JP2019536456A5 - - Google Patents
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- JP2019536456A5 JP2019536456A5 JP2019528833A JP2019528833A JP2019536456A5 JP 2019536456 A5 JP2019536456 A5 JP 2019536456A5 JP 2019528833 A JP2019528833 A JP 2019528833A JP 2019528833 A JP2019528833 A JP 2019528833A JP 2019536456 A5 JP2019536456 A5 JP 2019536456A5
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- Japan
- Prior art keywords
- nucleic acid
- exons
- mutation
- sequence
- egfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 108700024394 Exon Proteins 0.000 claims 12
- 230000035772 mutation Effects 0.000 claims 11
- 230000003321 amplification Effects 0.000 claims 8
- 238000003199 nucleic acid amplification method Methods 0.000 claims 8
- 238000012217 deletion Methods 0.000 claims 7
- 230000037430 deletion Effects 0.000 claims 7
- 230000037431 insertion Effects 0.000 claims 7
- 238000003780 insertion Methods 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 6
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 6
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 4
- 210000001808 exosome Anatomy 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 238000011529 RT qPCR Methods 0.000 claims 3
- 229940121647 egfr inhibitor Drugs 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
- 238000011123 anti-EGFR therapy Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- KHQCCEUMCUSZKM-KVQBGUIXSA-N (2r,3s,5r)-5-(6,8-diaminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol Chemical compound NC1=NC2=C(N)N=CN=C2N1[C@H]1C[C@H](O)[C@@H](CO)O1 KHQCCEUMCUSZKM-KVQBGUIXSA-N 0.000 claims 1
- ZKXCILYDBWPWKZ-UHFFFAOYSA-N 1,2,3-trimethoxy-4-(2-phenylethenyl)benzene Chemical compound COC1=C(OC)C(OC)=CC=C1C=CC1=CC=CC=C1 ZKXCILYDBWPWKZ-UHFFFAOYSA-N 0.000 claims 1
- RVWUFECBVNXJEN-YGOYTEALSA-N 1-[(2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)-2-prop-1-ynyloxolan-2-yl]pyrimidine-2,4-dione Chemical compound C1=CC(=O)NC(=O)N1[C@@]1(C#CC)C[C@H](O)[C@@H](CO)O1 RVWUFECBVNXJEN-YGOYTEALSA-N 0.000 claims 1
- MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 claims 1
- XSGZNYKZSOJIAM-XUOJEKSQSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;2-(10h-phenoxazin-1-yl)ethanamine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1.O1C2=CC=CC=C2NC2=C1C=CC=C2CCN XSGZNYKZSOJIAM-XUOJEKSQSA-N 0.000 claims 1
- MSHADEGKNJRMIU-YGOYTEALSA-N 4-amino-1-[(2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)-2-prop-1-ynyloxolan-2-yl]pyrimidin-2-one Chemical compound C1=CC(N)=NC(=O)N1[C@@]1(C#CC)C[C@H](O)[C@@H](CO)O1 MSHADEGKNJRMIU-YGOYTEALSA-N 0.000 claims 1
- MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 101150039808 Egfr gene Proteins 0.000 claims 1
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
- 239000002981 blocking agent Substances 0.000 claims 1
- 238000007418 data mining Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 108700021358 erbB-1 Genes Proteins 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000010801 machine learning Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000007619 statistical method Methods 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428059P | 2016-11-30 | 2016-11-30 | |
| US62/428,059 | 2016-11-30 | ||
| PCT/US2017/062370 WO2018102162A1 (en) | 2016-11-30 | 2017-11-17 | Methods and compositions to detect mutations in plasma using exosomal rna and cell free dna from non-small cell lung cancer patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536456A JP2019536456A (ja) | 2019-12-19 |
| JP2019536456A5 true JP2019536456A5 (cg-RX-API-DMAC7.html) | 2021-01-07 |
| JP7280823B2 JP7280823B2 (ja) | 2023-05-24 |
Family
ID=60766137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528833A Active JP7280823B2 (ja) | 2016-11-30 | 2017-11-17 | 非小細胞肺癌患者由来のエクソソームｒｎａ及び無細胞ｄｎａを使用して血漿中の変異を検出するための方法と組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11427864B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3548635B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7280823B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110446790B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017366813B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3044056A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018102162A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018102162A1 (en) | 2016-11-30 | 2018-06-07 | Exosome Diagnostics, Inc. | Methods and compositions to detect mutations in plasma using exosomal rna and cell free dna from non-small cell lung cancer patients |
| WO2019099629A1 (en) * | 2017-11-17 | 2019-05-23 | Gen-Probe Incorporated | COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID |
| CN108707671A (zh) * | 2018-06-12 | 2018-10-26 | 上海浦美生物医药科技有限公司 | 一种用于血液egfr c797s突变检测的引物探针组合物和试剂盒 |
| CN109207595A (zh) * | 2018-10-07 | 2019-01-15 | 浙江数问生物技术有限公司 | 一种人egfr基因t790m突变检测试剂盒及其检测方法 |
| US20220155304A1 (en) * | 2019-03-01 | 2022-05-19 | Mercy Bioanalytics, Inc. | Systems, compositions, and methods for target entity detection |
| CN110749734A (zh) * | 2019-12-06 | 2020-02-04 | 四川大学华西医院 | Gtf2i自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN111733158B (zh) * | 2020-02-11 | 2022-09-06 | 昆明医科大学 | 一种抑制hsa_circ_0003599表达的siRNA及其应用 |
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| CN111676290B (zh) * | 2020-07-02 | 2021-03-02 | 王伟佳 | 一种急性髓系白血病诱导分化治疗耐药的分子标志物及其应用 |
| CN111690752A (zh) * | 2020-07-16 | 2020-09-22 | 重庆浦洛通基因医学研究院有限公司 | 一种检测人类egfr基因突变的试剂盒及其方法 |
| CN112410335B (zh) * | 2020-11-03 | 2022-10-04 | 安徽大学 | 一种阻止lactb2表达来抑制非小细胞肺癌增殖生长的应用 |
| CN112501292B (zh) * | 2020-11-09 | 2022-12-02 | 中国人民解放军海军军医大学 | cFAM210A在制备肝癌诊断或术后预测试剂盒以及药物中的应用 |
| CN114480607B (zh) * | 2020-11-12 | 2024-04-30 | 上海昂朴生物科技有限公司 | 用于检测gipc1基因5’-utr区域cgg扩增次数的pcr检测试剂盒及应用 |
| CN112375810A (zh) * | 2020-11-16 | 2021-02-19 | 北京大学人民医院 | GnT-II基因下调表达作为肝癌预后标志物中的应用 |
| CN112370527B (zh) * | 2020-12-02 | 2022-11-01 | 成都医学院第一附属医院 | Dnajc19基因作为靶点在制备治疗非小细胞肺癌药物中的应用 |
| CN112481234B (zh) * | 2020-12-03 | 2023-09-22 | 重庆工业职业技术学院 | 一种焦磷酸酶突变体合成核酸糖类似物及其应用 |
| CN112795652A (zh) * | 2021-02-02 | 2021-05-14 | 中国科学院合肥物质科学研究院 | 环形RNAcircURI1在制备胃癌生物标志物的应用及其试剂盒 |
| US20240301413A1 (en) * | 2021-03-11 | 2024-09-12 | The Children's Hospital Of Philadelphia | Compositions and methods useful for the treatment of bone marrow failure diseases associated with ribosomopathies |
| CN113373206A (zh) * | 2021-08-03 | 2021-09-10 | 远辰生物科技(苏州)有限公司 | 一种egfr基因突变检测体系及其试剂盒 |
| CN113774135B (zh) * | 2021-09-17 | 2024-03-08 | 广东省人民医院 | 一组用于预测高级别浆液性卵巢癌预后的标志物及其应用 |
| CN113549697B (zh) * | 2021-09-23 | 2022-03-01 | 广州医科大学附属肿瘤医院 | 一种胃癌热化疗敏感标志物及其应用 |
| CN113913333B (zh) * | 2021-10-20 | 2022-09-02 | 南京世和基因生物技术股份有限公司 | 一种肺癌诊断标志物及用途 |
| CN114231529B (zh) * | 2021-11-17 | 2023-08-01 | 中国科学院昆明动物研究所 | 一种人pkmyt1ar基因及其应用 |
| CN114934048B (zh) * | 2022-02-22 | 2023-09-26 | 浙大城市学院 | 一种用于肿瘤治疗靶点和诊断生物标志物的circMTMR14及试剂盒和应用 |
| EP4491745A1 (en) * | 2022-03-08 | 2025-01-15 | Korea Advanced Institute of Science and Technology | Pharmaceutical composition comprising setmar inhibitor for preventing or treating cancer |
| CN114672564B (zh) * | 2022-03-31 | 2025-06-13 | 郑州颐和医院 | Tmod3和/或adsl在非小细胞癌中的应用 |
| CN114592006A (zh) * | 2022-04-29 | 2022-06-07 | 昆明理工大学 | Memo1基因的新用途 |
| CN114839375B (zh) * | 2022-05-23 | 2025-07-25 | 中国药科大学 | 与肺癌相关的尿液微囊泡蛋白及其应用 |
| CN114703287B (zh) * | 2022-06-06 | 2022-08-12 | 江苏省肿瘤医院 | CXorf56基因在治疗三阴性乳腺癌中的应用 |
| CN114703288B (zh) * | 2022-06-06 | 2022-09-13 | 珠海圣美生物诊断技术有限公司 | 用于扩增EGFR-T790M基因变异的blocker探针、引物组及其应用 |
| CN115896262B (zh) * | 2022-07-12 | 2025-05-30 | 重庆医科大学附属儿童医院 | 一种神经嵴疾病的诊断标志物及其应用 |
| CN115877004B (zh) * | 2022-08-09 | 2024-12-20 | 重庆大学 | 一种taok3抑制剂以及taok3及其抑制剂在调控天然免疫系统中的应用 |
| CN115948532A (zh) * | 2022-08-17 | 2023-04-11 | 湖南圣洲生物科技有限公司 | 基于数字pcr技术的sma检测试剂盒 |
| CN115354079A (zh) * | 2022-09-05 | 2022-11-18 | 复旦大学附属中山医院 | 一种用于检测egfr靶向药物治疗适用性的试剂盒 |
| WO2024064814A1 (en) * | 2022-09-21 | 2024-03-28 | Zephyr Ai, Inc. | Apparatus and methods for determining sensitivity to osimertinib |
| CN115595372B (zh) * | 2022-12-16 | 2023-03-14 | 南京世和基因生物技术股份有限公司 | 一种血浆游离dna来源的甲基化检测方法、肺癌诊断标志物以及试剂盒 |
| CN116240275A (zh) * | 2023-03-01 | 2023-06-09 | 申联生物医药（上海）股份有限公司 | 一种哺乳动物通用的rna内参基因及其引物和应用 |
| CN116751873B (zh) * | 2023-06-26 | 2025-04-08 | 宁夏大学 | 与牛十字部高相关的snp位点及应用 |
| CN117491636A (zh) * | 2023-11-21 | 2024-02-02 | 郑州大学 | 一种用于肺癌诊断的生物标志物及其应用 |
| CN118599905A (zh) * | 2024-02-21 | 2024-09-06 | 湖北文理学院 | Tm9sf1在用于抑制fen1进入细胞核中的应用 |
| CN120392963A (zh) * | 2024-03-26 | 2025-08-01 | 首都医科大学附属北京胸科医院 | 一种改善耐药性肺癌患者对egfr-tki抑制剂敏感性的药物 |
| CN118813812B (zh) * | 2024-06-26 | 2025-12-05 | 中国农业大学 | 一种与鸡不同周龄胸深相关的snp分子标记及应用 |
| CN118910268B (zh) * | 2024-06-26 | 2025-12-05 | 中国农业大学 | 一种与鸡六周龄体重性状相关的snp标记及其应用 |
| CN119709991B (zh) * | 2025-02-28 | 2025-06-24 | 华中科技大学同济医学院附属同济医院 | 芳基硫酸酯酶k在制备预防、延缓或治疗慢性阻塞性肺疾病药物中的应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| CA2218875C (en) | 1991-07-23 | 2000-11-07 | The Research Foundation Of State University Of New York | Improvements in the in situ pcr |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5556773A (en) | 1993-08-06 | 1996-09-17 | Yourno; Joseph | Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes |
| EP0954612A2 (en) | 1996-11-06 | 1999-11-10 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| US6994960B1 (en) | 1997-05-28 | 2006-02-07 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| US6277607B1 (en) | 1999-05-24 | 2001-08-21 | Sanjay Tyagi | High specificity primers, amplification methods and kits |
| GB9927320D0 (en) | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US6812023B1 (en) | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US6913879B1 (en) | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
| US6696271B2 (en) | 2001-08-23 | 2004-02-24 | The Regents Of The University Of California | Frozen tissue microarray technology for analysis of RNA, DNA, and proteins |
| WO2003023065A1 (en) | 2001-09-06 | 2003-03-20 | Syngenta Participations Ag | Dna methylation patterns |
| EP2339025B1 (en) | 2002-06-26 | 2013-10-09 | Cold Spring Harbor Laboratory | Methods for determining the methylation profiles |
| WO2004020667A1 (en) | 2002-09-02 | 2004-03-11 | Pamgene B.V. | Novel integrated microarray analysis |
| US7141371B2 (en) | 2002-09-06 | 2006-11-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for detecting and localizing DNA mutations by microarray |
| WO2006113590A2 (en) | 2005-04-15 | 2006-10-26 | Cedars-Sinai Medical Center | Flow-cytometric heteroduplex analysis for detection of genetic alterations |
| AU2007293280A1 (en) * | 2006-09-07 | 2008-03-13 | Astrazeneca Ab | Method for evaluating patients for treatment with drugs targeting RET receptor tyrosine kinase |
| CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
| US20090104120A1 (en) * | 2007-09-25 | 2009-04-23 | The Regents Of The University Of Michigan | Dlx1 cancer markers |
| KR101970908B1 (ko) * | 2008-02-01 | 2019-04-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| US20160041153A1 (en) * | 2008-11-12 | 2016-02-11 | Kirk Brown | Biomarker compositions and markers |
| WO2012135844A2 (en) * | 2011-04-01 | 2012-10-04 | Cornell University | Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers |
| CN105026911B (zh) | 2013-01-03 | 2019-01-22 | 外来体诊断公司 | 用于分离微囊泡的方法 |
| EP4253558B1 (en) * | 2013-03-15 | 2025-07-02 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| WO2014193999A2 (en) * | 2013-05-28 | 2014-12-04 | Caris Science, Inc. | Biomarker methods and compositions |
| US20150132256A1 (en) * | 2013-10-19 | 2015-05-14 | Trovagene, Inc. | Detecting and monitoring mutations in histiocytosis |
| US10519502B2 (en) * | 2013-10-31 | 2019-12-31 | The Children's Hospital Of Philadelphia | Mitochondrial disease genetic diagnostics |
| EP3125907A4 (en) * | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| CA3084920C (en) | 2014-07-09 | 2023-02-28 | Exosome Diagnostics, Inc. | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| WO2018102162A1 (en) | 2016-11-30 | 2018-06-07 | Exosome Diagnostics, Inc. | Methods and compositions to detect mutations in plasma using exosomal rna and cell free dna from non-small cell lung cancer patients |
-
2017
- 2017-11-17 WO PCT/US2017/062370 patent/WO2018102162A1/en not_active Ceased
- 2017-11-17 AU AU2017366813A patent/AU2017366813B2/en active Active
- 2017-11-17 EP EP17817952.9A patent/EP3548635B1/en active Active
- 2017-11-17 US US16/463,820 patent/US11427864B2/en active Active
- 2017-11-17 CN CN201780084970.6A patent/CN110446790B/zh active Active
- 2017-11-17 JP JP2019528833A patent/JP7280823B2/ja active Active
- 2017-11-17 CA CA3044056A patent/CA3044056A1/en active Pending
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