JP2020033359A5 - - Google Patents
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- Publication number
- JP2020033359A5 JP2020033359A5 JP2019186901A JP2019186901A JP2020033359A5 JP 2020033359 A5 JP2020033359 A5 JP 2020033359A5 JP 2019186901 A JP2019186901 A JP 2019186901A JP 2019186901 A JP2019186901 A JP 2019186901A JP 2020033359 A5 JP2020033359 A5 JP 2020033359A5
- Authority
- JP
- Japan
- Prior art keywords
- buprenorphine
- crystalline form
- admixture
- salt
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960001736 buprenorphine Drugs 0.000 claims 21
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 7
- 239000012458 free base Substances 0.000 claims 7
- -1 buprenorphine acetate salt Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000013078 crystal Substances 0.000 claims 5
- 238000001914 filtration Methods 0.000 claims 5
- 238000004090 dissolution Methods 0.000 claims 4
- 230000007704 transition Effects 0.000 claims 4
- 159000000021 acetate salts Chemical class 0.000 claims 3
- 239000012296 anti-solvent Substances 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000004685 tetrahydrates Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131114P | 2015-03-10 | 2015-03-10 | |
| US62/131,114 | 2015-03-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547399A Division JP6660399B2 (ja) | 2015-03-10 | 2016-03-09 | ブプレノルフィンの酢酸塩及びブプレノルフィンの調製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020033359A JP2020033359A (ja) | 2020-03-05 |
| JP2020033359A5 true JP2020033359A5 (https=) | 2020-04-16 |
Family
ID=55524412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547399A Expired - Fee Related JP6660399B2 (ja) | 2015-03-10 | 2016-03-09 | ブプレノルフィンの酢酸塩及びブプレノルフィンの調製方法 |
| JP2019186901A Pending JP2020033359A (ja) | 2015-03-10 | 2019-10-10 | ブプレノルフィンの酢酸塩及びブプレノルフィンの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547399A Expired - Fee Related JP6660399B2 (ja) | 2015-03-10 | 2016-03-09 | ブプレノルフィンの酢酸塩及びブプレノルフィンの調製方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US10406152B2 (https=) |
| EP (1) | EP3283490A1 (https=) |
| JP (2) | JP6660399B2 (https=) |
| KR (2) | KR20200045010A (https=) |
| CN (1) | CN107660207B (https=) |
| AR (1) | AR103902A1 (https=) |
| AU (2) | AU2016230750B2 (https=) |
| BR (1) | BR112017019357A2 (https=) |
| CA (2) | CA2977732C (https=) |
| CO (1) | CO2017009130A2 (https=) |
| EA (1) | EA201792014A1 (https=) |
| IL (1) | IL254384A0 (https=) |
| MA (1) | MA45902A (https=) |
| MX (1) | MX2017011606A (https=) |
| NZ (1) | NZ735736A (https=) |
| PH (1) | PH12017501641A1 (https=) |
| SG (1) | SG11201707350TA (https=) |
| TW (2) | TW202037597A (https=) |
| WO (1) | WO2016142877A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105247038B (zh) | 2013-03-15 | 2021-08-27 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)的微生物及其制备和使用方法 |
| CN112410379B (zh) | 2013-11-04 | 2024-12-31 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法 |
| CN107660207B (zh) | 2015-03-10 | 2020-09-29 | 罗德科技公司 | 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 |
| EP3292203A4 (en) | 2015-05-04 | 2019-10-09 | The Board of Trustees of the Leland Stanford Junior University | BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof |
| WO2016183023A1 (en) | 2015-05-08 | 2016-11-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of producing epimerases and benzylisoquinoline alkaloids |
| BR112019007884A2 (pt) | 2016-10-18 | 2019-07-02 | Antheia Inc | métodos para a produção de alcaloides nor-opioides e nal-opioides de benzilisoquinolina |
| GB2579940B (en) | 2017-08-03 | 2022-11-30 | Antheia Inc | Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids |
| BR112020016576A2 (pt) * | 2018-05-11 | 2020-12-15 | Alar Pharmaceuticals Inc. | Formulações injetáveis de ação prolongada e formas cristalinas de derivados de buprenorfina |
| CN113784758B (zh) | 2019-03-08 | 2025-03-07 | 小利兰·斯坦福大学托管委员会 | 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法 |
| IL317873A (en) * | 2022-06-24 | 2025-02-01 | Alar Pharmaceuticals Inc | Stable pharmaceutical composition of buprenorphine and method of preparation and use thereof |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
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| GB1312447A (en) | 1969-05-14 | 1973-04-04 | Nat Res Dev | Method of continuous addition of a component to a chemical or biological system and apparatus therefor |
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| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
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| CA2002299A1 (en) * | 1988-11-10 | 1990-05-10 | Eugene G. Drust | Compositions for the transdermal delivery of buprenorphine salts |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
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| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
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-
2016
- 2016-03-09 CN CN201680027202.2A patent/CN107660207B/zh not_active Expired - Fee Related
- 2016-03-09 WO PCT/IB2016/051332 patent/WO2016142877A1/en not_active Ceased
- 2016-03-09 CA CA2977732A patent/CA2977732C/en not_active Expired - Fee Related
- 2016-03-09 EP EP16709607.2A patent/EP3283490A1/en not_active Withdrawn
- 2016-03-09 MA MA045902A patent/MA45902A/fr unknown
- 2016-03-09 NZ NZ735736A patent/NZ735736A/en not_active IP Right Cessation
- 2016-03-09 JP JP2017547399A patent/JP6660399B2/ja not_active Expired - Fee Related
- 2016-03-09 US US15/507,453 patent/US10406152B2/en active Active
- 2016-03-09 MX MX2017011606A patent/MX2017011606A/es unknown
- 2016-03-09 KR KR1020207011729A patent/KR20200045010A/ko not_active Ceased
- 2016-03-09 AU AU2016230750A patent/AU2016230750B2/en not_active Ceased
- 2016-03-09 KR KR1020177028535A patent/KR20170137738A/ko not_active Ceased
- 2016-03-09 BR BR112017019357A patent/BR112017019357A2/pt not_active IP Right Cessation
- 2016-03-09 SG SG11201707350TA patent/SG11201707350TA/en unknown
- 2016-03-09 EA EA201792014A patent/EA201792014A1/ru unknown
- 2016-03-09 CA CA3104099A patent/CA3104099A1/en not_active Abandoned
- 2016-03-10 AR ARP160100641A patent/AR103902A1/es unknown
- 2016-03-10 TW TW109106564A patent/TW202037597A/zh unknown
- 2016-03-10 TW TW105107434A patent/TWI699367B/zh not_active IP Right Cessation
-
2017
- 2017-03-01 US US15/446,197 patent/US9926329B2/en active Active
- 2017-09-07 CO CONC2017/0009130A patent/CO2017009130A2/es unknown
- 2017-09-07 IL IL254384A patent/IL254384A0/en unknown
- 2017-09-08 PH PH12017501641A patent/PH12017501641A1/en unknown
-
2018
- 2018-02-12 US US15/894,520 patent/US10278967B2/en active Active
-
2019
- 2019-05-10 AU AU2019203308A patent/AU2019203308A1/en not_active Abandoned
- 2019-06-19 US US16/446,397 patent/US10874662B2/en active Active
- 2019-06-19 US US16/446,373 patent/US10835528B2/en active Active
- 2019-10-10 JP JP2019186901A patent/JP2020033359A/ja active Pending
-
2020
- 2020-10-29 US US17/084,588 patent/US20210046066A1/en not_active Abandoned
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