |
Family
ID=54767384
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570806A Expired - Fee Related JP6568110B2 (ja) | 2014-06-04 | 2015-06-04 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2019142333A Expired - Fee Related JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2021044545A Pending JP2021095416A (ja) | 2014-06-04 | 2021-03-18 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142333A Expired - Fee Related JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2021044545A Pending JP2021095416A (ja) | 2014-06-04 | 2021-03-18 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10023621B2 (enExample) |
| EP (2) | EP3721892B1 (enExample) |
| JP (3) | JP6568110B2 (enExample) |
| KR (4) | KR102132144B1 (enExample) |
| CN (2) | CN113583104A (enExample) |
| AU (2) | AU2015269333B2 (enExample) |
| BR (1) | BR112016028520A2 (enExample) |
| CA (1) | CA2950754C (enExample) |
| EA (2) | EA202090632A1 (enExample) |
| MA (2) | MA51074A (enExample) |
| MX (2) | MX382908B (enExample) |
| WO (1) | WO2015187977A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2781222B1 (en) | 2005-11-23 | 2017-08-02 | Acceleron Pharma, Inc. | Activin-actriia antagonists in use for promoting bone growth |
| CN102131822A (zh) | 2008-06-26 | 2011-07-20 | 阿塞勒隆制药公司 | 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法 |
| EA201590719A1 (ru) | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| KR102132144B1 (ko) | 2014-06-04 | 2020-07-09 | 악셀레론 파마 인코포레이티드 | 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물 |
| MA40008A (fr) | 2014-06-13 | 2021-05-05 | Acceleron Pharma Inc | Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie |
| CN107636154A (zh) | 2015-03-26 | 2018-01-26 | 阿塞勒隆制药公司 | 促滤泡素抑制素相关的融合蛋白及其用途 |
| MA43588A (fr) * | 2016-03-04 | 2021-06-02 | Takeda Pharmaceuticals Co | Protéines de fusion follistatine-fc recombinantes et leur utilisation dans le traitement de la dystrophie musculaire de duchenne |
| US10905766B2 (en) | 2017-03-23 | 2021-02-02 | Oregon State University | Therapeutic compositions and methods for treatment of muscle wasting diseases |
| KR101822633B1 (ko) * | 2017-08-22 | 2018-01-26 | (주)진셀팜 | 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도 |
| WO2019046903A1 (en) * | 2017-09-08 | 2019-03-14 | Baker Heart and Diabetes Institute | THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT |
| CN108218985B (zh) * | 2017-12-12 | 2021-04-30 | 山西农业大学 | 一种利用特征多肽制备fst蛋白特异性抗体的方法及其应用 |
| CN111936617A (zh) * | 2018-03-16 | 2020-11-13 | 益缪索夫特公司 | 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法 |
| CN111902157B (zh) * | 2018-03-21 | 2023-08-04 | 松阳生技股份有限公司 | 促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途 |
| WO2019191204A1 (en) * | 2018-03-28 | 2019-10-03 | Acceleron Pharma Inc. | Follistatin polypeptides for the treatment of muscle contracture |
| US20210207135A1 (en) * | 2018-05-17 | 2021-07-08 | Housey Pharmaceutical Research Laboratories, L.L.C. | Inhibition of follistatin |
| US12246042B2 (en) | 2018-08-29 | 2025-03-11 | Myos Corp. | Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals |
| WO2021222875A1 (en) | 2020-04-30 | 2021-11-04 | Keros Therapeutics, Inc. | Methods of using alk2 inhibitors |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| AU2022214780A1 (en) * | 2021-01-26 | 2023-09-07 | Immunis, Inc. | Molecular superstructure and methods of use thereof |
| AU2023291634C9 (en) | 2022-06-15 | 2026-01-22 | UCB Biopharma SRL | Follistatin fusion proteins |
| KR20250036807A (ko) | 2022-06-15 | 2025-03-14 | 유씨비 바이오파마 에스알엘 | 신장 질환의 예방, 치료 또는 완화를 위한 융합 단백질 |
| JP2026500221A (ja) * | 2022-12-07 | 2026-01-06 | カミノ エーピーエス | 治療薬または診断薬の局所的ローディングのための細胞外マトリックス結合化合物 |
| TW202530250A (zh) * | 2024-01-25 | 2025-08-01 | 大陸商四川至善唯新生物科技有限公司 | 編碼卵泡抑素的核酸及其用途 |
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| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| US5182375A (en) | 1987-08-28 | 1993-01-26 | The Salk Institute For Biological Studies | DNA encoding follistatin |
| US5041538A (en) | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
| CA2080226C (en) * | 1991-02-08 | 2004-05-04 | Gary A. Beaudry | Cd4-gamma2 and cd4-igg2 chimeras |
| DE69310525T2 (de) | 1992-09-16 | 1997-10-02 | Genentech Inc | Schutz gegen leberschäden mit hgf |
| US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| AU701623B2 (en) | 1993-10-14 | 1999-02-04 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5545616A (en) | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
| GB2306481A (en) | 1995-10-21 | 1997-05-07 | Univ Manchester | Pharmaceutical comprising a stimulator of activin and/or inhibin |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
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| JP4487376B2 (ja) | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
| AUPR638101A0 (en) | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| JP4429728B2 (ja) | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| CN1993048A (zh) * | 2002-02-21 | 2007-07-04 | 惠氏公司 | 包含促滤泡素抑制素结构域的蛋白质 |
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| US20070135336A1 (en) | 2003-09-15 | 2007-06-14 | De Kretser David | Follistatin isoforms and uses thereof |
| US7355018B2 (en) * | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
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| EP3489257A1 (en) * | 2004-07-23 | 2019-05-29 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
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| NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| PL2407486T3 (pl) | 2005-08-19 | 2018-05-30 | Wyeth Llc | Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8 |
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| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| WO2008076437A2 (en) | 2006-12-18 | 2008-06-26 | Acceleron Pharma Inc. | Activin-actrii antagonists and uses for increasing red blood cell levels |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| KR20110031951A (ko) * | 2008-06-26 | 2011-03-29 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒｉｉａ의 길항물질 및 적혈구 수준을 증가시키기 위한 이들의 용도 |
| CN102131822A (zh) * | 2008-06-26 | 2011-07-20 | 阿塞勒隆制药公司 | 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法 |
| JP6211767B2 (ja) * | 2009-09-09 | 2017-10-11 | アクセルロン ファーマ， インコーポレイテッド | ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用 |
| AR082518A1 (es) * | 2010-08-25 | 2012-12-12 | Hoffmann La Roche | Anticuerpos contra il-18r1 y usos de los mismos |
| PL2635607T3 (pl) | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US10034920B2 (en) | 2012-05-17 | 2018-07-31 | Paranta Biosciences Limited | Method of treatment and agents useful for same |
| AU2013281328B2 (en) * | 2012-06-27 | 2017-11-23 | MeiraGTx Gene Regulation Limited | Combination for treating an inflammatory disorder |
| EA201590719A1 (ru) | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| WO2014187807A1 (en) | 2013-05-21 | 2014-11-27 | Arcarios B.V. | Follistatin derivatives |
| KR102132144B1 (ko) * | 2014-06-04 | 2020-07-09 | 악셀레론 파마 인코포레이티드 | 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물 |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| CN107636154A (zh) | 2015-03-26 | 2018-01-26 | 阿塞勒隆制药公司 | 促滤泡素抑制素相关的融合蛋白及其用途 |
| JP2020519291A (ja) | 2017-05-12 | 2020-07-02 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 組み換えフォリスタチン−ｆｃ融合タンパク質およびデュシェンヌ型筋ジストロフィーの治療における使用 |
-
2015
- 2015-06-04 KR KR1020207003791A patent/KR102132144B1/ko not_active Expired - Fee Related
- 2015-06-04 EA EA202090632A patent/EA202090632A1/ru unknown
- 2015-06-04 CN CN202110533308.2A patent/CN113583104A/zh active Pending
- 2015-06-04 BR BR112016028520A patent/BR112016028520A2/pt not_active Application Discontinuation
- 2015-06-04 US US14/731,009 patent/US10023621B2/en active Active
- 2015-06-04 CA CA2950754A patent/CA2950754C/en active Active
- 2015-06-04 KR KR1020177000297A patent/KR102077286B1/ko not_active Expired - Fee Related
- 2015-06-04 MX MX2016015868A patent/MX382908B/es unknown
- 2015-06-04 EP EP20160287.7A patent/EP3721892B1/en active Active
- 2015-06-04 MA MA051074A patent/MA51074A/fr unknown
- 2015-06-04 AU AU2015269333A patent/AU2015269333B2/en not_active Ceased
- 2015-06-04 WO PCT/US2015/034245 patent/WO2015187977A1/en not_active Ceased
- 2015-06-04 MA MA051075A patent/MA51075A/fr unknown
- 2015-06-04 KR KR1020207018965A patent/KR102305109B1/ko not_active Expired - Fee Related
- 2015-06-04 KR KR1020217029755A patent/KR20210119546A/ko not_active Ceased
- 2015-06-04 EA EA201692529A patent/EA035455B1/ru not_active IP Right Cessation
- 2015-06-04 EP EP15802909.0A patent/EP3152237B1/en active Active
- 2015-06-04 JP JP2016570806A patent/JP6568110B2/ja not_active Expired - Fee Related
- 2015-06-04 CN CN201580041740.2A patent/CN106795224B/zh not_active Expired - Fee Related
-
2016
- 2016-12-01 MX MX2021006017A patent/MX2021006017A/es unknown
-
2018
- 2018-06-12 US US16/006,025 patent/US10954279B2/en active Active
-
2019
- 2019-08-01 JP JP2019142333A patent/JP6856716B2/ja not_active Expired - Fee Related
-
2020
- 2020-08-03 AU AU2020210315A patent/AU2020210315A1/en not_active Abandoned
-
2021
- 2021-03-18 JP JP2021044545A patent/JP2021095416A/ja active Pending
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