JP2020502544A5 - - Google Patents
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- Publication number
- JP2020502544A5 JP2020502544A5 JP2019553158A JP2019553158A JP2020502544A5 JP 2020502544 A5 JP2020502544 A5 JP 2020502544A5 JP 2019553158 A JP2019553158 A JP 2019553158A JP 2019553158 A JP2019553158 A JP 2019553158A JP 2020502544 A5 JP2020502544 A5 JP 2020502544A5
- Authority
- JP
- Japan
- Prior art keywords
- analytes
- tryptophan
- phenylacetylglutamine
- creatinine
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 12
- 150000002500 ions Chemical class 0.000 claims 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 6
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims 6
- PEDXUVCGOLSNLQ-WUJLRWPWSA-N N-acetyl-L-threonine Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(C)=O PEDXUVCGOLSNLQ-WUJLRWPWSA-N 0.000 claims 6
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 6
- 229940109239 creatinine Drugs 0.000 claims 6
- 229960004799 tryptophan Drugs 0.000 claims 6
- 229930185560 Pseudouridine Natural products 0.000 claims 5
- PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 claims 5
- WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 claims 5
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims 5
- 102100028630 Cytoskeleton-associated protein 2 Human genes 0.000 claims 4
- 101000766848 Homo sapiens Cytoskeleton-associated protein 2 Proteins 0.000 claims 4
- WOERBKLLTSWFBY-UHFFFAOYSA-M dihydrogen phosphate;tetramethylazanium Chemical compound C[N+](C)(C)C.OP(O)([O-])=O WOERBKLLTSWFBY-UHFFFAOYSA-M 0.000 claims 4
- -1 C-glycosyltryptophan Chemical compound 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 claims 2
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 claims 2
- KTHDTJVBEPMMGL-VKHMYHEASA-N N-acetyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(C)=O KTHDTJVBEPMMGL-VKHMYHEASA-N 0.000 claims 2
- JJIHLJJYMXLCOY-BYPYZUCNSA-N N-acetyl-L-serine Chemical compound CC(=O)N[C@@H](CO)C(O)=O JJIHLJJYMXLCOY-BYPYZUCNSA-N 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 claims 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 2
- 229960000367 inositol Drugs 0.000 claims 2
- YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 2
- JDHILDINMRGULE-FYFSCIFKSA-N (2S)-2-amino-3-[3-(trideuteriomethyl)imidazol-4-yl]propanoic acid Chemical compound C(N1C=NC=C1C[C@H](N)C(=O)O)([2H])([2H])[2H] JDHILDINMRGULE-FYFSCIFKSA-N 0.000 claims 1
- QJYMWMDDBANNAM-QXYVSOOMSA-N (2S)-2-deuterio-2-(dideuterioamino)-3-hydroxy-4-oxopentanoic acid Chemical compound C(C)(=O)C([C@](N([2H])[2H])(C(=O)O)[2H])O QJYMWMDDBANNAM-QXYVSOOMSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-HLTLGYGQSA-N (2s)-2-amino-3-(2,4,5,6,7-pentadeuterio-1h-indol-3-yl)propanoic acid Chemical compound [2H]C1=C([2H])C([2H])=C2C(C[C@H](N)C(O)=O)=C([2H])NC2=C1[2H] QIVBCDIJIAJPQS-HLTLGYGQSA-N 0.000 claims 1
- JFLIEFSWGNOPJJ-CJMNRESHSA-N (2s)-5-amino-5-oxo-2-[[2-(2,3,4,5,6-pentadeuteriophenyl)acetyl]amino]pentanoic acid Chemical compound [2H]C1=C([2H])C([2H])=C(CC(=O)N[C@@H](CCC(N)=O)C(O)=O)C([2H])=C1[2H] JFLIEFSWGNOPJJ-CJMNRESHSA-N 0.000 claims 1
- CDAISMWEOUEBRE-MZWXYZOWSA-N 1,2,3,4,5,6-hexadeuteriocyclohexane-1,2,3,4,5,6-hexol Chemical compound [2H]C1(O)C([2H])(O)C([2H])(O)C([2H])(O)C([2H])(O)C1([2H])O CDAISMWEOUEBRE-MZWXYZOWSA-N 0.000 claims 1
- CPXSBHKDEPPWIX-RAYCSJGISA-N 2'-alpha-mannosyl-L-tryptophan Chemical compound N1C2=CC=CC=C2C(C[C@H](N)C(O)=O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O CPXSBHKDEPPWIX-RAYCSJGISA-N 0.000 claims 1
- DDRJAANPRJIHGJ-FIBGUPNXSA-N 2-Amino-3-(trideuteriomethyl)-4H-imidazol-5-one Chemical compound [2H]C([2H])([2H])N1CC(=O)N=C1N DDRJAANPRJIHGJ-FIBGUPNXSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-OUBTZVSYSA-N Urea-13C Chemical compound N[13C](N)=O XSQUKJJJFZCRTK-OUBTZVSYSA-N 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- IDUWTCGPAPTSFB-UHFFFAOYSA-N hexyl hydrogen sulfate Chemical compound CCCCCCOS(O)(=O)=O IDUWTCGPAPTSFB-UHFFFAOYSA-N 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 1
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435967P | 2016-12-19 | 2016-12-19 | |
| US62/435,967 | 2016-12-19 | ||
| US201762526043P | 2017-06-28 | 2017-06-28 | |
| US62/526,043 | 2017-06-28 | ||
| US201762558014P | 2017-09-13 | 2017-09-13 | |
| US62/558,014 | 2017-09-13 | ||
| PCT/US2017/066364 WO2018118630A1 (en) | 2016-12-19 | 2017-12-14 | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502544A JP2020502544A (ja) | 2020-01-23 |
| JP2020502544A5 true JP2020502544A5 (https=) | 2021-01-21 |
| JP7393206B2 JP7393206B2 (ja) | 2023-12-06 |
Family
ID=62627087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553158A Active JP7393206B2 (ja) | 2016-12-19 | 2017-12-14 | 腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11619636B2 (https=) |
| EP (1) | EP3555615B9 (https=) |
| JP (1) | JP7393206B2 (https=) |
| CN (1) | CN110088615B (https=) |
| AU (1) | AU2017382744B2 (https=) |
| CA (1) | CA3045022C (https=) |
| ES (1) | ES3004083T3 (https=) |
| WO (1) | WO2018118630A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3004083T3 (en) | 2016-12-19 | 2025-03-11 | Metabolon Inc | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
| AU2019338183A1 (en) * | 2018-09-11 | 2021-03-11 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of microbiota-related metabolites |
| WO2020217333A1 (ja) * | 2019-04-24 | 2020-10-29 | 株式会社島津製作所 | イメージング質量分析装置 |
| JP2022534369A (ja) * | 2019-05-31 | 2022-07-29 | メタボロン，インコーポレイテッド | 代謝物を検出するための質量分析アッセイ法 |
| CN112946150B (zh) * | 2019-11-26 | 2024-06-18 | 深圳华大临床检验中心 | 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒 |
| CN111007173A (zh) * | 2019-12-20 | 2020-04-14 | 辉源生物科技（上海）有限公司 | 吲哚胺2，3-二氧化酶抑制剂的筛选方法 |
| CN114026427B (zh) * | 2020-05-19 | 2023-11-17 | 深圳市中医院 | 诊断肾病的标志物以及诊断方法 |
| JP2023527152A (ja) * | 2020-05-19 | 2023-06-27 | サノフイ | 乾燥血液サンプルを用いた薬物レベルの検証のための方法 |
| CN114518413B (zh) * | 2020-11-18 | 2024-12-31 | 江苏天士力帝益药业有限公司 | 一种卡托普利原料药中脯氨酸的含量测定方法 |
| CN114216984B (zh) * | 2021-12-16 | 2023-10-13 | 川北医学院附属医院 | 一种骨质疏松症负离子诊断标志物及其检测方法 |
| CN114414700A (zh) * | 2022-01-27 | 2022-04-29 | 重庆迪纳利医药科技有限责任公司 | 一种同时测定生物样品中多种内源性糖醇含量的方法和系统 |
| WO2025244008A1 (ja) * | 2024-05-23 | 2025-11-27 | 株式会社島津製作所 | 測定方法、プログラム、および高速液体クロマトグラフタンデム質量分析装置 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2248147A1 (en) | 2008-01-31 | 2010-11-10 | DH Technologies Development Pte. Ltd. | High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer |
| JP5624709B2 (ja) * | 2008-03-13 | 2014-11-12 | 大日本住友製薬株式会社 | 内因性代謝物の分析方法 |
| JP5197846B2 (ja) * | 2009-04-30 | 2013-05-15 | 紀陽 田仲 | 腎疾患重篤度を判定する方法又は装置若しくはその作動方法 |
| EP3270407B1 (en) * | 2010-12-28 | 2021-07-07 | Quest Diagnostics Investments LLC | Quantitation of insulin by mass spectrometry |
| CA2853202A1 (en) | 2011-12-09 | 2013-06-13 | Metabolon, Inc. | Biomarkers for kidney cancer and methods using the same |
| CN102680599A (zh) * | 2012-05-11 | 2012-09-19 | 上海特敏生物医药科技有限公司 | 尿肌氨酸及肌酐测定试剂盒 |
| WO2014120449A1 (en) * | 2013-01-31 | 2014-08-07 | Metabolon, Inc. | Biomarkers related to insulin resistance progression and methods using the same |
| CA3184836A1 (en) * | 2013-05-14 | 2014-11-20 | Metabolon, Inc. | Biomarkers related to kidney function and methods using the same |
| WO2014197754A1 (en) * | 2013-06-07 | 2014-12-11 | Pierce Biotechnology, Inc. | Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards |
| EP3028049B1 (en) * | 2013-07-31 | 2019-03-20 | Pharnext | Diagnostic tools for alzheimer's disease |
| US20170276669A1 (en) * | 2014-08-15 | 2017-09-28 | The Johns Hopkins University | Precise estimation of glomerular filtration rate from multiple biomarkers |
| CN105738626B (zh) | 2014-12-12 | 2017-07-14 | 中国科学院大连化学物理研究所 | 一种新的血清代谢物的组合及其作为肝癌诊断标志物的用途 |
| US20160282371A1 (en) * | 2015-03-28 | 2016-09-29 | Quantalytical Labs Inc. | Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits |
| JP2018515796A (ja) * | 2015-05-27 | 2018-06-14 | クエスト ダイアグノスティックス インヴェストメンツ エルエルシー | マイクロサンプリングデバイスにより抽出された被分析物の質量分析による定量のための方法 |
| CN104897821A (zh) * | 2015-06-03 | 2015-09-09 | 福建中烟工业有限责任公司 | 提取样品中肌醇的方法、试剂盒及其用途 |
| ES3004083T3 (en) | 2016-12-19 | 2025-03-11 | Metabolon Inc | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
-
2017
- 2017-12-14 ES ES17885159T patent/ES3004083T3/es active Active
- 2017-12-14 CN CN201780078615.8A patent/CN110088615B/zh active Active
- 2017-12-14 AU AU2017382744A patent/AU2017382744B2/en active Active
- 2017-12-14 EP EP17885159.8A patent/EP3555615B9/en active Active
- 2017-12-14 US US16/466,451 patent/US11619636B2/en active Active
- 2017-12-14 CA CA3045022A patent/CA3045022C/en active Active
- 2017-12-14 JP JP2019553158A patent/JP7393206B2/ja active Active
- 2017-12-14 WO PCT/US2017/066364 patent/WO2018118630A1/en not_active Ceased
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