JP2020514746A5 - - Google Patents

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JP2020514746A5
JP2020514746A5 JP2019550552A JP2019550552A JP2020514746A5 JP 2020514746 A5 JP2020514746 A5 JP 2020514746A5 JP 2019550552 A JP2019550552 A JP 2019550552A JP 2019550552 A JP2019550552 A JP 2019550552A JP 2020514746 A5 JP2020514746 A5 JP 2020514746A5
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Japan
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protein
peptides
determining
affinity reagents
proteins
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JP2019550552A
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JP2020514746A (ja
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Priority claimed from PCT/US2017/064322 external-priority patent/WO2018102759A1/en
Publication of JP2020514746A publication Critical patent/JP2020514746A/ja
Publication of JP2020514746A5 publication Critical patent/JP2020514746A5/ja
Priority to JP2022206984A priority Critical patent/JP2023030135A/ja
Priority to JP2024150202A priority patent/JP2024170480A/ja
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JP2019550552A 2016-12-01 2017-12-01 タンパク質をアッセイする方法 Pending JP2020514746A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022206984A JP2023030135A (ja) 2016-12-01 2022-12-23 タンパク質をアッセイする方法
JP2024150202A JP2024170480A (ja) 2016-12-01 2024-08-30 タンパク質をアッセイする方法

Applications Claiming Priority (5)

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US201662429063P 2016-12-01 2016-12-01
US62/429,063 2016-12-01
US201762500455P 2017-05-02 2017-05-02
US62/500,455 2017-05-02
PCT/US2017/064322 WO2018102759A1 (en) 2016-12-01 2017-12-01 Methods of assaying proteins

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JP2022206984A Division JP2023030135A (ja) 2016-12-01 2022-12-23 タンパク質をアッセイする方法

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JP2020514746A JP2020514746A (ja) 2020-05-21
JP2020514746A5 true JP2020514746A5 (enExample) 2021-01-21

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JP2022206984A Pending JP2023030135A (ja) 2016-12-01 2022-12-23 タンパク質をアッセイする方法
JP2024150202A Pending JP2024170480A (ja) 2016-12-01 2024-08-30 タンパク質をアッセイする方法

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JP2024150202A Pending JP2024170480A (ja) 2016-12-01 2024-08-30 タンパク質をアッセイする方法

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US (10) US10473654B1 (enExample)
EP (3) EP4614155A3 (enExample)
JP (3) JP2020514746A (enExample)
CN (1) CN110249082B (enExample)
DK (1) DK3548652T3 (enExample)
WO (1) WO2018102759A1 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2510488B (en) 2011-06-23 2020-04-08 Univ Texas Identifying peptides at the single molecule level
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
EP4614155A3 (en) 2016-12-01 2025-10-15 Nautilus Subsidiary, Inc. Methods of assaying proteins
EP3669018A4 (en) * 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
AU2018353967B2 (en) * 2017-10-23 2024-02-29 Nautilus Subsidiary, Inc. Methods and systems for protein identification
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
WO2019089836A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
AU2018395430B2 (en) 2017-12-29 2024-05-23 Nautilus Subsidiary, Inc. Decoding approaches for protein identification
EP3775196A4 (en) 2018-04-04 2021-12-22 Nautilus Biotechnology, Inc. NANOREWAL AND MICROREWAL GENERATION PROCESSES
CA3110800A1 (en) 2018-07-12 2020-01-16 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
EP3841234B1 (en) 2018-08-23 2023-10-04 ProteinSimple Systems and methods for the detection and analysis of free thiol
WO2020096631A2 (en) 2018-11-07 2020-05-14 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
CN113316638A (zh) 2018-11-20 2021-08-27 诺迪勒思生物科技公司 亲和试剂的设计和选择
GB2599796A (en) 2019-03-26 2022-04-13 Seer Inc Compositions, methods and systems for protein corona analysis from biofluids and uses thereof
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
WO2021087402A1 (en) 2019-10-30 2021-05-06 Nautilus Biotechnology, Inc. Flow cell systems and methods
CN115087746A (zh) * 2020-02-12 2022-09-20 贝克顿迪金森公司 细胞内AbSeq
CN111289425B (zh) * 2020-03-12 2021-03-30 中国计量科学研究院 基于荧光标记流式单分子计数的蛋白质含量计量基准方法
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
KR102576033B1 (ko) * 2020-07-17 2023-09-11 주식회사 아론티어 3d-컨벌루션 뉴럴 네트워크의 앙상블을 이용한 단백질-리간드 결합 친화도 예측 방법 및 이를 위한 시스템
CA3190719A1 (en) 2020-08-25 2022-03-03 Daniel Hornburg Compositions and methods for assaying proteins and nucleic acids
US11880345B2 (en) * 2020-09-14 2024-01-23 Tata Consultancy Services Limited Method and system for generating annotations and field-names for relational schema
KR20230118570A (ko) 2020-11-11 2023-08-11 노틸러스 서브시디어리, 인크. 강화된 결합 및 검출 특성을 갖는 친화성 시약
EP4281774B1 (en) 2021-01-20 2025-11-26 Nautilus Subsidiary, Inc. Biomolecule quantitation
CA3203535A1 (en) 2021-01-21 2022-07-28 Gregory KAPP Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CA3222270A1 (en) 2021-06-24 2022-12-29 Vadim Lobanov Methods and systems for assay refinement
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
AU2022352593A1 (en) * 2021-09-22 2024-02-15 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
KR20240074839A (ko) 2021-10-11 2024-05-28 노틸러스 서브시디어리, 인크. 단백질 및 프로테옴의 고도로 다중화 가능한 분석
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US12474346B2 (en) 2021-11-05 2025-11-18 Encodia, Inc. Methods and kits for multicycle encoding assay
AU2022402132A1 (en) 2021-11-30 2024-05-30 Nautilus Subsidiary, Inc. Particle-based isolation of proteins and other analytes
WO2023122589A2 (en) 2021-12-22 2023-06-29 Nautilus Subsidiary, Inc. Systems and methods for carrying out highly multiplexed bioanalyses
CN114388060B (zh) * 2022-01-13 2023-06-20 西湖大学 基于圆形控制器的蛋白球形截面生成方法
CN114388058A (zh) * 2022-01-13 2022-04-22 西湖大学 基于九轴imu的蛋白任意截面生成方法
CA3245990A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary Inc INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES
EP4515026A1 (en) 2022-04-25 2025-03-05 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
NL2032916B1 (en) 2022-08-31 2024-03-15 Univ Delft Tech Single-molecule aptamer FRET for protein identification and structural analysis
US20240087679A1 (en) 2022-09-13 2024-03-14 Nautilus Subsidiary, Inc. Systems and methods of validating new affinity reagents
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024072614A1 (en) 2022-09-27 2024-04-04 Nautilus Subsidiary, Inc. Polypeptide capture, in situ fragmentation and identification
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
EP4619766A1 (en) 2022-11-15 2025-09-24 Nautilus Subsidiary, Inc. Standard polypeptides
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
WO2024130000A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240241110A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
WO2024173261A2 (en) 2023-02-13 2024-08-22 Nautilus Subsidiary, Inc. Affinity reagents having artificial polymer scaffolds
US20240301469A1 (en) 2023-02-24 2024-09-12 Nautilus Subsidiary, Inc. Modifying, separating and detecting proteoforms
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
US20240353416A1 (en) 2023-04-13 2024-10-24 Nautilus Subsidiary, Inc. Artificial proteins for displaying epitopes
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20240417720A1 (en) 2023-06-14 2024-12-19 Nautilus Subsidiary, Inc. Making and using structured nucleic acid particles
WO2024263696A1 (en) 2023-06-21 2024-12-26 Nautilus Subsidiary, Inc. Compositions and methods for improving affinity reagent avidity
NL2035603B1 (en) 2023-08-14 2025-02-25 Univ Delft Tech Proximity labelling and FRET-based protein fingerprinting
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025128588A1 (en) 2023-12-11 2025-06-19 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
US20250205706A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation
US20250306015A1 (en) 2024-04-01 2025-10-02 Nautilus Subsidiary, Inc. Single molecule-resolved characterization of affinity reagent kinetics and thermodynamics
US20250354988A1 (en) 2024-05-14 2025-11-20 Nautilus Subsidiary, Inc. Time-dependent profiling of binding interactions

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1017524A (en) 1911-05-01 1912-02-13 Robert George Ferguson Flush-tank.
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US6682886B1 (en) 1994-04-28 2004-01-27 Gilead Sciences, Inc. Bivalent binding molecules of 7 transmembrane G protein-coupled receptors
SE9601676D0 (sv) 1996-04-30 1996-04-30 Ulf Landegren Improved probing of specific mucleic acids
US6762056B1 (en) 1997-11-12 2004-07-13 Protiveris, Inc. Rapid method for determining potential binding sites of a protein
US20060057573A1 (en) * 2002-02-15 2006-03-16 Somalogic, Inc Methods and reagents for detecting target binding by nucleic acid ligands
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
CA2303761C (en) 1999-04-06 2005-12-20 Micromass Limited A method of determining peptide sequences by mass spectrometry
WO2000073787A1 (en) 1999-05-27 2000-12-07 Rockefeller University An expert system for protein identification using mass spectrometric information combined with database searching
AU3436601A (en) 1999-12-23 2001-07-03 Illumina, Inc. Decoding of array sensors with microspheres
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
WO2002071067A1 (en) * 2001-03-07 2002-09-12 Bio-Rad Laboratories, Inc. Assay system for simultaneous detection and measurement of multiple modified cellular proteins
US20050074809A1 (en) 2001-03-10 2005-04-07 Vladimir Brusic System and method for systematic prediction of ligand/receptor activity
WO2002086081A2 (en) * 2001-04-20 2002-10-31 Carnegie Mellon University Methods and systems for identifying proteins
US6720595B2 (en) 2001-08-06 2004-04-13 International Business Machines Corporation Three-dimensional island pixel photo-sensor
CA2462819A1 (en) 2001-11-23 2003-05-30 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
WO2003046144A2 (en) 2001-11-26 2003-06-05 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
US20040067599A1 (en) * 2001-12-14 2004-04-08 Katz Joseph L. Separation identification and quantitation of protein mixtures
AU2003231980A1 (en) 2002-03-29 2003-10-13 Buck Institute Identification of apoptotic peptides and methods of use thereof
US6998241B2 (en) 2002-09-11 2006-02-14 Kimberly-Clark Worldwide, Inc. Antibody pair screening methods
CA2502246A1 (en) 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
WO2004094456A2 (en) 2003-04-18 2004-11-04 Becton, Dickinson And Company Immuno-amplification
US20040265938A1 (en) 2003-06-25 2004-12-30 Jose Remacle Method for the determination of cell activation
JP3788513B2 (ja) * 2003-09-11 2006-06-21 セイコーエプソン株式会社 固相基板上への分子の固定化方法およびそれを用いるバイオセンサの製造方法
US7593817B2 (en) 2003-12-16 2009-09-22 Thermo Finnigan Llc Calculating confidence levels for peptide and protein identification
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US20060160234A1 (en) * 2005-01-18 2006-07-20 Viorica Lopez-Avila Methods for assessing polypeptide array quality
CA2601394A1 (en) 2005-03-17 2006-09-28 Primex Clinical Laboratories, Inc. Immunogens for vaccines against antigenically variable pathogens and diseases
CA2606723A1 (en) 2005-05-09 2006-11-16 Panomics, Inc. Multiplex capture of nucleic acids
EP1907410B1 (en) 2005-06-10 2012-07-04 Saint Louis University Methods for the selection of aptamers
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
DK2620510T4 (da) 2005-06-15 2020-03-30 Complete Genomics Inc Enkeltmolekyle-arrays til genetisk og kemisk analyse
JP4724816B2 (ja) * 2005-09-06 2011-07-13 シャープ株式会社 タンパク質の測定方法
EP1941276A1 (de) 2005-10-29 2008-07-09 Bayer Technology Services GmbH Verfahren zur bestimmung eines oder mehrerer analyten in komplex zusammengesetzten proben biologischen ursprungs und dessen verwendung
WO2007120208A2 (en) 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
CN100500865C (zh) 2006-04-21 2009-06-17 华东师范大学 一种通过同时识别多个表位来检测CatD蛋白的方法
WO2007117444A2 (en) 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
AU2008237018B2 (en) 2007-04-10 2014-04-03 Bruker Spatial Biology, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
US8404830B2 (en) 2007-07-17 2013-03-26 Somalogic, Inc. Method for generating aptamers with improved off-rates
WO2009126290A2 (en) 2008-04-09 2009-10-15 Cornell University Coferons and methods of making and using them
US9102520B2 (en) 2008-08-13 2015-08-11 California Institute Of Technology Nanocomposite structures and related methods and systems
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
WO2010065531A1 (en) * 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
WO2010111686A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Labeled enzyme compositions, methods & systems
WO2010120385A1 (en) 2009-04-18 2010-10-21 Massachusetts Institute Of Technology pH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY
BR112012017483A2 (pt) 2010-01-14 2019-09-24 Haplomics Inc previsão e redução de aloimunogenicidade de terapêuticos de proteína
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
KR102185779B1 (ko) 2010-04-12 2020-12-03 소마로직, 인크. 5-위치 변경된 피리미딘 및 그것의 용도
US8774494B2 (en) * 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
CN102618940A (zh) 2011-01-31 2012-08-01 艾比玛特生物医药(上海)有限公司 抗体制备方法及所得抗体和抗体库
US20130053541A1 (en) 2011-03-11 2013-02-28 Lynntech, Inc. Methods for discovering molecules that bind to proteins
GB2510488B (en) 2011-06-23 2020-04-08 Univ Texas Identifying peptides at the single molecule level
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
US9410156B2 (en) 2012-03-28 2016-08-09 Somalogic, Inc. Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
HUE058723T2 (hu) 2012-11-19 2022-09-28 Apton Biosystems Inc Molekuláris analitok digitális elemzése egyetlen molekula kimutatásával
JP2016521134A (ja) * 2013-05-16 2016-07-21 バセトラ メディカル テクノロジー カンパニー リミテッド 母体血から捕捉する胎児細胞を使用する胎児診断
US9368187B2 (en) * 2013-07-11 2016-06-14 Qualcomm Incorporated Insertion-override counter to support multiple memory refresh rates
MX361451B (es) 2013-09-24 2018-12-06 Somalogic Inc Detección objetivo de múltiples aptámeros.
CA2928207C (en) 2013-11-21 2020-09-15 Somalogic, Inc. Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
EP3087083B1 (en) 2013-12-27 2019-10-16 F.Hoffmann-La Roche Ag Systemic discovery, maturation and extension of peptide binders to proteins
EP3009520B1 (en) 2014-10-14 2018-12-12 Karlsruher Institut für Technologie Site-specific immobilization of DNA origami structures on solid substrates
EP3274473B1 (en) 2015-03-24 2020-10-28 Pacific Biosciences of California, Inc. Methods and compositions for single molecule composition loading
US9881786B2 (en) 2015-04-02 2018-01-30 Micron Technology, Inc. Methods of forming nanostructures using self-assembled nucleic acids, and nanostructures thereof
WO2016174525A1 (en) 2015-04-29 2016-11-03 Biosims Technologies Enhanced sensitivity in ligand binding assays performed with secondary ion mass spectrometry
EP3298135B1 (en) 2015-05-18 2023-06-07 The Regents of the University of California Systems and methods for predicting glycosylation on proteins
WO2017127762A1 (en) 2016-01-20 2017-07-27 Vitrisa Therapeutics, Inc. Methods for improved aptamer selection
CN110199019B (zh) 2016-05-02 2024-09-10 Encodia有限公司 采用核酸编码的大分子分析
EP4614155A3 (en) 2016-12-01 2025-10-15 Nautilus Subsidiary, Inc. Methods of assaying proteins
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
US11125748B2 (en) 2017-09-01 2021-09-21 University Of British Columbia Method for organizing individual molecules on a patterned substrate and structures assembled thereby
US11391734B2 (en) 2017-09-25 2022-07-19 California Institute Of Technology Surface-immobilized bistable polynucleotide devices for the sensing and quantification of molecular events
AU2018353967B2 (en) 2017-10-23 2024-02-29 Nautilus Subsidiary, Inc. Methods and systems for protein identification
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
WO2019089836A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
CA3081446A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
AU2018395430B2 (en) 2017-12-29 2024-05-23 Nautilus Subsidiary, Inc. Decoding approaches for protein identification
EP3775196A4 (en) 2018-04-04 2021-12-22 Nautilus Biotechnology, Inc. NANOREWAL AND MICROREWAL GENERATION PROCESSES
US20210239705A1 (en) 2018-06-06 2021-08-05 Nautilus Biotechnology, Inc. Methods and applications of protein identification
CN113316638A (zh) 2018-11-20 2021-08-27 诺迪勒思生物科技公司 亲和试剂的设计和选择
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
WO2021003470A1 (en) 2019-07-03 2021-01-07 Nautilus Biotechnology, Inc. Decoding approaches for protein and peptide identification
WO2021087402A1 (en) 2019-10-30 2021-05-06 Nautilus Biotechnology, Inc. Flow cell systems and methods
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
EP4281774B1 (en) 2021-01-20 2025-11-26 Nautilus Subsidiary, Inc. Biomolecule quantitation

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