JP2020100622A5 - - Google Patents
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- JP2020100622A5 JP2020100622A5 JP2019233842A JP2019233842A JP2020100622A5 JP 2020100622 A5 JP2020100622 A5 JP 2020100622A5 JP 2019233842 A JP2019233842 A JP 2019233842A JP 2019233842 A JP2019233842 A JP 2019233842A JP 2020100622 A5 JP2020100622 A5 JP 2020100622A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- amino acid
- acid sequence
- seq
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 241000238631 Hexapoda Species 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 239000002158 endotoxin Substances 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 5
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- -1 t-butoxycarbonyl group Chemical group 0.000 claims 2
- 241001529572 Chaceon affinis Species 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- BABSVXFGKFLIGW-UWVGGRQHSA-N Leu-Gly-Arg Chemical group CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CCCNC(N)=N BABSVXFGKFLIGW-UWVGGRQHSA-N 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- YTNGABPUXFEOGU-SRVKXCTJSA-N Val-Pro-Arg Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O YTNGABPUXFEOGU-SRVKXCTJSA-N 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000010836 blood and blood product Substances 0.000 claims 1
- 229940125691 blood product Drugs 0.000 claims 1
- 238000010523 cascade reaction Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 108010049163 horseshoe crab coagulation factor B Proteins 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022085191A JP7372392B2 (ja) | 2011-02-28 | 2022-05-25 | エンドトキシン測定剤 |
| JP2023180059A JP7590530B2 (ja) | 2011-02-28 | 2023-10-19 | エンドトキシン測定剤 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161447556P | 2011-02-28 | 2011-02-28 | |
| US61/447,556 | 2011-02-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018074569A Division JP6640267B2 (ja) | 2011-02-28 | 2018-04-09 | エンドトキシン測定剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022085191A Division JP7372392B2 (ja) | 2011-02-28 | 2022-05-25 | エンドトキシン測定剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020100622A JP2020100622A (ja) | 2020-07-02 |
| JP2020100622A5 true JP2020100622A5 (enExample) | 2020-11-12 |
Family
ID=45888460
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538748A Pending JP2014510898A (ja) | 2011-02-28 | 2012-02-28 | エンドトキシン測定剤 |
| JP2018074569A Active JP6640267B2 (ja) | 2011-02-28 | 2018-04-09 | エンドトキシン測定剤 |
| JP2019233842A Pending JP2020100622A (ja) | 2011-02-28 | 2019-12-25 | エンドトキシン測定剤 |
| JP2022085191A Active JP7372392B2 (ja) | 2011-02-28 | 2022-05-25 | エンドトキシン測定剤 |
| JP2023180059A Active JP7590530B2 (ja) | 2011-02-28 | 2023-10-19 | エンドトキシン測定剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538748A Pending JP2014510898A (ja) | 2011-02-28 | 2012-02-28 | エンドトキシン測定剤 |
| JP2018074569A Active JP6640267B2 (ja) | 2011-02-28 | 2018-04-09 | エンドトキシン測定剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022085191A Active JP7372392B2 (ja) | 2011-02-28 | 2022-05-25 | エンドトキシン測定剤 |
| JP2023180059A Active JP7590530B2 (ja) | 2011-02-28 | 2023-10-19 | エンドトキシン測定剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US20140024062A1 (enExample) |
| EP (3) | EP3273244B1 (enExample) |
| JP (5) | JP2014510898A (enExample) |
| CN (2) | CN106432457A (enExample) |
| ES (2) | ES2763089T3 (enExample) |
| SG (3) | SG192578A1 (enExample) |
| WO (1) | WO2012118226A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2740791A1 (en) * | 2012-12-05 | 2014-06-11 | MicroCoat Biotechnologie GmbH | Method for recombinant production of horseshoe crab Factor C protein in protozoa |
| EP4219705A1 (en) | 2012-12-10 | 2023-08-02 | Seikagaku Corporation | Method for producing a recombinant factor c, method for mitigating reaction inhibition in endotoxin assays, and method for measuring endotoxin |
| CN109085357B (zh) | 2012-12-28 | 2021-09-21 | 生化学工业株式会社 | 付之鲎试验的抗凝血酶iii用的前处理剂及前处理方法 |
| JP6562765B2 (ja) * | 2015-08-13 | 2019-08-21 | 大日本印刷株式会社 | 電気化学式エンドトキシン濃度検出用容器、電極チップおよびエンドトキシンの検出方法 |
| JP6557090B2 (ja) * | 2015-08-13 | 2019-08-07 | 大日本印刷株式会社 | 電極チップおよび電極チップの製造方法 |
| WO2017131686A1 (en) * | 2016-01-28 | 2017-08-03 | Kimberly-Clark Worldwide, Inc. | Adherent composition for rna viruses and method of removing rna viruses from a surface |
| EP3418730A4 (en) | 2016-02-16 | 2019-10-30 | Seikagaku Corporation | ELECTROCHEMICAL MEASUREMENT USING A PHENYLENEDIAMINE DERIVATIVE |
| CN105866080B (zh) * | 2016-04-05 | 2019-11-12 | 中国科学院苏州生物医学工程技术研究所 | 重组鲎三因子试剂及其检测内毒素的方法 |
| CN109689681B (zh) * | 2016-10-18 | 2022-04-26 | 生化学工业株式会社 | 源自鲎属的重组蛋白及编码该重组蛋白的dna |
| CA3054780A1 (en) * | 2017-03-01 | 2018-09-07 | Seikagaku Corporation | Horseshoe crab factor b variant |
| CN108913707B (zh) * | 2018-07-23 | 2021-06-15 | 广东医科大学 | 一种特异性检测内毒素的试剂及其制备方法 |
| EP3862437A4 (en) | 2018-10-03 | 2022-07-06 | Seikagaku Corporation | METHOD OF INCREASING THE SENSITIVITY OF AN ENDOTOXIN DETECTION DEVICE |
| JPWO2021210669A1 (enExample) | 2020-04-16 | 2021-10-21 | ||
| FR3125336B1 (fr) * | 2021-07-19 | 2023-07-14 | Biomerieux Sa | Procédé de quantification d'endotoxines d'un échantillon biologique |
| JP7738073B2 (ja) | 2021-08-04 | 2025-09-11 | 生化学工業株式会社 | β－グルカン測定用試薬、その製造方法および使用 |
| CN114317504B (zh) * | 2021-12-28 | 2023-07-25 | 健帆生物科技集团股份有限公司 | 一种鲎因子c截短蛋白及其制备方法和应用 |
| AU2024283662A1 (en) * | 2023-06-05 | 2025-12-04 | Charles River Laboratories, Inc. | Recombinant amebocyte clotting factors and uses thereof |
| CN118581071B (zh) * | 2024-06-05 | 2025-10-10 | 郑州伊美诺生物技术有限公司 | 一种重组鲎试剂及其制备方法、应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK255887D0 (da) * | 1987-05-20 | 1987-05-20 | Claus Koch | Immunoassay |
| JP3322700B2 (ja) * | 1992-09-14 | 2002-09-09 | 生化学工業株式会社 | 固相系反応用エンドトキシン特異的測定剤 |
| JP3242733B2 (ja) * | 1993-02-26 | 2001-12-25 | 生化学工業株式会社 | エンドトキシン特異的測定剤 |
| JP3429036B2 (ja) * | 1993-09-30 | 2003-07-22 | 生化学工業株式会社 | エンドトキシンの特異的測定剤 |
| US5716834A (en) * | 1994-08-19 | 1998-02-10 | National University Of Singapore | Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme |
| US6645724B1 (en) * | 1997-09-19 | 2003-11-11 | National University Of Singapore | Assays for endotoxin |
| EP1015609B1 (en) * | 1997-09-19 | 2004-09-01 | National University Of Singapore | A novel generation of cloned horseshoe crab recombinant factor c for detection and removal of endotoxin |
| JP2005500520A (ja) | 2001-06-28 | 2005-01-06 | ケンブレックス バイオ サイエンス ウォカーズビル インコーポレーティッド | エンドトキシンを検出するための方法および試薬 |
| EP3190185A1 (en) * | 2006-07-07 | 2017-07-12 | Seikagaku Corporation | Pro-clotting enzyme, and method for detection of endotoxin or (1-3)-beta-d-glucan using the same |
| JP2011244760A (ja) * | 2010-05-28 | 2011-12-08 | Sumitomo Chemical Co Ltd | 生体組織再生を促進させる薬剤を製造するための加工細胞 |
| CN105866080B (zh) * | 2016-04-05 | 2019-11-12 | 中国科学院苏州生物医学工程技术研究所 | 重组鲎三因子试剂及其检测内毒素的方法 |
-
2012
- 2012-02-28 EP EP17190094.7A patent/EP3273244B1/en active Active
- 2012-02-28 SG SG2013055892A patent/SG192578A1/en unknown
- 2012-02-28 JP JP2013538748A patent/JP2014510898A/ja active Pending
- 2012-02-28 ES ES17190094T patent/ES2763089T3/es active Active
- 2012-02-28 US US14/001,138 patent/US20140024062A1/en not_active Abandoned
- 2012-02-28 ES ES12710808.2T patent/ES2650170T3/es active Active
- 2012-02-28 EP EP19160846.2A patent/EP3517962A1/en active Pending
- 2012-02-28 EP EP12710808.2A patent/EP2681564B1/en not_active Not-in-force
- 2012-02-28 SG SG10201601351WA patent/SG10201601351WA/en unknown
- 2012-02-28 CN CN201610799888.9A patent/CN106432457A/zh active Pending
- 2012-02-28 CN CN201280010708.4A patent/CN103562724B/zh active Active
- 2012-02-28 WO PCT/JP2012/055728 patent/WO2012118226A1/en not_active Ceased
- 2012-02-28 SG SG10202110031Y patent/SG10202110031YA/en unknown
-
2015
- 2015-05-05 US US14/704,230 patent/US20150252405A1/en not_active Abandoned
-
2016
- 2016-11-22 US US15/359,058 patent/US20170138945A1/en not_active Abandoned
-
2018
- 2018-04-09 JP JP2018074569A patent/JP6640267B2/ja active Active
- 2018-05-18 US US15/984,288 patent/US11162949B2/en active Active
-
2019
- 2019-12-25 JP JP2019233842A patent/JP2020100622A/ja active Pending
-
2021
- 2021-10-01 US US17/449,736 patent/US20220018841A1/en active Pending
-
2022
- 2022-05-25 JP JP2022085191A patent/JP7372392B2/ja active Active
-
2023
- 2023-10-19 JP JP2023180059A patent/JP7590530B2/ja active Active
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