JP2020169191A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020169191A5 JP2020169191A5 JP2020106978A JP2020106978A JP2020169191A5 JP 2020169191 A5 JP2020169191 A5 JP 2020169191A5 JP 2020106978 A JP2020106978 A JP 2020106978A JP 2020106978 A JP2020106978 A JP 2020106978A JP 2020169191 A5 JP2020169191 A5 JP 2020169191A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- pharmaceutical composition
- additional
- interval
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 102000023732 binding proteins Human genes 0.000 claims 5
- 108091008324 binding proteins Proteins 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 102000008102 Ankyrins Human genes 0.000 claims 3
- 108010049777 Ankyrins Proteins 0.000 claims 3
- 125000003827 glycol group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims 1
- -1 Cys thiol Chemical group 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022076645A JP2022107628A (ja) | 2013-11-05 | 2022-05-06 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900246P | 2013-11-05 | 2013-11-05 | |
| US61/900,246 | 2013-11-05 | ||
| US201462016620P | 2014-06-24 | 2014-06-24 | |
| US62/016,620 | 2014-06-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552455A Division JP2016536369A (ja) | 2013-11-05 | 2014-11-04 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076645A Division JP2022107628A (ja) | 2013-11-05 | 2022-05-06 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020169191A JP2020169191A (ja) | 2020-10-15 |
| JP2020169191A5 true JP2020169191A5 (enExample) | 2021-02-25 |
Family
ID=51947485
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552455A Pending JP2016536369A (ja) | 2013-11-05 | 2014-11-04 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
| JP2020106978A Pending JP2020169191A (ja) | 2013-11-05 | 2020-06-22 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
| JP2022076645A Pending JP2022107628A (ja) | 2013-11-05 | 2022-05-06 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552455A Pending JP2016536369A (ja) | 2013-11-05 | 2014-11-04 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076645A Pending JP2022107628A (ja) | 2013-11-05 | 2022-05-06 | 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20150126458A1 (enExample) |
| EP (2) | EP3628324A1 (enExample) |
| JP (3) | JP2016536369A (enExample) |
| KR (1) | KR20160070164A (enExample) |
| CN (1) | CN105960247A (enExample) |
| AU (2) | AU2014346921A1 (enExample) |
| CA (1) | CA2927012A1 (enExample) |
| DK (1) | DK3065761T3 (enExample) |
| ES (1) | ES2773317T3 (enExample) |
| HU (1) | HUE047910T2 (enExample) |
| PL (1) | PL3065761T3 (enExample) |
| PT (1) | PT3065761T (enExample) |
| TW (1) | TWI729970B (enExample) |
| WO (1) | WO2015069668A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252079B8 (en) | 2006-04-07 | 2020-09-09 | Aerpio Therapeutics LLC | Antibodies that bind human protein tyrosine phosphatase beta (hptp-beta) and uses thereof |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint Pharmaceuticals, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| US10568934B2 (en) | 2012-05-07 | 2020-02-25 | Allergan, Inc. | Method of treating AMD in patients refractory to anti-VEGF therapy |
| NZ770284A (en) | 2018-05-10 | 2025-11-28 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| US10894824B2 (en) | 2018-09-24 | 2021-01-19 | Aerpio Pharmaceuticals, Inc. | Multispecific antibodies that target HPTP-β (VE-PTP) and VEGF |
| EP3980045A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant fap binding proteins and their use |
| IL301762A (en) * | 2020-10-07 | 2023-05-01 | Line 6 Biotechnology Inc | Methods and materials for the treatment of eye diseases |
| WO2022074623A1 (en) | 2020-10-08 | 2022-04-14 | Notal Vision Ltd. | Oct guided therapy |
| CN114075290B (zh) * | 2022-01-20 | 2022-04-19 | 南京鼓楼医院 | Cd40靶向结合蛋白、其编码核酸以及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4723140B2 (ja) | 1999-06-08 | 2011-07-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 改善された薬物動態特性を有する改変キメラポリペプチド |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| EP1996937A4 (en) | 2006-03-06 | 2009-04-08 | Amunix Inc | GENETIC PACKS AND USES THEREOF |
| WO2008097497A2 (en) | 2007-02-02 | 2008-08-14 | Adnexus, A Bristol-Myers Squibb R & D Company | Vegf pathway blockade |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| RU2550258C2 (ru) | 2008-11-03 | 2015-05-10 | Молекьюлар Партнерс Аг | Связывающие белки, ингибирующие взаимодействия vegf-a рецептора |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| US10568934B2 (en) * | 2012-05-07 | 2020-02-25 | Allergan, Inc. | Method of treating AMD in patients refractory to anti-VEGF therapy |
-
2014
- 2014-11-04 CA CA2927012A patent/CA2927012A1/en not_active Abandoned
- 2014-11-04 KR KR1020167014741A patent/KR20160070164A/ko not_active Ceased
- 2014-11-04 US US14/532,397 patent/US20150126458A1/en not_active Abandoned
- 2014-11-04 WO PCT/US2014/063951 patent/WO2015069668A1/en not_active Ceased
- 2014-11-04 ES ES14802544T patent/ES2773317T3/es active Active
- 2014-11-04 PT PT148025448T patent/PT3065761T/pt unknown
- 2014-11-04 PL PL14802544T patent/PL3065761T3/pl unknown
- 2014-11-04 CN CN201480060463.5A patent/CN105960247A/zh active Pending
- 2014-11-04 HU HUE14802544A patent/HUE047910T2/hu unknown
- 2014-11-04 JP JP2016552455A patent/JP2016536369A/ja active Pending
- 2014-11-04 AU AU2014346921A patent/AU2014346921A1/en not_active Abandoned
- 2014-11-04 DK DK14802544.8T patent/DK3065761T3/da active
- 2014-11-04 EP EP19192065.1A patent/EP3628324A1/en not_active Withdrawn
- 2014-11-04 EP EP14802544.8A patent/EP3065761B1/en active Active
- 2014-11-05 TW TW103138456A patent/TWI729970B/zh not_active IP Right Cessation
-
2016
- 2016-08-05 US US15/230,244 patent/US20170157207A1/en not_active Abandoned
-
2020
- 2020-01-31 US US16/778,290 patent/US20210008158A1/en not_active Abandoned
- 2020-05-05 AU AU2020202968A patent/AU2020202968A1/en not_active Abandoned
- 2020-06-22 JP JP2020106978A patent/JP2020169191A/ja active Pending
-
2021
- 2021-10-13 US US17/500,315 patent/US20220175881A1/en not_active Abandoned
-
2022
- 2022-05-06 JP JP2022076645A patent/JP2022107628A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020169191A5 (enExample) | ||
| TWI816739B (zh) | 包含調酸素及免疫球蛋白片段之蛋白質接合物的液態製劑 | |
| JP2016511752A5 (enExample) | ||
| CN104507492B (zh) | 治疗高脂血症的包含泌酸调节肽衍生物的组合物 | |
| US10799565B2 (en) | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo | |
| Bansal et al. | Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo | |
| JP2010500399A5 (enExample) | ||
| JP2016536369A5 (enExample) | ||
| JP2017538395A5 (enExample) | ||
| MX2014012625A (es) | Variantes de oxintomodulina de accion prolongada y metodos para su produccion. | |
| JP2016512213A5 (enExample) | ||
| JP2016514132A5 (enExample) | ||
| CN104781276A (zh) | 肽-树枝状聚合物结合物及其用途 | |
| RU2012151205A (ru) | Модифицированные связывающие белки, ингибирующие взаимодействие vegf-a рецептора | |
| TW201408337A (zh) | 長效胰促泌素肽接合物之液體製劑 | |
| JP2014502252A5 (enExample) | ||
| CN102917726A (zh) | 干扰素类似物 | |
| CA2752608A1 (en) | Cytotoxic conjugates having neuropeptide y receptor binding compound | |
| US10815286B2 (en) | Fusion protein for treating intestinal diseases | |
| JP2009520758A5 (enExample) | ||
| JP2020527556A5 (enExample) | ||
| CA3193288A1 (en) | Immunogenic coronavirus fusion proteins and related methods | |
| JP2004533250A5 (enExample) | ||
| US20190358313A1 (en) | New flavivirus vaccine | |
| JP2020504081A5 (enExample) |