CA3045022C - Mass spectrometry assay method for detection and quantitation of kidney function metabolites - Google Patents
Mass spectrometry assay method for detection and quantitation of kidney function metabolites Download PDFInfo
- Publication number
- CA3045022C CA3045022C CA3045022A CA3045022A CA3045022C CA 3045022 C CA3045022 C CA 3045022C CA 3045022 A CA3045022 A CA 3045022A CA 3045022 A CA3045022 A CA 3045022A CA 3045022 C CA3045022 C CA 3045022C
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- analytes
- tryptophan
- acetylthreonine
- creatinine
- pseudouridine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/62—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0009—Calibration of the apparatus
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
- H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7057—(Intracellular) signaling and trafficking pathways
- G01N2800/7066—Metabolic pathways
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Diabetes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435967P | 2016-12-19 | 2016-12-19 | |
| US62/435,967 | 2016-12-19 | ||
| US201762526043P | 2017-06-28 | 2017-06-28 | |
| US62/526,043 | 2017-06-28 | ||
| US201762558014P | 2017-09-13 | 2017-09-13 | |
| US62/558,014 | 2017-09-13 | ||
| PCT/US2017/066364 WO2018118630A1 (en) | 2016-12-19 | 2017-12-14 | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3045022A1 CA3045022A1 (en) | 2018-06-28 |
| CA3045022C true CA3045022C (en) | 2024-01-16 |
Family
ID=62627087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3045022A Active CA3045022C (en) | 2016-12-19 | 2017-12-14 | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11619636B2 (https=) |
| EP (1) | EP3555615B9 (https=) |
| JP (1) | JP7393206B2 (https=) |
| CN (1) | CN110088615B (https=) |
| AU (1) | AU2017382744B2 (https=) |
| CA (1) | CA3045022C (https=) |
| ES (1) | ES3004083T3 (https=) |
| WO (1) | WO2018118630A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3004083T3 (en) | 2016-12-19 | 2025-03-11 | Metabolon Inc | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
| AU2019338183A1 (en) * | 2018-09-11 | 2021-03-11 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of microbiota-related metabolites |
| WO2020217333A1 (ja) * | 2019-04-24 | 2020-10-29 | 株式会社島津製作所 | イメージング質量分析装置 |
| JP2022534369A (ja) * | 2019-05-31 | 2022-07-29 | メタボロン，インコーポレイテッド | 代謝物を検出するための質量分析アッセイ法 |
| CN112946150B (zh) * | 2019-11-26 | 2024-06-18 | 深圳华大临床检验中心 | 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒 |
| CN111007173A (zh) * | 2019-12-20 | 2020-04-14 | 辉源生物科技（上海）有限公司 | 吲哚胺2，3-二氧化酶抑制剂的筛选方法 |
| CN114026427B (zh) * | 2020-05-19 | 2023-11-17 | 深圳市中医院 | 诊断肾病的标志物以及诊断方法 |
| JP2023527152A (ja) * | 2020-05-19 | 2023-06-27 | サノフイ | 乾燥血液サンプルを用いた薬物レベルの検証のための方法 |
| CN114518413B (zh) * | 2020-11-18 | 2024-12-31 | 江苏天士力帝益药业有限公司 | 一种卡托普利原料药中脯氨酸的含量测定方法 |
| CN114216984B (zh) * | 2021-12-16 | 2023-10-13 | 川北医学院附属医院 | 一种骨质疏松症负离子诊断标志物及其检测方法 |
| CN114414700A (zh) * | 2022-01-27 | 2022-04-29 | 重庆迪纳利医药科技有限责任公司 | 一种同时测定生物样品中多种内源性糖醇含量的方法和系统 |
| WO2025244008A1 (ja) * | 2024-05-23 | 2025-11-27 | 株式会社島津製作所 | 測定方法、プログラム、および高速液体クロマトグラフタンデム質量分析装置 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2248147A1 (en) | 2008-01-31 | 2010-11-10 | DH Technologies Development Pte. Ltd. | High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer |
| JP5624709B2 (ja) * | 2008-03-13 | 2014-11-12 | 大日本住友製薬株式会社 | 内因性代謝物の分析方法 |
| JP5197846B2 (ja) * | 2009-04-30 | 2013-05-15 | 紀陽 田仲 | 腎疾患重篤度を判定する方法又は装置若しくはその作動方法 |
| EP3270407B1 (en) * | 2010-12-28 | 2021-07-07 | Quest Diagnostics Investments LLC | Quantitation of insulin by mass spectrometry |
| CA2853202A1 (en) | 2011-12-09 | 2013-06-13 | Metabolon, Inc. | Biomarkers for kidney cancer and methods using the same |
| CN102680599A (zh) * | 2012-05-11 | 2012-09-19 | 上海特敏生物医药科技有限公司 | 尿肌氨酸及肌酐测定试剂盒 |
| WO2014120449A1 (en) * | 2013-01-31 | 2014-08-07 | Metabolon, Inc. | Biomarkers related to insulin resistance progression and methods using the same |
| CA3184836A1 (en) * | 2013-05-14 | 2014-11-20 | Metabolon, Inc. | Biomarkers related to kidney function and methods using the same |
| WO2014197754A1 (en) * | 2013-06-07 | 2014-12-11 | Pierce Biotechnology, Inc. | Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards |
| EP3028049B1 (en) * | 2013-07-31 | 2019-03-20 | Pharnext | Diagnostic tools for alzheimer's disease |
| US20170276669A1 (en) * | 2014-08-15 | 2017-09-28 | The Johns Hopkins University | Precise estimation of glomerular filtration rate from multiple biomarkers |
| CN105738626B (zh) | 2014-12-12 | 2017-07-14 | 中国科学院大连化学物理研究所 | 一种新的血清代谢物的组合及其作为肝癌诊断标志物的用途 |
| US20160282371A1 (en) * | 2015-03-28 | 2016-09-29 | Quantalytical Labs Inc. | Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits |
| JP2018515796A (ja) * | 2015-05-27 | 2018-06-14 | クエスト ダイアグノスティックス インヴェストメンツ エルエルシー | マイクロサンプリングデバイスにより抽出された被分析物の質量分析による定量のための方法 |
| CN104897821A (zh) * | 2015-06-03 | 2015-09-09 | 福建中烟工业有限责任公司 | 提取样品中肌醇的方法、试剂盒及其用途 |
| ES3004083T3 (en) | 2016-12-19 | 2025-03-11 | Metabolon Inc | Mass spectrometry assay method for detection and quantitation of kidney function metabolites |
-
2017
- 2017-12-14 ES ES17885159T patent/ES3004083T3/es active Active
- 2017-12-14 CN CN201780078615.8A patent/CN110088615B/zh active Active
- 2017-12-14 AU AU2017382744A patent/AU2017382744B2/en active Active
- 2017-12-14 EP EP17885159.8A patent/EP3555615B9/en active Active
- 2017-12-14 US US16/466,451 patent/US11619636B2/en active Active
- 2017-12-14 CA CA3045022A patent/CA3045022C/en active Active
- 2017-12-14 JP JP2019553158A patent/JP7393206B2/ja active Active
- 2017-12-14 WO PCT/US2017/066364 patent/WO2018118630A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN110088615B (zh) | 2023-08-22 |
| US20190346455A1 (en) | 2019-11-14 |
| EP3555615A1 (en) | 2019-10-23 |
| EP3555615B1 (en) | 2024-10-30 |
| AU2017382744B2 (en) | 2023-02-09 |
| WO2018118630A1 (en) | 2018-06-28 |
| CN110088615A (zh) | 2019-08-02 |
| JP2020502544A (ja) | 2020-01-23 |
| EP3555615A4 (en) | 2020-11-04 |
| ES3004083T3 (en) | 2025-03-11 |
| EP3555615B9 (en) | 2025-03-19 |
| CA3045022A1 (en) | 2018-06-28 |
| AU2017382744A1 (en) | 2019-06-13 |
| JP7393206B2 (ja) | 2023-12-06 |
| US11619636B2 (en) | 2023-04-04 |
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Effective date: 20220629 |
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Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241206 |