JP6568110B2 - フォリスタチンポリペプチドによる障害の処置のための方法および組成物 - Google Patents

フォリスタチンポリペプチドによる障害の処置のための方法および組成物 Download PDF

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JP6568110B2
JP6568110B2 JP2016570806A JP2016570806A JP6568110B2 JP 6568110 B2 JP6568110 B2 JP 6568110B2 JP 2016570806 A JP2016570806 A JP 2016570806A JP 2016570806 A JP2016570806 A JP 2016570806A JP 6568110 B2 JP6568110 B2 JP 6568110B2
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amino acid
polypeptide
acid sequence
follistatin
seq
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JP2017518303A5 (enExample
JP2017518303A (ja
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ラビンドラ クマール,
ラビンドラ クマール,
アシャ グリンバーグ,
アシャ グリンバーグ,
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アクセルロン ファーマ, インコーポレイテッド
アクセルロン ファーマ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4707Muscular dystrophy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016570806A 2014-06-04 2015-06-04 フォリスタチンポリペプチドによる障害の処置のための方法および組成物 Expired - Fee Related JP6568110B2 (ja)

Applications Claiming Priority (3)

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US201462007908P 2014-06-04 2014-06-04
US62/007,908 2014-06-04
PCT/US2015/034245 WO2015187977A1 (en) 2014-06-04 2015-06-04 Methods and compositions for treatment of disorders with follistatin polypeptides

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JP2019142333A Division JP6856716B2 (ja) 2014-06-04 2019-08-01 フォリスタチンポリペプチドによる障害の処置のための方法および組成物

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JP2017518303A JP2017518303A (ja) 2017-07-06
JP2017518303A5 JP2017518303A5 (enExample) 2018-02-08
JP6568110B2 true JP6568110B2 (ja) 2019-08-28

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JP2019142333A Expired - Fee Related JP6856716B2 (ja) 2014-06-04 2019-08-01 フォリスタチンポリペプチドによる障害の処置のための方法および組成物
JP2021044545A Pending JP2021095416A (ja) 2014-06-04 2021-03-18 フォリスタチンポリペプチドによる障害の処置のための方法および組成物

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JP2021044545A Pending JP2021095416A (ja) 2014-06-04 2021-03-18 フォリスタチンポリペプチドによる障害の処置のための方法および組成物

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US (2) US10023621B2 (enExample)
EP (2) EP3721892B1 (enExample)
JP (3) JP6568110B2 (enExample)
KR (4) KR102132144B1 (enExample)
CN (2) CN113583104A (enExample)
AU (2) AU2015269333B2 (enExample)
BR (1) BR112016028520A2 (enExample)
CA (1) CA2950754C (enExample)
EA (2) EA202090632A1 (enExample)
MA (2) MA51074A (enExample)
MX (2) MX382908B (enExample)
WO (1) WO2015187977A1 (enExample)

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MX382908B (es) 2025-03-13
KR102132144B1 (ko) 2020-07-09
KR20210119546A (ko) 2021-10-05
CN113583104A (zh) 2021-11-02
MX2021006017A (es) 2021-07-06
AU2015269333A1 (en) 2016-12-15
BR112016028520A2 (pt) 2017-10-24
JP2019203017A (ja) 2019-11-28
US10023621B2 (en) 2018-07-17
EP3152237B1 (en) 2020-04-01
KR102077286B1 (ko) 2020-02-13
JP2021095416A (ja) 2021-06-24
EP3721892B1 (en) 2024-05-22
EA202090632A1 (ru) 2020-07-31
CN106795224A (zh) 2017-05-31
MX2016015868A (es) 2017-04-05
AU2015269333B2 (en) 2020-05-07
US10954279B2 (en) 2021-03-23
KR20200017548A (ko) 2020-02-18
US20180340013A1 (en) 2018-11-29
CA2950754A1 (en) 2015-12-10
MA51074A (fr) 2020-10-14
EP3152237A4 (en) 2017-11-01
EA201692529A1 (ru) 2017-05-31
WO2015187977A1 (en) 2015-12-10
CA2950754C (en) 2021-10-26
KR102305109B1 (ko) 2021-09-27
EP3721892A1 (en) 2020-10-14
AU2020210315A1 (en) 2020-08-27
KR20170005891A (ko) 2017-01-16
JP6856716B2 (ja) 2021-04-07
JP2017518303A (ja) 2017-07-06
MA51075A (fr) 2020-10-14
US20160185836A1 (en) 2016-06-30
CN106795224B (zh) 2021-05-18
KR20200084064A (ko) 2020-07-09
EA035455B1 (ru) 2020-06-18
EP3152237A1 (en) 2017-04-12

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