JP2019532996A5 - - Google Patents
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- JP2019532996A5 JP2019532996A5 JP2019523626A JP2019523626A JP2019532996A5 JP 2019532996 A5 JP2019532996 A5 JP 2019532996A5 JP 2019523626 A JP2019523626 A JP 2019523626A JP 2019523626 A JP2019523626 A JP 2019523626A JP 2019532996 A5 JP2019532996 A5 JP 2019532996A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 63
- 238000000034 method Methods 0.000 claims description 42
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 40
- 108020001580 protein domains Proteins 0.000 claims description 27
- 150000001413 amino acids Chemical group 0.000 claims description 24
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 23
- 108020001507 fusion proteins Proteins 0.000 claims description 23
- 102000037865 fusion proteins Human genes 0.000 claims description 23
- 102000008300 Mutant Proteins Human genes 0.000 claims description 21
- 108010021466 Mutant Proteins Proteins 0.000 claims description 21
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 16
- 210000003289 regulatory T cell Anatomy 0.000 claims description 15
- 239000000090 biomarker Substances 0.000 claims description 14
- 238000006467 substitution reaction Methods 0.000 claims description 14
- 208000023275 Autoimmune disease Diseases 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 102220622777 Sphingomyelin phosphodiesterase_N88G_mutation Human genes 0.000 claims description 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 8
- 210000004899 c-terminal region Anatomy 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 102220273516 rs768267292 Human genes 0.000 claims description 8
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 6
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 6
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 6
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 4
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 claims description 4
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 claims description 4
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims description 4
- -1 ICOS Proteins 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000006052 T cell proliferation Effects 0.000 claims description 3
- 230000035755 proliferation Effects 0.000 claims description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 201000011152 Pemphigus Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 208000034189 Sclerosis Diseases 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 108700025316 aldesleukin Proteins 0.000 claims description 2
- 229960005310 aldesleukin Drugs 0.000 claims description 2
- 201000004988 autoimmune vasculitis Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 208000008795 neuromyelitis optica Diseases 0.000 claims description 2
- 201000001976 pemphigus vulgaris Diseases 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 230000003442 weekly effect Effects 0.000 claims 3
- 208000004631 alopecia areata Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010028289 Muscle atrophy Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000020763 muscle atrophy Effects 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080574A JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのｉｌ－２変異体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419118P | 2016-11-08 | 2016-11-08 | |
| US62/419,118 | 2016-11-08 | ||
| PCT/US2017/060534 WO2018089420A1 (en) | 2016-11-08 | 2017-11-08 | Il-2 variants for the treatment of autoimmune diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080574A Division JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのｉｌ－２変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532996A JP2019532996A (ja) | 2019-11-14 |
| JP2019532996A5 true JP2019532996A5 (enExample) | 2020-11-12 |
Family
ID=62065637
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523626A Pending JP2019532996A (ja) | 2016-11-08 | 2017-11-08 | 自己免疫疾患を処置するためのｉｌ−２変異体 |
| JP2022080574A Pending JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのｉｌ－２変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080574A Pending JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのｉｌ－２変異体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11077172B2 (enExample) |
| EP (1) | EP3538548A4 (enExample) |
| JP (2) | JP2019532996A (enExample) |
| KR (1) | KR20190083656A (enExample) |
| CN (1) | CN110167957A (enExample) |
| AU (1) | AU2017359172A1 (enExample) |
| CA (1) | CA3041334A1 (enExample) |
| CL (1) | CL2019001265A1 (enExample) |
| CO (1) | CO2019005922A2 (enExample) |
| EA (1) | EA201991142A1 (enExample) |
| EC (1) | ECSP19041447A (enExample) |
| IL (1) | IL266178A (enExample) |
| MX (1) | MX2019005400A (enExample) |
| SG (1) | SG11201903882VA (enExample) |
| WO (1) | WO2018089420A1 (enExample) |
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| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| MX2019013517A (es) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Inmunotolerancia dirigida. |
| WO2019104092A1 (en) | 2017-11-21 | 2019-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
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| AU2019233581B2 (en) | 2018-03-13 | 2025-08-28 | Cancer Research Technology Limited | Anti-CD25 for tumour specific cell depletion |
| US11359000B2 (en) | 2018-03-28 | 2022-06-14 | Bristol-Myers Squibb Company | Interleukin-2/Interleukin-2 receptor alpha fusion proteins and methods of use |
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| WO2020227019A1 (en) * | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| EP3972992A4 (en) | 2019-05-20 | 2023-07-19 | Pandion Operations, Inc. | MADCAM TARGETED IMMUNOTLERANCE |
| PH12022550165A1 (en) | 2019-07-26 | 2023-05-08 | Visterra Inc | Interleukin-2 agents and uses thereof |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| AU2020378282B2 (en) | 2019-11-05 | 2023-05-18 | Medikine, Inc. | Dual IL-2R and IL-7R binding compounds |
| JP7427286B2 (ja) | 2019-11-05 | 2024-02-05 | メディカイン、インコーポレイテッド | ＩＬ－２ＲβγＣ結合化合物 |
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| EP4304624A4 (en) * | 2021-03-11 | 2025-02-19 | The Methodist Hospital | METHODS AND COMPOSITIONS FOR THE TREATING OF DISEASES |
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| EP3482766B1 (en) | 2014-08-11 | 2020-05-20 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| WO2016025647A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| WO2016057651A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR20240115933A (ko) * | 2016-05-04 | 2024-07-26 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
-
2017
- 2017-11-08 CN CN201780068887.XA patent/CN110167957A/zh active Pending
- 2017-11-08 MX MX2019005400A patent/MX2019005400A/es unknown
- 2017-11-08 AU AU2017359172A patent/AU2017359172A1/en not_active Abandoned
- 2017-11-08 JP JP2019523626A patent/JP2019532996A/ja active Pending
- 2017-11-08 KR KR1020197016263A patent/KR20190083656A/ko not_active Ceased
- 2017-11-08 SG SG11201903882VA patent/SG11201903882VA/en unknown
- 2017-11-08 EP EP17869254.7A patent/EP3538548A4/en not_active Withdrawn
- 2017-11-08 EA EA201991142A patent/EA201991142A1/ru unknown
- 2017-11-08 CA CA3041334A patent/CA3041334A1/en active Pending
- 2017-11-08 WO PCT/US2017/060534 patent/WO2018089420A1/en not_active Ceased
- 2017-11-08 US US15/806,787 patent/US11077172B2/en not_active Expired - Fee Related
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2019
- 2019-04-22 IL IL266178A patent/IL266178A/en unknown
- 2019-05-08 CL CL2019001265A patent/CL2019001265A1/es unknown
- 2019-06-06 CO CONC2019/0005922A patent/CO2019005922A2/es unknown
- 2019-06-10 EC ECSENADI201941447A patent/ECSP19041447A/es unknown
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2021
- 2021-06-22 US US17/353,987 patent/US20210308222A1/en not_active Abandoned
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2022
- 2022-05-17 JP JP2022080574A patent/JP2022119829A/ja active Pending
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