JP2019537570A5 - - Google Patents
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- Publication number
- JP2019537570A5 JP2019537570A5 JP2019520525A JP2019520525A JP2019537570A5 JP 2019537570 A5 JP2019537570 A5 JP 2019537570A5 JP 2019520525 A JP2019520525 A JP 2019520525A JP 2019520525 A JP2019520525 A JP 2019520525A JP 2019537570 A5 JP2019537570 A5 JP 2019537570A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- formula
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- WDHOIABIERMLGY-CMJOXMDJSA-N N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine Chemical compound FCCCN1CC(C1)NC=1C=NC(=CC=1)[C@H]1N([C@@H](CC2=C3C(=CC=C12)NN=C3)C)CC(F)(F)F WDHOIABIERMLGY-CMJOXMDJSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 201000010255 female reproductive organ cancer Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000003566 oxetanyl group Chemical group 0.000 description 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662411799P | 2016-10-24 | 2016-10-24 | |
| US62/411,799 | 2016-10-24 | ||
| US201662435159P | 2016-12-16 | 2016-12-16 | |
| US62/435,159 | 2016-12-16 | ||
| PCT/EP2017/076191 WO2018077630A1 (en) | 2016-10-24 | 2017-10-13 | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020129457A Division JP6993477B2 (ja) | 2016-10-24 | 2020-07-30 | 癌の治療において有用な６，７，８，９－テトラヒドロ－３Ｈ－ピラゾロ［４，３－ｆ］イソキノリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537570A JP2019537570A (ja) | 2019-12-26 |
| JP2019537570A5 true JP2019537570A5 (cg-RX-API-DMAC10.html) | 2020-04-30 |
| JP6744489B2 JP6744489B2 (ja) | 2020-08-19 |
Family
ID=60083331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520525A Active JP6744489B2 (ja) | 2016-10-24 | 2017-10-13 | 癌の治療において有用な６，７，８，９−テトラヒドロ−３Ｈ−ピラゾロ［４，３−ｆ］イソキノリン誘導体 |
| JP2020129457A Active JP6993477B2 (ja) | 2016-10-24 | 2020-07-30 | 癌の治療において有用な６，７，８，９－テトラヒドロ－３Ｈ－ピラゾロ［４，３－ｆ］イソキノリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020129457A Active JP6993477B2 (ja) | 2016-10-24 | 2020-07-30 | 癌の治療において有用な６，７，８，９－テトラヒドロ－３Ｈ－ピラゾロ［４，３－ｆ］イソキノリン誘導体 |
Country Status (36)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IL310489A (en) | 2015-10-01 | 2024-03-01 | Olema Pharmaceuticals Inc | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS AND COMPOSITIONS COMPRISING SAME FOR USE IN TREATING CANCER |
| JP7241542B2 (ja) * | 2016-04-08 | 2023-03-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | テトラヒドロイソキノリン エストロゲン受容体モジュレーター及びその使用 |
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| WO2019002441A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| WO2019002442A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| NZ764463A (en) * | 2017-11-14 | 2023-07-28 | Kind Pharmaceutical | Heterocyclic compound and application thereof in medicine |
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| KR102754524B1 (ko) | 2018-08-17 | 2025-01-13 | 제넨테크, 인크. | 유방암 치료를 위한 진단 및 치료 방법들 |
| CN109053524A (zh) * | 2018-09-11 | 2018-12-21 | 山东谛爱生物技术有限公司 | 一种N-Boc-3-羟基氮杂环丁烷的制备方法 |
| KR20220034129A (ko) | 2019-07-07 | 2022-03-17 | 올레마 파마슈티컬스 인코포레이티드 | 에스트로겐 수용체 길항제 요법 |
| NZ790033A (en) * | 2019-12-20 | 2025-09-26 | Recurium Ip Holdings Llc | Combinations |
| KR20220125272A (ko) | 2020-01-10 | 2022-09-14 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 트리사이클릭 테트라하이드로이소퀴놀린 유도체, 이를 제조하기 위한 방법 및 의료분야에서 이의 용도 |
| EP4138787A1 (en) * | 2020-04-24 | 2023-03-01 | Astrazeneca AB | Pharmaceutical formulations |
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| JP7720906B2 (ja) * | 2020-05-15 | 2025-08-08 | シムサー ファーマシューティカル カンパニー リミテッド | ピロリジン化合物及びその使用 |
| TW202214626A (zh) * | 2020-06-12 | 2022-04-16 | 大陸商江蘇先聲藥業有限公司 | 雌激素受體調節劑化合物及其用途 |
| WO2022001971A1 (zh) * | 2020-06-28 | 2022-01-06 | 南京明德新药研发有限公司 | 并环吲唑类化合物 |
| CN114105977B (zh) * | 2020-08-28 | 2023-09-01 | 先声再明医药有限公司 | 雌激素受体调节剂化合物及其用途 |
| KR20220107752A (ko) | 2021-01-26 | 2022-08-02 | 충북대학교 산학협력단 | 피라졸로퀴놀린 유도체 및 이의 항암제로서의 용도 |
| CN116669729A (zh) * | 2021-02-08 | 2023-08-29 | 贝达药业股份有限公司 | 杂芳基并哌啶类衍生物及其药物组合物和应用 |
| EP4304590A1 (en) | 2021-03-11 | 2024-01-17 | Janssen Pharmaceutica NV | Lorpucitinib for use in the treatment of jak mediated disorders |
| US12410155B2 (en) | 2021-12-28 | 2025-09-09 | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. | Salt form and crystal form of tetrahydrocyclohepta indazole compound |
| EP4604957A1 (en) | 2022-10-17 | 2025-08-27 | Astrazeneca AB | Combinations of a serd for the treatment of cancer |
| CN120187416A (zh) | 2022-11-11 | 2025-06-20 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的组合疗法 |
| US20240180893A1 (en) | 2022-11-17 | 2024-06-06 | Astrazeneca Ab | Methods of treatment of breast cancer |
| WO2024231548A1 (en) | 2023-05-11 | 2024-11-14 | Astrazeneca Ab | Combination of a parp1 inhibitor and a selective estrogen degrader for treating cancer |
| WO2025175249A1 (en) * | 2024-02-14 | 2025-08-21 | Olema Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
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2017
- 2017-10-13 JO JOP/2019/0090A patent/JOP20190090B1/ar active
- 2017-10-13 EP EP19189010.2A patent/EP3640251B1/en active Active
- 2017-10-13 AU AU2017349797A patent/AU2017349797B2/en active Active
- 2017-10-13 ES ES19189010T patent/ES2907759T3/es active Active
- 2017-10-13 HU HUE17783857A patent/HUE045714T2/hu unknown
- 2017-10-13 SG SG11201903182XA patent/SG11201903182XA/en unknown
- 2017-10-13 SM SM20190602T patent/SMT201900602T1/it unknown
- 2017-10-13 HU HUE19189010A patent/HUE057524T2/hu unknown
- 2017-10-13 CN CN202210381693.8A patent/CN114656464B/zh active Active
- 2017-10-13 SI SI201730111T patent/SI3433256T1/sl unknown
- 2017-10-13 PT PT177838570T patent/PT3433256T/pt unknown
- 2017-10-13 PL PL17783857T patent/PL3433256T3/pl unknown
- 2017-10-13 US US15/782,904 patent/US10131663B2/en active Active
- 2017-10-13 LT LTEP19189010.2T patent/LT3640251T/lt unknown
- 2017-10-13 HR HRP20220255TT patent/HRP20220255T1/hr unknown
- 2017-10-13 MY MYPI2019002161A patent/MY205300A/en unknown
- 2017-10-13 LT LT17783857T patent/LT3433256T/lt unknown
- 2017-10-13 WO PCT/EP2017/076191 patent/WO2018077630A1/en not_active Ceased
- 2017-10-13 ES ES17783857T patent/ES2751902T3/es active Active
- 2017-10-13 JP JP2019520525A patent/JP6744489B2/ja active Active
- 2017-10-13 KR KR1020197014062A patent/KR102178692B1/ko active Active
- 2017-10-13 MX MX2019004685A patent/MX382331B/es unknown
- 2017-10-13 RS RSP20191371 patent/RS59445B1/sr unknown
- 2017-10-13 ME MEP-2019-306A patent/ME03547B/me unknown
- 2017-10-13 CR CR20190204A patent/CR20190204A/es unknown
- 2017-10-13 TW TW106135012A patent/TWI735681B/zh active
- 2017-10-13 PT PT191890102T patent/PT3640251T/pt unknown
- 2017-10-13 UA UAA201905126A patent/UA125824C2/uk unknown
- 2017-10-13 EP EP17783857.0A patent/EP3433256B1/en active Active
- 2017-10-13 SM SM20220098T patent/SMT202200098T1/it unknown
- 2017-10-13 NZ NZ753459A patent/NZ753459A/en unknown
- 2017-10-13 DK DK17783857T patent/DK3433256T3/da active
- 2017-10-13 CN CN201780064567.7A patent/CN109843888B/zh active Active
- 2017-10-13 PE PE2019000845A patent/PE20191078A1/es unknown
- 2017-10-13 SI SI201731087T patent/SI3640251T1/sl unknown
- 2017-10-13 DK DK19189010.2T patent/DK3640251T3/da active
- 2017-10-13 PL PL19189010T patent/PL3640251T3/pl unknown
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2018
- 2018-10-09 US US16/155,041 patent/US10590130B2/en active Active
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2019
- 2019-02-01 ZA ZA2019/00694A patent/ZA201900694B/en unknown
- 2019-04-16 PH PH12019500830A patent/PH12019500830A1/en unknown
- 2019-04-18 CO CONC2019/0003950A patent/CO2019003950A2/es unknown
- 2019-04-18 CL CL2019001077A patent/CL2019001077A1/es unknown
- 2019-04-22 IL IL266245A patent/IL266245B/en active IP Right Grant
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