JP2020079283A5 - - Google Patents
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- Publication number
- JP2020079283A5 JP2020079283A5 JP2020018408A JP2020018408A JP2020079283A5 JP 2020079283 A5 JP2020079283 A5 JP 2020079283A5 JP 2020018408 A JP2020018408 A JP 2020018408A JP 2020018408 A JP2020018408 A JP 2020018408A JP 2020079283 A5 JP2020079283 A5 JP 2020079283A5
- Authority
- JP
- Japan
- Prior art keywords
- solid preparation
- preparation according
- coating layer
- edible
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 claims 27
- 239000007787 solid Substances 0.000 claims 27
- 239000011247 coating layer Substances 0.000 claims 15
- 229920000642 polymer Polymers 0.000 claims 12
- 239000007884 disintegrant Substances 0.000 claims 10
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 8
- 239000000454 talc Substances 0.000 claims 8
- 229910052623 talc Inorganic materials 0.000 claims 8
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 8
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 7
- 229960003943 hypromellose Drugs 0.000 claims 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 5
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229960001681 croscarmellose sodium Drugs 0.000 claims 5
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 4
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 claims 2
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 2
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 229960005069 calcium Drugs 0.000 claims 2
- 235000001465 calcium Nutrition 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 229950008138 carmellose Drugs 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 235000012732 erythrosine Nutrition 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 claims 2
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 claims 2
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims 2
- 239000004611 light stabiliser Substances 0.000 claims 2
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 claims 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- -1 carboxymethyl ethyl Chemical group 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 claims 1
- WMVRXDZNYVJBAH-UHFFFAOYSA-N dioxoiron Chemical compound O=[Fe]=O WMVRXDZNYVJBAH-UHFFFAOYSA-N 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000007922 dissolution test Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 claims 1
- 229920002521 macromolecule Polymers 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- HTEAGOMAXMOFFS-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.COC(=O)C(C)=C HTEAGOMAXMOFFS-UHFFFAOYSA-N 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017222068 | 2017-11-17 | ||
| JP2017222068 | 2017-11-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549013A Division JP6660644B2 (ja) | 2017-11-17 | 2018-11-15 | 光安定性および溶出性に優れた医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020079283A JP2020079283A (ja) | 2020-05-28 |
| JP2020079283A5 true JP2020079283A5 (https=) | 2021-08-19 |
| JP7251891B2 JP7251891B2 (ja) | 2023-04-04 |
Family
ID=66540251
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549013A Active JP6660644B2 (ja) | 2017-11-17 | 2018-11-15 | 光安定性および溶出性に優れた医薬製剤 |
| JP2020018408A Active JP7251891B2 (ja) | 2017-11-17 | 2020-02-06 | 光安定性および溶出性に優れた医薬製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549013A Active JP6660644B2 (ja) | 2017-11-17 | 2018-11-15 | 光安定性および溶出性に優れた医薬製剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US12064438B2 (https=) |
| EP (2) | EP4650773A3 (https=) |
| JP (2) | JP6660644B2 (https=) |
| KR (1) | KR102562514B1 (https=) |
| CN (1) | CN111615390A (https=) |
| AR (1) | AR113890A1 (https=) |
| AU (1) | AU2018369241B2 (https=) |
| BR (1) | BR112020009634B1 (https=) |
| CA (2) | CA3299815A1 (https=) |
| ES (1) | ES3058136T3 (https=) |
| IL (1) | IL274625B (https=) |
| MX (1) | MX2020004680A (https=) |
| PL (1) | PL3711767T3 (https=) |
| TW (1) | TWI795462B (https=) |
| WO (1) | WO2019098259A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX395463B (es) * | 2018-04-24 | 2025-03-25 | Shionogi & Co | Forma de dosificacion solida que tiene excelente estabilidad |
| KR102501180B1 (ko) * | 2018-04-24 | 2023-02-21 | 시오노기세야쿠 가부시키가이샤 | 안정성이 우수한 고형 제제 |
| US20220008429A2 (en) * | 2019-03-22 | 2022-01-13 | Shionogi & Co., Ltd. | Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a severe influenza condition |
| EP3714889A1 (en) * | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Baloxavir for the prevention of transmission of influenza virus |
| WO2021038480A1 (en) * | 2019-08-27 | 2021-03-04 | Janssen Pharmaceuticals, Inc. | Combinations for treating influenza virus |
| WO2021084725A1 (ja) * | 2019-10-31 | 2021-05-06 | フジデノロ株式会社 | 検出装置、磁気組成物、及び、管理システム |
| CN111647005A (zh) * | 2020-06-15 | 2020-09-11 | 安徽皓元药业有限公司 | 巴洛沙韦新晶型及其制备方法 |
| JP7557863B2 (ja) * | 2020-10-12 | 2024-09-30 | 共和薬品工業株式会社 | イストラデフィリン含有医薬組成物 |
| CN112730682B (zh) * | 2020-12-25 | 2022-06-17 | 苏州海科医药技术有限公司 | 一种抗病毒药物临床研究血浆样本中奥司他韦及代谢物奥司他韦酸浓度的生物分析方法 |
| CN114306261A (zh) * | 2021-12-15 | 2022-04-12 | 澳美制药(苏州)有限公司 | 巴洛沙韦酯片及其制备方法 |
| CN116036035A (zh) * | 2023-02-28 | 2023-05-02 | 山东诚创蓝海医药科技有限公司 | 一种不含二氧化钛的富马酸伏诺拉生片剂制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2759293B1 (fr) | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| DE19831869A1 (de) * | 1998-07-16 | 2000-01-20 | Merck Patent Gmbh | Farbgebung mit Perlglanzpigmenten im Lebensmittel- und Pharmabereich |
| KR100891887B1 (ko) | 2001-01-29 | 2009-04-03 | 시오노기세이야쿠가부시키가이샤 | 5-메틸-1-페닐-2-(1ｈ)-피리돈을 활성 성분으로서 함유하는의약 제제 |
| WO2003057668A1 (en) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Nitrogenous cyclic ketone derivative, process for producing the same, and use |
| SE0203778D0 (sv) | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | A new oral immediated release dosage form |
| WO2004091600A1 (ja) * | 2003-04-16 | 2004-10-28 | Kyorin Pharmaceutical Co., Ltd. | 経口固形製剤 |
| PT1944029E (pt) | 2005-10-31 | 2012-02-09 | Nissan Chemical Ind Ltd | Preparação farmacêutica com excelente fotoestabilidade |
| TWI404726B (zh) * | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| JP2008201712A (ja) | 2007-02-20 | 2008-09-04 | Ss Pharmaceut Co Ltd | フィルムコーティング製剤 |
| WO2008114859A1 (ja) | 2007-03-22 | 2008-09-25 | Astellas Pharma Inc. | ピラゾール誘導体を含有する医薬組成物 |
| EP2320909B8 (en) | 2008-07-25 | 2016-03-30 | VIIV Healthcare Company | Chemical compounds |
| JP5644167B2 (ja) | 2009-04-21 | 2014-12-24 | 大正製薬株式会社 | 溶出改善されたケトチフェン又はその塩を含有する固形製剤 |
| US20110009347A1 (en) * | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| CA2770077A1 (en) * | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| EP2590631B1 (en) * | 2010-07-06 | 2016-10-26 | Janssen Pharmaceutica NV | Formulation for co-therapy treatment of diabetes |
| JP4803686B2 (ja) * | 2010-08-31 | 2011-10-26 | 協和発酵キリン株式会社 | 苦味を呈する薬物を含有する顆粒および口腔内崩壊錠 |
| CN103687596B (zh) | 2011-04-22 | 2016-08-17 | 安斯泰来制药有限公司 | 固态医药组合物 |
| CA2835364C (en) | 2011-05-20 | 2018-10-02 | Astrazeneca Uk Limited | Pharmaceutical composition of rosuvastatin calcium |
| JP5553132B2 (ja) * | 2011-09-30 | 2014-07-16 | アステラス製薬株式会社 | 粒子状医薬組成物 |
| US9827200B2 (en) | 2012-04-24 | 2017-11-28 | Daiichi Sankyo Company, Limited | Orally disintegrating tablet and production process therefor |
| JP2015054822A (ja) | 2013-09-10 | 2015-03-23 | ニプロ株式会社 | クロピドグレル含有錠剤およびその製造方法 |
| JP2015054851A (ja) | 2013-09-13 | 2015-03-23 | 大鵬薬品工業株式会社 | 被覆経口固形製剤 |
| CN105899232A (zh) * | 2013-11-13 | 2016-08-24 | 诺华股份有限公司 | 用于增强免疫应答的mTOR抑制剂 |
| US10287354B2 (en) * | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| BR112017022550B1 (pt) | 2015-04-28 | 2021-02-23 | Shionogi & Co., Ltd | derivados policíclicos de piridona substituída |
| WO2016204291A1 (ja) * | 2015-06-18 | 2016-12-22 | 共同印刷株式会社 | ブリスターパック用積層体、及びそれを用いたブリスターパック |
| AU2016374416A1 (en) * | 2015-12-15 | 2018-06-14 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| KR102501180B1 (ko) | 2018-04-24 | 2023-02-21 | 시오노기세야쿠 가부시키가이샤 | 안정성이 우수한 고형 제제 |
-
2018
- 2018-11-13 TW TW107140226A patent/TWI795462B/zh active
- 2018-11-15 US US16/764,067 patent/US12064438B2/en active Active
- 2018-11-15 AU AU2018369241A patent/AU2018369241B2/en active Active
- 2018-11-15 MX MX2020004680A patent/MX2020004680A/es unknown
- 2018-11-15 ES ES18877429T patent/ES3058136T3/es active Active
- 2018-11-15 KR KR1020207016914A patent/KR102562514B1/ko active Active
- 2018-11-15 JP JP2019549013A patent/JP6660644B2/ja active Active
- 2018-11-15 CA CA3299815A patent/CA3299815A1/en active Pending
- 2018-11-15 CN CN201880086457.5A patent/CN111615390A/zh active Pending
- 2018-11-15 CA CA3082522A patent/CA3082522A1/en active Pending
- 2018-11-15 EP EP25206613.9A patent/EP4650773A3/en active Pending
- 2018-11-15 BR BR112020009634-2A patent/BR112020009634B1/pt active IP Right Grant
- 2018-11-15 IL IL274625A patent/IL274625B/en unknown
- 2018-11-15 EP EP18877429.3A patent/EP3711767B1/en active Active
- 2018-11-15 PL PL18877429.3T patent/PL3711767T3/pl unknown
- 2018-11-15 WO PCT/JP2018/042220 patent/WO2019098259A1/ja not_active Ceased
- 2018-11-16 AR ARP180103378A patent/AR113890A1/es unknown
-
2020
- 2020-02-06 JP JP2020018408A patent/JP7251891B2/ja active Active
-
2024
- 2024-07-15 US US18/772,892 patent/US20240366622A1/en active Pending
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