MX2016015868A - Metodos y composiciones para el tratamiento de trastornos con polipeptidos de folistatina. - Google Patents

Metodos y composiciones para el tratamiento de trastornos con polipeptidos de folistatina.

Info

Publication number
MX2016015868A
MX2016015868A MX2016015868A MX2016015868A MX2016015868A MX 2016015868 A MX2016015868 A MX 2016015868A MX 2016015868 A MX2016015868 A MX 2016015868A MX 2016015868 A MX2016015868 A MX 2016015868A MX 2016015868 A MX2016015868 A MX 2016015868A
Authority
MX
Mexico
Prior art keywords
follistatin
disorders
compositions
treatment
methods
Prior art date
Application number
MX2016015868A
Other languages
English (en)
Inventor
Kumar Ravindra
Grinberg Asya
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of MX2016015868A publication Critical patent/MX2016015868A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4707—Muscular dystrophy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a proteínas de fusión folistatina-Fc que tienen efectos en el tejido donde se administra (tal como un músculo en el que se inyecta) más que efectos sistémicos. El dominio Fc produce la dimerización de la proteína de fusión folistatina-Fc y provee retención mejorada en el tejido. La descripción incluye proteínas de fusión que comprenden un polipéptido de folistatina humana que consiste en FST288, FST291 (una folistatina truncada no natural) o FST315; y un dominio Fc de lgG1 o lgG2 humana.
MX2016015868A 2014-06-04 2015-06-04 Metodos y composiciones para el tratamiento de trastornos con polipeptidos de folistatina. MX2016015868A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462007908P 2014-06-04 2014-06-04
PCT/US2015/034245 WO2015187977A1 (en) 2014-06-04 2015-06-04 Methods and compositions for treatment of disorders with follistatin polypeptides

Publications (1)

Publication Number Publication Date
MX2016015868A true MX2016015868A (es) 2017-04-05

Family

ID=54767384

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016015868A MX2016015868A (es) 2014-06-04 2015-06-04 Metodos y composiciones para el tratamiento de trastornos con polipeptidos de folistatina.
MX2021006017A MX2021006017A (es) 2014-06-04 2016-12-01 Polipeptidos de folistatina y sus usos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021006017A MX2021006017A (es) 2014-06-04 2016-12-01 Polipeptidos de folistatina y sus usos.

Country Status (12)

Country Link
US (2) US10023621B2 (es)
EP (2) EP3152237B1 (es)
JP (3) JP6568110B2 (es)
KR (4) KR102305109B1 (es)
CN (2) CN106795224B (es)
AU (2) AU2015269333B2 (es)
BR (1) BR112016028520A2 (es)
CA (1) CA2950754C (es)
EA (2) EA035455B1 (es)
MA (2) MA51075A (es)
MX (2) MX2016015868A (es)
WO (1) WO2015187977A1 (es)

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Also Published As

Publication number Publication date
US10023621B2 (en) 2018-07-17
JP2019203017A (ja) 2019-11-28
AU2015269333B2 (en) 2020-05-07
EA202090632A1 (ru) 2020-07-31
CN106795224A (zh) 2017-05-31
MA51074A (fr) 2020-10-14
EP3152237A4 (en) 2017-11-01
AU2015269333A1 (en) 2016-12-15
CN106795224B (zh) 2021-05-18
US10954279B2 (en) 2021-03-23
KR102077286B1 (ko) 2020-02-13
KR20200017548A (ko) 2020-02-18
CA2950754C (en) 2021-10-26
CN113583104A (zh) 2021-11-02
EP3152237A1 (en) 2017-04-12
EP3721892A1 (en) 2020-10-14
EP3721892B1 (en) 2024-05-22
BR112016028520A2 (pt) 2017-10-24
MA51075A (fr) 2020-10-14
KR20210119546A (ko) 2021-10-05
CA2950754A1 (en) 2015-12-10
JP6856716B2 (ja) 2021-04-07
KR102305109B1 (ko) 2021-09-27
US20160185836A1 (en) 2016-06-30
JP2017518303A (ja) 2017-07-06
AU2020210315A1 (en) 2020-08-27
JP2021095416A (ja) 2021-06-24
KR20170005891A (ko) 2017-01-16
JP6568110B2 (ja) 2019-08-28
EP3152237B1 (en) 2020-04-01
US20180340013A1 (en) 2018-11-29
WO2015187977A1 (en) 2015-12-10
EA035455B1 (ru) 2020-06-18
MX2021006017A (es) 2021-07-06
KR20200084064A (ko) 2020-07-09
EA201692529A1 (ru) 2017-05-31
KR102132144B1 (ko) 2020-07-09

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