JP2019535689A5 - - Google Patents
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- Publication number
- JP2019535689A5 JP2019535689A5 JP2019522867A JP2019522867A JP2019535689A5 JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5 JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- oxo
- triazolo
- benzamide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZAXQHZSTRFLUMJ-UHFFFAOYSA-N CCCCCCC(N1)=NN(C(C)CS=C)C1=O Chemical compound CCCCCCC(N1)=NN(C(C)CS=C)C1=O ZAXQHZSTRFLUMJ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022103480A JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| PCT/EP2017/077301 WO2018077944A2 (en) | 2016-10-27 | 2017-10-25 | 4,5-annulated 1,2,4-triazolones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Division JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535689A JP2019535689A (ja) | 2019-12-12 |
| JP2019535689A5 true JP2019535689A5 (enExample) | 2020-12-03 |
| JP7680184B2 JP7680184B2 (ja) | 2025-05-20 |
Family
ID=60293935
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522867A Active JP7680184B2 (ja) | 2016-10-27 | 2017-10-25 | ４，５－縮環１，２，４－トリアゾロン |
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10968216B2 (enExample) |
| EP (1) | EP3532474B1 (enExample) |
| JP (3) | JP7680184B2 (enExample) |
| CN (2) | CN110248937B (enExample) |
| CA (1) | CA3041650A1 (enExample) |
| TW (1) | TW201827430A (enExample) |
| UY (1) | UY37460A (enExample) |
| WO (1) | WO2018077944A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190094A1 (ar) | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| US10968216B2 (en) | 2016-10-27 | 2021-04-06 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| TW201945346A (zh) | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
| TW202043208A (zh) * | 2019-01-11 | 2020-12-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| AU2020338985A1 (en) * | 2019-08-29 | 2022-04-14 | Janssen Biotech, Inc. | Substituted urea dihydroorotate dehydrogenase inhibitors |
| CN114630822B (zh) * | 2019-10-10 | 2024-10-01 | 詹森生物科技公司 | 联芳基二氢乳清酸脱氢酶抑制剂 |
| EP4166551A4 (en) * | 2020-05-29 | 2024-07-10 | Medshine Discovery Inc. | Triazolone compound |
| JP2023535346A (ja) * | 2020-07-14 | 2023-08-17 | ナンジン ゼンシャイン ファーマシューティカルズ カンパニー リミテッド | Ｄｈｏｄｈ阻害剤としての化合物 |
| CN111773214B (zh) * | 2020-07-17 | 2021-04-20 | 中国人民解放军军事科学院军事医学研究院 | 2,4,5-三取代的1,2,4-三唑酮在制备抗病毒药物中的用途 |
| WO2022070069A1 (en) * | 2020-09-30 | 2022-04-07 | Janssen Biotech, Inc. | Dihydroorotate dehydrogenase inhibitors |
| US20240228482A1 (en) * | 2021-04-16 | 2024-07-11 | Hotspot Therapeutics, Inc. | Compounds, compositions and methods of treating cancer |
| CN117751115A (zh) * | 2021-04-16 | 2024-03-22 | 热点治疗公司 | 化合物、组合物和治疗癌症的方法 |
| WO2023280181A1 (zh) * | 2021-07-05 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | 用作dhodh抑制剂的1,2,4-三唑酮衍生物及其制备方法和用途 |
| CN118284603A (zh) * | 2021-11-26 | 2024-07-02 | 南京明德新药研发有限公司 | 三氮唑酮类化合物的晶型及其应用 |
| EP4554586A1 (en) * | 2022-07-12 | 2025-05-21 | Hotspot Therapeutics, Inc. | Cbl-b inhibitors and anti-pd1/anti-pd-l1 for use in the treatment of cancer |
| WO2024015863A1 (en) * | 2022-07-12 | 2024-01-18 | Hotspot Therapeutics, Inc. | Cbl-b inhibitor, compositions comprising a cbl-b inhibitor in a method of treating a disease associated with cell proliferation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19627901A1 (de) | 1996-07-11 | 1998-01-15 | Bayer Ag | Substituierte aromatische Carbonylverbindungen und ihre Derivate |
| DE19901846A1 (de) | 1999-01-19 | 2000-07-20 | Bayer Ag | Substituierte Arylheterocyclen |
| US6444613B1 (en) | 1999-03-12 | 2002-09-03 | Hoechst Schering Agrevo Gmbh | Defoliant |
| WO2002046386A2 (en) * | 2000-10-30 | 2002-06-13 | Pharmacia Corporation | Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| CA2746221A1 (en) | 2008-12-08 | 2010-07-08 | Sirtris Pharmaceuticals, Inc. | Isoindolinone and related analogs as sirtuin modulators |
| SG174125A1 (en) | 2009-04-02 | 2011-10-28 | Merck Serono Sa | Dihydroorotate dehydrogenase inhibitors |
| US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
| CN105441399A (zh) * | 2010-12-16 | 2016-03-30 | 细胞制药有限公司 | 新的7β-羟基类固醇脱氢酶突变体和制备熊去氧胆酸的方法 |
| EP2675440B1 (en) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| UA112096C2 (uk) | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| TWI568722B (zh) * | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| CN105121647A (zh) * | 2012-11-01 | 2015-12-02 | 不列颠哥伦比亚大学 | 细胞色素p450和细胞色素p450还原酶多肽、编码核酸分子及其用途 |
| ES2694829T3 (es) | 2013-02-25 | 2018-12-27 | Aurigene Discovery Technologies Limited | Derivados de benzotriazol trisustituido como inhibidores de dihidroorotato oxigenasa |
| CN104561093A (zh) * | 2014-12-25 | 2015-04-29 | 华东师范大学 | 一种重组人源CYP3A4/CPR/cyt b5蛋白共转染共表达的方法 |
| US20160251341A1 (en) | 2015-02-27 | 2016-09-01 | Verseon Corporation | Substituted triazole compounds as serine protease inhibitors |
| CN106543139B (zh) | 2015-09-17 | 2020-03-17 | 沈阳中化农药化工研发有限公司 | 一种三唑酮类化合物及其用途 |
| US10968216B2 (en) | 2016-10-27 | 2021-04-06 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| US20190307728A1 (en) * | 2018-04-10 | 2019-10-10 | Bayer Pharma Aktiengesellschaft | Methods of treatment with a 2,4,5-trisubstituted 1,2,4-triazolone |
| TW201945346A (zh) * | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
-
2017
- 2017-10-25 US US16/345,178 patent/US10968216B2/en active Active
- 2017-10-25 EP EP17797091.0A patent/EP3532474B1/en active Active
- 2017-10-25 CA CA3041650A patent/CA3041650A1/en active Pending
- 2017-10-25 WO PCT/EP2017/077301 patent/WO2018077944A2/en not_active Ceased
- 2017-10-25 CN CN201780067556.4A patent/CN110248937B/zh active Active
- 2017-10-25 JP JP2019522867A patent/JP7680184B2/ja active Active
- 2017-10-25 CN CN202210298141.0A patent/CN114921391B/zh active Active
- 2017-10-27 UY UY0001037460A patent/UY37460A/es unknown
- 2017-10-27 TW TW106137268A patent/TW201827430A/zh unknown
-
2021
- 2021-01-28 US US17/161,615 patent/US11787797B2/en active Active
-
2022
- 2022-06-28 JP JP2022103480A patent/JP2022130571A/ja active Pending
-
2024
- 2024-02-29 JP JP2024030029A patent/JP7747799B2/ja active Active
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