CN114921391B - 4,5-环状1,2,4-三唑酮 - Google Patents

4,5-环状1,2,4-三唑酮 Download PDF

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CN114921391B
CN114921391B CN202210298141.0A CN202210298141A CN114921391B CN 114921391 B CN114921391 B CN 114921391B CN 202210298141 A CN202210298141 A CN 202210298141A CN 114921391 B CN114921391 B CN 114921391B
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CN114921391A (zh
Inventor
S.N.格拉德尔
D.阮
K.艾斯
J.巩特尔
T.斯特菲尔德
A.詹泽
S.克里斯蒂安
T.米勒
S.埃尔谢赫
H.J.周
C.赵
D.B.赛克斯
S.J.费拉拉
K.刘
S.A.赫伯特
C.默兹
M.尼胡斯
C.F.尼辛格
M.谢弗
K.齐默尔曼
J.克纳布莱恩
K.泰德
T.福佩尔
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Bayer AG
Bayer Pharma AG
General Hospital Corp
Broad Institute Inc
Harvard University
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Bayer AG
Bayer Pharma AG
General Hospital Corp
Broad Institute Inc
Harvard University
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CN202210298141.0A 2016-10-27 2017-10-25 4,5-环状1,2,4-三唑酮 Active CN114921391B (zh)

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CNPCT/CN2016/103642 2016-10-27
CNPCT/CN2016/103642 2016-10-27
CN202210298141.0A CN114921391B (zh) 2016-10-27 2017-10-25 4,5-环状1,2,4-三唑酮
PCT/EP2017/077301 WO2018077944A2 (en) 2016-10-27 2017-10-25 4,5-annulated 1,2,4-triazolones
CN201780067556.4A CN110248937B (zh) 2016-10-27 2017-10-25 4,5-环状1,2,4-三唑酮

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EP (1) EP3532474B1 (enExample)
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CN (2) CN114921391B (enExample)
CA (1) CA3041650A1 (enExample)
TW (1) TW201827430A (enExample)
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WO2018077944A2 (en) 2016-10-27 2018-05-03 Bayer Aktiengesellschaft 4,5-annulated 1,2,4-triazolones
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CN115667245B (zh) * 2020-05-29 2024-05-17 南京明德新药研发有限公司 三氮唑酮类化合物
CA3184985A1 (en) * 2020-07-14 2022-01-20 Nanjing Zenshine Pharmaceuticals Co., Ltd. Compounds as dhodh inhibitors
CN111773214B (zh) * 2020-07-17 2021-04-20 中国人民解放军军事科学院军事医学研究院 2,4,5-三取代的1,2,4-三唑酮在制备抗病毒药物中的用途
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CN117616026A (zh) * 2021-07-05 2024-02-27 微境生物医药科技(上海)有限公司 用作dhodh抑制剂的1,2,4-三唑酮衍生物及其制备方法和用途
CN118284603A (zh) * 2021-11-26 2024-07-02 南京明德新药研发有限公司 三氮唑酮类化合物的晶型及其应用
AU2023306375A1 (en) * 2022-07-12 2025-02-06 Hotspot Therapeutics, Inc. Cbl-b inhibitors and anti-pd1/anti-pd-l1 for use in the treatment of cancer
EP4554582A1 (en) * 2022-07-12 2025-05-21 Hotspot Therapeutics, Inc. Cbl-b inhibitor, compositions comprising a cbl-b inhibitor in a method of treating a disease associated with cell proliferation

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