SG11201903182XA - 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer - Google Patents
6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancerInfo
- Publication number
- SG11201903182XA SG11201903182XA SG11201903182XA SG11201903182XA SG11201903182XA SG 11201903182X A SG11201903182X A SG 11201903182XA SG 11201903182X A SG11201903182X A SG 11201903182XA SG 11201903182X A SG11201903182X A SG 11201903182XA SG 11201903182X A SG11201903182X A SG 11201903182XA
- Authority
- SG
- Singapore
- Prior art keywords
- cambridge
- building
- astrazeneca
- owg
- darwin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Lin (CouNR? ° 8000 6000 4000 2000 W O 20 18/077 630 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 03 May 2018 (03.05.2018) WIPO I PCT ~~ll~~~~~~~~ 011101110VIIIOH olo olomo milo111110 Elio ow (10) International Publication Number WO 2018/077630 Al L 10 (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/497 (2006.01) A61K 31/4738 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2017/076191 (22) International Filing Date: 13 October 2017 (13.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/411,799 24 October 2016 (24.10.2016) US 62/435,159 16 December 2016 (16.12.2016) US (71) Applicant: ASTRAZENECA AB [SE/SE]; SE-151 85 Sodertalje (SE). (72) Inventors: SCOTT, James, Stewart; AstraZeneca Dar- win Building, Cambridge Science Park, Milton Road Cambridge CB4 OWG (GB). BARLAAM, Bernard, Christophe; AstraZeneca, Darwin Building Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 OWG (GB). YANG, Bin; AstraZeneca 35 Gatehouse Drive, Waltham, MA 02451 (US). MOSS, Thomas, An- drew; AstraZeneca, Darwin Building Darwin Building, Cambridge Science Park, Milton Road Cambridgeshire CB4 OWG (GB). HUGHES, Samantha, Jayne; As- traZeneca Darwin Building, Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 OWG (GB). NISSINK, Johannes, Wilhelmus, Maria; As- traZeneca, Darwin Building Cambridge Science Park, Mil- ton Road, Cambridge Canbridgeshire CB4 OWG (GB). O'DONOVAN, Daniel, Hillebrand; AstraZeneca Darwin Building, Cambridge Science Park, Milton Road, Cam- bridge Cambridgeshire CB4 OWG (GB). (74) Agent: COOK, Andrew, James; AstraZeneca Milstein Building, Cambridge Cambridgeshire CB21 6GH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (54) Title: 6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[4,3-F]ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER (57) : The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermedi- ates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders. (I) Figure 1: X-Ray Ponder Diffraction Pattern for Form A of 13-043- finoropropyhamtiffin 3 yl) 6 ((6S,8R) 8 methyl 7 (2,2,2 trifluoroethyl)-6,7,8.8- lelrahydro-311-pyrazoloi4,3-flisoquinolin-6-ylipyridin-3-amine 16000 14000 20 2-Theta - Scale [Continued on next page] WO 2018/077630 Al IMEDIMOM0101011MERI00 IIEMEHIIIIHMEDIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art. 21(3))
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662411799P | 2016-10-24 | 2016-10-24 | |
| US201662435159P | 2016-12-16 | 2016-12-16 | |
| PCT/EP2017/076191 WO2018077630A1 (en) | 2016-10-24 | 2017-10-13 | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201903182XA true SG11201903182XA (en) | 2019-05-30 |
Family
ID=60083331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201903182XA SG11201903182XA (en) | 2016-10-24 | 2017-10-13 | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US10131663B2 (en) |
| EP (2) | EP3640251B1 (en) |
| JP (2) | JP6744489B2 (en) |
| KR (1) | KR102178692B1 (en) |
| CN (2) | CN114656464A (en) |
| AU (1) | AU2017349797B2 (en) |
| BR (1) | BR112019007393A2 (en) |
| CA (1) | CA3040040A1 (en) |
| CL (1) | CL2019001077A1 (en) |
| CO (1) | CO2019003950A2 (en) |
| CR (1) | CR20190204A (en) |
| CY (1) | CY1122566T1 (en) |
| DK (2) | DK3640251T3 (en) |
| DO (1) | DOP2019000104A (en) |
| EC (1) | ECSP19028657A (en) |
| ES (2) | ES2907759T3 (en) |
| HR (1) | HRP20220255T1 (en) |
| HU (2) | HUE057524T2 (en) |
| IL (1) | IL266245B (en) |
| JO (1) | JOP20190090B1 (en) |
| LT (2) | LT3640251T (en) |
| ME (1) | ME03547B (en) |
| MX (1) | MX2019004685A (en) |
| NI (1) | NI201900039A (en) |
| NZ (1) | NZ753459A (en) |
| PE (1) | PE20191078A1 (en) |
| PH (1) | PH12019500830A1 (en) |
| PL (2) | PL3640251T3 (en) |
| PT (2) | PT3433256T (en) |
| RS (1) | RS59445B1 (en) |
| SG (1) | SG11201903182XA (en) |
| SI (2) | SI3433256T1 (en) |
| TW (1) | TWI735681B (en) |
| UA (1) | UA125824C2 (en) |
| WO (1) | WO2018077630A1 (en) |
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| JP7241542B2 (en) * | 2016-04-08 | 2023-03-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof |
| US10125135B2 (en) | 2016-04-20 | 2018-11-13 | Astrazeneca Ab | Chemical compounds |
| TW201815789A (en) | 2016-07-25 | 2018-05-01 | 瑞典商阿斯特捷利康公司 | Chemical compounds |
| HUE057524T2 (en) | 2016-10-24 | 2022-05-28 | Astrazeneca Ab | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer |
| UA125042C2 (en) | 2016-12-16 | 2021-12-29 | Янссен Фармацевтика Нв | Small molecule inhibitors of the jak family of kinases |
| CN110248932B (en) | 2016-12-16 | 2023-03-10 | 里亚塔医药公司 | Pyrimidine tricycloalkenone derivatives for ROR γ inhibition and other uses |
| JOP20190144A1 (en) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the jak family of kinases |
| SI3494116T1 (en) | 2017-01-30 | 2020-02-28 | Astrazeneca Ab | Estrogen receptor modulators |
| WO2019002441A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | Chemical compounds |
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| US11236088B2 (en) | 2017-11-14 | 2022-02-01 | Kind Pharmaceutical | Heterocyclic compounds and their application in medicine |
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2017
- 2017-10-13 HU HUE19189010A patent/HUE057524T2/en unknown
- 2017-10-13 PL PL19189010T patent/PL3640251T3/en unknown
- 2017-10-13 HU HUE17783857A patent/HUE045714T2/en unknown
- 2017-10-13 CN CN202210381693.8A patent/CN114656464A/en active Pending
- 2017-10-13 TW TW106135012A patent/TWI735681B/en active
- 2017-10-13 MX MX2019004685A patent/MX2019004685A/en unknown
- 2017-10-13 RS RSP20191371 patent/RS59445B1/en unknown
- 2017-10-13 US US15/782,904 patent/US10131663B2/en active Active
- 2017-10-13 JO JOP/2019/0090A patent/JOP20190090B1/en active
- 2017-10-13 SG SG11201903182XA patent/SG11201903182XA/en unknown
- 2017-10-13 SI SI201730111T patent/SI3433256T1/en unknown
- 2017-10-13 NZ NZ753459A patent/NZ753459A/en unknown
- 2017-10-13 DK DK19189010.2T patent/DK3640251T3/en active
- 2017-10-13 UA UAA201905126A patent/UA125824C2/en unknown
- 2017-10-13 KR KR1020197014062A patent/KR102178692B1/en active IP Right Grant
- 2017-10-13 PL PL17783857T patent/PL3433256T3/en unknown
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