JP2020502544A5 - - Google Patents
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- JP2020502544A5 JP2020502544A5 JP2019553158A JP2019553158A JP2020502544A5 JP 2020502544 A5 JP2020502544 A5 JP 2020502544A5 JP 2019553158 A JP2019553158 A JP 2019553158A JP 2019553158 A JP2019553158 A JP 2019553158A JP 2020502544 A5 JP2020502544 A5 JP 2020502544A5
- Authority
- JP
- Japan
- Prior art keywords
- analytes
- tryptophan
- phenylacetylglutamine
- creatinine
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 14
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 12
- 150000002500 ions Chemical class 0.000 claims 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 6
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims 6
- PEDXUVCGOLSNLQ-WUJLRWPWSA-N N-acetyl-L-threonine Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(C)=O PEDXUVCGOLSNLQ-WUJLRWPWSA-N 0.000 claims 6
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 6
- 229940109239 creatinine Drugs 0.000 claims 6
- 229960004799 tryptophan Drugs 0.000 claims 6
- 229930185560 Pseudouridine Natural products 0.000 claims 5
- PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 claims 5
- WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 claims 5
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims 5
- 102100028630 Cytoskeleton-associated protein 2 Human genes 0.000 claims 4
- 101000766848 Homo sapiens Cytoskeleton-associated protein 2 Proteins 0.000 claims 4
- WOERBKLLTSWFBY-UHFFFAOYSA-M dihydrogen phosphate;tetramethylazanium Chemical compound C[N+](C)(C)C.OP(O)([O-])=O WOERBKLLTSWFBY-UHFFFAOYSA-M 0.000 claims 4
- -1 C-glycosyltryptophan Chemical compound 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 claims 2
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 claims 2
- KTHDTJVBEPMMGL-VKHMYHEASA-N N-acetyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(C)=O KTHDTJVBEPMMGL-VKHMYHEASA-N 0.000 claims 2
- JJIHLJJYMXLCOY-BYPYZUCNSA-N N-acetyl-L-serine Chemical compound CC(=O)N[C@@H](CO)C(O)=O JJIHLJJYMXLCOY-BYPYZUCNSA-N 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 claims 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 2
- 229960000367 inositol Drugs 0.000 claims 2
- YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 2
- JDHILDINMRGULE-FYFSCIFKSA-N (2S)-2-amino-3-[3-(trideuteriomethyl)imidazol-4-yl]propanoic acid Chemical compound C(N1C=NC=C1C[C@H](N)C(=O)O)([2H])([2H])[2H] JDHILDINMRGULE-FYFSCIFKSA-N 0.000 claims 1
- QJYMWMDDBANNAM-QXYVSOOMSA-N (2S)-2-deuterio-2-(dideuterioamino)-3-hydroxy-4-oxopentanoic acid Chemical compound C(C)(=O)C([C@](N([2H])[2H])(C(=O)O)[2H])O QJYMWMDDBANNAM-QXYVSOOMSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-HLTLGYGQSA-N (2s)-2-amino-3-(2,4,5,6,7-pentadeuterio-1h-indol-3-yl)propanoic acid Chemical compound [2H]C1=C([2H])C([2H])=C2C(C[C@H](N)C(O)=O)=C([2H])NC2=C1[2H] QIVBCDIJIAJPQS-HLTLGYGQSA-N 0.000 claims 1
- JFLIEFSWGNOPJJ-CJMNRESHSA-N (2s)-5-amino-5-oxo-2-[[2-(2,3,4,5,6-pentadeuteriophenyl)acetyl]amino]pentanoic acid Chemical compound [2H]C1=C([2H])C([2H])=C(CC(=O)N[C@@H](CCC(N)=O)C(O)=O)C([2H])=C1[2H] JFLIEFSWGNOPJJ-CJMNRESHSA-N 0.000 claims 1
- CDAISMWEOUEBRE-MZWXYZOWSA-N 1,2,3,4,5,6-hexadeuteriocyclohexane-1,2,3,4,5,6-hexol Chemical compound [2H]C1(O)C([2H])(O)C([2H])(O)C([2H])(O)C([2H])(O)C1([2H])O CDAISMWEOUEBRE-MZWXYZOWSA-N 0.000 claims 1
- CPXSBHKDEPPWIX-RAYCSJGISA-N 2'-alpha-mannosyl-L-tryptophan Chemical compound N1C2=CC=CC=C2C(C[C@H](N)C(O)=O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O CPXSBHKDEPPWIX-RAYCSJGISA-N 0.000 claims 1
- DDRJAANPRJIHGJ-FIBGUPNXSA-N 2-Amino-3-(trideuteriomethyl)-4H-imidazol-5-one Chemical compound [2H]C([2H])([2H])N1CC(=O)N=C1N DDRJAANPRJIHGJ-FIBGUPNXSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-OUBTZVSYSA-N Urea-13C Chemical compound N[13C](N)=O XSQUKJJJFZCRTK-OUBTZVSYSA-N 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- IDUWTCGPAPTSFB-UHFFFAOYSA-N hexyl hydrogen sulfate Chemical compound CCCCCCOS(O)(=O)=O IDUWTCGPAPTSFB-UHFFFAOYSA-N 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 1
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435967P | 2016-12-19 | 2016-12-19 | |
| US62/435,967 | 2016-12-19 | ||
| US201762526043P | 2017-06-28 | 2017-06-28 | |
| US62/526,043 | 2017-06-28 | ||
| US201762558014P | 2017-09-13 | 2017-09-13 | |
| US62/558,014 | 2017-09-13 | ||
| PCT/US2017/066364 WO2018118630A1 (en) | 2016-12-19 | 2017-12-14 | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502544A JP2020502544A (ja) | 2020-01-23 |
| JP2020502544A5 true JP2020502544A5 (https=) | 2021-01-21 |
| JP7393206B2 JP7393206B2 (ja) | 2023-12-06 |
Family
ID=62627087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553158A Active JP7393206B2 (ja) | 2016-12-19 | 2017-12-14 | 腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11619636B2 (https=) |
| EP (1) | EP3555615B9 (https=) |
| JP (1) | JP7393206B2 (https=) |
| CN (1) | CN110088615B (https=) |
| AU (1) | AU2017382744B2 (https=) |
| CA (1) | CA3045022C (https=) |
| ES (1) | ES3004083T3 (https=) |
| WO (1) | WO2018118630A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3555615B9 (en) | 2016-12-19 | 2025-03-19 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
| CN112689755A (zh) * | 2018-09-11 | 2021-04-20 | 梅塔博隆股份有限公司 | 用于检测和定量微生物区系相关代谢物的质谱测定法 |
| CN113508293B (zh) * | 2019-04-24 | 2024-05-07 | 株式会社岛津制作所 | 成像质量分析装置 |
| WO2020242744A1 (en) * | 2019-05-31 | 2020-12-03 | Metabolon, Inc. | Mass spectrometry assay methods for detection of metabolites |
| CN112946150B (zh) * | 2019-11-26 | 2024-06-18 | 深圳华大临床检验中心 | 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒 |
| CN111007173A (zh) * | 2019-12-20 | 2020-04-14 | 辉源生物科技（上海）有限公司 | 吲哚胺2，3-二氧化酶抑制剂的筛选方法 |
| CN114026427B (zh) * | 2020-05-19 | 2023-11-17 | 深圳市中医院 | 诊断肾病的标志物以及诊断方法 |
| CN115917323A (zh) * | 2020-05-19 | 2023-04-04 | 赛诺菲 | 使用干血样验证药物水平的方法 |
| CN114518413B (zh) * | 2020-11-18 | 2024-12-31 | 江苏天士力帝益药业有限公司 | 一种卡托普利原料药中脯氨酸的含量测定方法 |
| CN114216984B (zh) * | 2021-12-16 | 2023-10-13 | 川北医学院附属医院 | 一种骨质疏松症负离子诊断标志物及其检测方法 |
| CN114414700A (zh) * | 2022-01-27 | 2022-04-29 | 重庆迪纳利医药科技有限责任公司 | 一种同时测定生物样品中多种内源性糖醇含量的方法和系统 |
| WO2025244008A1 (ja) * | 2024-05-23 | 2025-11-27 | 株式会社島津製作所 | 測定方法、プログラム、および高速液体クロマトグラフタンデム質量分析装置 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2248147A1 (en) | 2008-01-31 | 2010-11-10 | DH Technologies Development Pte. Ltd. | High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer |
| JP5624709B2 (ja) * | 2008-03-13 | 2014-11-12 | 大日本住友製薬株式会社 | 内因性代謝物の分析方法 |
| WO2010126146A1 (ja) | 2009-04-30 | 2010-11-04 | Tanaka Noriaki | 腎疾患重篤度を判定する方法又は装置若しくはその作動方法 |
| CN107064330B (zh) | 2010-12-28 | 2022-02-25 | 探索诊断投资公司 | 通过质谱法定量胰岛素 |
| JP2015505965A (ja) * | 2011-12-09 | 2015-02-26 | メタボロン，インコーポレイテッド | 腎癌のバイオマーカーおよびそれを用いる方法 |
| CN102680599A (zh) | 2012-05-11 | 2012-09-19 | 上海特敏生物医药科技有限公司 | 尿肌氨酸及肌酐测定试剂盒 |
| ES2987582T3 (es) * | 2013-01-31 | 2024-11-15 | Metabolon Inc | Biomarcadores relacionados con la progresión de la resistencia a la Insulina y métodos que lo utilizan |
| JP6595984B2 (ja) | 2013-05-14 | 2019-10-23 | メタボロン，インコーポレイテッド | 腎機能に関連付けられるバイオマーカーおよびそれを使用する方法 |
| CN105143872B (zh) * | 2013-06-07 | 2019-03-01 | 皮尔斯生物科技有限公司 | 通过质谱分析用复用内标物对蛋白质和蛋白质修饰的绝对定量 |
| WO2015014903A2 (en) | 2013-07-31 | 2015-02-05 | Pharnext | Diagnostic tools for alzheimer's disease |
| WO2016025429A1 (en) * | 2014-08-15 | 2016-02-18 | The Johns Hopkins University | Precise estimation of glomerular filtration rate from multiple biomarkers |
| CN105738626B (zh) * | 2014-12-12 | 2017-07-14 | 中国科学院大连化学物理研究所 | 一种新的血清代谢物的组合及其作为肝癌诊断标志物的用途 |
| US20160282371A1 (en) * | 2015-03-28 | 2016-09-29 | Quantalytical Labs Inc. | Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits |
| BR112017025097B1 (pt) * | 2015-05-27 | 2021-05-11 | Quest Diagnostics Investments Llc | método para quantificação espectrométrica de massa de analitos extraídos de um dispositivo de microamostragem |
| CN104897821A (zh) | 2015-06-03 | 2015-09-09 | 福建中烟工业有限责任公司 | 提取样品中肌醇的方法、试剂盒及其用途 |
| EP3555615B9 (en) | 2016-12-19 | 2025-03-19 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
-
2017
- 2017-12-14 EP EP17885159.8A patent/EP3555615B9/en active Active
- 2017-12-14 WO PCT/US2017/066364 patent/WO2018118630A1/en not_active Ceased
- 2017-12-14 US US16/466,451 patent/US11619636B2/en active Active
- 2017-12-14 CN CN201780078615.8A patent/CN110088615B/zh active Active
- 2017-12-14 AU AU2017382744A patent/AU2017382744B2/en active Active
- 2017-12-14 CA CA3045022A patent/CA3045022C/en active Active
- 2017-12-14 JP JP2019553158A patent/JP7393206B2/ja active Active
- 2017-12-14 ES ES17885159T patent/ES3004083T3/es active Active
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