JP2019535689A5 - - Google Patents
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- Publication number
- JP2019535689A5 JP2019535689A5 JP2019522867A JP2019522867A JP2019535689A5 JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5 JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019522867 A JP2019522867 A JP 2019522867A JP 2019535689 A5 JP2019535689 A5 JP 2019535689A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- oxo
- triazolo
- benzamide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZAXQHZSTRFLUMJ-UHFFFAOYSA-N CCCCCCC(N1)=NN(C(C)CS=C)C1=O Chemical compound CCCCCCC(N1)=NN(C(C)CS=C)C1=O ZAXQHZSTRFLUMJ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022103480A JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| CNPCT/CN2016/103642 | 2016-10-27 | ||
| PCT/EP2017/077301 WO2018077944A2 (en) | 2016-10-27 | 2017-10-25 | 4,5-annulated 1,2,4-triazolones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Division JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535689A JP2019535689A (ja) | 2019-12-12 |
| JP2019535689A5 true JP2019535689A5 (enExample) | 2020-12-03 |
| JP7680184B2 JP7680184B2 (ja) | 2025-05-20 |
Family
ID=60293935
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522867A Active JP7680184B2 (ja) | 2016-10-27 | 2017-10-25 | ４，５－縮環１，２，４－トリアゾロン |
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103480A Pending JP2022130571A (ja) | 2016-10-27 | 2022-06-28 | ４，５－縮環１，２，４－トリアゾロン |
| JP2024030029A Active JP7747799B2 (ja) | 2016-10-27 | 2024-02-29 | ４，５－縮環１，２，４－トリアゾロン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10968216B2 (enExample) |
| EP (1) | EP3532474B1 (enExample) |
| JP (3) | JP7680184B2 (enExample) |
| CN (2) | CN114921391B (enExample) |
| CA (1) | CA3041650A1 (enExample) |
| TW (1) | TW201827430A (enExample) |
| UY (1) | UY37460A (enExample) |
| WO (1) | WO2018077944A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190094A1 (ar) | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| WO2018077944A2 (en) | 2016-10-27 | 2018-05-03 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| TW201945346A (zh) | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
| TW202043208A (zh) * | 2019-01-11 | 2020-12-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| US20220298107A1 (en) * | 2019-08-29 | 2022-09-22 | Janssen Biotech, Inc. | Substituted urea dihydroorotate dehydrogenase inhibitors |
| MX2022004335A (es) * | 2019-10-10 | 2022-07-19 | Janssen Biotech Inc | Biarilos como inhibidores de la dihidroorotato deshidrogenasa. |
| US12606540B2 (en) | 2020-05-29 | 2026-04-21 | Medshine Discovery Inc. | Triazolone compound |
| WO2022012548A1 (en) * | 2020-07-14 | 2022-01-20 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Compounds as dhodh inhibitors |
| CN111773214B (zh) * | 2020-07-17 | 2021-04-20 | 中国人民解放军军事科学院军事医学研究院 | 2,4,5-三取代的1,2,4-三唑酮在制备抗病毒药物中的用途 |
| WO2022070069A1 (en) * | 2020-09-30 | 2022-04-07 | Janssen Biotech, Inc. | Dihydroorotate dehydrogenase inhibitors |
| IL307732A (en) * | 2021-04-16 | 2023-12-01 | Hotspot Therapeutics Inc | Compounds, preparations and methods for the treatment of cancer |
| WO2023280181A1 (zh) * | 2021-07-05 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | 用作dhodh抑制剂的1,2,4-三唑酮衍生物及其制备方法和用途 |
| CN118284603A (zh) * | 2021-11-26 | 2024-07-02 | 南京明德新药研发有限公司 | 三氮唑酮类化合物的晶型及其应用 |
| JP2025523057A (ja) * | 2022-07-12 | 2025-07-17 | ホットスポット セラピューティクス インコーポレイテッド | がん処置における使用のためのｃｂｌ－ｂ阻害剤及び抗ｐｄ１／抗ｐｄ－ｌ１ |
| JP2025523056A (ja) * | 2022-07-12 | 2025-07-17 | ホットスポット セラピューティクス インコーポレイテッド | 細胞増殖関連疾患の処置方法におけるｃｂｌ－ｂ阻害剤、ｃｂｌ－ｂ阻害剤を含む組成物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19627901A1 (de) | 1996-07-11 | 1998-01-15 | Bayer Ag | Substituierte aromatische Carbonylverbindungen und ihre Derivate |
| DE19901846A1 (de) | 1999-01-19 | 2000-07-20 | Bayer Ag | Substituierte Arylheterocyclen |
| AR022889A1 (es) | 1999-03-12 | 2002-09-04 | Bayer Cropscience Ag | Agente desfoliante |
| AU2002241768A1 (en) * | 2000-10-30 | 2002-06-18 | Pharmacia Corporation | Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase |
| WO2003006424A1 (en) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| MX2011006084A (es) | 2008-12-08 | 2011-09-06 | Sirtris Pharmaceuticals Inc | Isoindolinona y analogos relacionados como moduladores de sirtuina. |
| SG174125A1 (en) * | 2009-04-02 | 2011-10-28 | Merck Serono Sa | Dihydroorotate dehydrogenase inhibitors |
| US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
| AU2011343222B2 (en) * | 2010-12-16 | 2016-09-29 | Pharmazell Gmbh | Novel 7B-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid |
| WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| TWI568722B (zh) * | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| BR112015009774A2 (pt) * | 2012-11-01 | 2017-12-05 | Univ British Columbia | polipeptídeos citocromo p450 e citocromo p450 redutase, codificando moléculas de ácido nucléicos e usos das mesmas |
| HUE042032T2 (hu) | 2013-02-25 | 2019-06-28 | Aurigene Discovery Tech Ltd | Triszubsztituált benzotriazol-származékok, melyek dihidro-orotát-oxigenáz-inhibitor hatásúak |
| CN104561093A (zh) * | 2014-12-25 | 2015-04-29 | 华东师范大学 | 一种重组人源CYP3A4/CPR/cyt b5蛋白共转染共表达的方法 |
| US20160251341A1 (en) | 2015-02-27 | 2016-09-01 | Verseon Corporation | Substituted triazole compounds as serine protease inhibitors |
| CN106543139B (zh) | 2015-09-17 | 2020-03-17 | 沈阳中化农药化工研发有限公司 | 一种三唑酮类化合物及其用途 |
| WO2018077944A2 (en) | 2016-10-27 | 2018-05-03 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
| US20190307728A1 (en) * | 2018-04-10 | 2019-10-10 | Bayer Pharma Aktiengesellschaft | Methods of treatment with a 2,4,5-trisubstituted 1,2,4-triazolone |
| TW201945346A (zh) * | 2018-04-10 | 2019-12-01 | 德商拜耳廠股份有限公司 | 2,4,5-三取代的1,2,4-三唑酮之製備方法 |
| WO2019197269A1 (en) * | 2018-04-11 | 2019-10-17 | Bayer Aktiengesellschaft | Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer |
-
2017
- 2017-10-25 WO PCT/EP2017/077301 patent/WO2018077944A2/en not_active Ceased
- 2017-10-25 CN CN202210298141.0A patent/CN114921391B/zh active Active
- 2017-10-25 CA CA3041650A patent/CA3041650A1/en active Pending
- 2017-10-25 US US16/345,178 patent/US10968216B2/en active Active
- 2017-10-25 CN CN201780067556.4A patent/CN110248937B/zh active Active
- 2017-10-25 JP JP2019522867A patent/JP7680184B2/ja active Active
- 2017-10-25 EP EP17797091.0A patent/EP3532474B1/en active Active
- 2017-10-27 UY UY0001037460A patent/UY37460A/es unknown
- 2017-10-27 TW TW106137268A patent/TW201827430A/zh unknown
-
2021
- 2021-01-28 US US17/161,615 patent/US11787797B2/en active Active
-
2022
- 2022-06-28 JP JP2022103480A patent/JP2022130571A/ja active Pending
-
2024
- 2024-02-29 JP JP2024030029A patent/JP7747799B2/ja active Active
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