EA035455B1 - Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов - Google Patents

Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов Download PDF

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Publication number
EA035455B1
EA035455B1 EA201692529A EA201692529A EA035455B1 EA 035455 B1 EA035455 B1 EA 035455B1 EA 201692529 A EA201692529 A EA 201692529A EA 201692529 A EA201692529 A EA 201692529A EA 035455 B1 EA035455 B1 EA 035455B1
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EA201692529A
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EA201692529A1 (ru
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Равиндра КУМАР
Ася ГРИНБЕРГ
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Акселерон Фарма, Инк.
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Publication of EA201692529A1 publication Critical patent/EA201692529A1/ru
Publication of EA035455B1 publication Critical patent/EA035455B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4707Muscular dystrophy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201692529A 2014-06-04 2015-06-04 Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов EA035455B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462007908P 2014-06-04 2014-06-04
PCT/US2015/034245 WO2015187977A1 (en) 2014-06-04 2015-06-04 Methods and compositions for treatment of disorders with follistatin polypeptides

Publications (2)

Publication Number Publication Date
EA201692529A1 EA201692529A1 (ru) 2017-05-31
EA035455B1 true EA035455B1 (ru) 2020-06-18

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EA201692529A EA035455B1 (ru) 2014-06-04 2015-06-04 Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов
EA202090632A EA202090632A1 (ru) 2014-06-04 2015-06-04 Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов

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EA202090632A EA202090632A1 (ru) 2014-06-04 2015-06-04 Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов

Country Status (12)

Country Link
US (2) US10023621B2 (enExample)
EP (2) EP3152237B1 (enExample)
JP (3) JP6568110B2 (enExample)
KR (4) KR102077286B1 (enExample)
CN (2) CN113583104A (enExample)
AU (2) AU2015269333B2 (enExample)
BR (1) BR112016028520A2 (enExample)
CA (1) CA2950754C (enExample)
EA (2) EA035455B1 (enExample)
MA (2) MA51074A (enExample)
MX (2) MX382908B (enExample)
WO (1) WO2015187977A1 (enExample)

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US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
EP3152237B1 (en) 2014-06-04 2020-04-01 Acceleron Pharma Inc. Methods and compositions for treatment of disorders with follistatin polypeptides
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BR112018067747A2 (pt) * 2016-03-04 2019-01-08 Shire Human Genetic Therapies proteínas de fusão recombinantes de folistatina-fc e uso no tratamento da distrofia muscular de duchenne
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WO2019046903A1 (en) * 2017-09-08 2019-03-14 Baker Heart and Diabetes Institute THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT
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Also Published As

Publication number Publication date
US20160185836A1 (en) 2016-06-30
CN106795224B (zh) 2021-05-18
US10954279B2 (en) 2021-03-23
KR20200084064A (ko) 2020-07-09
EA201692529A1 (ru) 2017-05-31
KR102305109B1 (ko) 2021-09-27
CA2950754A1 (en) 2015-12-10
JP6856716B2 (ja) 2021-04-07
AU2015269333B2 (en) 2020-05-07
CN106795224A (zh) 2017-05-31
BR112016028520A2 (pt) 2017-10-24
JP2019203017A (ja) 2019-11-28
AU2015269333A1 (en) 2016-12-15
JP2017518303A (ja) 2017-07-06
EP3721892B1 (en) 2024-05-22
JP6568110B2 (ja) 2019-08-28
KR20210119546A (ko) 2021-10-05
KR102077286B1 (ko) 2020-02-13
MA51075A (fr) 2020-10-14
CA2950754C (en) 2021-10-26
EP3721892A1 (en) 2020-10-14
WO2015187977A1 (en) 2015-12-10
MX2021006017A (es) 2021-07-06
JP2021095416A (ja) 2021-06-24
EA202090632A1 (ru) 2020-07-31
CN113583104A (zh) 2021-11-02
KR20200017548A (ko) 2020-02-18
US20180340013A1 (en) 2018-11-29
KR20170005891A (ko) 2017-01-16
MX382908B (es) 2025-03-13
MA51074A (fr) 2020-10-14
EP3152237A4 (en) 2017-11-01
AU2020210315A1 (en) 2020-08-27
EP3152237B1 (en) 2020-04-01
MX2016015868A (es) 2017-04-05
US10023621B2 (en) 2018-07-17
EP3152237A1 (en) 2017-04-12
KR102132144B1 (ko) 2020-07-09

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