SG11201902949PA - Pharmaceutical compositions and methods of treating cardiovascular diseases - Google Patents
Pharmaceutical compositions and methods of treating cardiovascular diseasesInfo
- Publication number
- SG11201902949PA SG11201902949PA SG11201902949PA SG11201902949PA SG11201902949PA SG 11201902949P A SG11201902949P A SG 11201902949PA SG 11201902949P A SG11201902949P A SG 11201902949PA SG 11201902949P A SG11201902949P A SG 11201902949PA SG 11201902949P A SG11201902949P A SG 11201902949PA
- Authority
- SG
- Singapore
- Prior art keywords
- histamine
- international
- receptor antagonist
- agonist
- pct
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo Holosmomimionom oimIE (10) International Publication Number WO 2018/208723 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 45/00 (2006.01) A61K 31/00 (2006.01) A61K 47/00 (2006.01) A61K 38/00 (2006.01) A61P 9/00 (2006.01) (21) International Application Number: PCT/US2018/031505 (22) International Filing Date: 08 May 2018 (08.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/503,902 09 May 2017 (09.05.2017) US 62/652,812 04 April 2018 (04.04.2018) US (71) Applicant: CARDIX THERAPEUTICS LLC [US/US]; 8351 Gold Coast Drive, Unit 5, San Diego, CA 92126 (US). (72) Inventors: WANG, Jin, Jean; 8351 Gold Coast Drive, San Diego, CA 92126 (US). YAKATAN, Gerald, J.; 13813 Boquita Drive, Del Mar, CA 92014 (US). LIN, Ting, N.; 999 Cao Ling Road, Building 8, Lakexangdu, Suite 2, Room 304, Bengbu, Anhui (CN). GAO, Jing, H.; 999 Cao Ling Road, Building 8, Lakexangdu, Suite 2, Room 304, Beng- bu, Anhui (CN). (74) Agent: YU, Lin et al.; Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 1-1 • N N QC O N 00 O 1-1 N C (54) Title: PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES (57) : Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine Hi-receptor agonist, a histamine H2 -receptor agonist, a histamine H 3 -receptor antagonist, or a [3 2 -adrenoreceptor agonist. Also provided herein is a method of treating, preventing, or ameliorating a cardiovascular disease in a subject, comprising administering to the subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine Hi- receptor agonist, a histamine H 2 -receptor agonist, a histamine H 3 -receptor antagonist, or a [32-adrenoreceptor agonist.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762503902P | 2017-05-09 | 2017-05-09 | |
| US201862652812P | 2018-04-04 | 2018-04-04 | |
| PCT/US2018/031505 WO2018208723A1 (en) | 2017-05-09 | 2018-05-08 | Pharmaceutical compositions and methods of treating cardiovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201902949PA true SG11201902949PA (en) | 2019-05-30 |
Family
ID=64096944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201902949PA SG11201902949PA (en) | 2017-05-09 | 2018-05-08 | Pharmaceutical compositions and methods of treating cardiovascular diseases |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US11266651B2 (en) |
| EP (1) | EP3621593A4 (en) |
| JP (1) | JP6714796B2 (en) |
| KR (1) | KR102197429B1 (en) |
| CN (1) | CN109890366B (en) |
| AR (1) | AR113827A1 (en) |
| AU (1) | AU2018266106B2 (en) |
| BR (1) | BR112019023101B1 (en) |
| CA (1) | CA3038153C (en) |
| CL (1) | CL2019003216A1 (en) |
| CO (1) | CO2019010510A2 (en) |
| IL (1) | IL269901B (en) |
| JO (1) | JOP20190219A1 (en) |
| MX (1) | MX2019006233A (en) |
| PE (1) | PE20200741A1 (en) |
| PH (1) | PH12019502330A1 (en) |
| RU (1) | RU2715419C1 (en) |
| SG (1) | SG11201902949PA (en) |
| WO (1) | WO2018208723A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190219A1 (en) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | Pharmaceutical compositions and methods of treating cardiovascular diseases |
| US11510924B2 (en) | 2017-05-09 | 2022-11-29 | CARDIX Therapeutics, LLC | Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases |
| US10582716B1 (en) | 2019-06-14 | 2020-03-10 | Lennham Pharmaceuticals, Inc. | Deuterated caffeine and uses thereof |
| US20220226302A1 (en) * | 2021-01-20 | 2022-07-21 | Altos Neuroscience, Inc. | Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions |
| CN112717092A (en) * | 2021-01-22 | 2021-04-30 | 行艳丽 | Traditional Chinese medicine for preventing cardiovascular and cerebrovascular diseases and preparation method thereof |
| US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
| WO2023076547A1 (en) * | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Deuterated forms of alkaloid compounds and therapeutic uses thereof |
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2017
- 2017-06-16 JO JOP/2019/0219A patent/JOP20190219A1/en unknown
-
2018
- 2018-05-07 US US15/973,132 patent/US11266651B2/en active Active
- 2018-05-08 SG SG11201902949PA patent/SG11201902949PA/en unknown
- 2018-05-08 WO PCT/US2018/031505 patent/WO2018208723A1/en unknown
- 2018-05-08 BR BR112019023101-3A patent/BR112019023101B1/en not_active IP Right Cessation
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