JP2020500528A5 - - Google Patents
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- JP2020500528A5 JP2020500528A5 JP2019529497A JP2019529497A JP2020500528A5 JP 2020500528 A5 JP2020500528 A5 JP 2020500528A5 JP 2019529497 A JP2019529497 A JP 2019529497A JP 2019529497 A JP2019529497 A JP 2019529497A JP 2020500528 A5 JP2020500528 A5 JP 2020500528A5
- Authority
- JP
- Japan
- Prior art keywords
- nanopore
- sample
- adapter
- strand
- tag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1620450.5 | 2016-12-01 | ||
| GBGB1620450.5A GB201620450D0 (en) | 2016-12-01 | 2016-12-01 | Method |
| US201762471338P | 2017-03-14 | 2017-03-14 | |
| US62/471,338 | 2017-03-14 | ||
| PCT/GB2017/053603 WO2018100370A1 (en) | 2016-12-01 | 2017-11-29 | Methods and systems for characterizing analytes using nanopores |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500528A JP2020500528A (ja) | 2020-01-16 |
| JP2020500528A5 true JP2020500528A5 (enExample) | 2021-01-14 |
| JP7055805B2 JP7055805B2 (ja) | 2022-04-18 |
Family
ID=58159754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529497A Active JP7055805B2 (ja) | 2016-12-01 | 2017-11-29 | ナノポアを用いて検体を特徴付けるための方法及びシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11466317B2 (enExample) |
| EP (2) | EP3548636B1 (enExample) |
| JP (1) | JP7055805B2 (enExample) |
| CN (3) | CN110168104A (enExample) |
| AU (1) | AU2017367238B2 (enExample) |
| CA (1) | CA3044351A1 (enExample) |
| GB (1) | GB201620450D0 (enExample) |
| WO (1) | WO2018100370A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| EP3575410A3 (en) | 2013-10-18 | 2020-03-04 | Oxford Nanopore Technologies Limited | Modified enzymes |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| KR102222191B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| EP3464616B1 (en) | 2016-05-25 | 2022-05-04 | Oxford Nanopore Technologies plc | Method |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| CN121472373A (zh) | 2018-05-22 | 2026-02-06 | 安序源有限公司 | 用于核酸测序的方法、系统和组合物 |
| EP3801901A1 (en) | 2018-05-24 | 2021-04-14 | Oxford Nanopore Technologies Limited | Droplet interfaces in electro-wetting devices |
| GB201809323D0 (en) * | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB2585816A (en) * | 2018-12-12 | 2021-01-27 | Univ York | Proof-of-work for blockchain applications |
| CN111455031A (zh) * | 2019-01-18 | 2020-07-28 | 中国科学院微生物研究所 | 基于Nanopore测序技术的多组学测序及分析方法 |
| WO2020183172A1 (en) * | 2019-03-12 | 2020-09-17 | Oxford Nanopore Technologies Inc. | Nanopore sensing device and methods of operation and of forming it |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| GB2603061A (en) * | 2019-09-18 | 2022-07-27 | Hitachi High Tech Corp | Adapter molecule, biomolecule-adapter molecule complex composed of adapter molecule and biomolecule bound together, biomolecule analyzer and biomolecule |
| CN115398007A (zh) * | 2020-02-10 | 2022-11-25 | 帕洛根公司 | 纳米孔装置和使用其检测和分类带电粒子的方法 |
| US20230003648A1 (en) * | 2020-03-20 | 2023-01-05 | GeneSense Technology Inc. | High throughput analytical system for molecule detection and sensing |
| EP4168582B1 (en) | 2020-06-18 | 2025-11-19 | Oxford Nanopore Technologies plc | A method of selectively characterising a polynucleotide using a detector |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| CA3182250A1 (en) * | 2020-07-06 | 2022-01-13 | Maria Candelaria Rogert BACIGALUPO | Separating polynucleotide fragments |
| CN112309503A (zh) * | 2020-10-19 | 2021-02-02 | 深圳市儒翰基因科技有限公司 | 基于纳米孔电信号的碱基判读方法、判读设备及存储介质 |
| US12090477B2 (en) * | 2021-03-05 | 2024-09-17 | Taiwan Semiconductor Manufacturing Company Ltd. | System and method for detecting biomolecules |
| GB202107192D0 (en) * | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| US20240240248A1 (en) | 2021-05-19 | 2024-07-18 | Oxford Nanopore Technologies Plc | Methods for complement strand sequencing |
| CN113322180B (zh) * | 2021-05-31 | 2022-07-15 | 中国科学院物理研究所 | 基于纳米孔测序的力谱分析方法和分析装置 |
| CN115537413A (zh) * | 2021-06-29 | 2022-12-30 | 中国农业大学 | 一种双链功能核酸纳米花的组装和形貌调控方法及其应用 |
| CN113462764B (zh) * | 2021-09-01 | 2021-12-17 | 北京齐碳科技有限公司 | 用于表征双链靶多核苷酸的类发夹衔接子、构建体和方法 |
| WO2023055752A2 (en) | 2021-09-28 | 2023-04-06 | Axbio Inc. | Methods for processing a nucleic acid sample and compositions thereof |
| CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
| CN118591641A (zh) * | 2021-12-30 | 2024-09-03 | 深圳华大生命科学研究院 | 单分子纳米孔测序方法 |
| US20250136974A1 (en) * | 2021-12-31 | 2025-05-01 | Bgi Shenzhen | Nucleic acid molecule capable of blocking motor protein, and construction method and application thereof |
| US12559791B2 (en) | 2022-05-06 | 2026-02-24 | 10X Genomics, Inc. | Methods and compositions for in situ analysis of V(D)J sequences |
| CN119173641A (zh) | 2022-05-17 | 2024-12-20 | 牛津纳米孔科技公开有限公司 | 方法和衔接子 |
| GB202207267D0 (en) | 2022-05-18 | 2022-06-29 | Oxford Nanopore Tech Plc | Calibration and profiling of a nanopore array device |
| CN117587110A (zh) * | 2022-08-16 | 2024-02-23 | 北京齐碳科技有限公司 | 富集方法、表征分析物的方法及其装置 |
| WO2024077281A2 (en) * | 2022-10-06 | 2024-04-11 | Cornell University | Genotyping and sequencing assays for prrsv |
| GB202215442D0 (en) | 2022-10-19 | 2022-11-30 | Oxford Nanopore Tech Plc | Analysis of a polymer |
| CN120418447A (zh) * | 2022-10-21 | 2025-08-01 | 安序源有限公司 | 用于分析靶分子的系统和方法 |
| GB202216905D0 (en) | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| WO2024101988A1 (en) | 2022-11-11 | 2024-05-16 | Umc Utrecht Holding B.V. | Computer-implemented method for identifying a dna modification |
| CN116478983B (zh) * | 2022-11-21 | 2023-10-24 | 北京普译生物科技有限公司 | 一种rna-dna嵌合接头及其应用 |
| WO2024124567A1 (zh) * | 2022-12-16 | 2024-06-20 | 深圳华大生命科学研究院 | 纳米孔测序方法和试剂盒 |
| GB202301095D0 (en) | 2023-01-25 | 2023-03-08 | Oxford Nanopore Tech Plc | Calibration of a nanopore array device |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
| GB202305524D0 (en) | 2023-04-14 | 2023-05-31 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| GB202307141D0 (en) | 2023-05-12 | 2023-06-28 | Oxford Nanopore Tech Plc | Modified helicases |
| EP4737587A1 (en) * | 2023-06-30 | 2026-05-06 | BGI Hangzhou CycloneSEQ Technoloy Co., Ltd. | Nanopore sequencing method using closer |
| WO2025223677A1 (en) * | 2024-04-26 | 2025-10-30 | Helmholtz-Zentrum für Infektionsforschung GmbH | Method for analyzing molecules of interest, method for automatically selecting electrical signals related to a set of known barcode molecules, signal processing unit and computer program for executing the method |
| WO2026057755A1 (en) | 2024-09-13 | 2026-03-19 | Oxford Nanopore Technologies Plc | Adaptors and kits for rna molecules labelling and characterising |
| GB202418735D0 (en) | 2024-12-19 | 2025-02-05 | Oxford Nanpore Tech Plc | Methods and kits |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US20120160687A1 (en) | 1995-03-17 | 2012-06-28 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
| AU2206800A (en) | 1998-12-11 | 2000-06-26 | Regents Of The University Of California, The | Targeted molecular bar codes and methods for using the same |
| US6916665B2 (en) * | 2000-02-11 | 2005-07-12 | The Texas A&M University System | Biosensor compositions and methods of use |
| FR2814939B1 (fr) | 2000-10-05 | 2002-12-20 | Sofradim Production | Ensemble de soutenement sous-uretral dans le traitement de l'incontinence urinaire d'effort de la femme |
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| US8278055B2 (en) * | 2002-05-01 | 2012-10-02 | Intel Corporation | Methods and device for analyte characterization |
| WO2006028508A2 (en) | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| WO2005124888A1 (en) | 2004-06-08 | 2005-12-29 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
| GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
| EP2122344B8 (en) | 2007-02-20 | 2019-08-21 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
| EP3540436B1 (en) | 2007-09-12 | 2023-11-01 | President And Fellows Of Harvard College | High-resolution molecular sensor |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| CA2730068A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20110229877A1 (en) * | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| CN102482330A (zh) | 2009-01-30 | 2012-05-30 | 牛津纳米孔技术有限公司 | 酶突变体 |
| GB0901588D0 (en) | 2009-02-02 | 2009-03-11 | Itis Holdings Plc | Apparatus and methods for providing journey information |
| EP2507387B1 (en) | 2009-12-01 | 2017-01-25 | Oxford Nanopore Technologies Limited | Biochemical analysis instrument and method |
| WO2012003330A2 (en) | 2010-06-30 | 2012-01-05 | Stratos Genomics, Inc | Multiplexed identification of nucleic acid sequences |
| WO2012042226A2 (en) | 2010-10-01 | 2012-04-05 | Oxford Nanopore Technologies Limited | Biochemical analysis apparatus and rotary valve |
| BR112013020411B1 (pt) | 2011-02-11 | 2021-09-08 | Oxford Nanopore Technologies Limited | Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo |
| US9347929B2 (en) | 2011-03-01 | 2016-05-24 | The Regents Of The University Of Michigan | Controlling translocation through nanopores with fluid wall |
| SG10201604316WA (en) * | 2011-05-27 | 2016-07-28 | Oxford Nanopore Tech Ltd | Coupling method |
| KR20140050067A (ko) | 2011-07-25 | 2014-04-28 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법 |
| EP3663412B1 (en) | 2011-09-23 | 2022-03-09 | Oxford Nanopore Technologies PLC | Analysis of a polymer comprising polymer units by means of translocation through a nanopore |
| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| EP2798083B1 (en) | 2011-12-29 | 2017-08-09 | Oxford Nanopore Technologies Limited | Method for characterising a polynucelotide by using a xpd helicase |
| CA2861808C (en) | 2011-12-29 | 2021-02-23 | Oxford Nanopore Technologies Limited | Enzyme method |
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| SMT202100154T1 (it) * | 2012-02-17 | 2021-05-07 | Hutchinson Fred Cancer Res | Composizioni e metodi per identificare precisamente mutazioni |
| WO2013153359A1 (en) * | 2012-04-10 | 2013-10-17 | Oxford Nanopore Technologies Limited | Mutant lysenin pores |
| AU2013267609C1 (en) | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| GB2559073A (en) * | 2012-06-08 | 2018-07-25 | Pacific Biosciences California Inc | Modified base detection with nanopore sequencing |
| ES2779699T3 (es) * | 2012-06-20 | 2020-08-18 | Univ Columbia | Secuenciación de ácidos nucleicos mediante detección en nanoporos de moléculas de etiqueta |
| CA2879355C (en) | 2012-07-19 | 2021-09-21 | Oxford Nanopore Technologies Limited | Helicase construct and its use in characterising polynucleotides |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| JP6375301B2 (ja) | 2012-10-26 | 2018-08-15 | オックスフォード ナノポール テクノロジーズ リミテッド | 液滴界面 |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| WO2014074922A1 (en) | 2012-11-09 | 2014-05-15 | Stratos Genomics, Inc. | Concentrating a target molecule for sensing by a nanopore |
| US9605309B2 (en) * | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| CA2901545C (en) | 2013-03-08 | 2019-10-08 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201314695D0 (en) * | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| US10732183B2 (en) | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
| CN203450281U (zh) | 2013-08-01 | 2014-02-26 | 大行科技(深圳)有限公司 | 一种折叠自行车走线结构 |
| EP3575410A3 (en) | 2013-10-18 | 2020-03-04 | Oxford Nanopore Technologies Limited | Modified enzymes |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| EP3097210B2 (en) | 2014-01-22 | 2022-04-20 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| WO2015127387A1 (en) | 2014-02-21 | 2015-08-27 | Northeastern University | Fluorescence-based analysis of biopolymers using nanopores |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| CN106255767A (zh) | 2014-03-21 | 2016-12-21 | 牛津楠路珀尔科技有限公司 | 由多维测量分析聚合物 |
| US10337060B2 (en) | 2014-04-04 | 2019-07-02 | Oxford Nanopore Technologies Ltd. | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
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| CA3221500A1 (en) | 2014-06-03 | 2015-12-10 | Illumina, Inc. | Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores |
| CN119899249A (zh) * | 2014-09-01 | 2025-04-29 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| WO2016059436A1 (en) | 2014-10-17 | 2016-04-21 | Oxford Nanopore Technologies Limited | Method for nanopore rna characterisation |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| US9557294B2 (en) * | 2014-12-19 | 2017-01-31 | Genia Technologies, Inc. | Nanopore-based sequencing with varying voltage stimulus |
| WO2016133764A1 (en) * | 2015-02-17 | 2016-08-25 | Complete Genomics, Inc. | Dna sequencing using controlled strand displacement |
| CA2981515A1 (en) | 2015-04-03 | 2016-10-06 | Abbott Laboratories | Devices and methods for sample analysis |
| KR102713216B1 (ko) | 2015-06-25 | 2024-10-02 | 로스웰 엠이 아이엔씨. | 바이오분자 센서들 및 방법들 |
| US20200216887A1 (en) | 2016-01-21 | 2020-07-09 | Genia Technologies, Inc. | Nanopore sequencing complexes |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
-
2016
- 2016-12-01 GB GBGB1620450.5A patent/GB201620450D0/en not_active Ceased
-
2017
- 2017-11-29 CA CA3044351A patent/CA3044351A1/en active Pending
- 2017-11-29 WO PCT/GB2017/053603 patent/WO2018100370A1/en not_active Ceased
- 2017-11-29 CN CN201780083105.XA patent/CN110168104A/zh active Pending
- 2017-11-29 US US16/465,987 patent/US11466317B2/en active Active
- 2017-11-29 EP EP17817029.6A patent/EP3548636B1/en active Active
- 2017-11-29 CN CN202310379925.0A patent/CN116377044B/zh active Active
- 2017-11-29 EP EP23182828.6A patent/EP4269617A3/en active Pending
- 2017-11-29 AU AU2017367238A patent/AU2017367238B2/en active Active
- 2017-11-29 JP JP2019529497A patent/JP7055805B2/ja active Active
- 2017-11-29 CN CN202310379929.9A patent/CN116334200B/zh active Active
-
2022
- 2022-08-03 US US17/817,065 patent/US12509721B2/en active Active
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