BR112017019357A2 - sal acetato de buprenorfina e métodos para preparar buprenorfina - Google Patents

sal acetato de buprenorfina e métodos para preparar buprenorfina

Info

Publication number
BR112017019357A2
BR112017019357A2 BR112017019357A BR112017019357A BR112017019357A2 BR 112017019357 A2 BR112017019357 A2 BR 112017019357A2 BR 112017019357 A BR112017019357 A BR 112017019357A BR 112017019357 A BR112017019357 A BR 112017019357A BR 112017019357 A2 BR112017019357 A2 BR 112017019357A2
Authority
BR
Brazil
Prior art keywords
buprenorphine
preparing
methods
acetate salt
acetate salts
Prior art date
Application number
BR112017019357A
Other languages
English (en)
Inventor
Sharma Archana
Wayne Kataisto Erik
Huntley Frederick
Alfred REISCH Helge
Larry STYMIEST Jake
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of BR112017019357A2 publication Critical patent/BR112017019357A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

a presente divulgação proporciona sais acetato de buprenorfina e seus anidratos, solvatos, hidratos e formas cristalinas dos mesmos, onde os sais acetato de buprenorfina são essencialmente isentos de impurezas. a divulgação proporciona ainda um método de preparação de sais acetato, base livre de buprenorfina preparada a partir dos sais acetato, outros sais preparados a partir da base livre e composições farmacêuticas dos mesmos essencialmente isentas de impurezas.
BR112017019357A 2015-03-10 2016-03-09 sal acetato de buprenorfina e métodos para preparar buprenorfina BR112017019357A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
PCT/IB2016/051332 WO2016142877A1 (en) 2015-03-10 2016-03-09 Acetate salt of buprenorphine and methods for preparing buprenorphine

Publications (1)

Publication Number Publication Date
BR112017019357A2 true BR112017019357A2 (pt) 2018-06-05

Family

ID=55524412

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017019357A BR112017019357A2 (pt) 2015-03-10 2016-03-09 sal acetato de buprenorfina e métodos para preparar buprenorfina

Country Status (19)

Country Link
US (6) US10406152B2 (pt)
EP (1) EP3283490A1 (pt)
JP (2) JP6660399B2 (pt)
KR (2) KR20200045010A (pt)
CN (1) CN107660207B (pt)
AR (1) AR103902A1 (pt)
AU (2) AU2016230750B2 (pt)
BR (1) BR112017019357A2 (pt)
CA (2) CA2977732C (pt)
CO (1) CO2017009130A2 (pt)
EA (1) EA201792014A1 (pt)
IL (1) IL254384A0 (pt)
MA (1) MA45902A (pt)
MX (1) MX2017011606A (pt)
NZ (1) NZ735736A (pt)
PH (1) PH12017501641A1 (pt)
SG (1) SG11201707350TA (pt)
TW (2) TWI699367B (pt)
WO (1) WO2016142877A1 (pt)

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US11124814B2 (en) 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
EP3283490A1 (en) 2015-03-10 2018-02-21 Rhodes Technologies Inc. Acetate salt of buprenorphine and methods for preparing buprenorphine
CA2983419A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
EP4253525A3 (en) 2015-05-08 2023-10-18 The Board of Trustees of the Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
KR20190084262A (ko) 2016-10-18 2019-07-16 앤테이아 인코포레이티드 노르-오피오이드 및 날-오피오이드 벤질이소퀴놀린 알칼로이드를 생산하는 방법
JP7199417B2 (ja) 2017-08-03 2023-01-05 アンテイア インコーポレイテッド 遺伝子操作されたベンジルイソキノリンアルカロイドエピメラーゼおよびベンジルイソキノリンアルカロイドの生成方法
CN111954672B (zh) 2018-05-11 2023-09-01 昱展新药生技股份有限公司 丁丙诺啡衍生物的长效注射制剂及结晶形式
TW202416980A (zh) * 2022-06-24 2024-05-01 昱展新藥生技股份有限公司 丁基原啡因的穩定醫藥組成物、其製備方法及其用途

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Also Published As

Publication number Publication date
CA2977732A1 (en) 2016-09-15
US20180162866A1 (en) 2018-06-14
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
PH12017501641A1 (en) 2018-02-12
AU2016230750B2 (en) 2019-05-30
JP2018507882A (ja) 2018-03-22
CN107660207B (zh) 2020-09-29
WO2016142877A1 (en) 2016-09-15
MX2017011606A (es) 2017-10-26
KR20170137738A (ko) 2017-12-13
AR103902A1 (es) 2017-06-14
NZ735736A (en) 2019-02-22
CA2977732C (en) 2021-02-23
US20190298713A1 (en) 2019-10-03
US20210046066A1 (en) 2021-02-18
CN107660207A (zh) 2018-02-02
JP2020033359A (ja) 2020-03-05
CA3104099A1 (en) 2016-09-15
CO2017009130A2 (es) 2017-11-21
IL254384A0 (en) 2017-11-30
JP6660399B2 (ja) 2020-03-11
US20190314364A1 (en) 2019-10-17
US9926329B2 (en) 2018-03-27
US20170197975A1 (en) 2017-07-13
US10406152B2 (en) 2019-09-10
US10278967B2 (en) 2019-05-07
KR20200045010A (ko) 2020-04-29
TWI699367B (zh) 2020-07-21
US20180235955A1 (en) 2018-08-23
AU2019203308A1 (en) 2019-05-30
US10874662B2 (en) 2020-12-29
EP3283490A1 (en) 2018-02-21
AU2016230750A1 (en) 2017-10-12
MA45902A (fr) 2019-06-19
TW201639856A (zh) 2016-11-16
TW202037597A (zh) 2020-10-16
EA201792014A1 (ru) 2018-01-31

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2661 DE 04-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.